Xenobiotica, Volume 36, Issue 10-11 (2006)

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Xenobiotica, Volume 36, Issue 10-11 (2006)

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Editorial

Editorial
Editorial: The absorption, distribution, metabolism and excretion (ADME) transcriptome
Pages: 857-859
Published online: 11 Aug 2009
First Page PreviewforEditorial: The absorption, distribution, metabolism and excretion (ADME) transcriptome | Full Text | PDF (32.9 KB)
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Original

Article
Expressed sequence tags (ESTs) and single nucleotide polymorphisms (SNPs): What large-scale sequencing projects can tell us about ADME
N. Plant
Pages: 860-876
Published online: 11 Aug 2009
AbstractforExpressed sequence tags (ESTs) and single nucleotide polymorphisms (SNPs): What large-scale sequencing projects can tell us about ADME | Full Text | References | PDF (93.3 KB)
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Article
Algorithms for network analysis in systems-ADME/Tox using the MetaCore and MetaDrug platforms
S. Ekins, A. Bugrim, L. Brovold, E. Kirillov, Y. Nikolsky, E. Rakhmatulin, S. Sorokina, A. Ryabov, T. Serebryiskaya, A. Melnikov, J. Metz & T. Nikolskaya
Pages: 877-901
Published online: 11 Aug 2009
AbstractforAlgorithms for network analysis in systems-ADME/Tox using the MetaCore and MetaDrug platforms | Full Text | References | PDF (1.3 MB)
  • 567 Views
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Article
Microarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and mice in vivo
J. G. Slatter, O. Cheng, P. D. Cornwell, A. De Souza, J. Rockett, T. Rushmore, D. Hartley, R. Evers, Y. He, X. Dai, R. Hu, M. Caguyong, C. J. Roberts, J. Castle & R. G. Ulrich
Pages: 902-937
Published online: 11 Aug 2009
AbstractforMicroarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and mice in vivo | Full Text | References | PDF (4 MB) | Supplemental
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Article
Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome
J. G. Slatter, I. E. Templeton, J. C. Castle, A. Kulkarni, T. H. Rushmore, K. Richards, Y. He, X. Dai, O. J. Cheng, M. Caguyong & R. G. Ulrich
Pages: 938-962
Published online: 11 Aug 2009
AbstractforCompendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome | Full Text | References | PDF (403.7 KB) | Supplemental
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Article
Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition
K. Bleasby, J. C. Castle, C. J. Roberts, C. Cheng, W. J. Bailey, J. F. Sina, A. V. Kulkarni, M. J. Hafey, R. Evers, J. M. Johnson, R. G. Ulrich & J. G. Slatter
Pages: 963-988
Published online: 11 Aug 2009
AbstractforExpression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition | Full Text | References | PDF (548.8 KB) | Supplemental
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Article
ADME transcriptome in Hispanic versus White donor livers: Evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics
D. Finkelstein, V. Lamba, M. Assem, J. Rengelshausen, K. Yasuda, S. Strom & E. Schuetz
Pages: 989-1012
Published online: 11 Aug 2009
AbstractforADME transcriptome in Hispanic versus White donor livers: Evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics | Full Text | References | PDF (336.1 KB)
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Article
Drug-induced changes in P450 enzyme expression at the gene expression level: A new dimension to the analysis of drug–drug interactions
M. D. Lee, E. Ayanoglu & L. Gong
Pages: 1013-1080
Published online: 11 Aug 2009
AbstractforDrug-induced changes in P450 enzyme expression at the gene expression level: A new dimension to the analysis of drug–drug interactions | Full Text | References | PDF (352 KB)
  • 378 Views
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Article
Tissue and species distribution of the glutathione pathway transcriptome
W. B. Mattes, K. K. Daniels, M. Summan, Z. A. Xu & D. L. Mendrick
Pages: 1081-1121
Published online: 11 Aug 2009
AbstractforTissue and species distribution of the glutathione pathway transcriptome | Full Text | References | PDF (2 MB)
  • 217 Views
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Article
Predictive models of hepatotoxicity using gene expression data from primary rat hepatocytes
L. Hultin-Rosenberg, S. Jagannathan, K. C. Nilsson, S. A. Matis, N. Sjögren, R. D. J. Huby, A. H. Salter & J. D. Tugwood
Pages: 1122-1139
Published online: 11 Aug 2009
AbstractforPredictive models of hepatotoxicity using gene expression data from primary rat hepatocytes | Full Text | References | PDF (1.3 MB)
  • 79 Views
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Article
Emerging evidence for the interrelationship of xenobiotic exposure and circadian rhythms: a review
F. L. Lim, R. A. Currie, G. Orphanides & J. G. Moggs
Pages: 1140-1151
Published online: 11 Aug 2009
AbstractforEmerging evidence for the interrelationship of xenobiotic exposure and circadian rhythms: a review | Full Text | References | PDF (88.2 KB)
  • 139 Views
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Article
Nuclear receptors CAR and PXR in the regulation of hepatic metabolism
E. S. Tien & M. Negishi
Pages: 1152-1163
Published online: 11 Aug 2009
AbstractforNuclear receptors CAR and PXR in the regulation of hepatic metabolism | Full Text | References | PDF (160.9 KB)
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