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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 2
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Research Article

Characterization of benzimidazole and other oxidative and conjugative metabolites of brimonidine in vitro and in rats in vivo using on-line H/D exchange LC-MS/MS and stable-isotope tracer techniques

J. Ni Department of Drug Safety Evaluation, 2525 Dupont Dr., Irvine, CA 92612, USA
,
J. Rowe Department of Drug Safety Evaluation, 2525 Dupont Dr., Irvine, CA 92612, USA
,
T. Heidelbaugh Department of Medicinal Chemistry Allergan, 2525 Dupont Dr., Irvine, CA 92612, USA
,
S. Sinha Department of Medicinal Chemistry Allergan, 2525 Dupont Dr., Irvine, CA 92612, USA
&
A. Acheampong Department of Drug Safety Evaluation, 2525 Dupont Dr., Irvine, CA 92612, USA
Pages 205-220 | Received 30 Aug 2006, Accepted 04 Oct 2006, Published online: 22 Sep 2008

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