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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 11
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Research Article

Rat cytochromes P450 (CYP) specifically contribute to the reductive bioactivation of AQ4N, an alkylaminoanthraquinone-di-N-oxide anticancer prodrug

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Pages 1115-1122 | Published online: 22 Sep 2008

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Yasushi Yamazoe, Kazumi Ito & Kouichi Yoshinari. (2011) Construction of a CYP2E1-template system for prediction of the metabolism on both site and preference order. Drug Metabolism Reviews 43:4, pages 409-439.
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Ming Zheng, Jun Jiang, Junping Wang, Xianqing Tang, Man Ouyang & Yiqun Deng. (2011) The mechanism of enzymatic and non-enzymatic N-oxide reductive metabolism of cyadox in pig liver. Xenobiotica 41:11, pages 964-971.
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Peter Ebbesen, Erik O. Pettersen, Thomas A. Gorr, Gerhard Jobst, Kaye Williams, Jochen Kieninger, Roland H. Wenger, Silvia Pastorekova, Ludwig Dubois, Philippe Lambin, Brad G. Wouters, Twan Van Den Beucken, Claudiu T. Supuran, Lorenz Poellinger, Peter Ratcliffe, Arvydas Kanopka, Agnes Görlach, Max Gasmann, Adrian L. Harris, Patrick Maxwell & Andrea Scozzafava. (2009) Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies. Journal of Enzyme Inhibition and Medicinal Chemistry 24:sup1, pages 1-39.
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Articles from other publishers (14)

Mircea Ivan, Melissa L. Fishel, Oana M. Tudoran, Karen E. Pollok, Xue Wu & Paul J. Smith. (2022) Hypoxia signaling: Challenges and opportunities for cancer therapy. Seminars in Cancer Biology 85, pages 185-195.
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Yasushi Yamazoe, Norie Murayama & Kouichi Yoshinari. (2021) Refined CYP2E1∗ Template∗∗ system to decipher the ligand-interactions. Drug Metabolism and Pharmacokinetics 41, pages 100413.
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Hamid Zia, Graeme I. Murray, Carrie A. Vyhlidal, J. Steven Leeder, Ahmed E. Anwar, Marilyn M. Bui & Atif A. Ahmed. (2015) CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation. International Journal of Experimental Pathology 96:2, pages 81-86.
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B. Wahlang, K. Cameron Falkner, Matt C. Cave & Russell A. Prough. 2015. Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer. Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer 1 33 .
Kyriakos P. Papadopoulos, Sanjay Goel, Murali Beeram, Alvin Wong, Kavita Desai, Missak Haigentz, María L. Milián, Sridhar Mani, Anthony Tolcher, Alshad S. Lalani & John Sarantopoulos. (2008) A Phase 1 Open-Label, Accelerated Dose-Escalation Study of the Hypoxia-Activated Prodrug AQ4N in Patients with Advanced Malignancies. Clinical Cancer Research 14:21, pages 7110-7115.
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María Laura Lavaggi, Mauricio Cabrera, Mercedes González & Hugo Cerecetto. (2008) Differential Enzymatic Reductions Governing the Differential Hypoxia-Selective Cytotoxicities of Phenazine 5,10-Dioxides. Chemical Research in Toxicology 21:9, pages 1900-1906.
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Mark R. Albertella, Paul M. Loadman, Philip H. Jones, Roger M. Phillips, Roy Rampling, Neil Burnet, Chris Alcock, Alan Anthoney, Egils Vjaters, Chris R. Dunk, Peter A. Harris, Alvin Wong, Alshad S. Lalani & Chris J. Twelves. (2008) Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study. Clinical Cancer Research 14:4, pages 1096-1104.
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Alshad S. Lalani, Susan E. Alters, Alvin Wong, Mark R. Albertella, Jeffrey L. Cleland & William David Henner. (2007) Selective Tumor Targeting by the Hypoxia-Activated Prodrug AQ4N Blocks Tumor Growth and Metastasis in Preclinical Models of Pancreatic Cancer. Clinical Cancer Research 13:7, pages 2216-2225.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
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Vincent de Groot. 2007. Prodrugs. Prodrugs 447 506 .
A Yakkundi, V McErlane, M Murray, H O McCarthy, C Ward, C M Hughes, L H Patterson, D G Hirst, S R McKeown & T Robson. (2006) Tumor-selective drug activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N. Cancer Gene Therapy 13:6, pages 598-605.
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G-One Ahn & J. Martin Brown. 2006. Multimodal Concepts for Integration of Cytotoxic Drugs. Multimodal Concepts for Integration of Cytotoxic Drugs 67 91 .
Martijn Rooseboom, Jan N. M. Commandeur & Nico P. E. Vermeulen. (2004) Enzyme-Catalyzed Activation of Anticancer Prodrugs. Pharmacological Reviews 56:1, pages 53-102.
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Helen O McCarthy, Anita Yakkundi, Verna McErlane, Ciara M Hughes, Gillian Keilty, Margaret Murray, Laurence H Patterson, David G Hirst, Stephanie R McKeown & Tracy Robson. (2002) Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N. Cancer Gene Therapy 10:1, pages 40-48.
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