Antioxidant activity of taxifolin: an activity–structure relationship

Abstract

Taxifolin is a kind of flavanonol, whose biological ability. The objectives of this study were to investigate the antioxidants and antiradical activities of taxifolin by using different in vitro bioanalytical antioxidant methods including DMPD√⁺, ABTS√⁺, , and DPPH√-scavenging effects, the total antioxidant influence, reducing capabilities, and Fe²⁺-chelating activities. Taxifolin demonstrated 81.02% inhibition of linoleic acid emulsion peroxidation at 30 µg/mL concentration. At the same concentration, standard antioxidants including trolox, α-tocopherol, BHT, and BHA exhibited inhibitions of linoleic acid emulsion as 88.57, 73.88, 94.29, and 90.12%, respectively. Also, taxifolin exhibited effective DMPD√⁺, ABTS√⁺, , and DPPH√-scavenging effects, reducing capabilities, and Fe²⁺-chelating effects. The results obtained from this study clearly showed that taxifolin had marked antioxidant, reducing ability, radical scavenging and metal-chelating activities. Also, this study exhibits a scientific shore for the significant antioxidant activity of taxifolin and its structure-activity insight.

• Antioxidant activity
• radical scavenging
• structure–activity insight
• taxifolin

Declaration of interest

The authors declare no conflict of interest. S. H. Alwasel would like to extend his sincere appreciation to the Research Chairs Program at King Saud University for funding this research.