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Xenobiotica
the fate of foreign compounds in biological systems
Volume 36, 2006 - Issue 10-11: Special Issue: The absorption, distribution, metabolism and excretion (ADME) transcriptome
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Original

Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome

J. G. Slatter Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc), Seattle, WA, USACorrespondence[email protected]
,
I. E. Templeton Department of Pharmaceutics, University of Washington, Seattle, WA, USA
,
J. C. Castle Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc), Seattle, WA, USA
,
A. Kulkarni Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc), Seattle, WA, USA
,
T. H. Rushmore Drug Metabolism, Merck Research Laboratories, West PointPA, USA
,
K. Richards Drug Metabolism, Merck Research Laboratories, West PointPA, USA
,
Y. He Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc), Seattle, WA, USA
,
X. Dai Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc), Seattle, WA, USA
,
O. J. Cheng Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc), Seattle, WA, USA
,
M. Caguyong Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc), Seattle, WA, USA
&
R. G. Ulrich Rosetta Inpharmatics LLC (a wholly owned subsidiary of Merck & Co., Inc), Seattle, WA, USA
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Pages 938-962 | Received 09 Feb 2006, Accepted 02 Jun 2006, Published online: 11 Aug 2009

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J. G. Slatter, O. Cheng, P. D. Cornwell, A. De Souza, J. Rockett, T. Rushmore, D. Hartley, R. Evers, Y. He, X. Dai, R. Hu, M. Caguyong, C. J. Roberts, J. Castle & R. G. Ulrich. (2006) Microarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and mice in vivo. Xenobiotica 36:10-11, pages 902-937.
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Articles from other publishers (23)

J. Christopher Corton, Janice S. Lee, Jie Liu, Hongzu Ren, Beena Vallanat & Michael DeVito. (2022) Determinants of gene expression in the human liver: Impact of aging and sex on xenobiotic metabolism. Experimental Gerontology 169, pages 111976.
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Dong Gui Hu, Shashikanth Marri, Ross A. McKinnon, Peter I. Mackenzie & Robyn Meech. (2019) Deregulation of the Genes that Are Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Hepatocellular Carcinoma. Journal of Pharmacology and Experimental Therapeutics 368:3, pages 363-381.
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Yuanfu Lu, Xue-Mei Zhao, Zhaoyong Hu, Li Wang & Feng Li. (2018) LC–MS-Based Metabolomics in the Study of Drug-Induced Liver Injury. Current Pharmacology Reports 5:1, pages 56-67.
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Danica E. DeGroot, Adam Swank, Russell S. Thomas, Mark Strynar, Mi-Young Lee, Paul L. Carmichael & Steven O. Simmons. (2018) mRNA transfection retrofits cell-based assays with xenobiotic metabolism. Journal of Pharmacological and Toxicological Methods 92, pages 77-94.
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Jurjen Duintjer Tebbens, Malek Azar, Elfriede Friedmann, Martin Lanzendörfer & Petr Pávek. (2018) Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction. International Journal of Molecular Sciences 19:6, pages 1785.
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Ariane Ambolet-Camoit, Chris Ottolenghi, Alix Leblanc, Min Ji Kim, Franck Letourneur, Sébastien Jacques, Nicolas Cagnard, Christiane Guguen-Guillouzo, Robert Barouki & Martine Aggerbeck. (2015) Two persistent organic pollutants which act through different xenosensors (alpha-endosulfan and 2,3,7,8 tetrachlorodibenzo-p-dioxin) interact in a mixture and downregulate multiple genes involved in human hepatocyte lipid and glucose metabolism. Biochimie 116, pages 79-91.
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Feng Li, Jie Lu, Jie Cheng, Laiyou Wang, Tsutomu Matsubara, Iván L Csanaky, Curtis D Klaassen, Frank J Gonzalez & Xiaochao Ma. (2013) Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nature Medicine 19:4, pages 418-420.
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Alexander V. LyubimovJi Young Lee, Timothy A. Moeller, Rob Shipman, Alexis Kaushansky & Jasminder Sahi. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 19 .
J. Christopher Corton, Pierre R. Bushel, Jennifer Fostel & Raegan B. O’Lone. (2012) Sources of variance in baseline gene expression in the rodent liver. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 746:2, pages 104-112.
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David Hecht. (2010) Applications of machine learning and computational intelligence to drug discovery and development. Drug Development Research 72:1, pages 53-65.
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Nicholas S. Luke, Michael J. DeVito, Imran Shah & Hisham A. El-Masri. (2010) Development of a Quantitative Model of Pregnane X Receptor (PXR) Mediated Xenobiotic Metabolizing Enzyme Induction. Bulletin of Mathematical Biology 72:7, pages 1799-1819.
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Xia Yang, Bin Zhang, Cliona Molony, Eugene Chudin, Ke Hao, Jun Zhu, Andrea Gaedigk, Christine Suver, Hua Zhong, J. Steven Leeder, F. Peter Guengerich, Stephen C. Strom, Erin Schuetz, Thomas H. Rushmore, Roger G. Ulrich, J. Greg Slatter, Eric E. Schadt, Andrew Kasarskis & Pek Yee Lum. (2010) Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Research 20:8, pages 1020-1036.
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Karol Thompson. (2010) Toxicogenomics and Studies of Genomic Effects of Dietary Components. Journal of Nutrigenetics and Nutrigenomics 3:4-6, pages 251-258.
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Benjamin L. de Bivort. 2010. Systems Biology in Drug Discovery and Development. Systems Biology in Drug Discovery and Development 149 165 .
Benjamin de Bivort. 2010. Systems Biology for Signaling Networks. Systems Biology for Signaling Networks 429 446 .
Marshall B. Elam, George S. CowanJrJr, Robert J. Rooney, M. Lloyd Hiler, Chandrahasa R. Yellaturu, Xiong Deng, George E. Howell, Edwards A. Park, Ivan C. Gerling, Divyan Patel, J. Christopher Corton, Lauren M. Cagen, Henry G. Wilcox, Malay Gandhi, Micheal H. Bahr, Micheal C. Allan, Linus A. Wodi, George A. Cook, Thomas A. Hughes & Rajendra Raghow. (2012) Hepatic Gene Expression in Morbidly Obese Women: Implications for Disease Susceptibility. Obesity 17:8, pages 1563-1573.
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J.P. Hernandez, L.C. Mota, W. Huang, D.D. Moore & W.S. Baldwin. (2009) Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR). Toxicology 256:1-2, pages 53-64.
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Naoki KiyosawaYosuke AndoSunao ManabeTakashi Yamoto. (2009) Toxicogenomic Biomarkers for Liver Toxicity. Journal of Toxicologic Pathology 22:1, pages 35-52.
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Michael J Boedigheimer, Russell D Wolfinger, Michael B Bass, Pierre R Bushel, Jeff W Chou, Matthew Cooper, J Christopher Corton, Jennifer Fostel, Susan Hester, Janice S Lee, Fenglong Liu, Jie Liu, Hui-Rong Qian, John Quackenbush, Syril Pettit & Karol L Thompson. (2008) Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories. BMC Genomics 9:1.
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Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
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Stephen J Walker. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
Georges Natsoulis, Cecelia I Pearson, Jeremy Gollub, Barrett P Eynon, Joe Ferng, Ramesh Nair, Radha Idury, May D Lee, Mark R Fielden, Richard J Brennan, Alan H Roter & Kurt Jarnagin. (2008) The liver pharmacological and xenobiotic gene response repertoire. Molecular Systems Biology 4:1.
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Matthew Wortham, Maciej Czerwinski, Lin He, Andrew Parkinson & Yu-Jui Yvonne Wan. (2007) Expression of Constitutive Androstane Receptor, Hepatic Nuclear Factor 4α, and P450 Oxidoreductase Genes Determines Interindividual Variability in Basal Expression and Activity of a Broad Scope of Xenobiotic Metabolism Genes in the Human Liver. Drug Metabolism and Disposition 35:9, pages 1700-1710.
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