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Research Article

In vitro–in vivo extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations

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Pages 1066-1089 | Received 08 Jun 2007, Accepted 09 Aug 2007, Published online: 22 Sep 2008

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Crossref
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Crossref
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Crossref
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Crossref
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Nigel J. Waters, R. Scott Obach & Li Di. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 119 145 .
Eleanore Seibert & Timothy S. Tracy. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 9 22 .
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Khaled M. Abass. (2013) From in vitro hepatic metabolic studies towards human health risk assessment: Two case studies of diuron and carbosulfan. Pesticide Biochemistry and Physiology 107:2, pages 258-265.
Crossref
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Crossref
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Crossref
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Crossref
Alan Boobis, Alessandro Chiodini, Jeljer Hoekstra, Pagona Lagiou, Hildegard Przyrembel, Josef Schlatter, Katrin Schütte, Hans Verhagen & Bernhard Watzl. (2013) Critical appraisal of the assessment of benefits and risks for foods, ‘BRAFO Consensus Working Group’. Food and Chemical Toxicology 55, pages 659-675.
Crossref
Ismael Zamora, Fabien Fontaine, Blanca Serra & Guillem Plasencia. (2013) High-throughput, computer assisted, specific MetID. A revolution for drug discovery. Drug Discovery Today: Technologies 10:1, pages e199-e205.
Crossref
Patrick Poulin, Cornelis E.C.A. Hop, Quynh Ho, Jason S. Halladay, Sami Haddad & Jane R. Kenny. (2012) Comparative Assessment of In Vitro–In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs. Journal of Pharmaceutical Sciences 101:11, pages 4308-4326.
Crossref
Aki T. Heikkinen, Guillaume Baneyx, Antonello Caruso & Neil Parrott. (2012) Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus™. European Journal of Pharmaceutical Sciences 47:2, pages 375-386.
Crossref
Raimo A. Ketola & Timo Mauriala. (2012) Mass spectrometric tools for cell and tissue studies. European Journal of Pharmaceutical Sciences 46:5, pages 293-314.
Crossref
Jong Hwan Sung & Michael L. Shuler. (2012) Microtechnology for Mimicking In Vivo Tissue Environment. Annals of Biomedical Engineering 40:6, pages 1289-1300.
Crossref
Jean Matthieu Prot & Eric Leclerc. (2011) The Current Status of Alternatives to Animal Testing and Predictive Toxicology Methods Using Liver Microfluidic Biochips. Annals of Biomedical Engineering 40:6, pages 1228-1243.
Crossref
Michaela Meyer, Sebastian Schneckener, Bernd Ludewig, Lars Kuepfer & Joerg Lippert. (2012) Using Expression Data for Quantification of Active Processes in Physiologically Based Pharmacokinetic Modeling. Drug Metabolism and Disposition 40:5, pages 892-901.
Crossref
Ulrich M. Zanger. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 285 300 .
Patrick Poulin, Jane R. Kenny, Cornelis E.C.A. Hop & Sami Haddad. (2012) In Vitro–In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Assessment with Existing Calculation Methods. Journal of Pharmaceutical Sciences 101:2, pages 838-851.
Crossref
Alexander V. LyubimovMeihua Rose Feng, Nan Zheng, Xinyuan Zhang, Yea Min Huh & Jing‐yu Yu. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 36 .
Djomangan A. Ouattara, Sue-Hyung Choi, Yasuyuki Sakai, Alexandre R.R. Péry & Céline Brochot. (2011) Kinetic modelling of in vitro cell-based assays to characterize non-specific bindings and ADME processes in a static and a perfused fluidic system. Toxicology Letters 205:3, pages 310-319.
Crossref
Olavi Pelkonen, Miia Turpeinen & Hannu Raunio. (2011) In Vivo-In Vitro-In Silico Pharmacokinetic Modelling in Drug Development. Clinical Pharmacokinetics 50:8, pages 483-491.
Crossref
W. Griffith Humphreys. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition 229 253 .
Sarah Adler, David Basketter, Stuart Creton, Olavi Pelkonen, Jan van Benthem, Valérie Zuang, Klaus Ejner Andersen, Alexandre Angers-Loustau, Aynur Aptula, Anna Bal-Price, Emilio Benfenati, Ulrike Bernauer, Jos Bessems, Frederic Y. Bois, Alan Boobis, Esther Brandon, Susanne Bremer, Thomas Broschard, Silvia Casati, Sandra Coecke, Raffaella Corvi, Mark Cronin, George Daston, Wolfgang Dekant, Susan Felter, Elise Grignard, Ursula Gundert-Remy, Tuula Heinonen, Ian Kimber, Jos Kleinjans, Hannu Komulainen, Reinhard Kreiling, Joachim Kreysa, Sofia Batista Leite, George Loizou, Gavin Maxwell, Paolo Mazzatorta, Sharon Munn, Stefan Pfuhler, Pascal Phrakonkham, Aldert Piersma, Albrecht Poth, Pilar Prieto, Guillermo Repetto, Vera Rogiers, Greet Schoeters, Michael Schwarz, Rositsa Serafimova, Hanna Tähti, Emanuela Testai, Joost van Delft, Henk van Loveren, Mathieu Vinken, Andrew Worth & José-Manuel Zaldivar. (2011) Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010. Archives of Toxicology 85:5, pages 367-485.
Crossref
Marjo Volotinen, Timo Korjamo, Ari Tolonen, Miia Turpeinen, Olavi Pelkonen, Jukka Hakkola & Jukka Mäenpää. (2010) Effects of Selective Serotonin Reuptake Inhibitors on Timolol Metabolism in Human Liver Microsomes and Cryo‐Preserved Hepatocytes. Basic & Clinical Pharmacology & Toxicology 106:4, pages 302-309.
Crossref
Paulo Paixão, Luís F. Gouveia & José A.G. Morais. (2010) Prediction of the in vitro intrinsic clearance determined in suspensions of human hepatocytes by using artificial neural networks. European Journal of Pharmaceutical Sciences 39:5, pages 310-321.
Crossref
R.I. Sanchez & F.C. Kauffman. 2010. Comprehensive Toxicology. Comprehensive Toxicology 109 128 .
Stacy S. ShordKanan Shah & Alvina Lukose. (2009) Drug—Botanical Interactions: A Review of the Laboratory, Animal, and Human Data for 8 Common Botanicals. Integrative Cancer Therapies 8:3, pages 208-227.
Crossref
Francesca Toselli, Anita Matthias & Elizabeth M.J. Gillam. (2009) Echinacea metabolism and drug interactions: The case for standardization of a complementary medicine. Life Sciences 85:3-4, pages 97-106.
Crossref
Marianthi G. Lerapetritou, Panos G. Georgopoulos, Charles M. Roth & Loannis P. Androulakis. (2009) Tissue‐Level Modeling of Xenobiotic Metabolism in Liver: An Emerging Tool for Enabling Clinical Translational Research. Clinical and Translational Science 2:3, pages 228-237.
Crossref
Ari Tolonen, Miia Turpeinen & Olavi Pelkonen. (2009) Liquid chromatography–mass spectrometry in in vitro drug metabolite screening. Drug Discovery Today 14:3-4, pages 120-133.
Crossref

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