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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 7
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Animal Pharmacokinetics and Metabolism

Oral bioavailability and pharmacokinetics of esculetin following intravenous and oral administration in rats

Jae-Hwan Kwaka College of Pharmacy, Kyungsung University, Busan, Republic of Korea;b Functional Food & Drug Convergence Research Center, Industry-Academic Cooperation Foundation, Kyungsung University, Busan, Republic of KoreaORCID Iconhttps://orcid.org/0000-0003-2020-699XView further author information
ORCID Icon,
Younghwa Kimb Functional Food & Drug Convergence Research Center, Industry-Academic Cooperation Foundation, Kyungsung University, Busan, Republic of Korea;c School of Food Biotechnology and Nutrition, Kyungsung University, Busan, Republic of KoreaORCID Iconhttps://orcid.org/0000-0003-4186-887XView further author information
ORCID Icon,
Christine E. Staatzd School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, Brisbane, AustraliaORCID Iconhttps://orcid.org/0000-0002-4595-9376View further author information
ORCID Icon &
In-hwan Baeka College of Pharmacy, Kyungsung University, Busan, Republic of Korea;b Functional Food & Drug Convergence Research Center, Industry-Academic Cooperation Foundation, Kyungsung University, Busan, Republic of Korea;d School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, Brisbane, AustraliaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9538-0565View further author information
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Pages 811-817 | Received 10 Mar 2021, Accepted 30 Apr 2021, Published online: 17 May 2021

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Feng Shi, Wenxiong Yin, Michael Adu-Frimpong, Xiaoxiao Li, Xiaoli Xia, Weigang Sun, Hao Ji, Elmurat Toreniyazov, Wang Qilong, Xia Cao, Jiangnan Yu & Ximing Xu. (2023) In-vitro and in-vivo evaluation and anti-colitis activity of esculetin-loaded nanostructured lipid carrier decorated with DSPE-MPEG2000. Journal of Microencapsulation 40:6, pages 442-455.
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Jannatul Ferdous, Md. Shimul Bhuia, Raihan Chowdhury, Asraful Islam Rakib, Mst. Asma Aktar, Md. Sakib Al Hasan, Henrique Douglas Melo Coutinho & Muhammad Torequl Islam. (2024) Pharmacological Activities of Plant‐Derived Fraxin with Molecular Mechanisms: A Comprehensive Review. Chemistry & Biodiversity.
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Mithun Rudrapal, Gourav Rakshit, Ravi Pratap Singh, Samiksha Garse, Johra Khan & Soumi Chakraborty. (2024) Dietary Polyphenols: Review on Chemistry/Sources, Bioavailability/Metabolism, Antioxidant Effects, and Their Role in Disease Management. Antioxidants 13:4, pages 429.
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Mengmeng Xia, Zongmei Wu, Junyu Wang, Manon Buist-Homan & Han Moshage. (2023) The Coumarin-Derivative Esculetin Protects against Lipotoxicity in Primary Rat Hepatocytes via Attenuating JNK-Mediated Oxidative Stress and Attenuates Free Fatty Acid-Induced Lipid Accumulation. Antioxidants 12:11, pages 1922.
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Ting Cai & Bin Cai. (2023) Pharmacological activities of esculin and esculetin: A review. Medicine 102:40, pages e35306.
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Fang Liu, Jin-Yang Li, Cai-Bei Han, Jun-Hao Wang, Si-Yi Tong, Xue-Kun Wang, Yan-Tuan Li & Wen-Jun Sun. (2023) First cocrystal of esculetin: Simultaneously optimized in vitro/vivo properties and antioxidant effect. European Journal of Pharmaceutical Sciences 187, pages 106469.
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Vitalii Kostenko, Oleh Akimov, Oleksandr Gutnik, Heorhii Kostenko, Viktoriia Kostenko, Tamara Romantseva, Yevhen Morhun, Svitlana Nazarenko & Olena Taran. (2023) Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response. Heliyon 9:5, pages e15551.
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Sourbh Suren Garg, Jeena Gupta, Debasis Sahu & Chuan-Ju Liu. (2022) Pharmacological and Therapeutic Applications of Esculetin. International Journal of Molecular Sciences 23:20, pages 12643.
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Qian-Hui Wang, Si-Wen Qin & Jian-Guo Jiang. (2022) Improvement effects of esculetin on the formation and development of atherosclerosis. Biomedicine & Pharmacotherapy 150, pages 113001.
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Hyehyun Hong, Tae-Jin Park, Sungchan Jang, Min-Seon Kim, Jin-Soo Park, Won-Jae Chi & Seung-Young Kim. (2022) Anti-inflammatory activity of 6- O -phospho-7-hydroxycoumarin in LPS-induced RAW 264.7 cells . Journal of Applied Biological Chemistry 65:1, pages 33-41.
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Biswanath Dinda & Ankita Chakraborty. 2022. Natural Products in Obesity and Diabetes. Natural Products in Obesity and Diabetes 469 505 .
Linlin Zhang, Qingxuan Xie & Xiaofang Li. (2021) Esculetin: A review of its pharmacology and pharmacokinetics. Phytotherapy Research 36:1, pages 279-298.
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