Xenobiotica, Volume 37, Issue 10-11 (2007)

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Xenobiotica, Volume 37, Issue 10-11 (2007)

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Editorial

Editorial
Modelling and simulation in prediction of human xenobiotic absorption, distribution, metabolism and excretion (ADME): in vitro–in vivo extrapolations (IVIVE)
Pages: 1013-1014
Published online: 22 Sep 2008
CitationforModelling and simulation in prediction of human xenobiotic absorption, distribution, metabolism and excretion (ADME): in vitro–in vivo extrapolations (IVIVE) | Full Text | References | PDF (25.6 KB)
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Research Article

Article
Intestinal permeability and its relevance for absorption and elimination
H. Lennernäs
Pages: 1015-1051
Published online: 29 Aug 2013
AbstractforIntestinal permeability and its relevance for absorption and elimination | PDF (364.7 KB)
  • 1314 Views
  • 225 CrossRef citations
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Article
Modelling and simulation in drug absorption processes
A. Dokoumetzidis, G. Valsami & P. Macheras
Pages: 1052-1065
Published online: 22 Sep 2008
AbstractforModelling and simulation in drug absorption processes | Full Text | References | PDF (206.7 KB)
  • 424 Views
  • 15 CrossRef citations
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Article
In vitro–in vivo extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations
O. Pelkonen & M. Turpeinen
Pages: 1066-1089
Published online: 22 Sep 2008
AbstractforIn vitro–in vivo extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations | Full Text | References | PDF (305.3 KB)
  • 1437 Views
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Article
In vitro–in vivo extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects
P. J. H. Webborn, A. J. Parker, R. L. Denton & R. J. Riley
Pages: 1090-1109
Published online: 05 Jan 2010
AbstractforIn vitro–in vivo extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects | Full Text | References | PDF (160.5 KB)
  • 682 Views
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Article
Kinetic determinants of hepatic clearance: Plasma protein binding and hepatic uptake
M. Baker & T. Parton
Pages: 1110-1134
Published online: 22 Sep 2008
AbstractforKinetic determinants of hepatic clearance: Plasma protein binding and hepatic uptake | Full Text | References | PDF (1.8 MB)
  • 1007 Views
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Article
Challenges for blood–brain barrier (BBB) screening
P. Jeffrey & S. G. Summerfield
Pages: 1135-1151
Published online: 22 Sep 2008
AbstractforChallenges for blood–brain barrier (BBB) screening | Full Text | References | PDF (118.6 KB)
  • 572 Views
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Article
Future directions for drug transporter modelling
S. Ekins, G. F. Ecker, P. Chiba & P. W. Swaan
Pages: 1152-1170
Published online: 22 Sep 2008
AbstractforFuture directions for drug transporter modelling | Full Text | References | PDF (1 MB)
  • 276 Views
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Article
Transporter-mediated uptake into cellular compartments
S. Oswald, M. Grube, W. Siegmund & H. K. Kroemer
Pages: 1171-1195
Published online: 22 Sep 2008
AbstractforTransporter-mediated uptake into cellular compartments | Full Text | References | PDF (267 KB)
  • 416 Views
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Article
Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro–in vivo correlations
N. J. Hewitt, E. L. Lecluyse & S. S. Ferguson
Pages: 1196-1224
Published online: 22 Sep 2008
AbstractforInduction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro–in vivo correlations | Full Text | References | PDF (377.3 KB)
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Article
Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug–drug interaction risk assessment
K. Venkatakrishnan, R. S. Obach & A. Rostami-Hodjegan
Pages: 1225-1256
Published online: 22 Sep 2008
AbstractforMechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug–drug interaction risk assessment | Full Text | References | PDF (385.7 KB)
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Original

Article
Comparison of different approaches to predict metabolic drug–drug interactions
H. J. Einolf
Pages: 1257-1294
Published online: 12 Jul 2010
AbstractforComparison of different approaches to predict metabolic drug–drug interactions | Full Text | References | PDF (300 KB)
  • 559 Views
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Research Article

Article
Challenges and opportunities with modelling and simulation in drug discovery and drug development
T. Lavé, N. Parrott, H. P. Grimm, A. Fleury & M. Reddy
Pages: 1295-1310
Published online: 22 Sep 2008
AbstractforChallenges and opportunities with modelling and simulation in drug discovery and drug development | Full Text | References | PDF (231.8 KB)
  • 821 Views
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Original

Article
Design of population pharmacokinetic experiments using prior information
K. Ogungbenro & L. Aarons
Pages: 1311-1330
Published online: 12 Jul 2010
AbstractforDesign of population pharmacokinetic experiments using prior information | Full Text | References | PDF (716.4 KB)
  • 222 Views
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Research Article

Article
On the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development
P. J. Lowe, Y. Hijazi, O. Luttringer, H. Yin, R. Sarangapani & D. Howard
Pages: 1331-1354
Published online: 22 Sep 2008
AbstractforOn the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development | Full Text | References | PDF (288.1 KB)
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