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Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 7
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General Xenobiochemistry

Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes

Yasuhiro Unoa Department of Basic Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9040-1681View further author information
ORCID Icon,
Genki Ushirozakoa Department of Basic Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, JapanView further author information
,
Shotaro Ueharab Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, JapanORCID Iconhttps://orcid.org/0000-0002-1359-8828View further author information
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Norie Murayamab Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, JapanView further author information
,
Yuki Fujikib Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, JapanView further author information
,
Hiroaki Kawaguchic School of Veterinary Medicine, Kitasato University, Towada, JapanView further author information
,
Kyoko Tsukiyama-Koharad Transboundary Animal Diseases Center, Kagoshima University, Kagoshima, Japan;e Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, JapanView further author information
&
Hiroshi Yamazakib Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1068-4261View further author information
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Pages 687-696 | Received 13 Oct 2022, Accepted 25 Oct 2022, Published online: 03 Nov 2022

Citations (9)

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Read on this site (3)

Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki & Yasuhiro Uno. (2023) Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p-nitrophenol. Xenobiotica 53:10-11, pages 573-580.
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Yasuhiro Uno, Yutaro Noda, Saho Morikuni, Norie Murayama & Hiroshi Yamazaki. (2023) Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs. Xenobiotica 53:3, pages 140-148.
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Yasuhiro Uno, Saho Morikuni, Norie Murayama & Hiroshi Yamazaki. (2023) 2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22. Xenobiotica 53:1, pages 60-65.
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Articles from other publishers (6)

Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki & Yasuhiro Uno. (2024) Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan. Drug Metabolism and Disposition 52:4, pages 305-311.
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Yasuhiro Uno, Miaki Makiguchi, Genki Ushirozako, Kyoko Tsukiyama-Kohara, Makiko Shimizu & Hiroshi Yamazaki. (2024) Molecular and functional characterization of flavin-containing monooxygenases (FMO1–6) in tree shrews. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 277, pages 109835.
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Yasuhiro Uno, Makiko Shimizu & Hiroshi Yamazaki. (2024) A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models. Biochemical Pharmacology, pages 116124.
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Yasuhiro Uno, Yuhki Minami, Kyoko Tsukiyama-Kohara, Norie Murayama & Hiroshi Yamazaki. (2023) Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity. Biochemical Pharmacology, pages 115990.
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Genki Ushirozako, Yutaro Noda, Norie Murayama, Hiroaki Kawaguchi, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki & Yasuhiro Uno. (2023) Newly Identified Tree Shrew Cytochrome P450 2A13 is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog Cytochrome P450 2A13 and Pig Cytochrome P450 2A19 . Drug Metabolism and Disposition 51:5, pages 610-617.
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Yasuhiro Uno, Shiori Jikuya, Yutaro Noda, Asuka Oguchi, Norie Murayama, Hiroaki Kawaguchi, Kyoko Tsukiyama-Kohara & Hiroshi Yamazaki. (2023) Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 267, pages 109579.
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