Relaxant effects of selected sildenafil analogues in the rat aorta

Abstract

A new series of sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazine with chiral amino group has been synthesized and characterized. The compounds were tested for their relaxant effects in the rat aorta. Evaluation of prepared derivatives demonstrated that compound (8a) is probably a non-selective phosphodiesterase (PDE) inhibitor, as it induced aortic relaxation through endothelium-independent mechanism.

• PDE5 inhibitors
• pyrazolo[4,3-e][1,2,4]triazine
• relaxant effect
• sildenafil analogues
• sulfonamides

Declaration of interest

The authors declare no conflicts of interest. The authors alone are responsible for the content and writing of this article.

This research was partially funded by the National Science Centre, Poland (grant NN405 092340). The authors gratefully acknowledge use of the mass spectrometry services and facilities of the Center for Interdisciplinary Research of The John Paul II Catholic University of Lublin, Lublin, Poland, funded by POPW.01.03.00-06-003/09-00.