Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 28, Issue 5 (2013)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 28, Issue 5 (2013)

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Research Article

Article
Synthesis, characterization and antimicrobial activity of novel xanthene sulfonamide and carboxamide derivatives
Muharrem Kaya, Ersin Demir & Hatice Bekci
Pages: 885-893
Published online: 18 Jul 2012
AbstractforSynthesis, characterization and antimicrobial activity of novel xanthene sulfonamide and carboxamide derivatives | Full Text | References | PDF (773.3 KB)
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Article
Analysis of enzyme activity regulation by non-denaturing electrophoresis and application of this regulation for enzyme reactor production
Youji Shimazaki & Shizuka Miki
Pages: 894-899
Published online: 18 Jul 2012
AbstractforAnalysis of enzyme activity regulation by non-denaturing electrophoresis and application of this regulation for enzyme reactor production | Full Text | References | PDF (695.1 KB)
  • 753 Views
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Article
Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present in Azadirachta indica (neem) useful for the treatment of diabetes
Abhishek Mukherjee & Subhabrata Sengupta
Pages: 900-910
Published online: 18 Jul 2012
AbstractforCharacterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present in Azadirachta indica (neem) useful for the treatment of diabetes | Full Text | References | PDF (1 MB)
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Article
Purification of glutathione S-transferase isoenzymes from tumour and nontumour human stomach and inhibitory effects of some heavy metals on enzymes activities
Ramazan Demirdag, Emrah Yerlikaya, Omer Irfan Kufrevioglu & Cemal Gundogdu
Pages: 911-915
Published online: 18 Jul 2012
AbstractforPurification of glutathione S-transferase isoenzymes from tumour and nontumour human stomach and inhibitory effects of some heavy metals on enzymes activities | Full Text | References | PDF (615.4 KB)
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Article
Structure-based design and biochemical evaluation of sulfanilamide derivatives as hepatitis B virus capsid assembly inhibitors
Min-Hyung Cho, Jin-Su Song, Hie-Joon Kim, Sung-Gyoo Park & Guhung Jung
Pages: 916-925
Published online: 18 Jul 2012
AbstractforStructure-based design and biochemical evaluation of sulfanilamide derivatives as hepatitis B virus capsid assembly inhibitors | Full Text | References | PDF (1.4 MB)
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Article
Synthesis and characterization of some hydroxypyridone derivatives and their evaluation as antimicrobial agents
Hassan M. Faidallah, Sherif A. F. Rostom, Khalid A. Khan & Salem A. Basaif
Pages: 926-935
Published online: 18 Jul 2012
AbstractforSynthesis and characterization of some hydroxypyridone derivatives and their evaluation as antimicrobial agents | Full Text | References | PDF (770.6 KB)
  • 1458 Views
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Article
Insight into the structural similarity between HIV protease and secreted aspartic protease-2 and binding mode analysis of HIV-Candida albicans inhibitors
Chiara Calugi, Antonio Guarna & Andrea Trabocchi
Pages: 936-943
Published online: 18 Jul 2012
AbstractforInsight into the structural similarity between HIV protease and secreted aspartic protease-2 and binding mode analysis of HIV-Candida albicans inhibitors | Full Text | References | PDF (1.3 MB)
  • 1141 Views
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Article
Antibacterial and antifungal metal based triazole Schiff bases
Zahid H. Chohan & Muhammad Hanif
Pages: 944-953
Published online: 18 Jul 2012
AbstractforAntibacterial and antifungal metal based triazole Schiff bases | Full Text | References | PDF (759.6 KB)
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Article
(−)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells
Hwa Jin Lee, Hua Li, Hee Ryun Chang, Hyeyoun Jung, Da Yeon Lee & Jae-Ha Ryu
Pages: 954-959
Published online: 18 Jul 2012
Abstractfor(−)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells | Full Text | References | PDF (747.4 KB)
  • 765 Views
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Article
Synthesis and antileishmanial activity of novel pyridinium-hydrazone derivatives
Vildan Alptuzun, Gokcer Cakiroglu, M. Emin Limoncu, Bayri Erac, Mine Hosgor-Limoncu & Ercin Erciyas
Pages: 960-967
Published online: 18 Jul 2012
AbstractforSynthesis and antileishmanial activity of novel pyridinium-hydrazone derivatives | Full Text | References | PDF (721.2 KB)
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Article
Synthesis, characterization, and antimicrobial evaluation of some new hydrazinecarbothioamide, 1,2,4-triazole and 1,3,4-thiadiazole derivatives
Nuray Ulusoy Güzeldemirci, Dilek Şatana & Ömer Küçükbasmacı
Pages: 968-973
Published online: 30 Jul 2012
AbstractforSynthesis, characterization, and antimicrobial evaluation of some new hydrazinecarbothioamide, 1,2,4-triazole and 1,3,4-thiadiazole derivatives | Full Text | References | PDF (793.6 KB)
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Article
1-(3-Aminomethyl-4-hydroxyphenyl)-3-pyridinyl-2-propen-1-ones: A novel group of tumour-selective cytotoxins
Sinan Bilginer, Halise Inci Gul, Ebru Mete, Umashankar Das, Hiroshi Sakagami, Naoki Umemura & Jonathan Richard Dimmock
Pages: 974-980
Published online: 18 Jul 2012
Abstractfor1-(3-Aminomethyl-4-hydroxyphenyl)-3-pyridinyl-2-propen-1-ones: A novel group of tumour-selective cytotoxins | Full Text | References | PDF (818.9 KB) | Supplemental
  • 811 Views
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Article
1,2,4-thiadiazol-5(4H)-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition
Guzmán Alvarez, Beatriz Aguirre-López, Nallely Cabrera, Eliã B. Marins, Luzineide Tinoco, Carlos Ignacio Batthyány, Marieta Tuena de Gómez-Puyou, Armando Gómez Puyou, Ruy Pérez-Montfort, Hugo Cerecetto & Mercedes González
Pages: 981-989
Published online: 18 Jul 2012
Abstractfor1,2,4-thiadiazol-5(4H)-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition | Full Text | References | PDF (1.1 MB)
  • 691 Views
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Article
OXA-162, a novel variant of OXA-48 displays extended hydrolytic activity towards imipenem, meropenem and doripenem
Murat Kasap, Sinem Torol, Fetiye Kolayli, Devrim Dundar & Haluk Vahaboglu
Pages: 990-996
Published online: 30 Jul 2012
AbstractforOXA-162, a novel variant of OXA-48 displays extended hydrolytic activity towards imipenem, meropenem and doripenem | Full Text | References | PDF (743.5 KB)
  • 1470 Views
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Article
Isolation of a new bioactive cinnamic acid derivative from the whole plant of Viola betonicifolia
Naveed Muhammad, Muhammad Saeed, Achyut Adhikari, Khalid Muhammad Khan & Haroon Khan
Pages: 997-1001
Published online: 18 Jul 2012
AbstractforIsolation of a new bioactive cinnamic acid derivative from the whole plant of Viola betonicifolia | Full Text | References | PDF (676.4 KB)
  • 1736 Views
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Article
Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors
Laura De Luca, Stefania Ferro, Francesca Morreale, Frauke Christ, Zeger Debyser, Alba Chimirri & Rosaria Gitto
Pages: 1002-1009
Published online: 18 Jul 2012
AbstractforFragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors | Full Text | References | PDF (886.6 KB)
  • 743 Views
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Article
Analysis of the activation of acetylcholinesterase by carbon nanoparticles using a monolithic immobilized enzyme microreactor: role of the water molecules in the active site gorge
Firas Ibrahim, Claire Andre, Anne Iutzeler & Yves Claude Guillaume
Pages: 1010-1014
Published online: 10 Sep 2013
AbstractforAnalysis of the activation of acetylcholinesterase by carbon nanoparticles using a monolithic immobilized enzyme microreactor: role of the water molecules in the active site gorge | Full Text | References | PDF (715.3 KB)
  • 647 Views
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Article
Pharmacological descriptors related to the binding of Gp120 to CD4 corresponding to 60 representative HIV-1 strains
Octavian Calborean, Maria Mernea, Speranta Avram & Dan Florin Mihailescu
Pages: 1015-1025
Published online: 07 Sep 2012
AbstractforPharmacological descriptors related to the binding of Gp120 to CD4 corresponding to 60 representative HIV-1 strains | Full Text | References | PDF (944.8 KB)
  • 333 Views
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Article
Evaluation of new antimicrobial agents on Bacillus spp. strains: docking affinity and in vitro inhibition of glutamate-racemase
Feliciano Tamay-Cach, José Correa-Basurto, Lourdes Villa-Tanaca, Teresa Mancilla-Percino, Margarita Juárez-Montiel & José G. Trujillo-Ferrara
Pages: 1026-1033
Published online: 07 Aug 2012
AbstractforEvaluation of new antimicrobial agents on Bacillus spp. strains: docking affinity and in vitro inhibition of glutamate-racemase | Full Text | References | PDF (1,023.1 KB)
  • 832 Views
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Article
C-terminal trans,trans-muconic acid ethyl ester partial retro-inverso pseudopeptides as proteasome inhibitors
Christian Franceschini, Claudio Trapella, Rosaria Calia, Alessandra Scotti, Fabio Sforza, Riccardo Gavioli & Mauro Marastoni
Pages: 1034-1039
Published online: 07 Aug 2012
AbstractforC-terminal trans,trans-muconic acid ethyl ester partial retro-inverso pseudopeptides as proteasome inhibitors | Full Text | References | PDF (773.5 KB)
  • 763 Views
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Article
Design, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors
Leyla Yurttaş, Zafer Asım Kaplancıklı & Yusuf Özkay
Pages: 1040-1047
Published online: 07 Aug 2012
AbstractforDesign, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors | Full Text | References | PDF (785.3 KB)
  • 1837 Views
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Article
Design and synthesis of 3-[(7-chloro-1-oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents
V. Raja Solomon, W. Haq, Kumkum Srivastava, Sunil K. Puri & S. B. Katti
Pages: 1048-1053
Published online: 07 Sep 2012
AbstractforDesign and synthesis of 3-[(7-chloro-1-oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents | Full Text | References | PDF (737.9 KB)
  • 645 Views
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Article
Physicochemical characterization of an aspin (rBm-33) from a filarial parasite Brugia malayi against the important human aspartic proteases
Nagampalli Raghavendra Sashi Krishna, N. S. A. Krushna, R. B. Narayanan, S. S. Rajan & K. Gunasekaran
Pages: 1054-1060
Published online: 07 Sep 2012
AbstractforPhysicochemical characterization of an aspin (rBm-33) from a filarial parasite Brugia malayi against the important human aspartic proteases | Full Text | References | PDF (992.5 KB)
  • 636 Views
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Article
Inhibitory role of monovalent ions on rat brain cortex adenylyl cyclase activity
Ivana Nikolic, Marina Mitrovic, Ivanka Zelen, Milan Zaric, Tatjana Kastratovic, Marijana Stanojevic, Milutin Nenadovic & Tomislav Stojanovic
Pages: 1061-1066
Published online: 20 Sep 2012
AbstractforInhibitory role of monovalent ions on rat brain cortex adenylyl cyclase activity | Full Text | References | PDF (674.7 KB)
  • 363 Views
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Article
In vitro effects of cinnamic acid derivatives on protein tyrosine phosphatase 1B
Sirichai Adisakwattana, Jirawan Pongsuwan, Chompunut Wungcharoen & Sirintorn Yibchok-anun
Pages: 1067-1072
Published online: 07 Sep 2012
AbstractforIn vitro effects of cinnamic acid derivatives on protein tyrosine phosphatase 1B | Full Text | References | PDF (720.4 KB)
  • 1321 Views
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Article
Synthesis and paroxonase activities of novel bromophenols
Yusuf Akbaba, Cüneyt Türkeş, Leyla Polat, Hakan Söyüt, Ertan Şahin, Abdullah Menzek, Süleyman Göksu & Şükrü Beydemir
Pages: 1073-1079
Published online: 20 Sep 2012
AbstractforSynthesis and paroxonase activities of novel bromophenols | Full Text | References | PDF (1 MB)
  • 942 Views
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Article
Synthesis, biological evaluation and docking studies of new pyrrolo[2,3-d] pyrimidine derivatives as Src family-selective tyrosine kinase inhibitors
Sebla Dincer, Kadir Taylan Cetin, Arzu Onay-Besikci & Süreyya Ölgen
Pages: 1080-1087
Published online: 07 Sep 2012
AbstractforSynthesis, biological evaluation and docking studies of new pyrrolo[2,3-d] pyrimidine derivatives as Src family-selective tyrosine kinase inhibitors | Full Text | References | PDF (964.3 KB)
  • 1466 Views
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Article
Regioselective acylation of congeners of 3-amino-1H-pyrazolo[3,4-b]quinolines, their activity on bacterial serine/threonine protein kinases and in vitro antibacterial (including antimycobacterial) activity
Gennady B. Lapa, O. B. Bekker, E. P. Mirchink, V. N. Danilenko & M. N. Preobrazhenskaya
Pages: 1088-1093
Published online: 07 Sep 2012
AbstractforRegioselective acylation of congeners of 3-amino-1H-pyrazolo[3,4-b]quinolines, their activity on bacterial serine/threonine protein kinases and in vitro antibacterial (including antimycobacterial) activity | Full Text | References | PDF (766.7 KB)
  • 671 Views
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Article
Inhibition of extracellular lipase from Streptomyces rimosus with 3,4-dichloroisocoumarin
Ivana Leščić Ašler, Filip Kovačić, Martina Marchetti-Deschmann, Günter Allmaier, Zoran Štefanić & Biserka Kojić-Prodić
Pages: 1094-1104
Published online: 20 Sep 2012
AbstractforInhibition of extracellular lipase from Streptomyces rimosus with 3,4-dichloroisocoumarin | Full Text | References | PDF (842.4 KB)
  • 780 Views
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Short Communication

Synthesis and anti-inflammatory activity of celecoxib like compounds
Syed Ovais, Shafiya Yaseen, Rafia Bashir, Pooja Rathore, Mohammed Samim, Surender Singh, Vinod Nair & Kalim Javed
Pages: 1105-1112
Published online: 07 Sep 2012
AbstractforSynthesis and anti-inflammatory activity of celecoxib like compounds | Full Text | References | PDF (1.3 MB)
  • 1597 Views
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