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Xenobiotica
the fate of foreign compounds in biological systems
Volume 30, 2000 - Issue 1
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Research Article

Pronounced differences in inhibition potency of lactone and non-lactone compounds for mouse and human coumarin 7-hydroxylases (CYP2A5 and CYP2A6)

Pages 81-92 | Published online: 27 Aug 2009

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Risto O. Juvonen, Mira Kuusisto, Carolin Fohrgrup, Mari H. Pitkänen, Tapio J. Nevalainen, Seppo Auriola, Hannu Raunio, Markku Pasanen & Olli T. Pentikäinen. (2016) Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes. Xenobiotica 46:1, pages 14-24.
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H. Raunio, N. Pokela, K. Puhakainen, M. Rahnasto, T. Mauriala, S. Auriola & R. O. Juvonen. (2008) Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo. Xenobiotica 38:1, pages 34-47.
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M. Rypka, J. Veselý, Z. Chmela, D. Riegrová, K. Červenková, L. Havlíček, K. Lemr, J. Hanuš, B. Černý, J. Lukeš & K. Michalíková. (2002) In vitro biotransformation of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine by mouse liver microsomes. Xenobiotica 32:11, pages 1017-1031.
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Xiao Deng, Qianghong Pu, Erhao Wang & Chao Yu. (2016) Celery extract inhibits mouse CYP2A5 and human CYP2A6 activities via different mechanisms. Oncology Letters 12:6, pages 5309-5314.
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Suzanne van de Nobelen, Anne S. Kienhuis & Reinskje Talhout. (2016) An Inventory of Methods for the Assessment of Additive Increased Addictiveness of Tobacco Products: Table 1.. Nicotine & Tobacco Research 18:7, pages 1546-1555.
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M. Shoaib & Y. Buhidma. 2016. Animal Models for Medications Screening to Treat Addiction. Animal Models for Medications Screening to Treat Addiction 121 156 .
Niina Tani, Risto O. Juvonen, Hannu Raunio, Muluneh Fashe, Jukka Leppänen, Bin Zhao, Rachel F. Tyndale & Minna Rahnasto-Rilla. (2014) Rational design of novel CYP2A6 inhibitors. Bioorganic & Medicinal Chemistry 22:23, pages 6655-6664.
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Minna K. Rahnasto, Hannu A. Raunio, Carsten Wittekindt, Kaisa A. Salminen, Jukka Leppänen, Risto O. Juvonen, Antti Poso & Maija K. Lahtela-Kakkonen. (2011) Identification of novel CYP2A6 inhibitors by virtual screening. Bioorganic & Medicinal Chemistry 19:23, pages 7186-7193.
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Alfonso T. García-Sosa, Sulev Sild, Kalev Takkis & Uko Maran. (2011) Combined Approach Using Ligand Efficiency, Cross-Docking, and Antitarget Hits for Wild-Type and Drug-Resistant Y181C HIV-1 Reverse Transcriptase. Journal of Chemical Information and Modeling 51:10, pages 2595-2611.
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Yoshie Hirano & Takaharu Mizutani. (2003) Study of inhibition of CYP2A6 by some drugs derived from quinoline. Journal of Pharmacy and Pharmacology 55:12, pages 1667-1672.
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Chunzhi Ai, Yan Li, Yonghua Wang, Wei Li, Peipei Dong, Guangbo Ge & Ling Yang. (2010) Investigation of binding features: Effects on the interaction between CYP2A6 and inhibitors. Journal of Computational Chemistry, pages NA-NA.
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Antoinette Chougnet, Wolf-D. Woggon, Esther Locher & Boris Schilling. (2009) Synthesis and in vitro Activity of Heterocyclic Inhibitors of CYP2A6 and CYP2A13, Two Cytochrome P450 Enzymes Present in the Respiratory Tract. ChemBioChem 10:9, pages 1562-1567.
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Helena A. Soini, Donald Wiesler, Sachiko Koyama, Christophe Féron, Claude Baudoin & Milos V. Novotny. (2009) Comparison of Urinary Scents of Two Related Mouse Species, Mus spicilegus and Mus domesticus. Journal of Chemical Ecology 35:5, pages 580-589.
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Max K. Leong, Yen-Ming Chen, Hong-Bin Chen & Po-Hong Chen. (2008) Development of a New Predictive Model for Interactions with Human Cytochrome P450 2A6 Using Pharmacophore Ensemble/Support Vector Machine (PhE/SVM) Approach. Pharmaceutical Research 26:4, pages 987-1000.
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M Rahnasto, C Wittekindt, R O Juvonen, M Turpeinen, A Petsalo, O Pelkonen, A Poso, G Stahl, H-D Höltje & H Raunio. (2007) Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme—an in silico approach. The Pharmacogenomics Journal 8:5, pages 328-338.
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Michael RabinoffNicholas CaskeyAnthony RisslingCandice Park. (2007) Pharmacological and Chemical Effects of Cigarette Additives. American Journal of Public Health 97:11, pages 1981-1991.
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Kimiko Aoki, Yasuharu Kashiwagura, Toru Horie, Hitoshi Sato, Chise Tateno, Naoki Ozawa & Katsutoshi Yoshizato. (2006) Characterization of Humanized Liver from Chimeric Mice Using Coumarin as a Human CYP2A6 and Mouse CYP2A5 Probe. Drug Metabolism and Pharmacokinetics 21:4, pages 277-285.
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Arja Asikainen, Juhani Tarhanen, Antti Poso, Markku Pasanen, Esko Alhava & Risto O Juvonen. (2003) Predictive value of comparative molecular field analysis modelling of naphthalene inhibition of human CYP2A6 and mouse CYP2A5 enzymes. Toxicology in Vitro 17:4, pages 449-455.
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