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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 1
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Research Article

Identification of CYP3A4 as the predominant isoform responsible for the metabolism of ambroxol in human liver microsomes

Pages 71-80 | Published online: 27 Aug 2009

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Read on this site (5)

Uday S. Ganapathy, Véronique Dartois & Thomas Dick. (2019) Repositioning rifamycins for Mycobacterium abscessus lung disease. Expert Opinion on Drug Discovery 14:9, pages 867-878.
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Vojo Deretic & Graham S. Timmins. (2019) Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opinion on Drug Metabolism & Toxicology 15:3, pages 213-218.
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Mario Malerba & Beatrice Ragnoli. (2008) Ambroxol in the 21st century: pharmacological and clinical update. Expert Opinion on Drug Metabolism & Toxicology 4:8, pages 1119-1129.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Articles from other publishers (19)

Sergey L. Babak, Marina V. Gorbunova & Andrey G. Malyavin. (2023) Rational mucolytic therapy with ambroxol: controversial and indisputable. A review. Consilium Medicum 25:9, pages 623-628.
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Sisir Nandi, Bhabani Shankar Nayak, Mayank Kumar Khede & Anil Kumar Saxena. (2022) Repurposing of Chemotherapeutics to Combat COVID-19. Current Topics in Medicinal Chemistry 22:32, pages 2660-2694.
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Pritam D. Sonawane, Suraj R. Chaudhari, Saurabh B. Ganorkar, Amod S. Patil & Atul A. Shirkhedkar. (2022) A brief review on critical analytical aspects for quantification of ambroxol in biological samples. Analytical Biochemistry 657, pages 114888.
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Hao Zhou, Min Zhang, Ling Sun, Wenfang Li & Qian Liu. (2021) A simple LC-MS/MS method for simultaneous determination of cilostazol and ambroxol in Sprague-Dawley rat plasma and its application to drug-drug pharmacokinetic interaction study following oral delivery in rats. Journal of Chromatography B 1179, pages 122766.
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Chao-Nan Yang, Wen-Ya Peng, Lie-Chwen Lin & Tung-Hu Tsai. (2021) Protein unbound pharmacokinetics of ambroxol in the blood and brains of rats and the interaction of ambroxol with Polygala tenuifolia by multiple microdialysis. Journal of Ethnopharmacology 269, pages 113764.
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K. A. Zagorodnikova, K. B. Mirzaev & D. A. Sychev. (2020) Possibility for the use of bromhexine to prevent infection with SARS-CoV-2. Kachestvennaya klinicheskaya praktika:4S, pages 8-10.
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Yasushi Yamazoe, Takahiro Goto & Masahiro Tohkin. (2020) Versatile applicability of a grid-based CYP3A4 Template to understand the interacting mechanisms with the small-size ligands; part 3 of CYP3A4 Template study. Drug Metabolism and Pharmacokinetics 35:3, pages 253-265.
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Yoon-Myung Kim, Mi-Sun Yum, Sun Hee Heo, Taeho Kim, Hee Kyung Jin, Jae-sung Bae, Go Hun Seo, Arum Oh, Hee Mang Yoon, Hyun Taek Lim, Hyo-Won Kim, Tae-Sung Ko, Hyeong‐Seok Lim, Mark J Osborn, Jakub Tolar, Claudia Cozma, Arndt Rolfs, Ari Zimran, Beom Hee Lee & Han-Wook Yoo. (2020) Pharmacologic properties of high-dose ambroxol in four patients with Gaucher disease and myoclonic epilepsy. Journal of Medical Genetics 57:2, pages 124-131.
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Maria A. Grishina & Vladimir A. Potemkin. (2019) Topological Analysis of Electron Density in Large Biomolecular Systems. Current Drug Discovery Technologies 16:4, pages 437-448.
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Seong Won Choi, Yuexi Gu, Ryan Scott Peters, Padmini Salgame, Jerrold J. Ellner, Graham S. Timmins & Vojo Deretic. (2018) Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity. Antimicrobial Agents and Chemotherapy 62:9.
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Jinjun Wu, Zaixing Cheng, Shugui He, Jian Shi, Shuqiang Liu, Guiyu Zhang, Lijun Zhu, Liang Liu, Zhongqiu Liu, Na Lin & Linlin Lu. (2015) Pinelliae Rhizoma, a Toxic Chinese Herb, Can Significantly Inhibit CYP3A Activity in Rats. Molecules 20:1, pages 792-806.
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Xin Zhou, Liang Li, Pan Deng, Xiaoyan Chen & Dafang Zhong. (2013) Characterization of metabolites of GLS4 in humans using ultrahigh‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry. Rapid Communications in Mass Spectrometry 27:21, pages 2483-2492.
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Jia Liu. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Bachir Latli, Matt Hrapchak, Heinz‐Karl Switek, Daniel M. Retz, Dhileepkumar Krishnamurthy & Chris H. Senanayake. (2009) Synthesis of labeled ambroxol and its major metabolites. Journal of Labelled Compounds and Radiopharmaceuticals 53:1, pages 15-23.
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Vladimir A. Potemkin, Alexander A. Pogrebnoy & Maria A. Grishina. (2009) Technique for Energy Decomposition in the Study of “Receptor-Ligand” Complexes. Journal of Chemical Information and Modeling 49:6, pages 1389-1406.
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M. A. Grishina, V. A. Potemkin, A. A. Pogrebnoi & N. N. Ivshina. (2009) A study of conformational states of substrates of isoform 3A4 of cytochrome P450. Biophysics 53:5, pages 355-360.
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Fazlul Huq. (2008) Molecular Modelling Analysis of the Metabolism of Ambroxol. Journal of Pharmacology and Toxicology 3:2, pages 147-152.
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Tomasz Drewa, Bartosz Misterek, Hanna Pachnowska, Zbigniew Wolski, Magdalena Mikulska‐Jovanovic & Joanna Drewa. (2007) Parenteral ambroxol treatment causes xanthine and calcium oxalate stones in rats. International Journal of Urology 14:5, pages 463-465.
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. (2006) Effect of Clarithromycin on the Pharmacokinetics of Ambroxol in Rats. Journal of Korean Pharmaceutical Sciences 36:3, pages 157-160.
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