Synthesis and biological evaluation of (E)-1-(substituted)-3-phenylprop-2-en-1-ones bearing rhodanines as potent anti-microbial agents

Ming-Xia SongDepartment of Pharmacy, Jing Gangshan University College of Medicine Ji’anPeople’s Republic of China

Xian-Qing DengDepartment of Pharmacy, Jing Gangshan University College of Medicine Ji’anPeople’s Republic of China

Ya-Ru LiKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy YanjiPeople’s Republic of China

Chang-Ji ZhengKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy YanjiPeople’s Republic of China

Lan HongDepartment of Physiology, Yanbian University College of Medicine YanjiPeople’s Republic of China

Hu-Ri PiaoKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy YanjiPeople’s Republic of ChinaCorrespondence[email protected] [email protected]

Abstract

Herein, we report the design, syntheses and in vitro anti-microbial activity of two series of rhodanines with chalcone moiety. Anti-microbial tests showed that some of the synthesized compounds exhibited good inhibition (MIC = 1–8 µg/mL) against multi-drug-resistant Gram-positive organisms, including methicillin resistant and quinolone-resistant Staphylococcus aureus, in which the compound 4g was found to be the most potent with minimum inhibitory concentration (MIC) value of 1 µg/mL against two methicillin-resistant S. aureus.

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Synthesis and biological evaluation of (E)-1-(substituted)-3-phenylprop-2-en-1-ones bearing rhodanines as potent anti-microbial agents

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Synthesis and biological evaluation of (E)-1-(substituted)-3-phenylprop-2-en-1-ones bearing rhodanines as potent anti-microbial agents

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