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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 11
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Research Article

Correlation of the intrinsic clearance of donepezil (Aricept®) between in vivo and in vitro studies in rat, dog and human

K. Matsui Drug Dynamics Research Section, Drug Safety & Disposition Research Laboratories, EisaiCo. Ltd, 13 Tokodai 5chome, Tsukubashi, Ibaraki 300 2635, Japan
,
S. Taniguchi Drug Dynamics Research Section, Drug Safety & Disposition Research Laboratories, EisaiCo. Ltd, 13 Tokodai 5chome, Tsukubashi, Ibaraki 300 2635, Japan
&
T. Yoshimura Drug Dynamics Research Section, Drug Safety & Disposition Research Laboratories, EisaiCo. Ltd, 13 Tokodai 5chome, Tsukubashi, Ibaraki 300 2635, Japan
Pages 1059-1072 | Published online: 22 Sep 2008

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David Prvulovic & Barbara Schneider. (2014) Pharmacokinetic and pharmacodynamic evaluation of donepezil for the treatment of Alzheimer's disease. Expert Opinion on Drug Metabolism & Toxicology 10:7, pages 1039-1050.
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Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
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Articles from other publishers (20)

Akiko Kiriyama, Shunsuke Kimura & Shugo Yamashita. (2023) Pharmacokinetic/Pharmacodynamic Models of an Alzheimer’s Drug, Donepezil, in Rats. Drug Metabolism and Disposition 51:3, pages 329-337.
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Go-Wun Choi, Sangno Lee, Dong Wook Kang, Ju Hee Kim, Ju Hee Kim & Hea-Young Cho. (2021) Long-acting injectable donepezil microspheres: Formulation development and evaluation. Journal of Controlled Release 340, pages 72-86.
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Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova & Jana Zdarova Karasova. (2021) The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs. Molecules 26:8, pages 2160.
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Jin Lu, Xiuzhe Wang, Lili Wan, Jianliang Fu, Yan Huo, Yuwu Zhao & Cheng Guo. (2020) Gene Polymorphisms Affecting the Pharmacokinetics and Pharmacodynamics of Donepezil Efficacy. Frontiers in Pharmacology 11.
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Gabriela Dumitrita Stanciu, Andrei Luca, Razvan Nicolae Rusu, Veronica Bild, Sorin Ioan Beschea Chiriac, Carmen Solcan, Walther Bild & Daniela Carmen Ababei. (2019) Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement. Biomolecules 10:1, pages 40.
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Joseph A. Araujo, Jessica Baulk & Christina de Rivera. 2017. Canine and Feline Dementia. Canine and Feline Dementia 69 92 .
Jin Lu, Lili Wan, Yuan Zhong, Qi Yu, Yonglong Han, Pengguo Chen, Beiyun Wang, Wei Li, Ya Miao & Cheng Guo. (2015) Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer's disease. Journal of Pharmacological Sciences 129:3, pages 188-195.
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Kan Zhong. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 4 .
Sonal Saluja, Purna C. Kasha, Jyotsna Paturi, Carter Anderson, Russell Morris & Ajay K. Banga. (2013) A novel electronic skin patch for delivery and pharmacokinetic evaluation of donepezil following transdermal iontophoresis. International Journal of Pharmaceutics 453:2, pages 395-399.
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Muriel Noetzli & Chin B. Eap. (2013) Pharmacodynamic, Pharmacokinetic and Pharmacogenetic Aspects of Drugs Used in the Treatment of Alzheimer’s Disease. Clinical Pharmacokinetics 52:4, pages 225-241.
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Susan R. Meier-Davis, Min Meng, Weiwei Yuan, Lisa Diehl, Fatima M. Arjmand, Rebecca M. Lucke, Betsy Huang, Jianye Wen, Jutaro Shudo & Tetsuto Nagata. (2012) Dried Blood Spot Analysis of Donepezil in Support of a GLP 3-month Dose-Range Finding Study in Rats. International Journal of Toxicology 31:4, pages 337-347.
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Mi‐Hwa Kim, Han‐Joo Maeng, Kyung‐Ha Yu, Kyeong‐Ryoon Lee, Takashi Tsuruo, Dae‐Duk Kim, Chang‐Koo Shim & Suk‐Jae Chung. (2010) Evidence of carrier‐mediated transport in the penetration of donepezil into the rat brain. Journal of Pharmaceutical Sciences 99:3, pages 1548-1566.
Crossref
Urban Fagerholm. (2007) Prediction of human pharmacokinetics—evaluation of methods for prediction of hepatic metabolic clearance. Journal of Pharmacy and Pharmacology 59:6, pages 803-828.
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Kristin Huse Haug, Trond Myhrer & Frode Fonnum. (2007) The combination of donepezil and procyclidine protects against soman-induced seizures in rats. Toxicology and Applied Pharmacology 220:2, pages 156-163.
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Gary Landsberg. (2006) Therapeutic Options for Cognitive Decline in Senior Pets. Journal of the American Animal Hospital Association 42:6, pages 407-413.
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Ragulan Ramanathan, Swapan K. Chowdhury & Kevin B. Alton. 2005. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS 225 276 .
Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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Ivan Nestorov, Ivelina Gueorguieva, Hannah M. Jones, Brian Houston & Malcolm Rowland. (2002) Incorporating Measures of Variability and Uncertainty into the Prediction of in Vivo Hepatic Clearance from in Vitro Data. Drug Metabolism and Disposition 30:3, pages 276-282.
Crossref
R.H Wang & M Weinstock. (2001) Steroid hormones mediate sex difference in brain levels of tacrine and its hypothermic effect in the rat. Neuropharmacology 41:7, pages 887-894.
Crossref
Barbra H. Stewart & Yi Wang. 2000. 299 307 .

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