Antiproliferative activity of some 1,4-dimethylcarbazoles on cells that express estrogen receptors: part I

Anna CarusoDepartment of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende (CS), Italy

Adele ChimentoDepartment of Pharmaco-Biology, University of Calabria, Arcavacata di Rende (CS), Italy

Hussein El-KashefChemistry Department, Faculty of Science, Assiut University, Assiut, Egypt

Jean-Charles LancelotUniversité de Caen Basse-Normandie, U.F.R. des Sciences Pharmaceutiques, Centre d’Etudes et de Recherche sur le Médicament de Normandie, Boulevard Becquerel, Caen Cedex, France

Antonella PannoDepartment of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende (CS), Italy

Vincenzo PezziDepartment of Pharmaco-Biology, University of Calabria, Arcavacata di Rende (CS), Italy

Carmela SaturninoDepartment of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano (SA), Italy

Maria Stefania SinicropiDepartment of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende (CS), ItalyCorrespondence[email protected]

Rosa SirianniDepartment of Pharmaco-Biology, University of Calabria, Arcavacata di Rende (CS), Italy

Sylvain RaultUniversité de Caen Basse-Normandie, U.F.R. des Sciences Pharmaceutiques, Centre d’Etudes et de Recherche sur le Médicament de Normandie, Boulevard Becquerel, Caen Cedex, France

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Abstract

Several 9H-carbazole derivatives are used for various pharmacological applications. Many of these compounds demonstrated cytotoxic and anticancer activities. In this work, we have investigated the cytotoxic activity of some substituted carbazoles against cancer cell lines (MCF-7, and ISK). The derivative 2a showed the highest inhibitory activity against both cell lines.

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Acknowledgements

We are thankful to Dr. Ewa Surmacz (Sbarro Institute for Cancer Research and Molecular Medicine, Philadelphia, PA, USA) and to Dr. D. Picard (University of Geneva, Geneva, Switzerland) for their kind offer of MCF-7 and Ishikawa cell lines, respectively.

Declaration of interest

The authors report no conflicts of interest.

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Antiproliferative activity of some 1,4-dimethylcarbazoles on cells that express estrogen receptors: part I

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Antiproliferative activity of some 1,4-dimethylcarbazoles on cells that express estrogen receptors: part I

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