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Research Article

Steroid Perfusion of the Inner Ear for Sudden Sensorineural Hearing Loss after Failure of Conventional Therapy: A Pilot Study

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Pages 698-702 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Edoardo Covelli, Khaled Altabaa, Benjamin Verillaud, Domitille Camous, Charlotte Hautefort, Maurizio Barbara, Philippe Herman & Romain Kania. (2018) Intratympanic steroids as a salvage therapy for severe to profound idiopathic sudden sensorineural hearing loss. Acta Oto-Laryngologica 138:11, pages 966-971.
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Jafri Kuthubutheen, Leah Smith, Euna Hwang & Vincent Lin. (2016) Preoperative steroids for hearing preservation cochlear implantation: A review. Cochlear Implants International 17:2, pages 63-74.
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Andrew M Ayoob & Jeffrey T Borenstein. (2015) The role of intracochlear drug delivery devices in the management of inner ear disease. Expert Opinion on Drug Delivery 12:3, pages 465-479.
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Hui Cai, Xingxing Wen, Lu Wen, Nicola Tirelli, Xiao Zhang, Yue Zhang, Huanpeng Su, Fan Yang & Gang Chen. (2014) Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration. International Journal of Nanomedicine 9, pages 5591-5601.
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Hinrich Staecker & Brian Rodgers. (2013) Developments in delivery of medications for inner ear disease. Expert Opinion on Drug Delivery 10:5, pages 639-650.
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Katharina Niedermeier, Susanne Braun, Claudius Fauser, Jan Kiefer, Reinhard K. Straubinger & Thomas Stark. (2012) A safety evaluation of dexamethasone-releasing cochlear implants: Comparative study on the risk of otogenic meningitis after implantation. Acta Oto-Laryngologica 132:12, pages 1252-1260.
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Takayuki Nakagawa & Juichi Ito. (2011) Local Drug Delivery to the Inner Ear Using Biodegradable Materials. Therapeutic Delivery 2:6, pages 807-814.
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Joong Ho Ahn, Myung Woul Han, Ji Heui Kim, Jong Woo Chung & Tae Hyun Yoon. (2008) Therapeutic effectiveness over time of intratympanic dexamethasone as salvage treatment of sudden deafness. Acta Oto-Laryngologica 128:2, pages 128-131.
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Takayuki Nakagawa & Juichi Ito. (2007) Drug delivery systems for the treatment of sensorineural hearing loss. Acta Oto-Laryngologica 127:sup557, pages 30-35.
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France van Wijck, Hinrich Staecker & Philippe P. Lefebvre. (2007) Topical steroid therapy using the Silverstein Microwick™ in sudden sensorineural hearing loss after failure of conventional treatment. Acta Oto-Laryngologica 127:10, pages 1012-1017.
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Niels Wagner, Per Cayé-Thomasen, Göran Laurell, Dan Bagger-Sjöbäck & Jens Thomsen. (2005) Cochlear hair cell loss in single-dose versus continuous round window administration of gentamicin. Acta Oto-Laryngologica 125:4, pages 340-345.
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>Stefan Plontke, >Stefan Plontke, Hubert Löwenheim, >Stefan Plontke, Hubert Löwenheim, Serena Preyer, Patrick Leins, Klaus Dietz, Assen Koitschev, Rainer Zimmermann & Hans-Peter Zenner. (2005) Outcomes research analysis of continuous intratympanic glucocorticoid delivery in patients with acute severe to profound hearing loss: Basis for planning randomized controlled trials. Acta Oto-Laryngologica 125:8, pages 830-839.
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Jan Kiefer, Wolfgang Gstoettner, Wolfgang Baumgartner, Stephen Marcel Pok, Jochen Tillein, Qing Ye & Christoph von Ilberg. (2004) Conservation of low-frequency hearing in cochlear implantation. Acta Oto-Laryngologica 124:3, pages 272-280.
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Articles from other publishers (42)

Mehrdad Rogha & Ehsan Moshtaghi. (2024) The Effect of Rivaroxaban in the Complementary Therapy of Sudden Sensorineural Hearing Loss. Advanced Biomedical Research 13.
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Hamed Emami, Ardavan Tajdini, Behrooz Amirzargar, Saleh Habibi, Hesam Aldin Varpaei, Reza Gholami, Ahang Karimi, Saber Jazini Zadeh & Amir Hosein Mehrban. (2023) Intratympanic Triamcinolone or Dexamethasone in Sudden Sensory Neural Hearing Loss: A Randomized Clinical Trial. Indian Journal of Otolaryngology and Head & Neck Surgery 75:4, pages 3545-3552.
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Xia Si, Zhiying Yu, Xiaolei Ren, Lin Huang & Yufei Feng. (2022) Efficacy and safety of standardized Ginkgo biloba L. leaves extract as an adjuvant therapy for sudden sensorineural hearing loss: A systematic review and meta-analysis. Journal of Ethnopharmacology 282, pages 114587.
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Busheng Tong, Qiang Wang, Qingqing Dai, Sten Hellstrom & Maoli Duan. (2021) Efficacy of Various Corticosteroid Treatment Modalities for the Initial Treatment of Idiopathic Sudden Hearing Loss: A Prospective Randomized Controlled Trial. Audiology and Neurotology 26:1, pages 45-52.
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Yang Li, Sho Kanzaki, Shinsuke Shibata, Masaya Nakamura, Masahiro Ozaki, Hideyuki Okano & Kaoru Ogawa. (2020) Comparison of inner ear drug availability of combined treatment with systemic or local drug injections alone. Neuroscience Research 155, pages 27-33.
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Anup Singh & David Victor Kumar Irugu. (2020) Sudden sensorineural hearing loss – A contemporary review of management issues. Journal of Otology 15:2, pages 67-73.
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Michael H. Froehlich & Paul R. Lambert. (2020) The Physiologic Role of Corticosteroids in Menière's Disease: An Update on Glucocorticoid-mediated Pathophysiology and Corticosteroid Inner Ear Distribution. Otology & Neurotology 41:2, pages 271-276.
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Fabrice Piu & Kathie M. Bishop. (2019) Local Drug Delivery for the Treatment of Neurotology Disorders. Frontiers in Cellular Neuroscience 13.
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A. I. Kryukov, N. L. Kunelskaya, E. A. Shershunova, I. E. Rebrov, V. A. Yamshchikov, E. V. Garov, G. Yu. Tsarapkin & V. V. Mishchenko. (2019) Topical drug administration to the inner ear. Modern state of the problem and development perspectives. Vestnik otorinolaringologii 84:5, pages 6.
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Arne Liebau, Olivia Pogorzelski, Alec N. Salt & Stefan K. Plontke. (2018) Hearing Changes After Intratympanic Steroids for Secondary (Salvage) Therapy of Sudden Hearing Loss: A Meta-Analysis Using Mathematical Simulations of Drug Delivery Protocols. Otology & Neurotology 39:7, pages 803-815.
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Diego Zanetti, Federica Di Berardino, Nader Nassif & Luca Oscar Redaelli De Zinis. (2018) Intratympanic steroid delivery by an indwelling catheter in refractory severe sudden sensorineural hearing loss. Auris Nasus Larynx 45:2, pages 227-233.
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Phillip J.P. Sale, Aaron Uschakov, Tasfia Saief, David P. Rowe, Carla J. Abbott, Chi D. Luu, Amy J. Hampson, Stephen J. O'Leary & David J. Sly. (2017) Cannula-based drug delivery to the guinea pig round window causes a lasting hearing loss that may be temporarily mitigated by BDNF. Hearing Research 356, pages 104-115.
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Diaa El Din M. El Hennawi, Mohamed R. Ahmed, Wael Abdelkafy, Ahmed Geneid & Ibrahim H. Ibrahim. (2017) Intratympanic methylprednisolone acetate versus intratympanic lidocaine in the treatment of idiopathic subjective unilateral tinnitus of less than 1-year duration: a randomized, double-blind, clinical trial. The Egyptian Journal of Otolaryngology 33:3, pages 564-568.
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Filippo Valente, Laura Astolfi, Edi Simoni, Serena Danti, Valeria Franceschini, Milvia Chicca & Alessandro Martini. (2017) Nanoparticle drug delivery systems for inner ear therapy: An overview. Journal of Drug Delivery Science and Technology 39, pages 28-35.
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Lilun Li, Tiffany Chao, Jason Brant, Bert O'MalleyJr.Jr., Andrew Tsourkas & Daqing Li. (2017) Advances in nano-based inner ear delivery systems for the treatment of sensorineural hearing loss. Advanced Drug Delivery Reviews 108, pages 2-12.
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M. Müller, M. Tisch, H. Maier & H. Löwenheim. (2016) Reduction of permanent hearing loss by local glucocorticoid application. HNO 65:S1, pages 59-67.
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Naila El Kechai, Florence Agnely, Elisabeth Mamelle, Yann Nguyen, Evelyne Ferrary & Amélie Bochot. (2015) Recent advances in local drug delivery to the inner ear. International Journal of Pharmaceutics 494:1, pages 83-101.
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Sesha Prasad A, Ravishankar V, Muneeruddin Ahmed S & Mahendra Kumar M. (2015) A CLINICAL STUDY ON INTRATYMPANIC METHYL PREDNISOLONE AS PRIMARY AND RESCUE THERAPIES VERSUS ORAL PREDNISOLONE IN THE TREATMENT OF SSNHL: A STUDY ON 90 PATIENTS. Journal of Evolution of Medical and Dental Sciences 4:36, pages 6193-6204.
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S Belhassen & I Saliba. (2014) Intratympanic steroid injection as a salvage treatment for sudden sensorineural hearing loss. The Journal of Laryngology & Otology 128:12, pages 1044-1049.
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Tarek F. Youssef & Mohamed R. Ahmed. (2014) Treatment of idiopathic sudden sensorineural hearing loss: systemic versus intratympanic methylprednisolone acetate. The Egyptian Journal of Otolaryngology 28:3, pages 184-188.
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Y-J Tsai, J-G Liang, W-B Wu, Y-F Ding, R P-Y Chiang & S-M Wu. (2010) Intratympanic injection with dexamethasone for sudden sensorineural hearing loss. The Journal of Laryngology & Otology 125:2, pages 133-137.
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Sarah Havenith, Huib Versnel, Martijn J.H. Agterberg, John C.M.J. de Groot, Robert-Jan Sedee, Wilko Grolman & Sjaak F.L. Klis. (2011) Spiral ganglion cell survival after round window membrane application of brain-derived neurotrophic factor using gelfoam as carrier. Hearing Research 272:1-2, pages 168-177.
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Ioannis Seggas, Petros Koltsidopoulos, Athanasios Bibas, Anastasia Tzonou & Aristides Sismanis. (2011) Intratympanic Steroid Therapy for Sudden Hearing Loss. Otology & Neurotology 32:1, pages 29-35.
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Sarah N Bowe & Abraham Jacob. (2010) Round window perfusion dynamics: implications for intracochlear therapy. Current Opinion in Otolaryngology & Head & Neck Surgery 18:5, pages 377-385.
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S.K. Plontke. (2010) Intratympanale Glukokortikoidtherapie bei Hörsturz. HNO 58:10, pages 1025-1030.
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Emrah Kara, Fikret Çetik, Özgür Tarkan & Özgür Sürmelioğlu. (2009) Modified intratympanic treatment for idiopathic sudden sensorineural hearing loss. European Archives of Oto-Rhino-Laryngology 267:5, pages 701-707.
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Andrew A. McCall, Erin E. Leary Swan, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa & Michael J. McKenna. (2010) Drug Delivery for Treatment of Inner Ear Disease: Current State of Knowledge. Ear & Hearing 31:2, pages 156-165.
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Iacopo Dallan, Andrea De Vito, Bruno Fattori, Augusto Pietro Casani, Erica Panicucci, Stefano Berrettini, Manuela Marchetti & Andrea Nacci. (2010) Intratympanic Methylprednisolone in Refractory Sudden Hearing Loss. Otology & Neurotology 31:1, pages 25-30.
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Necat Alatas. (2008) Use of intratympanic dexamethasone for the therapy of low frequency hearing loss. European Archives of Oto-Rhino-Laryngology 266:8, pages 1205-1212.
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Philip A. Bird, Evan J. Begg, Mei Zhang, Allan T. Keast, Daran P. Murray & Thomas J. Balkany. (2007) Intratympanic Versus Intravenous Delivery of Methylprednisolone to Cochlear Perilymph. Otology & Neurotology 28:8, pages 1124-1130.
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Jian-jun SUN, Ya LIU, Wei-jia KONG, Ping JIANG & Wei JIANG. (2007) In vitro permeability of round window membrane to transforming dexamethasone with delivery vehicles — a dosage estimation. Chinese Medical Journal 120:24, pages 2284-2289.
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Kyu Yup Lee, Takayuki Nakagawa, Takayuki Okano, Ryusuke Hori, Kazuya Ono, Yasuhiko Tabata, Sang Heun Lee & Juichi Ito. (2007) Novel Therapy for Hearing Loss. Otology & Neurotology 28:7, pages 976-981.
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Qing Ye, Jochen Tillein, Rainer Hartmann, Wolfgang Gstoettner & Jan Kiefer. (2007) Application of a Corticosteroid (Triamcinolon) Protects Inner Ear Function after Surgical Intervention. Ear & Hearing 28:3, pages 361-369.
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Dennis C. Fitzgerald & John F. McGuire. (2016) Intratympanic Steroids for Idiopathic Sudden Sensorineural Hearing Loss. Annals of Otology, Rhinology & Laryngology 116:4, pages 253-256.
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Rahmi Kiliç, Mustafa Asim Şafak, Haldun Oğuz, Selda Kargin, Münir Demirci, Erdal Samim & Levent Naci Özlüoğlu. (2007) Intratympanic Methylprednisolone for Sudden Sensorineural Hearing Loss. Otology & Neurotology 28:3, pages 312-316.
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Stefan K. Plontke, Rainer Zimmermann, Hans-Peter Zenner & Hubert Löwenheim. (2006) Technical Note on Microcatheter Implantation for Local Inner Ear Drug Delivery. Otology & Neurotology 27:7, pages 912-917.
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Avik Banerjee & Lorne S Parnes. (2005) Intratympanic Corticosteroids for Sudden Idiopathic Sensorineural Hearing Loss. Otology & Neurotology 26:5, pages 878-881.
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Jürgen Lautermann, Holger Sudhoff & Rüdiger Junker. (2005) Transtympanic corticoid therapy for acute profound hearing loss. European Archives of Oto-Rhino-Laryngology 262:7, pages 587-591.
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Guan-Min Ho. (2005) Response: Effectiveness of Intratympanic Dexamethasone Injection in Sudden-Deafness Patients as Salvage Treatment. The Laryngoscope 115:2, pages 378-379.
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Guiscard Seebohm, Nathalie Strutz-Seebohm, Ravshan Baltaev, Ganna Korniychuk, Martina Knirsch, Jutta Engel & Florian Lang. (2005) Regulation of KCNQ4 Potassium Channel Prepulse Dependence and Current Amplitude by SGK1 in <i>Xenopus</i> oocytes. Cellular Physiology and Biochemistry 16:4-6, pages 255-262.
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Gregory C. Barkdull, Cong Vu, Elizabeth M. Keithley & Jeffrey P. Harris. (2005) Cochlear Microperfusion: Experimental Evaluation of a Potential New Therapy for Severe Hearing Loss Caused by Inflammation. Otology & Neurotology 26:1, pages 19-26.
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Karen K. Hoffmann & Herbert Silverstein. (2003) Inner ear perfusion: indications and applications. Current Opinion in Otolaryngology & Head and Neck Surgery 11:5, pages 334-339.
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