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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 1
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Research Article

Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT1D receptor agonist

T. Prueksaritanont, P. Lu, L. Gorham, F. Sternfeld, K. P. Vyas Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
Pages 47-59 | Published online: 27 Aug 2009

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Ian R. Phillips & Elizabeth A. Shephard. (2020) Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease. Xenobiotica 50:1, pages 19-33.
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Ian R. Phillips & Elizabeth A. Shephard. (2017) Drug metabolism by flavin-containing monooxygenases of human and mouse. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 167-181.
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Jing Ning, Jie Hou, Ping Wang, Jing-Jing Wu, Zi-Ru Dai, Li-Wei Zou, Wei Li, Guang-Bo Ge, Xiao-Chi Ma & Ling Yang. (2015) Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human. Xenobiotica 45:11, pages 954-960.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Articles from other publishers (11)

Yasushi Yamazoe, Yoshiya Yamamura & Kouichi Yoshinari. (2023) Construction of a fused grid-based CYP2C8-Template system and the application. Drug Metabolism and Pharmacokinetics, pages 100492.
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Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
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Xiaoyan Pang, Chongzhuang Tang, Runcong Guo & Xiaoyan Chen. (2022) Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity. Pharmacology & Therapeutics 233, pages 108020.
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Gianluca Catucci, Gianfranco Gilardi & Sheila J. Sadeghi. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 509 562 .
Tomomi Taniguchi-Takizawa, Harutoshi Kato, Makiko Shimizu & Hiroshi Yamazaki. (2021) Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants. Current Drug Metabolism 22:3, pages 208-214.
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Janne T. Backman, Anne M. Filppula, Mikko Niemi & Pertti J. Neuvonen. (2015) Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacological Reviews 68:1, pages 168-241.
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Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha & Michael Martin. (2007) Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N -Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine) . Drug Metabolism and Disposition 35:6, pages 929-936.
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Russell J. Mortishire-Smith, Desmond O'Connor, Jose M. Castro-Perez & Jane Kirby. (2005) Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis. Rapid Communications in Mass Spectrometry 19:18, pages 2659-2670.
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. 2005. Drug Metabolism. Drug Metabolism 243 268 .
Virginie Lattard, Christiane Longin-Sauvageon, Joel Lachuer, Paul Delatour & Etienne Benoit. (2002) Cloning, Sequencing, and Tissue-Dependent Expression of Flavin-Containing Monooxygenase (FMO) 1 and FMO3 in the Dog. Drug Metabolism and Disposition 30:2, pages 119-128.
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Alexander Imhof & Roland Walter. 2002. 287 330 .

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