Ethylene Glycol Poisoning. The Value of Glycolic Acid Determinations for Diagnosis and Treatment

Tracy P. Hewlett Department of Pharmacology and Therapeutics, Section of Toxicology and Louisiana Regional Poison Control Center Louisiana State University Medical Center in Shreveport, Shreveport, Louisiana, 71130

Kenneth E. McMartin Department of Pharmacology and Therapeutics, Section of Toxicology and Louisiana Regional Poison Control Center Louisiana State University Medical Center in Shreveport, Shreveport, Louisiana, 71130

Alert J. Lauro Departments of Medicine and Pathology, Louisiana State University Medical Center in New Orleans, New Orleans, Louisiana, 70140

Francis Avery Ragan Departments of Medicine and Pathology, Louisiana State University Medical Center in New Orleans, New Orleans, Louisiana, 70140

Abstract

Glycolic acid is the ethylene glycol (EG) metabolite that accumulates in the highest concentrations in the blood and may be the major contributing factor to the acute toxicity of EG. Serum and urine levels of glycolic acid have been found to correlate directly with clinical symptoms and mortality in poisoning cases, making it a valuable diagnostic tool. A high pressure liquid chromatographic (HPLC) method for quantitation of glycolic acid in serum was used in several cases of EG ingestion presented to the Louisiana Regional Poison Control Center. The data collected in this study support the value of glycolic acid determination for diagnosis and evaluation of patients poisoned by EG.

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Ethylene Glycol Poisoning. The Value of Glycolic Acid Determinations for Diagnosis and Treatment

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