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Abstract
A new series of four biologically active triazole derived Schiff base ligands (L1–L4) and their cobalt(II), nickel(II), copper(II) and zinc(II) complexes (1–16) have been synthesized and characterized. The ligands were prepared by the condensation reaction of 3-amino-5-methylthio-1H-1,2,4-triazole with chloro-, bromo- and nitro-substituted 2-hydroxybenzaldehyde in an equimolar ratio. The antibacterial and antifungal bioactivity data showed the metal(II) complexes to be more potent antibacterial and antifungal than the parent Schiff bases against one or more bacterial and fungal species.
Acknowledgment
One of us (M.H.) is grateful to Higher Education Commission (HEC), Government of Pakistan for the award to carry out this research. We are also thankful to HEJ research Institute of Chemistry, University of Karachi, Pakistan, for providing help in undertaking NMR, mass spectral and antibacterial/antifungal data.
Declaration of interest
The authors report no conflict of interest and are responsible for the contents.