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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 5
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General Xenobiochemistry

Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms

Prashant B. NigadeDepartment of Drug Metabolism and Pharmacokinetics, Lupin Limited (Research Park), Pune, India; Correspondence[email protected]
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,
Jayasagar GunduDepartment of Drug Metabolism and Pharmacokinetics, Lupin Limited (Research Park), Pune, India; View further author information
,
K. Sreedhara PaiDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India; ORCID Iconhttp://orcid.org/0000-0002-2017-9533View further author information
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Kumar V. S. NemmaniDepartment of Pharmacology, Lupin Limited (Research Park), Pune, IndiaView further author information
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Rashmi TalwarDepartment of Pharmacology, Lupin Limited (Research Park), Pune, IndiaView further author information
Pages 528-539 | Received 27 Mar 2018, Accepted 05 May 2018, Published online: 07 Jun 2018

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Carl Petersson, Orestis Papasouliotis, Marc Lecomte, Lassina Badolo & Hugues Dolgos. (2020) Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery. Xenobiotica 50:3, pages 270-279.
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Articles from other publishers (5)

David Tess, George C. Chang, Christopher Keefer, Anthony Carlo, Rhys Jones & Li Di. (2023) In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes. The AAPS Journal 25:3.
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Zhiwei Zhang, Shuang Fu, Furun Wang, Chunmiao Yang, Lingchao Wang, Meiyan Yang, Wenpeng Zhang, Wu Zhong & Xiaomei Zhuang. (2022) A PBPK Model of Ternary Cyclodextrin Complex of ST-246 Was Built to Achieve a Reasonable IV Infusion Regimen for the Treatment of Human Severe Smallpox. Frontiers in Pharmacology 13.
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Shibin Mathew, David Tess, Woodrow Burchett, George Chang, Nathaniel Woody, Christopher Keefer, Christine Orozco, Jian Lin, Samantha Jordan, Shinji Yamazaki, Rhys Jones & Li Di. (2021) Evaluation of Prediction Accuracy for Volume of Distribution in Rat and Human Using In Vitro, In Vivo, PBPK and QSAR Methods. Journal of Pharmaceutical Sciences 110:4, pages 1799-1823.
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Neha Murad, Kishore K. Pasikanti, Benjamin D. Madej, Amanda Minnich, Juliet M. McComas, Sabrinia Crouch, Joseph W. Polli & Andrew D. Weber. (2021) Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds. Drug Metabolism and Disposition 49:2, pages 169-178.
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Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker & Philip Lienau. (2021) Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat. Drug Metabolism and Disposition 49:1, pages 53-61.
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