Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 2
Submit an article Journal homepage
251
Views
16
CrossRef citations to date
0
Altmetric
Research Article

Characterization of benzimidazole and other oxidative and conjugative metabolites of brimonidine in vitro and in rats in vivo using on-line H/D exchange LC-MS/MS and stable-isotope tracer techniques

J. Ni Department of Drug Safety Evaluation, 2525 Dupont Dr., Irvine, CA 92612, USA
,
J. Rowe Department of Drug Safety Evaluation, 2525 Dupont Dr., Irvine, CA 92612, USA
,
T. Heidelbaugh Department of Medicinal Chemistry Allergan, 2525 Dupont Dr., Irvine, CA 92612, USA
,
S. Sinha Department of Medicinal Chemistry Allergan, 2525 Dupont Dr., Irvine, CA 92612, USA
&
A. Acheampong Department of Drug Safety Evaluation, 2525 Dupont Dr., Irvine, CA 92612, USA
Pages 205-220 | Received 30 Aug 2006, Accepted 04 Oct 2006, Published online: 22 Sep 2008

Citations (16)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Narges Cheshmazar, Siavoush Dastmalchi, Mineko Terao, Enrico Garattini & Maryam Hamzeh-Mivehroud. (2019) Aldehyde oxidase at the crossroad of metabolism and preclinical screening. Drug Metabolism Reviews 51:4, pages 428-452.
Read now

Articles from other publishers (15)

Gianluca Catucci, Gianfranco Gilardi & Sheila J. Sadeghi. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 509 562 .
Vijayakumar Baksam, Saritha Nimmakayala, Subba Rao Devineni, Rama Mohan R. Muchumarri, Sanjeev Shandilya & Pramod Kumar. (2021) Isolation and characterization of thermal degradation impurity in brimonidine tartrate by HPLC, LC–MS/MS, and 2DNMR. Journal of Pharmaceutical and Biomedical Analysis 205, pages 114297.
Crossref
Rhys B. Murphy, Naomi A. Wyatt, Benjamin H. Fraser, Nageshwar R. Yepuri, Peter J. Holden, Andrew T.L. Wotherspoon & Tamim A. Darwish. (2019) A rapid MS/MS method to assess the deuterium kinetic isotope effect and associated improvement in the metabolic stability of deuterated biological and pharmacological molecules as applied to an imaging agent. Analytica Chimica Acta 1064, pages 65-70.
Crossref
Jens Atzrodt, Volker Derdau, William J. Kerr & Marc Reid. (2018) Deuterium‐ and Tritium‐Labelled Compounds: Applications in the Life Sciences. Angewandte Chemie International Edition 57:7, pages 1758-1784.
Crossref
Jens Atzrodt, Volker Derdau, William J. Kerr & Marc Reid. (2018) Deuterium‐ und tritiummarkierte Verbindungen: Anwendungen in den modernen Biowissenschaften. Angewandte Chemie 130:7, pages 1774-1802.
Crossref
E. Garattini & M. Terao. 2018. Comprehensive Toxicology. Comprehensive Toxicology 208 232 .
Yasushi Yamazoe & Kouichi Yoshinari. (2017) Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system. Drug Metabolism and Pharmacokinetics 32:5, pages 229-247.
Crossref
Yuan Xu, Liang Li, Yulan Wang, Jing Xing, Lei Zhou, Dafang Zhong, Xiaomin Luo, Hualiang Jiang, Kaixian Chen, Mingyue Zheng, Pan Deng & Xiaoyan Chen. (2017) Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: A Combined Computational and Experimental Study. Journal of Medicinal Chemistry 60:7, pages 2973-2982.
Crossref
Tyler B. Hughes & S. Joshua Swamidass. (2017) Deep Learning to Predict the Formation of Quinone Species in Drug Metabolism. Chemical Research in Toxicology 30:2, pages 642-656.
Crossref
Lin Xu. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Lin Xu. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Pritam Jain, Rahul Khatal, Hardik Jivani & Sanjay Surana. (2011) Stability-indicating densitometric HPTLC analysis of brimonidine tartrate in the bulk drug and in eye drops. Journal of Planar Chromatography ? Modern TLC 24:2, pages 166-171.
Crossref
C. Beedham. 2010. Comprehensive Toxicology. Comprehensive Toxicology 185 205 .
Ragu Ramanathan, S Çömezoglu & W Humphreys. 2009. Using Mass Spectrometry for Drug Metabolism Studies, Second Edition. Using Mass Spectrometry for Drug Metabolism Studies, Second Edition 127 203 .
. (2007) Current literature in mass spectrometry. Journal of Mass Spectrometry 42:9, pages 1251-1262.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.