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Research Article

Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro–in vivo correlations

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Pages 1196-1224 | Received 22 May 2007, Accepted 25 Jun 2007, Published online: 22 Sep 2008

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Crossref
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Crossref
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Crossref
Ali Navid, David M Ng, Benjamin J Stewart, Sergio E Wong & Felice C Lightstone. (2013) Quantitative In Silico analysis of transient metabolism of acetaminophen and associated causes of hepatotoxicity in humans. In Silico Pharmacology 1:1.
Crossref
Tonika Bohnert & Lawrence L. Gan. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 61 .
Joshua C. Kwekel, Varsha G. Desai, Carrie L. Moland, Vikrant Vijay & James C. Fuscoe. (2013) Life Cycle Analysis of Kidney Gene Expression in Male F344 Rats. PLoS ONE 8:10, pages e75305.
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Shannon Dallas, Carlo Sensenhauser, Souvik Chattopadhyay & Jose Silva. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 24 .
Xiaocui Ma, Yuyou Duan, Benjamin Tschudy-Seney, Garrett Roll, Iman Saramipoor Behbahan, Tijess P. Ahuja, Vladimir Tolstikov, Charles Wang, Jeannine McGee, Shiva Khoobyari, Jan A. Nolta, Holger Willenbring & Mark A. Zern. (2013) Highly Efficient Differentiation of Functional Hepatocytes From Human Induced Pluripotent Stem Cells. Stem Cells Translational Medicine 2:6, pages 409-419.
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Silvio Caccia, Luca Pasina & Alessandro Nobili. (2013) How pre-marketing data can be used for predicting the weight of drug interactions in clinical practice. European Journal of Internal Medicine 24:3, pages 217-221.
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Ariel R. Topletz, Huong N. Le, Nora Lee, John D. Chapman, Edward J. Kelly, Joanne Wang & Nina Isoherranen. (2013) Hepatic Cyp2d and Cyp26a1 mRNAs and Activities Are Increased During Mouse Pregnancy. Drug Metabolism and Disposition 41:2, pages 312-319.
Crossref
Peter Bünning. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays 975 987 .
Alexander V. LyubimovPeter L. Bullock & Olga V. Trubetskoy. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 26 .
Alexander V. LyubimovKarthik Venkatakrishnan. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 62 .
Alexander V. LyubimovCostas Ioannides & Brian G. Lake. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 26 .
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Crossref
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Guillaume Baneyx, Yumi Fukushima & Neil Parrott. (2012) Use of physiologically based pharmacokinetic modeling for assessment of drug–drug interactions. Future Medicinal Chemistry 4:5, pages 681-693.
Crossref
Johannes Kirchmair, Mark J. Williamson, Jonathan D. Tyzack, Lu Tan, Peter J. Bond, Andreas Bender & Robert C. Glen. (2012) Computational Prediction of Metabolism: Sites, Products, SAR, P450 Enzyme Dynamics, and Mechanisms. Journal of Chemical Information and Modeling 52:3, pages 617-648.
Crossref
Shaojun Shi & Ulrich Klotz. (2012) Drug Interactions with Herbal Medicines. Clinical Pharmacokinetics 51:2, pages 77-104.
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Junling Yang, Minxia M. He, Wei Niu, Steven A. Wrighton, Li Li, Yang Liu & Chuan Li. (2012) Metabolic capabilities of cytochrome P450 enzymes in Chinese liver microsomes compared with those in Caucasian liver microsomes. British Journal of Clinical Pharmacology 73:2, pages 268-284.
Crossref
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Wayne Y.W. Lee, Xuelin Zhou, Penelope M.Y. Or, Yiu Wa Kwan & John H.K. Yeung. (2012) Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes. Phytomedicine 19:2, pages 169-176.
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Donna M. Platt & James K. Rowlett. 2012. Nonhuman Primates in Biomedical Research. Nonhuman Primates in Biomedical Research 817 839 .
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Grace Zhixia Yan, Kim L. R. Brouwer, Gary M. Pollack, Michael Zhuo Wang, Richard R. Tidwell, James E. Hall & Mary F. Paine. (2011) Mechanisms Underlying Differences in Systemic Exposure of Structurally Similar Active Metabolites: Comparison of Two Preclinical Hepatic Models. Journal of Pharmacology and Experimental Therapeutics 337:2, pages 503-512.
Crossref
Irene Antolino-Lobo, Jan Meulenbelt, Sandra M. Nijmeijer, Roel F. Maas-Bakker, Irma Meijerman, Martin van den Berg & Majorie B.M. van Duursen. (2011) 3,4-Methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition. Toxicology Letters 203:1, pages 82-91.
Crossref
Lei Guo, Stacey Dial, Leming Shi, William Branham, Jie Liu, Jia-Long Fang, Bridgett Green, Helen Deng, Jim Kaput & Baitang Ning. (2011) Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes. Drug Metabolism and Disposition 39:3, pages 528-538.
Crossref
Paola Motta, Nicoletta Pons, Sabrina Pagliarusco, Mario Pellegatti & Fiorenza Bonomo. (2011) Casopitant: In Vitro Data and SimCyp Simulation to Predict In Vivo Metabolic Interactions Involving Cytochrome P450 3A4. Drug Metabolism and Disposition 39:3, pages 363-372.
Crossref
Maryam Modarai, Elisabete Silva, Andy Suter, Michael Heinrich & Andreas Kortenkamp. (2011) Safety of Herbal Medicinal Products: Echinacea and Selected Alkylamides Do Not Induce CYP3A4 mRNA Expression. Evidence-Based Complementary and Alternative Medicine 2011, pages 1-7.
Crossref
Stephanie M. Martinez, Blair U. Bradford, Valerie Y. Soldatow, Oksana Kosyk, Amelia Sandot, Rafal Witek, Robert Kaiser, Todd Stewart, Kirsten Amaral, Kimberly Freeman, Chris Black, Edward L. LeCluyse, Stephen S. Ferguson & Ivan Rusyn. (2010) Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity. Toxicology and Applied Pharmacology 249:3, pages 208-216.
Crossref
Karthik Venkatakrishnan, Michael D. Pickard & Lisa L. von Moltke. (2010) A Quantitative Framework and Strategies for Management and Evaluation of Metabolic Drug-Drug Interactions in Oncology Drug Development. Clinical Pharmacokinetics 49:11, pages 703-727.
Crossref
Stefano Zamuner, Brendan M. Johnson, Sabrina Pagliarusco, Paolo Fina, Michela Peroni, Monica Fiore, Laurel M. Adams & Sofia A. Fernandes. (2010) Effect of single and repeat doses of casopitant on the pharmacokinetics of CYP450 3A4 substrates midazolam and nifedipine. British Journal of Clinical Pharmacology 70:4, pages 537-546.
Crossref
Michael A. Mohutsky, Annette Romeike, Vince Meador, William M. Lee, John Fowler & Sabine Francke-Carroll. (2010) Hepatic Drug-Metabolizing Enzyme Induction and Implications for Preclinical and Clinical Risk Assessment. Toxicologic Pathology 38:5, pages 799-809.
Crossref
Daniela Ennulat, Dana Walker, Frances Clemo, Michal Magid-Slav, David Ledieu, Mark Graham, Suzanne Botts & Laura Boone. (2010) Effects of Hepatic Drug-metabolizing Enzyme Induction on Clinical Pathology Parameters in Animals and Man. Toxicologic Pathology 38:5, pages 810-828.
Crossref
Peter L. Bullock. 2010. Early Drug Development. Early Drug Development 89 130 .
Amin A. Nomeir. 2010. Early Drug Development. Early Drug Development 25 88 .
Jenni Küblbeck, Mika Reinisalo, Riitta Mustonen & Paavo Honkakoski. (2010) Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors. European Journal of Pharmaceutical Sciences 40:4, pages 263-272.
Crossref
Gernot Zollner, Martin Wagner & Michael Trauner. (2010) Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity. Pharmacology & Therapeutics 126:3, pages 228-243.
Crossref
Yuyou Duan, Xiaochui Ma, Wei Zou, Charles Wang, Iman Saramipoor Bahbahan, Tijess P. Ahuja, Vladimir Tolstikov & Mark A. Zern. (2010) Differentiation and Characterization of Metabolically Functioning Hepatocytes from Human Embryonic Stem Cells. Stem Cells 28:4, pages 674-686.
Crossref
Izet M. Kapetanovic, Thomas L. Horn, William D. Johnson, Michael J. Cwik, Carol J. Detrisac & David L. McCormick. (2010) Murine Oncogenicity and Pharmacokinetics Studies of 9- cis -UAB30, an RXR Agonist, for Breast Cancer Chemoprevention . International Journal of Toxicology 29:2, pages 157-164.
Crossref
Catherine Abadie-Viollon, Hélène Martin, Nadège Blanchard, Dumrongsak Pekthong, Philippe Bachellier, Georges Mantion, Bruno Heyd, Frantz Schuler, Philippe Coassolo, Eliane Alexandre & Lysiane Richert. (2010) Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions. Toxicology in Vitro 24:1, pages 346-356.
Crossref
Akihiro Hisaka, Yoshiyuki Ohno, Takehito Yamamoto & Hiroshi Suzuki. (2010) Prediction of pharmacokinetic drug–drug interaction caused by changes in cytochrome P450 activity using in vivo information. Pharmacology & Therapeutics 125:2, pages 230-248.
Crossref
R.I. Sanchez & F.C. Kauffman. 2010. Comprehensive Toxicology. Comprehensive Toxicology 109 128 .
Tonika Bohnert & Liang‐Shang Gan. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development 91 176 .
Nelly Aranibar, Vasanthi Bhaskaran, Karl-Heinz Ott, Jeff Vassallo, David Nelson, Lloyd Lecureux, Lei Gong, Steve Stryker & Lois Lehman-McKeeman. (2009) Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling. Magnetic Resonance in Chemistry 47:S1, pages S12-S19.
Crossref
Silvio Caccia, Silvio Garattini, Luca Pasina & Alessandro Nobili. (2009) Predicting the Clinical Relevance of Drug Interactions From Pre-Approval Studies. Drug Safety 32:11, pages 1017-1039.
Crossref
Michiko Sugawara, Kiyoshi Okamoto, Tadashi Kadowaki, Kazutomi Kusano, Akiyoshi Fukamizu & Tsutomu Yoshimura. (2009) Inoculation of Human Tumor Cells Alters the Basal Expression but Not the Inducibility of Cytochrome P450 Enzymes in Tumor-Bearing Mouse Liver. Drug Metabolism and Disposition 37:11, pages 2244-2254.
Crossref
Stacy S. ShordKanan Shah & Alvina Lukose. (2009) Drug—Botanical Interactions: A Review of the Laboratory, Animal, and Human Data for 8 Common Botanicals. Integrative Cancer Therapies 8:3, pages 208-227.
Crossref
Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz & Andrej Skerjanec. (2009) In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective. Drug Metabolism and Disposition 37:7, pages 1339-1354.
Crossref
Dermot F. McGinnity, George Zhang, Jane R. Kenny, Geraldine A. Hamilton, Sara Otmani, Karen R. Stams, Suzzette Haney, Patrick Brassil, David M. Stresser & Robert J. Riley. (2009) Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells. Drug Metabolism and Disposition 37:6, pages 1259-1268.
Crossref
Stefano Petti. (2009) Lifestyle risk factors for oral cancer. Oral Oncology 45:4-5, pages 340-350.
Crossref
L. Richert, G. Tuschl, C. Abadie, N. Blanchard, D. Pekthong, G. Mantion, J.-C. Weber & S.O. Mueller. (2009) Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicology and Applied Pharmacology 235:1, pages 86-96.
Crossref
Katsutoshi Yoshizato & Chise Tateno. (2009) A Human Hepatocyte-Bearing Mouse: An Animal Model to Predict Drug Metabolism and Effectiveness in Humans. PPAR Research 2009, pages 1-11.
Crossref
Jordan A. Firestone & Sidney M. GospeJr.Jr.. 2009. Clinical Neurotoxicology. Clinical Neurotoxicology 401 414 .
Jinghai J. Xu & Li J. Yu. 2008. Drug Efficacy, Safety, and Biologics Discovery. Drug Efficacy, Safety, and Biologics Discovery 1 28 .
Mark J. Graham & Brian G. Lake. (2008) Induction of drug metabolism: Species differences and toxicological relevance. Toxicology 254:3, pages 184-191.
Crossref
Ali A. Asadi-Pooya, Scott Mintzer & Michael R. Sperling. (2008) Nutritional supplements, foods, and epilepsy: Is there a relationship?. Epilepsia 49:11, pages 1819-1827.
Crossref
Olavi Pelkonen, Miia Turpeinen, Jukka Hakkola, Paavo Honkakoski, Janne Hukkanen & Hannu Raunio. (2008) Inhibition and induction of human cytochrome P450 enzymes: current status. Archives of Toxicology 82:10, pages 667-715.
Crossref
Paul Baldrick. (2008) Safety evaluation to support First-In-Man investigations I: Kinetic and safety pharmacology studies. Regulatory Toxicology and Pharmacology 51:2, pages 230-236.
Crossref

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