Citations (31)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
Rachel E. Peters, Mark Wickstrom & Steven D Siciliano. (2016) Do biomarkers of exposure and effect correlate with internal exposure to PAHs in swine?. Biomarkers 21:3, pages 283-291.
Read now
Read now
Inge AM de Graaf, Geny MM Groothuis & Peter Olinga. (2007) Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 879-898.
Read now
Read now
C. Emoto, H. Yamazaki, S. Yamasaki, N. Shimada, M. Nakajima & T. Yokoi. (2000) Use of everted sacs of mouse small intestine as enzyme sources for the study of drug oxidation activities in vitro. Xenobiotica 30:10, pages 971-982.
Read now
Read now
Articles from other publishers (28)
Christopher M. Arian, Tomoki Imaoka, Jade Yang, Edward J. Kelly & Kenneth E. Thummel. (2022) Gutsy science: In vitro systems of the human intestine to model oral drug disposition. Pharmacology & Therapeutics 230, pages 107962.
Crossref
Crossref
Albert P. Li, Ming‐Chih D. Ho, Novera Alam, Walter Mitchell, Susan Wong, Zhengyin Yan, Jane R. Kenny & Cornelis E. C. A. Hop. (2020) Inter‐individual and inter‐regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small intestines of 14 donors. Pharmacology Research & Perspectives 8:5.
Crossref
Crossref
Martin Krøyer Rasmussen. (2020) Porcine cytochrome P450 3A: current status on expression and regulation. Archives of Toxicology 94:6, pages 1899-1914.
Crossref
Crossref
Wim Schelstraete, Laura De Clerck, Elisabeth Govaert, Joske Millecam, Mathias Devreese, Dieter Deforce, Jan Van Bocxlaer & Siska Croubels. (2019) Characterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from A Quantitative, Activity and Selectivity Perspective. Scientific Reports 9:1.
Crossref
Crossref
Ryosuke Negoro, Kazuo Takayama, Kanae Kawai, Kazuo Harada, Fuminori Sakurai, Kazumasa Hirata & Hiroyuki Mizuguchi. (2018) Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies. Stem Cell Reports 11:6, pages 1539-1550.
Crossref
Crossref
Albert P. Li, Novera Alam, Kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell & Qian Yang. (2018) Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity. Drug Metabolism and Disposition 46:11, pages 1562-1571.
Crossref
Crossref
Laura M. Langan, Stewart F. Owen & Awadhesh N. Jha. (2018)
Establishment and long-term maintenance of primary intestinal epithelial cells cultured from the rainbow trout,
Oncorhynchus mykiss
. Biology Open 7:3.
Crossref
Crossref
Laura M. Langan, Silvia Arossa, Stewart F. Owen & Awadhesh N. Jha. (2018) Assessing the impact of benzo[ a ]pyrene with the in vitro fish gut model: An integrated approach for eco-genotoxicological studies. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 826, pages 53-64.
Crossref
Crossref
Ming-Chih David Ho, Nicholas Ring, Kirsten Amaral, Utkarsh Doshi & Albert P. Li. (2017) Human Enterocytes as an In Vitro Model for the Evaluation of Intestinal Drug Metabolism: Characterization of Drug-Metabolizing Enzyme Activities of Cryopreserved Human Enterocytes from Twenty-Four Donors. Drug Metabolism and Disposition 45:6, pages 686-691.
Crossref
Crossref
Min Yao, Menghong Dai, Zhaoying Liu, Wenlong Cui, Daoyuan Li, Huahai Zhang, Juan Li, Yahui Liu & Zonghui Yuan. (2012) mRNA expression profiles of P450 3A enzymes in the liver and small intestine of the domestic pig. Research in Veterinary Science 93:1, pages 360-365.
Crossref
Crossref
Mery Giantin, Vanessa Zancanella, Rosa Maria Lopparelli, Anna Granato, Monica Carletti, Maria Teresa Vilei, Maurizio Muraca, Chiara Baratto & Mauro Dacasto. (2012) Effects of Time Culture and Prototypical Cytochrome P450 3A (CYP3A) Inducers on CYP2B22, CYP2C, CYP3A and Nuclear Receptor (NR) mRNAs in Long-term Cryopreserved Pig Hepatocytes (CPHs). Drug Metabolism and Pharmacokinetics 27:5, pages 495-505.
Crossref
Crossref
Desmond B.S. Pink, Stephanie K. Gatrell, Rajavel Elango, Joan Turchinsky, Aaron S. Kiess, Kenneth P. Blemings, Walter T. Dixon & Ronald O. Ball. (2011) Lysine α-ketoglutarate reductase, but not saccharopine dehydrogenase, is subject to substrate inhibition in pig liver. Nutrition Research 31:7, pages 544-554.
Crossref
Crossref
Paul M. van Midwoud, Marjolijn T. Merema, Elisabeth Verpoorte & Geny M. M. Groothuis. (2010) A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices. Lab on a Chip 10:20, pages 2778.
Crossref
Crossref
Min Yao, Zhaoying Liu, Menghong Dai, Lingli Huang, Dongmei Chen, Yulian Wang, Yanfei Tao, Xu Wang, Zhenli Liu & Zonghui Yuan. (2009) Transcriptional Profile of CYP3As and Functional Expression of CYP3A29 from Piglets. Transcriptional Profile of CYP3As and Functional Expression of CYP3A29 from Piglets.
E. Baldini, R. Cursio, G. DeSousa, A. Margara, J. Honiger, M.-C. Saint-Paul, P. Bayer, V. Raimondi, R. Rahmani, J. Mouiel & J. Gugenheim. (2009) Cryopreserved Porcine Hepatocytes: Expression and Induction of Cytochrome P450, Isoform CYP2E1. Transplantation Proceedings 41:4, pages 1367-1369.
Crossref
Crossref
Kasiram Katneni, Susan A. Charman & Christopher J.H. Porter. (2008) Use of plasma proteins as solubilizing agents in in vitro permeability experiments: Correction for unbound drug concentration using the reciprocal permeability approach. Journal of Pharmaceutical Sciences 97:1, pages 209-224.
Crossref
Crossref
Dorina Rusu, Suzanne Loret, Olivier Peulen, Jacques Mainil & Guy Dandrifosse. (2005) Immunochemical, biomolecular and biochemical characterization of bovine epithelial intestinal primocultures. BMC Cell Biology 6:1.
Crossref
Crossref
Volker Mersch-Sundermann, Siegfried Knasmüller, Xin-jiang Wu, Firouz Darroudi & Fekadu Kassie. (2004) Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicology 198:1-3, pages 329-340.
Crossref
Crossref
Masaaki Kobayashi, Nobuhiro Sugihara, Hirohiko Ise, Takeshi Omasa & Naoki Negishi. (2004) Real time monitoring of drug metabolic enzyme response inside human hepatoma GS‐3A4‐HepG2 cells by means of electrochemical impedance measurement. Polymers for Advanced Technologies 15:5, pages 232-243.
Crossref
Crossref
Wayne M Mullett, Markus Walles, Karsten Levsen, Jürgen Borlak & Janusz Pawliszyn. (2004) Multidimensional on-line sample preparation of verapamil and its metabolites by a molecularly imprinted polymer coupled to liquid chromatography–mass spectrometry. Journal of Chromatography B 801:2, pages 297-306.
Crossref
Crossref
Takakazu Matsushita, Toshikazu Yagi, Joseph A. Hardin, Jennifer D. Cragun, Frank W. Crow, H. Robert BergenIIIIII, Gregory J. Gores & Scott L. Nyberg. (2017) Apoptotic Cell Death and Function of Cryopreserved Porcine Hepatocytes in a Bioartificial Liver. Cell Transplantation 12:2, pages 109-121.
Crossref
Crossref
M Walles, W.M Mullett, K Levsen, J Borlak, G Wünsch & J Pawliszyn. (2002) Verapamil drug metabolism studies by automated in-tube solid phase microextraction. Journal of Pharmaceutical and Biomedical Analysis 30:2, pages 307-319.
Crossref
Crossref
Pavel Anzenbacher, Eva Anzenbacherová, Roman Zuber, Pavel Soucek & F. Peter Guengerich. (2002) Pig and Minipig Cytochromes P450. Drug Metabolism and Disposition 30:1, pages 100-102.
Crossref
Crossref
Junji Washizu, François Berthiaume, Yasuji Mokuno, Ronald G. Tompkins, Mehmet Toner & Martin L. Yarmush. (2001) Long-Term Maintenance of Cytochrome P450 Activities by Rat Hepatocyte/3T3 Cell Co-cultures in Heparinized Human Plasma. Tissue Engineering 7:6, pages 691-703.
Crossref
Crossref
V Carrière, J Chambaz & M Rousset. (2001) Intestinal responses to xenobiotics. Toxicology in Vitro 15:4-5, pages 373-378.
Crossref
Crossref
Quan Zhou. (2001) Chiral metabolism of propafenone in rat hepatic microsomes treated with two inducers. World Journal of Gastroenterology 7:6, pages 830.
Crossref
Crossref
Jürgen Borlak & Thomas Thum. (2001) Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures11Abbreviations: Ah, aryl hydrocarbon; c/EBP, CCAAT/enhancer-binding protein; cDNA, complementary DNA CYP, cytochrome P450; EROD, ethoxyresorufin-O-deethylase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GSTA, glutathione S-transferase alpha; HNF, hepatic nuclear factor; RT–PCR, reverse transcription–polymerase chain reaction; and TF, transcription factor.. Biochemical Pharmacology 61:2, pages 145-153.
Crossref
Crossref
Thomas Thum & Jürgen Borlak. (2009) Cytochrome P450 mono‐oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat. British Journal of Pharmacology 130:8, pages 1745-1752.
Crossref
Crossref