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Gobardhan Bal, Lakshmi Kanakaraj & Bibhash Chandra Mohanta. (2023) Prediction of pharmacokinetics of an anaplastic lymphoma kinase inhibitor in rat and monkey: application of physiologically based pharmacokinetic model as an alternative tool to minimise animal studies. Xenobiotica 53:12, pages 621-633.
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Eleni Karatza, George Ismailos, Markos Marangos & Vangelis Karalis. (2021) Optimization of hydroxychloroquine dosing scheme based on COVID-19 patients’ characteristics: a review of the literature and simulations. Xenobiotica 51:2, pages 127-138.
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Miguel Ángel Cabrera-Pérez & Hai Pham-The. (2018) Computational modeling of human oral bioavailability: what will be next?. Expert Opinion on Drug Discovery 13:6, pages 509-521.
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Andrea N Edginton & Ghanashyam Joshi. (2011) Have physiologically-based pharmacokinetic models delivered?. Expert Opinion on Drug Metabolism & Toxicology 7:8, pages 929-934.
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Charlotte Kloft & Italo Poggesi. (2010) Current and future directions of pharmacokinetic and pharmacokinetic–pharmacodynamic modelling and simulation: Population Approach Group in Europe 19th annual meeting. Expert Opinion on Drug Metabolism & Toxicology 6:12, pages 1599-1604.
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Yurong Lai. (2009) Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1175-1187.
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Thierry Lavé, Kathryn Chapman, Paul Goldsmith & Malcolm Rowland. (2009) Human clearance prediction: shifting the paradigm. Expert Opinion on Drug Metabolism & Toxicology 5:9, pages 1039-1048.
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Pascal Espié, Dominique Tytgat, Maria-Laura Sargentini-Maier, Italo Poggesi & Jean-Baptiste Watelet. (2009) Physiologically based pharmacokinetics (PBPK). Drug Metabolism Reviews 41:3, pages 391-407.
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Nikoletta Fotaki. (2009) Pros and cons of methods used for the prediction of oral drug absorption. Expert Review of Clinical Pharmacology 2:2, pages 195-208.
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Scott Summerfield & Phil Jeffrey. (2009) Discovery DMPK: changing paradigms in the eighties, nineties and noughties. Expert Opinion on Drug Discovery 4:3, pages 207-218.
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S. G. Summerfield, A. J. Lucas, R. A. Porter, P. Jeffrey, R. N. Gunn, K. R. Read, A. J. Stevens, A. C. Metcalf, M. C. Osuna, P. J. Kilford, J. Passchier & A. D. Ruffo. (2008) Toward an improved prediction of human brain penetration. Xenobiotica 38:12, pages 1518-1535.
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Andrea N Edginton, Frank-Peter Theil, Walter Schmitt & Stefan Willmann. (2008) Whole body physiologically-based pharmacokinetic models: their use in clinical drug development. Expert Opinion on Drug Metabolism & Toxicology 4:9, pages 1143-1152.
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Simon Thomas. (2008) Clinical relevance of predictive physiologically based pharmacokinetic methods. Expert Opinion on Drug Discovery 3:7, pages 725-732.
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Christoph Funk. (2008) The role of hepatic transporters in drug elimination. Expert Opinion on Drug Metabolism & Toxicology 4:4, pages 363-379.
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Articles from other publishers (73)
Yoochan Myung, Alex G C de Sá & David B Ascher. (2024) Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction. Nucleic Acids Research.
Crossref
Crossref
Anjali Setiya, Vinod Jani, Uddhavesh Sonavane & Rajendra Joshi. (2024) MolToxPred: small molecule toxicity prediction using machine learning approach. RSC Advances 14:6, pages 4201-4220.
Crossref
Crossref
Sandra Cvijić, Jelisaveta Ignjatović, Jelena Parojčić & Zorica Đurić. 2024. Computer-Aided Applications in Pharmaceutical Technology. Computer-Aided Applications in Pharmaceutical Technology
199
283
.
Veli B. Shakhmurov, Muhammet Kurulay, Aida Sahmurova, Mustafa Can Gursesli & Antonio Lanata. (2023) A Novel Nonlinear Dynamic Model Describing the Spread of Virus. Mathematics 11:20, pages 4226.
Crossref
Crossref
Shayne Cox Gad & Dexter SullivanJr.Jr.. 2023. Drug Safety Evaluation. Drug Safety Evaluation
425
456
.
Arian Emami Riedmaier. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development
293
304
.
Architha Aithal, Shubhrajyotsna Aithal & P. S. Aithal. (2022) Case Study on Certara’s Simcyp PBPK Simulator to Eliminate Lengthy Clinical Trails. International Journal of Health Sciences and Pharmacy, pages 69-109.
Crossref
Crossref
Alex G C de Sá, Yangyang Long, Stephanie Portelli, Douglas E V Pires & David B Ascher. (2022) toxCSM: comprehensive prediction of small molecule toxicity profiles. Briefings in Bioinformatics 23:5.
Crossref
Crossref
Juliet Rebello, Bill Brashier & Sharvari Shukla. (2022) Assessment of the predictive capability of modelling and simulation to determine bioequivalence of inhaled drugs: A systematic review. DARU Journal of Pharmaceutical Sciences 30:1, pages 229-243.
Crossref
Crossref
Zening Li, Jianan Hui, Panhui Yang & Hongju Mao. (2022) Microfluidic Organ-on-a-Chip System for Disease Modeling and Drug Development. Biosensors 12:6, pages 370.
Crossref
Crossref
Manthena V. S. Varma, Ayman El‐Kattan & Yurong Lai. 2022. Drug Transporters. Drug Transporters
433
452
.
Ruchi Chawla, Varsha Rani, Mohini Mishra & Krishan Kumar. 2022. Computer Aided Pharmaceutics and Drug Delivery. Computer Aided Pharmaceutics and Drug Delivery
217
254
.
Saheli Datta Burton. 2022. Artificial Intelligence and Its Discontents. Artificial Intelligence and Its Discontents
147
178
.
Takafumi Kato, Tsuyoshi Mikkaichi, Yasushi Yoshigae, Noriko Okudaira, Takako Shimizu, Takashi Izumi, Shuichi Ando & Yoshiaki Matsumoto. (2021) Quantitative analysis of an impact of P-glycoprotein on edoxaban's disposition using a human physiologically based pharmacokinetic (PBPK) model. International Journal of Pharmaceutics 597, pages 120349.
Crossref
Crossref
Kyoung Ah Min & Gus R. Rosania. 2021. Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery. Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery
3
39
.
Fengxu Wu, Yuquan Zhou, Langhui Li, Xianhuan Shen, Ganying Chen, Xiaoqing Wang, Xianyang Liang, Mengyuan Tan & Zunnan Huang. (2020) Computational Approaches in Preclinical Studies on Drug Discovery and Development. Frontiers in Chemistry 8.
Crossref
Crossref
Ivana Kurcubic, Sandra Cvijic, Bojana Filipcev, Jelisaveta Ignjatovic, Svetlana Ibric & Jelena Djuris. (2020) Development of propranolol hydrochloride bilayer mucoadhesive buccal tablets supported by in silico physiologically-based modeling. Reactive and Functional Polymers 151, pages 104587.
Crossref
Crossref
Rob C. van Wijk, Rami Ayoun Alsoud, Hans Lennernäs & Ulrika S. H. Simonsson. (2020) Model-Informed Drug Discovery and Development Strategy for the Rapid Development of Anti-Tuberculosis Drug Combinations. Applied Sciences 10:7, pages 2376.
Crossref
Crossref
Jitao David Zhang, Lisa Sach-Peltason, Christian Kramer, Ken Wang & Martin Ebeling. (2020) Multiscale modelling of drug mechanism and safety. Drug Discovery Today 25:3, pages 519-534.
Crossref
Crossref
Neil A. Miller, Micaela B. Reddy, Aki T. Heikkinen, Viera Lukacova & Neil Parrott. (2019) Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies. Clinical Pharmacokinetics 58:6, pages 727-746.
Crossref
Crossref
Byeong ill Lee, Min-Ho Park, Seok-Ho Shin, Jin-Ju Byeon, Yuri Park, Nahye Kim, Jangmi Choi & Young G. Shin. (2019) Quantitative Analysis of Tozadenant Using Liquid Chromatography-Mass Spectrometric Method in Rat Plasma and Its Human Pharmacokinetics Prediction Using Physiologically Based Pharmacokinetic Modeling. Molecules 24:7, pages 1295.
Crossref
Crossref
Shinji Yamazaki, Cho-Ming Loi, Emi Kimoto, Chester Costales & Manthena V. Varma. (2018) Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein. Drug Metabolism and Disposition 46:8, pages 1200-1211.
Crossref
Crossref
Rachelle Prantil-BaunRichard NovakDebarun Das, Mahadevabharath R. Somayaji, Andrzej Przekwas & Donald E. Ingber. (2018) Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips. Annual Review of Pharmacology and Toxicology 58:1, pages 37-64.
Crossref
Crossref
J.B. Watkins & C.D. Klaassen. 2018. Comprehensive Toxicology. Comprehensive Toxicology
99
112
.
Chiho Ono, Poe-Hirr Hsyu, Richat Abbas, Cho-Ming Loi & Shinji Yamazaki. (2017) Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug–Drug and Drug–Disease Interactions. Drug Metabolism and Disposition 45:4, pages 390-398.
Crossref
Crossref
T.H. Grasela, V. Lukacova, D.N. Morris, R.D. Clark, K.A. Andrews & M.B. Bolger. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III
51
82
.
Simone Hansmann, Adam Darwich, Alison Margolskee, Leon Aarons & Jennifer Dressman. (2016) Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models. Journal of Pharmacy and Pharmacology 68:12, pages 1501-1515.
Crossref
Crossref
Shayne Cox Gad. 2016. Drug Safety Evaluation. Drug Safety Evaluation
381
411
.
Z. Lin, R. Gehring, J. P. Mochel, T. Lavé & J. E. Riviere. (2016)
Mathematical modeling and simulation in animal health – Part
II
: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment
. Journal of Veterinary Pharmacology and Therapeutics 39:5, pages 421-438.
Crossref
Crossref
Leena-Stiina Kontturi, Estelle C. Collin, Lasse Murtomäki, Abhay S. Pandit, Marjo Yliperttula & Arto Urtti. (2015) Encapsulated cells for long-term secretion of soluble VEGF receptor 1: Material optimization and simulation of ocular drug response. European Journal of Pharmaceutics and Biopharmaceutics 95, pages 387-397.
Crossref
Crossref
M Sundqvist, A Lundahl, MB Någård, U Bredberg & P Gennemark. (2015) Quantifying and Communicating Uncertainty in Preclinical Human Dose‐Prediction. CPT: Pharmacometrics & Systems Pharmacology 4:4, pages 243-254.
Crossref
Crossref
HM Jones, Y Chen, C Gibson, T Heimbach, N Parrott, SA Peters, J Snoeys, VV Upreti, M Zheng & SD Hall. (2015) Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective. Clinical Pharmacology & Therapeutics 97:3, pages 247-262.
Crossref
Crossref
Ayman El‐Kattan, Manthena V. Varma & Yurong Lai. 2014. Drug Transporters. Drug Transporters
371
387
.
Christos Reppas, Horst-Dieter Friedel, Amy R. Barker, Lucinda F. Buhse, Todd L. Cecil, Susanne Keitel, Johannes Kraemer, J. Michael Morris, Vinod P. Shah, Mary P. Stickelmeyer, Chikako Yomota & Cynthia K. Brown. (2014) Biorelevant In Vitro Performance Testing of Orally Administered Dosage Forms—Workshop Report. Pharmaceutical Research 31:7, pages 1867-1876.
Crossref
Crossref
Luz Romero & José Miguel Vela. 2014. In Vivo Models for Drug Discovery. In Vivo Models for Drug Discovery
27
58
.
John M. Harrold & Anson K. Abraham. (2014) Ubiquity: a framework for physiological/mechanism-based pharmacokinetic/pharmacodynamic model development and deployment. Journal of Pharmacokinetics and Pharmacodynamics 41:2, pages 141-151.
Crossref
Crossref
Hannah M. Jones & Neil Parrott. 2014. Predictive ADMET. Predictive ADMET
167
188
.
Kyoung Ah Min, Xinyuan Zhang, Jing‐yu Yu & Gus R. Rosania. (2013) Computational approaches to analyse and predict small molecule transport and distribution at cellular and subcellular levels. Biopharmaceutics & Drug Disposition 35:1, pages 15-32.
Crossref
Crossref
Patricio Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E. P. Goldring, María José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M. Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak-Ublick, Edward L. LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A. Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiss, Agata Widera, Courtney G. Woods, Jinghai James Xu, Kathy M. Yarborough & Jan G. Hengstler. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology 87:8, pages 1315-1530.
Crossref
Crossref
Jialin Mao, Theodore R. Johnson, Zhongzhou Shen & Shinji Yamazaki. (2013) Prediction of Crizotinib-Midazolam Interaction Using the Simcyp Population-Based Simulator: Comparison of CYP3A Time-Dependent Inhibition between Human Liver Microsomes versus Hepatocytes. Drug Metabolism and Disposition 41:2, pages 343-352.
Crossref
Crossref
Sandra Grbic, Jelena Parojcic & Zorica Djuric. 2013. Computer-Aided Applications in Pharmaceutical Technology. Computer-Aided Applications in Pharmaceutical Technology
177
232
.
Yurong Lai. 2013. Transporters in Drug Discovery and Development. Transporters in Drug Discovery and Development
675
718
.
Claudia Suenderhauf & Neil Parrott. (2012) A Physiologically Based Pharmacokinetic Model of the Minipig: Data Compilation and Model Implementation. Pharmaceutical Research 30:1, pages 1-15.
Crossref
Crossref
Helena Anna Thörn, Erik Sjögren, Paul Alfred Dickinson & Hans Lennernäs. (2012)
Binding Processes Determine the Stereoselective Intestinal and Hepatic Extraction of Verapamil
in Vivo
. Molecular Pharmaceutics 9:11, pages 3034-3045.
Crossref
Crossref
Guo-fu Li, Kun Wang, Rui Chen, Hao-ru Zhao, Jin Yang & Qing-shan Zheng. (2012) Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling. Acta Pharmacologica Sinica 33:11, pages 1359-1371.
Crossref
Crossref
Brett A. Howell, Yuching Yang, Rukmini Kumar, Jeffrey L. Woodhead, Alison H. Harrill, Harvey J. ClewellIIIIII, Melvin E. Andersen, Scott Q. Siler & Paul B. Watkins. (2012) In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI. Journal of Pharmacokinetics and Pharmacodynamics 39:5, pages 527-541.
Crossref
Crossref
Gian Camenisch & Ken‐ichi Umehara. (2012)
Predicting human hepatic clearance from
in vitro
drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug–drug interactions
. Biopharmaceutics & Drug Disposition 33:4, pages 179-194.
Crossref
Crossref
Yuan Chen, Jin Y. Jin, Sophie Mukadam, Vikram Malhi & Jane R. Kenny. (2012) Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies. Biopharmaceutics & Drug Disposition 33:2, pages 85-98.
Crossref
Crossref
John F. Graf, Bernhard J. Scholz & Maria I. Zavodszky. (2011) BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems. Journal of Pharmacokinetics and Pharmacodynamics 39:1, pages 37-54.
Crossref
Crossref
Alexander V. LyubimovHan‐Joo Maeng, Edwin C. Y. Chow, Jianghong Fan & K. Sandy Pang. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
48
.
Viness Pillay, Yahya E. Choonara, Pradeep Kumar, Valence M. K. Ndesendo & Lisa C. du Toit. 2012. Patenting Nanomedicines. Patenting Nanomedicines
49
96
.
Patrick Poulin, Rhys D.O. Jones, Hannah M. Jones, Christopher R. Gibson, Malcolm Rowland, Jenny Y. Chien, Barbara J. Ring, Kimberly K. Adkison, M. Sherry Ku, Handan He, Ragini Vuppugalla, Punit Marathe, Volker Fischer, Sandeep Dutta, Vikash K. Sinha, Thorir Björnsson, Thierry Lavé & James W.T. Yates. (2011) PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach. Journal of Pharmaceutical Sciences 100:10, pages 4127-4157.
Crossref
Crossref
Hans Peter Grimm, Ying Ou, Micaela Reddy, Pascale David‐Pierson & Thierry Lavé. 2011. Systems Biology in Drug Discovery and Development. Systems Biology in Drug Discovery and Development
175
199
.
Marko Goličnik. (2011) Explicit reformulations of the Lambert W-omega function for calculations of the solutions to one-compartment pharmacokinetic models with Michaelis–Menten elimination kinetics. European Journal of Drug Metabolism and Pharmacokinetics 36:3, pages 121-127.
Crossref
Crossref
Hannah M. Jones, Iain B. Gardner, Wendy T. Collard, Phil J. Stanley, Penny Oxley, Natilie A. Hosea, David Plowchalk, Steve Gernhardt, Jing Lin, Maurice Dickins, S. Ravi Rahavendran, Barry C. Jones, Kenny J. Watson, Henry Pertinez, Vikas Kumar & Susan Cole. (2011) Simulation of Human Intravenous and Oral Pharmacokinetics of 21 Diverse Compounds Using Physiologically Based Pharmacokinetic Modelling. Clinical Pharmacokinetics 50:5, pages 331-347.
Crossref
Crossref
Qingyu Zhou & James M. Gallo. (2011) The Pharmacokinetic/Pharmacodynamic Pipeline: Translating Anticancer Drug Pharmacology to the Clinic. The AAPS Journal 13:1, pages 111-120.
Crossref
Crossref
Shinji Yamazaki, Judith Skaptason, David Romero, Sylvia Vekich, Hannah M. Jones, Weiwei Tan, Keith D. Wilner & Tatiana Koudriakova. (2011) Prediction of Oral Pharmacokinetics of cMet Kinase Inhibitors in Humans: Physiologically Based Pharmacokinetic Model Versus Traditional One-Compartment Model. Drug Metabolism and Disposition 39:3, pages 383-393.
Crossref
Crossref
Malcolm RowlandCarl Peck & Geoffrey Tucker. (2011) Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science. Annual Review of Pharmacology and Toxicology 51:1, pages 45-73.
Crossref
Crossref
Siamak Cyrus Khojasteh, Harvey Wong & Cornelis E.C.A. HopSiamak Cyrus Khojasteh, Harvey Wong & Cornelis E. C. A. Hop. 2011. Drug Metabolism and Pharmacokinetics Quick Guide. Drug Metabolism and Pharmacokinetics Quick Guide
183
191
.
K. Sandy Pang & Matthew R. Durk. (2010) Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion. Journal of Pharmacokinetics and Pharmacodynamics 37:6, pages 591-615.
Crossref
Crossref
Yi Gao, Robert A. Carr, Julie K. Spence, Weili W. Wang, Teresa M. Turner, John M. Lipari & Jonathan M. Miller. (2010) A pH-Dilution Method for Estimation of Biorelevant Drug Solubility along the Gastrointestinal Tract: Application to Physiologically Based Pharmacokinetic Modeling. Molecular Pharmaceutics 7:5, pages 1516-1526.
Crossref
Crossref
Brett A. Howell & Anuj Chauhan. (2010) A Physiologically Based Pharmacokinetic (PBPK) Model for Predicting the Efficacy of Drug Overdose Treatment With Liposomes in Man. Journal of Pharmaceutical Sciences 99:8, pages 3601-3619.
Crossref
Crossref
Nathalie Perdaems, Helene Blasco, Cedric Vinson, Marylore Chenel, Sarah Whalley, Fanny Cazade & François Bouzom. (2010) Predictions of Metabolic Drug-Drug Interactions Using Physiologically Based Modelling. Clinical Pharmacokinetics 49:4, pages 239-258.
Crossref
Crossref
J.B. WatkinsIIIIII & C.D. Klaassen. 2010. Comprehensive Toxicology. Comprehensive Toxicology
77
91
.
Agnès Poirier, Christoph Funk, Jean-Michel Scherrmann & Thierry Lavé. (2009) Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and Fexofenadine. Molecular Pharmaceutics 6:6, pages 1716-1733.
Crossref
Crossref
Agnès Poirier, Anne-Christine Cascais, Christoph Funk & Thierry Lavé. (2009) Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data. Journal of Pharmacokinetics and Pharmacodynamics 36:6, pages 585-611.
Crossref
Crossref
Patrick Poulin & Frank-Peter Theil. (2009) Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods. Journal of Pharmaceutical Sciences 98:12, pages 4941-4961.
Crossref
Crossref
Simon Thomas. (2009) Physiologically-based Simulation Modelling for the Reduction of Animal Use in the Discovery of Novel Pharmaceuticals. Alternatives to Laboratory Animals 37:5, pages 497-511.
Crossref
Crossref
Agnès Poirier, Anne‐Christine Cascais, Christoph Funk & Thierry Lavé. (2009)
Prediction of Pharmacokinetic Profile of Valsartan in Humans Based on
in vitro
Uptake‐Transport Data
. Chemistry & Biodiversity 6:11, pages 1975-1987.
Crossref
Crossref
Sarah Shugarts & Leslie Z. Benet. (2009) The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs. Pharmaceutical Research 26:9, pages 2039-2054.
Crossref
Crossref
Pamela Berry, Neil Parrott, Micaela Reddy, Pascale David‐Pierson & Thierry Lavé. 2009. Hit and Lead Profiling. Hit and Lead Profiling
221
240
.
Junli Liu, Melissa Brazier-Hicks & Robert Edwards. (2009) A kinetic model for the metabolism of the herbicide safener fenclorim in Arabidopsis thaliana. Biophysical Chemistry 143:1-2, pages 85-94.
Crossref
Crossref
Kimberley A. Lentz. (2008) Current Methods for Predicting Human Food Effect. The AAPS Journal 10:2, pages 282-288.
Crossref
Crossref