Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue 4 (2016)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue 4 (2016)

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Review Article

Review
Inhibitors of alanine racemase enzyme: a review
Mohammed Afzal Azam & Unni Jayaram
Pages: 517-526
Published online: 29 May 2015
AbstractforInhibitors of alanine racemase enzyme: a review | Full Text | References | PDF (1.5 MB)
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Review
The history and rationale of using carbonic anhydrase inhibitors in the treatment of peptic ulcers. In memoriam Ioan Puşcaş (1932–2015)
György M. Buzás & Claudiu T. Supuran
Pages: 527-533
Published online: 25 Jun 2015
AbstractforThe history and rationale of using carbonic anhydrase inhibitors in the treatment of peptic ulcers. In memoriam Ioan Puşcaş (1932–2015) | Full Text | References | PDF (325.8 KB) | Supplemental
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Research Article

Article
In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1)
Basak Gokce, Nahit Gencer, Oktay Arslan, Mert Olgun Karatas & Bulent Alici
Pages: 534-537
Published online: 18 May 2015
AbstractforIn vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1) | Full Text | References | PDF (164.5 KB)
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Article
Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect
Luana Lugini, Cristina Federici, Martina Borghi, Tommaso Azzarito, Maria Lucia Marino, Albino Cesolini, Enrico Pierluigi Spugnini & Stefano Fais
Pages: 538-545
Published online: 28 May 2015
AbstractforProton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect | Full Text | References | PDF (603.3 KB)
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Article
Purification of glutathione S-transferase from Van Lake fish (Chalcalburnus tarichii Pallas) muscle and investigation of some metal ions effect on enzyme activity
Mine Aksoy, M. Serhat Ozaslan & O. Irfan Kufrevioglu
Pages: 546-550
Published online: 28 May 2015
AbstractforPurification of glutathione S-transferase from Van Lake fish (Chalcalburnus tarichii Pallas) muscle and investigation of some metal ions effect on enzyme activity | Full Text | References | PDF (532.5 KB)
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Article
Inactivation of peptidylglycine α-hydroxylating monooxygenase by cinnamic acid analogs
Neil R. McIntyre, Edward W. Lowe Jr, Matthew R. Battistini, James W. Leahy & David J. Merkler
Pages: 551-562
Published online: 29 May 2015
AbstractforInactivation of peptidylglycine α-hydroxylating monooxygenase by cinnamic acid analogs | Full Text | References | PDF (1 MB)
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Original Articles

Article
Protein tyrosine phosphatase 1B inhibitors isolated from Artemisia roxburghiana
Muhammad Raza Shah, Ishtiaq, Syed Muhammad Hizbullah, Solomon Habtemariam, Armando Zarrelli, Akhtar Muhammad, Simona Collina & Inamulllah Khan
Pages: 563-567
Published online: 29 Jun 2015
AbstractforProtein tyrosine phosphatase 1B inhibitors isolated from Artemisia roxburghiana | Full Text | References | PDF (723.3 KB)
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Research Article

Article
Synthesis of 4-(2-substituted hydrazinyl)benzenesulfonamides and their carbonic anhydrase inhibitory effects
Halise Inci Gul, Kaan Kucukoglu, Cem Yamali, Sinan Bilginer, Hafize Yuca, Iknur Ozturk, Parham Taslimi, Ilhami Gulcin & Claudiu T. Supuran
Pages: 568-573
Published online: 05 Jun 2015
AbstractforSynthesis of 4-(2-substituted hydrazinyl)benzenesulfonamides and their carbonic anhydrase inhibitory effects | Full Text | References | PDF (855.3 KB)
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Reserach Article

Article
Synthesis and in vitro pharmacological evaluation of N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]-carboxamides on d-secoestrone scaffolds
Johanna Szabó, Ildikó Bacsa, János Wölfling, Gyula Schneider, István Zupkó, Mónika Varga, Bianka E. Herman, László Kalmár, Mihály Szécsi & Erzsébet Mernyák
Pages: 574-579
Published online: 11 Sep 2015
AbstractforSynthesis and in vitro pharmacological evaluation of N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]-carboxamides on d-secoestrone scaffolds | Full Text | References | PDF (258.8 KB) | Supplemental
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Research Article

Article
Design, synthesis and preliminary structure–activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives
Haoran Liu, Haoqun Fan, Xiaohui Gao, Xueqing Huang, Xianjun Liu, Linbo Liu, Chao Zhou, Jingjing Tang, Qiuan Wang & Wukun Liu
Pages: 580-589
Published online: 17 Jul 2015
AbstractforDesign, synthesis and preliminary structure–activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives | Full Text | References | PDF (795.6 KB)
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Article
Metal based drugs: design, synthesis and in-vitro antimicrobial screening of Co(II), Ni(II), Cu(II) and Zn(II) complexes with some new carboxamide derived compounds: crystal structures of N-[ethyl(propan-2-yl)carbamothioyl]thiophene-2-carboxamide and its copper(II) complex
Sajjad H. Sumrra, Muhammad Hanif, Zahid H. Chohan, Muhammad Safwan Akram, Javeed Akhtar & Saad M. Al-Shehri
Pages: 590-598
Published online: 11 Jun 2015
AbstractforMetal based drugs: design, synthesis and in-vitro antimicrobial screening of Co(II), Ni(II), Cu(II) and Zn(II) complexes with some new carboxamide derived compounds: crystal structures of N-[ethyl(propan-2-yl)carbamothioyl]thiophene-2-carboxamide and its copper(II) complex | Full Text | References | PDF (921.4 KB) | Supplemental
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Article
Honey shows potent inhibitory activity against the bovine testes hyaluronidase
Sevgi Kolayli, Huseyin Sahin, Zehra Can, Oktay Yildiz & Kübra Sahin
Pages: 599-602
Published online: 15 Jun 2015
AbstractforHoney shows potent inhibitory activity against the bovine testes hyaluronidase | Full Text | References | PDF (279.6 KB)
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Article
The effects of some bromophenols on human carbonic anhydrase isoenzymes
Parham Taslimi, İlhami Gülçin, Necla Öztaşkın, Yasin Çetinkaya, Süleyman Göksu, Saleh H. Alwasel & Claudiu T. Supuran
Pages: 603-607
Published online: 02 Jul 2015
AbstractforThe effects of some bromophenols on human carbonic anhydrase isoenzymes | Full Text | References | PDF (178.6 KB)
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Article
Discovery of nitroaryl urea derivatives with antiproliferative properties
Tomasz M. Wróbel, Michał Kiełbus, Agnieszka A. Kaczor, Vladimír Kryštof, Zbigniew Karczmarzyk, Waldemar Wysocki, Andrzej Fruziński, Sylwia K. Król, Aneta Grabarska, Andrzej Stepulak & Dariusz Matosiuk
Pages: 608-618
Published online: 26 Jun 2015
AbstractforDiscovery of nitroaryl urea derivatives with antiproliferative properties | Full Text | References | PDF (991.6 KB)
  • 1102 Views
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Article
1-Substituted carbamoyl and thiocarbamoyl-4,5-dihydro-1H-pyrazoles as possible cytotoxic and antimicrobial agents
Khalid A. Khan & Hassan M. Faidallah
Pages: 619-627
Published online: 26 Jun 2015
Abstractfor1-Substituted carbamoyl and thiocarbamoyl-4,5-dihydro-1H-pyrazoles as possible cytotoxic and antimicrobial agents | Full Text | References | PDF (244.2 KB)
  • 863 Views
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Article
Cinnoline derivatives as human neutrophil elastase inhibitors
Maria Paola Giovannoni, Igor A. Schepetkin, Letizia Crocetti, Giovanna Ciciani, Agostino Cilibrizzi, Gabriella Guerrini, Andrei I. Khlebnikov, Mark T. Quinn & Claudia Vergelli
Pages: 628-639
Published online: 21 Jul 2015
AbstractforCinnoline derivatives as human neutrophil elastase inhibitors | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1892 Views
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Article
Inhibition of soluble epoxide hydrolase activity by compounds isolated from the aerial parts of Glycosmis stenocarpa
Jang Hoon Kim, Abubaker M. A. Morgan, Bui Huu Tai, Doan Thi Van, Nguyen Manh Cuong & Young Ho Kim
Pages: 640-644
Published online: 07 Oct 2015
AbstractforInhibition of soluble epoxide hydrolase activity by compounds isolated from the aerial parts of Glycosmis stenocarpa | Full Text | References | PDF (287.8 KB) | Supplemental
  • 1069 Views
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Article
Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target
Claudia Beato, Chiara Pecchini, Chiara Cocconcelli, Barbara Campanini, Marialaura Marchetti, Marco Pieroni, Andrea Mozzarelli & Gabriele Costantino
Pages: 645-652
Published online: 02 Jul 2015
AbstractforCyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1170 Views
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Article
Structure–activity relationship studies on 1-heteroaryl-3-phenoxypropan-2-ones acting as inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase: replacement of the activated ketone group by other serine traps
Tom Sundermann, Walburga Hanekamp & Matthias Lehr
Pages: 653-663
Published online: 07 Jul 2015
AbstractforStructure–activity relationship studies on 1-heteroaryl-3-phenoxypropan-2-ones acting as inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase: replacement of the activated ketone group by other serine traps | Full Text | References | PDF (568.3 KB) | Supplemental
  • 943 Views
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Article
Synthesis of 3,4-dihydro-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxides and their evaluation as ligands for NMDA receptor glycine binding site
Zanda Bluke, Einars Paass, Meik Sladek, Ulrich Abel & Valerjans Kauss
Pages: 664-673
Published online: 26 Jun 2015
AbstractforSynthesis of 3,4-dihydro-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxides and their evaluation as ligands for NMDA receptor glycine binding site | Full Text | References | PDF (319.2 KB) | Supplemental
  • 1327 Views
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Article
Antioxidant activity of taxifolin: an activity–structure relationship
Fevzi Topal, Meryem Nar, Hulya Gocer, Pınar Kalin, Umit M. Kocyigit, İlhami Gülçin & Saleh H. Alwasel
Pages: 674-683
Published online: 06 Jul 2015
AbstractforAntioxidant activity of taxifolin: an activity–structure relationship | Full Text | References | PDF (513.8 KB)
  • 7719 Views
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Short Communication

Rapid Communication
RETRACTED ARTICLE: Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol
Giuseppina Tommonaro, Boris Pejin, Carmine Iodice, Antonietta Tafuto & Salvatore De Rosa
Pages: 684-686
Published online: 26 Jun 2015
AbstractforRETRACTED ARTICLE: Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol | Full Text | References | PDF (673.5 KB)
  • 824 Views
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List of Reviewers

Thank you to Reviewers for the Journal of Enzyme Inhibition and Medicinal Chemistry 2015
Pages: 687-688
Published online: 27 Apr 2016
CitationforThank you to Reviewers for the Journal of Enzyme Inhibition and Medicinal Chemistry 2015 | Full Text | PDF (115.5 KB)
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