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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 12
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Research Article

Inhibition and induction of human cytochrome P450 (CYP) enzymes

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Pages 1203-1253 | Published online: 22 Sep 2008

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Read on this site (36)

Tomohiko Ichikawa, Hirofumi Tsujino, Takahiro Miki, Masaya Kobayashi, Chiaki Matsubara, Sara Miyata, Taku Yamashita, Kohei Takeshita, Yasushige Yonezawa & Tadayuki Uno. (2018) Allosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding. Xenobiotica 48:12, pages 1227-1236.
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Yuki Yamasaki, Kaoru Kobayashi, Asumi Inaba, Daisuke Uehara, Hiroki Tojima, Satoru Kakizaki & Kan Chiba. (2018) Indirect activation of pregnane X receptor in the induction of hepatic CYP3A11 by high-dose rifampicin in mice. Xenobiotica 48:11, pages 1098-1105.
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Jukka Mäenpää & Olavi Pelkonen. (2016) Cardiac safety of ophthalmic timolol. Expert Opinion on Drug Safety 15:11, pages 1549-1561.
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Aziz Eftekhari, Yadollah Azarmi, Alireza Parvizpur & Mohammad Ali Eghbal. (2016) Involvement of oxidative stress and mitochondrial/lysosomal cross-talk in olanzapine cytotoxicity in freshly isolated rat hepatocytes. Xenobiotica 46:4, pages 369-378.
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Wajd Amly & Rafik Karaman. (2016) Recent updates in utilizing prodrugs in drug delivery (2013–2015). Expert Opinion on Drug Delivery 13:4, pages 571-591.
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Martina Galdíková, Katarína Šiviková, Beáta Holečková, Ján Dianovský, Monika Drážovská & Viera Schwarzbacherová. (2015) The effect of thiacloprid formulation on DNA/chromosome damage and changes in GST activity in bovine peripheral lymphocytes. Journal of Environmental Science and Health, Part B 50:10, pages 698-707.
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Xiaoxiang Du, Huizhou Ye, Chunxia Zhang, Lei Ye & Guanyang Lin. (2015) Effect of kanglaite on rat cytochrome P450. Pharmaceutical Biology 53:7, pages 995-1001.
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Yohei Kosugi & Junzo Takahashi. (2015) Species differences and substrate specificity of CYP3A heteroactivation by efavirenz. Xenobiotica 45:4, pages 345-352.
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Amrita Saxena, Girish K. Jain, Hefazat H. Siddiqui, Shom S. Bhunia, Anil K. Saxena & Jiaur R. Gayen. (2014) In vitro metabolism of a novel antithrombotic compound, S002-333, and its enantiomers: quantitative cytochrome P450 phenotyping, metabolic profiling and enzyme kinetic studies. Xenobiotica 44:4, pages 295-308.
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Paul R Ortiz de Montellano. (2013) Cytochrome P450-Activated Prodrugs. Future Medicinal Chemistry 5:2, pages 213-228.
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Kornphimol Kulthong, Rawiwan Maniratanachote, Yuki Kobayashi, Tatsuki Fukami & Tsuyoshi Yokoi. (2012) Effects of silver nanoparticles on rat hepatic cytochrome P450 enzyme activity. Xenobiotica 42:9, pages 854-862.
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Yohei Kosugi, Hideki Hirabayashi, Tomoko Igari, Yasushi Fujioka, Yoko Hara, Teruaki Okuda & Toshiya Moriwaki. (2012) Evaluation of cytochrome P450-mediated drug–drug interactions based on the strategies recommended by regulatory authorities. Xenobiotica 42:2, pages 127-138.
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Kyeong-Ryoon Lee, Yoon-Jee Chae, Jong-Hwa Lee, Dae-Duk Kim, Saeho Chong, Chang-Koo Shim & Suk-Jae Chung. (2012) QUANTIFICATION OF CILNIDIPINE IN HUMAN PLASMA BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY. Journal of Liquid Chromatography & Related Technologies 35:2, pages 308-320.
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Nobuyuki Koga, Chiho Ohta, Yoshihisa Kato, Koichi Haraguchi, Tetsuya Endo, Kazunori Ogawa, Hideaki Ohta & Masamichi Yano. (2011) In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450. Xenobiotica 41:11, pages 927-933.
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Thomas G. Osimitz & Brian G. Lake. (2009) Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk. Critical Reviews in Toxicology 39:6, pages 501-511.
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R. J. Price, M. P. Scott, A. M. Giddings, D. G. Walters, R. H. Stierum, C. Meredith & B. G. Lake. (2008) Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes. Xenobiotica 38:6, pages 574-586.
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H. Raunio, N. Pokela, K. Puhakainen, M. Rahnasto, T. Mauriala, S. Auriola & R. O. Juvonen. (2008) Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo. Xenobiotica 38:1, pages 34-47.
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Jianling Wang, Laszlo Urban & Dejan Bojanic. (2007) Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety. Expert Opinion on Drug Metabolism & Toxicology 3:5, pages 641-665.
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Jos V Castell, Ramiro Jover, Celia P Martnez-Jimnez & Mara Jos Gmez-Lechn. (2006) Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies. Expert Opinion on Drug Metabolism & Toxicology 2:2, pages 183-212.
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Alastair E. Cribb, Mathieu Peyrou, Shanmugam Muruganandan & Laetitia Schneider. (2005) The Endoplasmic Reticulum in Xenobiotic Toxicity. Drug Metabolism Reviews 37:3, pages 405-442.
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D. Tenmizu, Y. Endo, K. Noguchi & H. Kamimura. (2004) Identification of the novel canine CYP1A2 1117 C>T SNP causing protein deletion. Xenobiotica 34:9, pages 835-846.
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Shufeng Zhou, Yihuai Gao, Wenqi Jiang, Min Huang, Anlong Xu & James W. Paxton. (2003) Interactions of Herbs with Cytochrome P450. Drug Metabolism Reviews 35:1, pages 35-98.
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David F. V. Lewis & Maruice Dickins. (2003) Baseline Lipophilicity Relationships in Human Cytochromes P450 Associated with Drug Metabolism. Drug Metabolism Reviews 35:1, pages 1-18.
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Paavo Honkakoski, Tatsuya Sueyoshi & Masahiko Negishi. (2003) Drug-activated nuclear receptors CAR and PXR. Annals of Medicine 35:3, pages 172-182.
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Jens Standop, Matthias B. Schneider, Alexis Ulrich, Subhash Chauhan, Nicolas Moniaux, Markus W. Büchler, Surinder K. Batra & Parviz M. Pour. (2002) The Pattern of Xenobiotic-Metabolizing Enzymes in the Human Pancreas. Journal of Toxicology and Environmental Health, Part A 65:19, pages 1379-1400.
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Olavi Pelkonen. (2002) Human CYPs: in vivo and clinical aspects. Drug Metabolism Reviews 34:1-2, pages 37-46.
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N. Hagen, A. K. Olsen, J. V. Andersen, J. Tjørnelund & S. H. Hansen. (2002) Characterization of mixtures of recombinant human cytochrome P450s as a screening model for metabolic stability in drug discovery. Xenobiotica 32:9, pages 749-759.
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M. Rypka, J. Veselý, Z. Chmela, D. Riegrová, K. Červenková, L. Havlíček, K. Lemr, J. Hanuš, B. Černý, J. Lukeš & K. Michalíková. (2002) In vitro biotransformation of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine by mouse liver microsomes. Xenobiotica 32:11, pages 1017-1031.
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A. B. Renwick, G. Lavignette, P. D. Worboys, B. Williams, D. Surry, D. F. V. Lewis, R. J. Price, B. G. Lake & D. C. Evans. (2001) Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes. Xenobiotica 31:12, pages 861-878.
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O. Pelkonen, P. Myllynen, P. Taavitsainen, A. R. Boobis, P. Watts, B. G. Lake, R. J. Price, A. B. Renwick, M.-J. Gómez-Lechón, J. V. Castell, M. Ingelman-Sundberg, M. Hidestrand, A. Guillouzo, L. Corcos, P. S. Goldfarb & D. F. V. Lewis. (2001) Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems. Xenobiotica 31:6, pages 321-343.
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D. C. Mankowski, M. P. Lawton & S. Ekins. (2000) Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates. Xenobiotica 30:8, pages 745-754.
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