Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 29, Issue 5 (2014)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 29, Issue 5 (2014)

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Original Article

Article
Synthesis, bioevaluation and docking study of 5-substitutedphenyl-1,3,4-thiadiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents
Nguyen-Hai Nam, Tran Lan Huong, Do Thi Mai Dung, Phan Thi Phuong Dung, Dao Thi Kim Oanh, Sang Ho Park, Kyungrok Kim, Byung Woo Han, Jieun Yun, Jong Soon Kang, Youngsoo Kim & Sang-Bae Han
Pages: 611-618
Published online: 11 Sep 2013
AbstractforSynthesis, bioevaluation and docking study of 5-substitutedphenyl-1,3,4-thiadiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents | Full Text | References | PDF (918.8 KB)
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Research Article

Article
Design, synthesis and molecular docking of novel N,N-dimethylbenzenesulfonamide derivatives as potential antiproliferative agents
Mahmoud S. Bashandy, Mansour S. Alsaid, Reem K. Arafa & Mostafa M. Ghorab
Pages: 619-627
Published online: 03 Oct 2013
AbstractforDesign, synthesis and molecular docking of novel N,N-dimethylbenzenesulfonamide derivatives as potential antiproliferative agents | Full Text | References | PDF (1.5 MB)
  • 1100 Views
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Article
5-Nitroisatin-derived thiosemicarbazones: potential antileishmanial agents
Humayun Pervez, Nazia Manzoor, Muhammad Yaqub & Khalid Mohammed Khan
Pages: 628-632
Published online: 03 Oct 2013
Abstractfor5-Nitroisatin-derived thiosemicarbazones: potential antileishmanial agents | Full Text | References | PDF (162.7 KB)
  • 1122 Views
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Article
Biochemical characterization of Acacia schweinfurthii serine proteinase inhibitor
Frank Odei-Addo, Carminita Frost, Nanette Smith, Tomohisa Ogawa, Koji Muramoto, Maria Luiza Vilela Oliva, László Gráf & Ryno Naude
Pages: 633-638
Published online: 03 Oct 2013
AbstractforBiochemical characterization of Acacia schweinfurthii serine proteinase inhibitor | Full Text | References | PDF (751.8 KB)
  • 656 Views
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Article
Design, synthesis and biological evaluation of 2-aminopyrimidinones and their 6-aza-analogs as a new class of CK2 inhibitors
Maksym O. Chekanov, Olga V. Ostrynska, Sergii S. Tarnavskyi, Anatoliy R. Synyugin, Nadiia V. Briukhovetska, Volodymyr G. Bdzhola, Alexander E. Pashenko, Andrey A. Fokin & Sergiy M. Yarmoluk
Pages: 639-646
Published online: 03 Oct 2013
AbstractforDesign, synthesis and biological evaluation of 2-aminopyrimidinones and their 6-aza-analogs as a new class of CK2 inhibitors | Full Text | References | PDF (798.8 KB) | Supplemental
  • 877 Views
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Article
Synthesis and biological evaluation of (E)-1-(substituted)-3-phenylprop-2-en-1-ones bearing rhodanines as potent anti-microbial agents
Ming-Xia Song, Xian-Qing Deng, Ya-Ru Li, Chang-Ji Zheng, Lan Hong & Hu-Ri Piao
Pages: 647-653
Published online: 09 Oct 2013
AbstractforSynthesis and biological evaluation of (E)-1-(substituted)-3-phenylprop-2-en-1-ones bearing rhodanines as potent anti-microbial agents | Full Text | References | PDF (296 KB)
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Article
(S)-1-(Pent-4′-enoyl)-4-(hydroxymethyl)-azetidin-2-one derivatives as inhibitors of human fatty acid amide hydrolase (hFAAH): synthesis, biological evaluation and molecular modelling
Joséphine Caruano, Marion Feledziak, Geoffray Labar, Catherine Michaux, Eric A. Perpète, Giulio G. Muccioli, Raphaël Robiette & Jacqueline Marchand-Brynaert
Pages: 654-662
Published online: 09 Oct 2013
Abstractfor(S)-1-(Pent-4′-enoyl)-4-(hydroxymethyl)-azetidin-2-one derivatives as inhibitors of human fatty acid amide hydrolase (hFAAH): synthesis, biological evaluation and molecular modelling | Full Text | References | PDF (860.7 KB) | Supplemental
  • 732 Views
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Article
Inhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives
Anthony C. Antonelli, Yu Zhang, Lorne M. Golub, Francis Johnson & Sanford R. Simon
Pages: 663-669
Published online: 09 Oct 2013
AbstractforInhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives | Full Text | References | PDF (481.7 KB) | Supplemental
  • 2153 Views
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Article
Exploring QSARs of the interaction of flavonoids with GABA (A) receptor using MLR, ANN and SVM techniques
Omar Deeb, Basheerulla Shaik & Vijay K. Agrawal
Pages: 670-676
Published online: 09 Oct 2013
AbstractforExploring QSARs of the interaction of flavonoids with GABA (A) receptor using MLR, ANN and SVM techniques | Full Text | References | PDF (555 KB) | Supplemental
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Article
Chemical profiling and in vitro biological effects of Cardiospermum halicacabum L. (Sapindaceae) aerial parts and seeds for applications in neurodegenerative disorders
Francesco Menichini, Luigi Losi, Marco Bonesi, Alessandro Pugliese, Monica R. Loizzo & Rosa Tundis
Pages: 677-685
Published online: 09 Oct 2013
AbstractforChemical profiling and in vitro biological effects of Cardiospermum halicacabum L. (Sapindaceae) aerial parts and seeds for applications in neurodegenerative disorders | Full Text | References | PDF (225 KB)
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Article
Sulfonamides incorporating fluorine and 1,3,5-triazine moieties are effective inhibitors of three β-class carbonic anhydrases from Mycobacterium tuberculosis
Mariangela Ceruso, Daniela Vullo, Andrea Scozzafava & Claudiu T. Supuran
Pages: 686-689
Published online: 24 Oct 2013
AbstractforSulfonamides incorporating fluorine and 1,3,5-triazine moieties are effective inhibitors of three β-class carbonic anhydrases from Mycobacterium tuberculosis | Full Text | References | PDF (233.4 KB)
  • 895 Views
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Article
Total monoamine oxidase (MAO) inhibition by chestnut honey, pollen and propolis
O. Yildiz, F. Karahalil, Z. Can, H. Sahin & S. Kolayli
Pages: 690-694
Published online: 24 Oct 2013
AbstractforTotal monoamine oxidase (MAO) inhibition by chestnut honey, pollen and propolis | Full Text | References | PDF (258.7 KB)
  • 4494 Views
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Article
Synthesis and characterization of some metal complexes of a proton transfer salt, and their inhibition studies on carbonic anhydrase isozymes and the evaluation of the results by statistical analysis
Halil İlkimen, Cengiz Yenikaya, Musa Sarı, Metin Bülbül, Melike Aslan & Yasemin Süzen
Pages: 695-701
Published online: 22 Oct 2013
AbstractforSynthesis and characterization of some metal complexes of a proton transfer salt, and their inhibition studies on carbonic anhydrase isozymes and the evaluation of the results by statistical analysis | Full Text | References | PDF (557.3 KB) | Supplemental
  • 767 Views
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Article
Docking and molecular dynamics studies of the binding between Peloruside A and tubulin
Si-Yan Liao, Guang-Quan Mo, Jin-Can Chen & Kang-Cheng Zheng
Pages: 702-709
Published online: 24 Oct 2013
AbstractforDocking and molecular dynamics studies of the binding between Peloruside A and tubulin | Full Text | References | PDF (2.2 MB)
  • 1143 Views
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Article
Pharmacokinetic evaluation of C-3 modified 1,8-naphthyridine-3-carboxamide derivatives with potent anticancer activity: lead finding
Anshumali Awasthi, Mohtashim Lohani, Manoj K. Singh, Anu T. Singh & Manu Jaggi
Pages: 710-721
Published online: 24 Oct 2013
AbstractforPharmacokinetic evaluation of C-3 modified 1,8-naphthyridine-3-carboxamide derivatives with potent anticancer activity: lead finding | Full Text | References | PDF (1,019.5 KB)
  • 669 Views
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Article
Design, synthesis and anticancer activity of oxoaporphine alkaloid derivatives
Yong-Biao Wei, Ying-Xin Li, Hui Song & Xian-Jin Feng
Pages: 722-727
Published online: 25 Jun 2014
AbstractforDesign, synthesis and anticancer activity of oxoaporphine alkaloid derivatives | Full Text | References | PDF (359 KB)
  • 1063 Views
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Article
In vitro inhibition effects of some coumarin derivatives on human erythrocytes glucose-6-phosphate dehydrogenase activities
Ersin Hopa, Ismet Basaran, Selma Sinan, Yusuf Turan & Umit Cakir
Pages: 728-732
Published online: 10 Feb 2014
AbstractforIn vitro inhibition effects of some coumarin derivatives on human erythrocytes glucose-6-phosphate dehydrogenase activities | Full Text | References | PDF (548.1 KB)
  • 901 Views
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Article
Synthesis and characterization of quinazoline derivatives: search for hybrid molecule as diuretic and antihypertensive agents
Mujeeb Ur Rahman, Ankita Rathore, Anees A. Siddiqui, Gazala Parveen & M. Shahar Yar
Pages: 733-743
Published online: 24 Oct 2013
AbstractforSynthesis and characterization of quinazoline derivatives: search for hybrid molecule as diuretic and antihypertensive agents | Full Text | References | PDF (764.2 KB)
  • 2644 Views
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Article
A study of the inhibition of catalase by dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH]
Safija Islamovic, Borivoj Galic & Mladen Milos
Pages: 744-748
Published online: 10 Feb 2014
AbstractforA study of the inhibition of catalase by dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] | Full Text | References | PDF (318 KB)
  • 5716 Views
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Article
Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
Renata Kubínová, Radka Pořízková, Alice Navrátilová, Oldřich Farsa, Zuzana Hanáková, Adriana Bačinská, Alois Čížek & Marie Valentová
Pages: 749-752
Published online: 10 Feb 2014
AbstractforAntimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth | Full Text | References | PDF (185.1 KB) | Supplemental
  • 1821 Views
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Review Article

Review Article
Agents described in the Molecular Imaging and Contrast Agent Database for imaging carbonic anhydrase IX expression
Deborah Sneddon & Sally-Ann Poulsen
Pages: 753-763
Published online: 10 Feb 2014
AbstractforAgents described in the Molecular Imaging and Contrast Agent Database for imaging carbonic anhydrase IX expression | Full Text | References | PDF (1 MB)
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