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Research Article

Intestinal permeability and its relevance for absorption and elimination

Pages 1015-1051 | Received 21 Sep 2006, Accepted 25 Sep 2007, Published online: 29 Aug 2013

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Ditlev Birch, Ragna G. Diedrichsen, Philip C. Christophersen, Huiling Mu & Hanne M. Nielsen. (2018) Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium. European Journal of Pharmaceutical Sciences 118, pages 144-153.
Crossref
Johanna Eriksson, Erik Sjögren, Helena Thörn, Katarina Rubin, Per Bäckman & Hans Lennernäs. (2018) Pulmonary absorption – estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis. European Journal of Pharmaceutics and Biopharmaceutics 124, pages 1-12.
Crossref
R. G. Lentle. (2018) Deconstructing the physical processes of digestion: reductionist approaches may provide greater understanding. Food & Function 9:8, pages 4069-4084.
Crossref
Isabel Lozoya-Agullo, Isabel Gonzalez-Alvarez, Moran Zur, Noa Fine-Shamir, Yael Cohen, Milica Markovic, Teresa M. Garrigues, Arik Dahan, Marta Gonzalez-Alvarez, Matilde Merino-Sanjuán, Marival Bermejo & Alex Avdeef. (2017) Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat—Biophysical Model and Predictions Based on Caco-2. Pharmaceutical Research 35:1.
Crossref
David Dahlgren, Carl Roos, Anders Lundqvist, Christer Tannergren, Peter Langguth, Markus Sjöblom, Erik Sjögren & Hans Lennernäs. (2017) Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker 51 Cr-EDTA . Molecular Pharmaceutics 14:12, pages 4243-4251.
Crossref
Carl Roos, David Dahlgren, Erik Sjögren, Christer Tannergren, Bertil Abrahamsson & Hans Lennernäs. (2017) Regional Intestinal Permeability in Rats: A Comparison of Methods. Molecular Pharmaceutics 14:12, pages 4252-4261.
Crossref
Alejandro Ruiz-Picazo, Isabel Lozoya-Agullo, Miguel Ortiz-Azcarate, Matilde Merino-Sanjuán, Marta González-Álvarez, Isabel González-Álvarez & Marival Bermejo. (2017) Comparison of segmental-dependent permeability in human and in situ perfusion model in rat. European Journal of Pharmaceutical Sciences 107, pages 191-196.
Crossref
Dongyang Liu, Yi Zhang, Ji Jiang, John Choi, Xuening Li, Dalong Zhu, Dawei Xiao, Yanhua Ding, Hongwei Fan, Li Chen & Pei Hu. (2016) Translational Modeling and Simulation in Supporting Early-Phase Clinical Development of New Drug: A Learn–Research–Confirm Process. Clinical Pharmacokinetics 56:8, pages 925-939.
Crossref
Le Sun, Jin Sun & Zhonggui He. (2016) Exploring the Feasibility of Biowaiver Extension of BCS Class III Drugs with Site-Specific Absorption Using Gastrointestinal Simulation Technology. European Journal of Drug Metabolism and Pharmacokinetics 42:3, pages 471-487.
Crossref
Assmaa O. Selim, Zienab A. Gouda & Sally A. Selim. (2017) An experimental study of a rat model of emphysema induced by cigarette smoke exposure and the effect of Survanta therapy. Annals of Anatomy - Anatomischer Anzeiger 211, pages 69-77.
Crossref
B.F. Thomazini & M.A.H. Dolder. (2017) Dose dependent treatment with isotretinoin induces more changes in the ileum than in the duodenum and jejunum in Wistar rats. Tissue and Cell 49:2, pages 203-208.
Crossref
Luai Al Rabadi & Raymond Bergan. (2017) A Way Forward for Cancer Chemoprevention: Think Local. Cancer Prevention Research 10:1, pages 14-35.
Crossref
Vladimir I. Razinkov & Gerd R. Kleemann. 2017. High-Throughput Formulation Development of Biopharmaceuticals. High-Throughput Formulation Development of Biopharmaceuticals 11 43 .
Chie EmotoAlexander A. VinksTsuyoshi Fukuda. (2016) Risk Assessment of Drug–Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients. Therapeutic Drug Monitoring 38:5, pages 607-613.
Crossref
Peng Zhang, Teresa Zardán Gómez de la Torre, Ken Welch, Christel Bergström & Maria Strømme. (2016) Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate. European Journal of Pharmaceutical Sciences 93, pages 468-474.
Crossref
L Kuepfer, C Niederalt, T Wendl, J‐F Schlender, S Willmann, J Lippert, M Block, T Eissing & D Teutonico. (2016) Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model. CPT: Pharmacometrics & Systems Pharmacology 5:10, pages 516-531.
Crossref
David Dahlgren, Carl Roos, Pernilla Johansson, Anders Lundqvist, Christer Tannergren, Bertil Abrahamsson, Erik Sjögren & Hans Lennernäs. (2016) Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms. Molecular Pharmaceutics 13:9, pages 3022-3033.
Crossref
David Dahlgren, Carl Roos, Anders Lundqvist, Bertil Abrahamsson, Christer Tannergren, Per M. Hellström, Erik Sjögren & Hans Lennernäs. (2016) Regional Intestinal Permeability of Three Model Drugs in Human. Molecular Pharmaceutics 13:9, pages 3013-3021.
Crossref
Erik Sjögren, Helena Thörn & Christer Tannergren. (2016) In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models . Molecular Pharmaceutics 13:6, pages 1763-1778.
Crossref
Kristi L. Helke, Keith N. Nelson, Aaron M. Sargeant, Binod Jacob, Sean McKeag, Julius Haruna, Vimala Vemireddi, Melanie Greeley, Derek Brocksmith, Nicole Navratil, Alain Stricker-Krongrad & Charlotte Hollinger. (2016) Pigs in Toxicology. Toxicologic Pathology 44:4, pages 575-590.
Crossref
Stefanie D. Krämer. (2016) Quantitative aspects of drug permeation across in vitro and in vivo barriers. European Journal of Pharmaceutical Sciences 87, pages 30-46.
Crossref
Brahma N. Singh. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 2782 2811 .
Jia He, Michael H. Abraham, William E. AcreeJr.Jr. & Yuan H. Zhao. (2015) A linear free energy analysis of PAMPA models for biological systems. International Journal of Pharmaceutics 496:2, pages 717-722.
Crossref
Cuyue Tang, Jerome Hochman & Thomayant Prueksaritanont. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 263 282 .
Andrés Olivares-Morales, Hans Lennernäs, Leon Aarons & Amin Rostami-Hodjegan. (2015) Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption. The AAPS Journal 17:5, pages 1177-1192.
Crossref
David Dahlgren, Carl Roos, Erik Sjögren & Hans Lennernäs. (2015) Direct In Vivo Human Intestinal Permeability (Peff) Determined with Different Clinical Perfusion and Intubation Methods. Journal of Pharmaceutical Sciences 104:9, pages 2702-2726.
Crossref
Mary S. Kleppe, Kelly M. Forney-Stevens, Roy J. Haskell & Robin H. Bogner. (2015) Mathematical Models to Explore Potential Effects of Supersaturation and Precipitation on Oral Bioavailability of Poorly Soluble Drugs. The AAPS Journal 17:4, pages 902-917.
Crossref
Moran Zur, Noa Cohen, Riad Agbaria & Arik Dahan. (2015) The biopharmaceutics of successful controlled release drug product: Segmental-dependent permeability of glipizide vs. metoprolol throughout the intestinal tract. International Journal of Pharmaceutics 489:1-2, pages 304-310.
Crossref
Raj K. Singh Badhan. 2015. Computational Pharmaceutics. Computational Pharmaceutics 263 291 .
Erik Sjögren, David Dahlgren, Carl Roos & Hans Lennernäs. (2015) Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data . Molecular Pharmaceutics 12:6, pages 2026-2039.
Crossref
Isabel Lozoya-Agullo, Moran Zur, Omri Wolk, Avital Beig, Isabel González-Álvarez, Marta González-Álvarez, Matilde Merino-Sanjuán, Marival Bermejo & Arik Dahan. (2015) In-situ intestinal rat perfusions for human Fabs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches. International Journal of Pharmaceutics 480:1-2, pages 1-7.
Crossref
Jerome Hochman, Cuyue Tang & Thomayant Prueksaritanont. (2015) Drug–Drug Interactions Related to Altered Absorption and Plasma Protein Binding: Theoretical and Regulatory Considerations, and an Industry Perspective. Journal of Pharmaceutical Sciences 104:3, pages 916-929.
Crossref
Benjamin Wuyts, Danny Riethorst, Joachim Brouwers, Jan Tack, Pieter Annaert & Patrick Augustijns. (2015) Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability. International Journal of Pharmaceutics 478:2, pages 736-744.
Crossref
Benjamin Wuyts, Danny Riethorst, Joachim Brouwers, Jan Tack, Pieter Annaert & Patrick Augustijns. (2015) Evaluation of fasted state human intestinal fluid as apical solvent system in the Caco-2 absorption model and comparison with FaSSIF. European Journal of Pharmaceutical Sciences 67, pages 126-135.
Crossref
Andrés Olivares-Morales, Yoshiteru Kamiyama, Adam S. Darwich, Leon Aarons & Amin Rostami-Hodjegan. (2015) Analysis of the impact of controlled release formulations on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model. European Journal of Pharmaceutical Sciences 67, pages 32-44.
Crossref
Salvador Marí-Bauset, Itziar Zazpe, Amelia Mari-Sanchis, Agustín Llopis-González & María Morales-Suárez-Varela. (2014) Evidence of the Gluten-Free and Casein-Free Diet in Autism Spectrum Disorders. Journal of Child Neurology 29:12, pages 1718-1727.
Crossref
Warren M. Miner-Williams, Bruce R. Stevens & Paul J. Moughan. (2015) Are intact peptides absorbed from the healthy gut in the adult human?. Nutrition Research Reviews 27:2, pages 308-329.
Crossref
Natsuki Kogure, Takeshi Akiyoshi, Ayuko Imaoka & Hisakazu Ohtani. (2014) Prediction of the extent and variation of grapefruit juice–drug interactions from the pharmacokinetic profile in the absence of grapefruit juice. Biopharmaceutics & Drug Disposition 35:7, pages 373-381.
Crossref
Samir Mitragotri, Paul A. Burke & Robert Langer. (2014) Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nature Reviews Drug Discovery 13:9, pages 655-672.
Crossref
Moran Zur, Allison S. Hanson & Arik Dahan. (2014) The complexity of intestinal permeability: Assigning the correct BCS classification through careful data interpretation. European Journal of Pharmaceutical Sciences 61, pages 11-17.
Crossref
Serena Giusti, Tommaso Sbrana, Margherita La Marca, Valentina Di Patria, Valentina Martinucci, Annalisa Tirella, Claudio Domenici & Arti Ahluwalia. (2014) A novel dual‐flow bioreactor simulates increased fluorescein permeability in epithelial tissue barriers. Biotechnology Journal 9:9, pages 1175-1184.
Crossref
Michael H. Abraham. (2014) Human Intestinal Absorption—Neutral Molecules and Ionic Species. Journal of Pharmaceutical Sciences 103:7, pages 1956-1966.
Crossref
Erik Sjögren, Bertil Abrahamsson, Patrick Augustijns, Dieter Becker, Michael B. Bolger, Marcus Brewster, Joachim Brouwers, Talia Flanagan, Matthew Harwood, Christian Heinen, René Holm, Hans-Paul Juretschke, Marlies Kubbinga, Anders Lindahl, Viera Lukacova, Uwe Münster, Sibylle Neuhoff, Mai Anh Nguyen, Achiel van Peer, Christos Reppas, Amin Rostami Hodjegan, Christer Tannergren, Werner Weitschies, Clive Wilson, Patricia Zane, Hans Lennernäs & Peter Langguth. (2014) In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects. European Journal of Pharmaceutical Sciences 57, pages 99-151.
Crossref
Edmund S. Kostewicz, Leon Aarons, Martin Bergstrand, Michael B. Bolger, Aleksandra Galetin, Oliver Hatley, Masoud Jamei, Richard Lloyd, Xavier Pepin, Amin Rostami-Hodjegan, Erik Sjögren, Christer Tannergren, David B. Turner, Christian Wagner, Werner Weitschies & Jennifer Dressman. (2014) PBPK models for the prediction of in vivo performance of oral dosage forms. European Journal of Pharmaceutical Sciences 57, pages 300-321.
Crossref
Hans Lennernäs. (2014) Regional intestinal drug permeation: Biopharmaceutics and drug development. European Journal of Pharmaceutical Sciences 57, pages 333-341.
Crossref
Hannah K. Batchelor, Nikoletta Fotaki & Sandra Klein. (2014) Paediatric oral biopharmaceutics: Key considerations and current challenges. Advanced Drug Delivery Reviews 73, pages 102-126.
Crossref
Caroline A. Larregieu & Leslie Z. Benet. (2014) Distinguishing between the Permeability Relationships with Absorption and Metabolism To Improve BCS and BDDCS Predictions in Early Drug Discovery. Molecular Pharmaceutics 11:4, pages 1335-1344.
Crossref
Donna A. Volpe, Hong Shen & Praveen V. Balimane. 2014. Predictive ADMET. Predictive ADMET 263 290 .
Sara Carlert, Hans Lennernäs & Bertil Abrahamsson. (2014) Evaluation of the use of Classical Nucleation Theory for predicting intestinal crystalline precipitation of two weakly basic BSC class II drugs. European Journal of Pharmaceutical Sciences 53, pages 17-27.
Crossref
Hans Lennernäs. (2013) Human in Vivo Regional Intestinal Permeability: Importance for Pharmaceutical Drug Development . Molecular Pharmaceutics 11:1, pages 12-23.
Crossref
Aleksandra Galetin. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 255 288 .
Omri Wolk & Arik Dahan. 2014. Focal Controlled Drug Delivery. Focal Controlled Drug Delivery 343 357 .
David G Levitt. (2013) Quantitation of small intestinal permeability during normal human drug absorption. BMC Pharmacology and Toxicology 14:1.
Crossref
Arik Dahan, Omri Wolk, Young Hoon Kim, Chandrasekharan Ramachandran, Gordon M. Crippen, Toshihide Takagi, Marival Bermejo & Gordon L. Amidon. (2013) Purely in Silico BCS Classification: Science Based Quality Standards for the World’s Drugs. Molecular Pharmaceutics 10:11, pages 4378-4390.
Crossref
Salvador Marí Bauset, Itziar Zazpe, Amelia Marí Sanchis, Agustín Llopis González & María Morales Suárez-Varela. (2012) Are There Anthropometric Differences Between Autistic and Healthy Children?. Journal of Child Neurology 28:10, pages 1226-1232.
Crossref
Le Sun, Xiaohong Liu, Rongwu Xiang, Chunnuan Wu, Yongjun Wang, Yinghua Sun, Jin Sun & Zhonggui He. (2013) Structure‐based prediction of human intestinal membrane permeability for rapid in silico BCS classification . Biopharmaceutics & Drug Disposition 34:6, pages 321-335.
Crossref
Erik Sjögren, Jan Westergren, Iain Grant, Gunilla Hanisch, Lennart Lindfors, Hans Lennernäs, Bertil Abrahamsson & Christer Tannergren. (2013) In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim. European Journal of Pharmaceutical Sciences 49:4, pages 679-698.
Crossref
Moran Fairstein, Rotem Swissa & Arik Dahan. (2013) Regional-Dependent Intestinal Permeability and BCS Classification: Elucidation of pH-Related Complexity in Rats Using Pseudoephedrine. The AAPS Journal 15:2, pages 589-597.
Crossref
Caroline A. Larregieu & Leslie Z. Benet. (2013) Drug Discovery and Regulatory Considerations for Improving In Silico and In Vitro Predictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements. The AAPS Journal 15:2, pages 483-497.
Crossref
Arik Dahan, Avital Beig, Viktoriya Ioffe-Dahan, Riad Agbaria & Jonathan M Miller. (2012) The Twofold Advantage of the Amorphous Form as an Oral Drug Delivery Practice for Lipophilic Compounds: Increased Apparent Solubility and Drug Flux Through the Intestinal Membrane. The AAPS Journal 15:2, pages 347-353.
Crossref
Aki T. Heikkinen, Stephen Fowler, Lynn Gray, Jia Li, Ying Peng, Preeti Yadava, Aruna Railkar & Neil Parrott. (2013) In Vitro to in Vivo Extrapolation and Physiologically Based Modeling of Cytochrome P450 Mediated Metabolism in Beagle Dog Gut Wall and Liver. Molecular Pharmaceutics 10:4, pages 1388-1399.
Crossref
Sandra M. Gómez, Diana M. Cristancho & Fleming Martínez. (2013) Solubilization thermodynamics of ibuprofen in modified and classical FeSSIF biorelevant media. Journal of Molecular Liquids 179, pages 110-117.
Crossref
Michael Gertz, Catherine M. Cartwright, Michael J. Hobbs, Kathryn E. Kenworthy, Malcolm Rowland, J. Brian Houston & Aleksandra Galetin. (2012) Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential. Pharmaceutical Research 30:3, pages 761-780.
Crossref
Carl-Christer Johansson, Peter Gennemark, Per Artursson, Angela Äbelö, Michael Ashton & Rasmus Jansson-Löfmark. (2013) Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat. Journal of Pharmacokinetics and Pharmacodynamics 40:1, pages 117-128.
Crossref
Yurong Lai. 2013. Transporters in Drug Discovery and Development. Transporters in Drug Discovery and Development 633 674 .
M. D. Harwood, S. Neuhoff, G. L. Carlson, G. Warhurst & A. Rostami‐Hodjegan. (2012) Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro–in vivo extrapolation of oral drug absorption . Biopharmaceutics & Drug Disposition 34:1, pages 2-28.
Crossref
Helena Anna Thörn, Erik Sjögren, Paul Alfred Dickinson & Hans Lennernäs. (2012) Binding Processes Determine the Stereoselective Intestinal and Hepatic Extraction of Verapamil in Vivo . Molecular Pharmaceutics 9:11, pages 3034-3045.
Crossref
Alexander V. LyubimovJasminder Sahi, Yurong Lai & Caroline Lee. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 51 .
Anne Sophie Grandvuinet, Henrik Tang Vestergaard, Nicolas Rapin & Bente Steffansen. (2012) Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in-vitro kinetic parameters for the prediction of clinically relevant drug–drug interactions. Journal of Pharmacy and Pharmacology 64:11, pages 1523-1548.
Crossref
Aki T. Heikkinen, Guillaume Baneyx, Antonello Caruso & Neil Parrott. (2012) Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus™. European Journal of Pharmaceutical Sciences 47:2, pages 375-386.
Crossref
Kiyohiko Sugano. 2012. Biopharmaceutics Modeling and Simulations. Biopharmaceutics Modeling and Simulations 266 321 .
Kiyohiko Sugano. 2012. Biopharmaceutics Modeling and Simulations. Biopharmaceutics Modeling and Simulations 206 265 .
Kiyohiko Sugano. 2012. Biopharmaceutics Modeling and Simulations. Biopharmaceutics Modeling and Simulations 160 205 .
Kiyohiko Sugano. 2012. Biopharmaceutics Modeling and Simulations. Biopharmaceutics Modeling and Simulations 64 121 .
Arik Dahan, Hans Lennernäs & Gordon L. Amidon. (2012) The Fraction Dose Absorbed, in Humans, and High Jejunal Human Permeability Relationship. Molecular Pharmaceutics 9:6, pages 1847-1851.
Crossref
Alex Avdeef. 2012. Absorption and Drug Development. Absorption and Drug Development 499 574 .
Alex Avdeef. 2012. Absorption and Drug Development. Absorption and Drug Development 319 498 .
Manthena V. Varma, Iain GardnerStefanus J. Steyn, Paul Nkansah, Charles J. Rotter, Carrie Whitney-Pickett, Hui Zhang, Li Di, Michael CramKatherine S. FennerAyman F. El-Kattan. (2012) pH-Dependent Solubility and Permeability Criteria for Provisional Biopharmaceutics Classification (BCS and BDDCS) in Early Drug Discovery. Molecular Pharmaceutics 9:5, pages 1199-1212.
Crossref
Bilal S. Abuasal, Michael B. Bolger, Don K. WalkerAmal Kaddoumi. (2012) In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate . Molecular Pharmaceutics 9:3, pages 492-504.
Crossref
Hyun Jung Kim, Dongeun Huh, Geraldine Hamilton & Donald E. Ingber. (2012) Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab on a Chip 12:12, pages 2165.
Crossref
Leslie Z. Benet, Fabio Broccatelli & Tudor I. Oprea. (2011) BDDCS Applied to Over 900 Drugs. The AAPS Journal 13:4, pages 519-547.
Crossref
E. Neirinckx, S. Croubels, S. De Boever, J.P. Remon, T. Bosmans, S. Daminet, P. De Backer & C. Vervaet. (2011) Species comparison of enantioselective oral bioavailability and pharmacokinetics of ketoprofen. Research in Veterinary Science 91:3, pages 415-421.
Crossref
Kirstin Thelen, Katrin Coboeken, Stefan Willmann, Rolf Burghaus, Jennifer B. Dressman & Jörg Lippert. (2011) Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions. Journal of Pharmaceutical Sciences 100:12, pages 5324-5345.
Crossref
Matěj Velický, Kin Y. Tam & Robert A.W. Dryfe. (2011) In situ artificial membrane permeation assay under hydrodynamic control: Correlation between drug in vitro permeability and fraction absorbed in humans. European Journal of Pharmaceutical Sciences 44:3, pages 299-309.
Crossref
Jacqueline Pusch, Miriam Votteler, Stella Göhler, Jasmin Engl, Martina Hampel, Heike Walles & Katja Schenke-Layland. (2011) The physiological performance of a three-dimensional model that mimics the microenvironment of the small intestine. Biomaterials 32:30, pages 7469-7478.
Crossref
K S Amidon, P Langguth, H Lennernäs, L Yu & G L Amidon. (2011) Bioequivalence of Oral Products and the Biopharmaceutics Classification System: Science, Regulation, and Public Policy. Clinical Pharmacology & Therapeutics 90:3, pages 467-470.
Crossref
Wei Zhu & Eun Ju Jeong. 2011. Oral Bioavailability. Oral Bioavailability 461 473 .
Mei-Ling Chen, Gordon L. Amidon, Leslie Z. Benet, Hans Lennernas & Lawrence X. Yu. (2011) The BCS, BDDCS, and Regulatory Guidances. Pharmaceutical Research 28:7, pages 1774-1778.
Crossref
Helena Anna Thörn, Anna Lundahl, Johannes Antonius Schrickx, Paul Alfred Dickinson & Hans Lennernäs. (2011) Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans. European Journal of Pharmaceutical Sciences 43:3, pages 89-98.
Crossref
Arik Dahan, Yasuhiro Tsume, Jing Sun, Jonathan M. Miller & Gordon L. Amidon. 2011. Amino Acids, Peptides and Proteins in Organic Chemistry. Amino Acids, Peptides and Proteins in Organic Chemistry 277 292 .
Xinyuan Zhang, Robert A. Lionberger, Barbara M. Davit & Lawrence X. Yu. (2011) Utility of Physiologically Based Absorption Modeling in Implementing Quality by Design in Drug Development. The AAPS Journal 13:1, pages 59-71.
Crossref
Paul A. Dawson. 2011. Drug Transporters. Drug Transporters 169 203 .
Nick Plant. 2011. Understanding the Dynamics of Biological Systems. Understanding the Dynamics of Biological Systems 59 82 .
Majid Y. Moridani. 2010. Prodrugs and Targeted Delivery. Prodrugs and Targeted Delivery 79 109 .
James M. Butler & Jennifer B. Dressman. (2010) The Developability Classification System: Application of Biopharmaceutics Concepts to Formulation Development. Journal of Pharmaceutical Sciences 99:12, pages 4940-4954.
Crossref
Kiyohiko Sugano. (2010) Aqueous Boundary Layers Related to Oral Absorption of a Drug: From Dissolution of a Drug to Carrier Mediated Transport and Intestinal Wall Metabolism. Molecular Pharmaceutics 7:5, pages 1362-1373.
Crossref
Pilar Prieto, Sebastian Hoffmann, Valentina Tirelli, Francesco Tancredi, Isabel González, Marival Bermejo & Isabella De Angelis. (2010) An Exploratory Study of Two Caco-2 Cell Models for Oral Absorption: A Report on Their Within-laboratory and Between-laboratory Variability, and Their Predictive Capacity. Alternatives to Laboratory Animals 38:5, pages 367-386.
Crossref
L Z Benet & C A Larregieu. (2010) The FDA Should Eliminate the Ambiguities in the Current BCS Biowaiver Guidance and Make Public the Drugs for Which BCS Biowaivers Have Been Granted. Clinical Pharmacology & Therapeutics 88:3, pages 405-407.
Crossref
Jonathan M. Miller, Arik Dahan, Deepak Gupta, Sheeba Varghese & Gordon L. Amidon. (2010) Enabling the Intestinal Absorption of Highly Polar Antiviral Agents: Ion-Pair Facilitated Membrane Permeation of Zanamivir Heptyl Ester and Guanidino Oseltamivir. Molecular Pharmaceutics 7:4, pages 1223-1234.
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