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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 11
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Research Article

Metabolism of furazolidone: alternative pathways and modes of toxicity in different cell lines

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Pages 1157-1169 | Published online: 22 Sep 2008

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Ivan Brito Feitosa, Bruno Mori, Ana Paula de Azevedo dos Santos, Janaína Cecília Oliveira Villanova, Carolina Bioni Garcia Teles & Allyson Guimarães Costa. (2021) What are the immunopharmacological effects of furazolidone? A systematic review. Immunopharmacology and Immunotoxicology 43:6, pages 674-679.
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Articles from other publishers (22)

Yongsong Zhou, Jingneng Wang, Buling Wu & Bofeng Zhu. (2024) Rapid determination of furazolidone residues in animal foods by time-resolved fluorescence immunochromatography. Food Chemistry 445, pages 138711.
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Suzana Gonçalves Carvalho, Larissa Ataíde Siqueira, Marcos Santos Zanini, Ana Paula dos Santos Matos, Carla Holandino Quaresma, Luisa Mota da Silva, Sérgio Faloni de Andrade, Juliana Aparecida Severi & Janaina Cecília Oliveira Villanova. (2018) Physicochemical and in vitro biological evaluations of furazolidone-based β-cyclodextrin complexes in Leishmania amazonensis. Research in Veterinary Science 119, pages 143-153.
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Chongshan Dai, Daowen Li, Lijing Gong, Xilong Xiao & Shusheng Tang. (2016) Curcumin Ameliorates Furazolidone-Induced DNA Damage and Apoptosis in Human Hepatocyte L02 Cells by Inhibiting ROS Production and Mitochondrial Pathway. Molecules 21:8, pages 1061.
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Sijun Deng, Shusheng Tang, Chongshan Dai, Yan Zhou, Xiayun Yang, Daowen Li & Xilong Xiao. (2016) P21Waf1/Cip1 plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food and Chemical Toxicology 88, pages 1-12.
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. (2015) Scientific Opinion on nitrofurans and their metabolites in food. EFSA Journal 13:6.
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Sijun Deng, Shusheng Tang, Shen Zhang, Chaoming Zhang, Congcong Wang, Yan Zhou, Chongshan Dai & Xilong Xiao. (2015) Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells. Food and Chemical Toxicology 75, pages 173-186.
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Kevin Woodward & Kevin WoodwardK. N. Woodward. 2012. Toxicological Effects of Veterinary Medicinal Products in Humans. Toxicological Effects of Veterinary Medicinal Products in Humans 273 380 .
Nobuo Sasaki, Tomoyuki Matsumoto, Yoshinori Ikenaka, Akio Kazusaka, Mayumi Ishizuka & Shoichi Fujita. (2011) Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens. Pesticide Biochemistry and Physiology 100:2, pages 135-139.
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Xi Jin, Shusheng Tang, Qian Chen, Jiajie Zou, Ting Zhang, Fengying Liu, Shen Zhang, Chundi Sun & Xilong Xiao. (2011) Furazolidone induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in human hepatoma G2 cells. Toxicology Letters 201:3, pages 205-212.
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Piotr Drożdżewski, Halina Zasłona & Maria Kubiak. (2009) The X-ray revision of the structure of bis(4-hydroxybenzhydrazide)copper(II) sulfate(VI) dihydrate and its vibrational spectroscopy. Structural Chemistry 21:2, pages 405-414.
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Piotr Drożdżewski, Halina Zasłona & Maria Kubiak. (2009) Vibrational spectroscopy of 4-hydroxybenzhydrazide and its O,N-deuterated isotopologue accompanied by X-ray structure refinement. Vibrational Spectroscopy 50:2, pages 185-192.
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K. N. Woodward. 2009. Veterinary Pharmacovigilance. Veterinary Pharmacovigilance 297 345 .
Annamaria Lilienkampf, Jialin Mao, Baojie Wan, Yuehong Wang, Scott G. Franzblau & Alan P. Kozikowski. (2009) Structure−Activity Relationships for a Series of Quinoline-Based Compounds Active against Replicating and Nonreplicating Mycobacterium tuberculosis . Journal of Medicinal Chemistry 52:7, pages 2109-2118.
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María I. Amaro, Melina Monasterios, Milagros Avendaño & Jaime Charris. (2008) Preliminary evaluation of the toxicity of some synthetic furan derivatives in two cell lines and Artemia salina . Journal of Applied Toxicology 29:1, pages 36-41.
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M. Vass, K. Hruska & M. Franek. (2008) Nitrofuran antibiotics: a review on the application, prohibition and residual analysis. Veterinární medicína 53:9, pages 469-500.
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J.V. Samsonova, A.J. Douglas, K.M. Cooper, D.G. Kennedy & C.T. Elliott. (2008) The identification of potential alternative biomarkers of nitrofurazone abuse in animal derived food products. Food and Chemical Toxicology 46:5, pages 1548-1554.
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Hanaa H. Ahmed, Sekena H. Abd El-Aziem & Mosaad A. Abdel-Wahhab. (2008) Potential role of cysteine and methionine in the protection against hormonal imbalance and mutagenicity induced by furazolidone in female rats. Toxicology 243:1-2, pages 31-42.
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Annalaura Stammati, Carlo Nebbia, Isabella De Angelis, Alessandra Giuliano Albo, Monica Carletti, Claudia Rebecchi, Franco Zampaglioni & Mauro Dacasto. (2005) Effects of malachite green (MG) and its major metabolite, leucomalachite green (LMG), in two human cell lines. Toxicology in Vitro 19:7, pages 853-858.
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M. Vass, L. Kotkova, I. Diblikova, Z. Nevorankova, K.M. Cooper, D.G. Kennedy & M. Franek. (2005) Production and characterisation of monoclonal antibodies for the detection of AOZ, a tissue bound metabolite of furazolidone. Veterinární medicína 50:7, pages 300-310.
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T. Zuidema, P.P.J. Mulder, J.A. van Rhijn, N.G.M. Keestra, L.A.P. Hoogenboom, B. Schat & D.G. Kennedy. (2005) Metabolism and depletion of nifursol in broilers. Analytica Chimica Acta 529:1-2, pages 339-346.
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K.N. Woodward. 2004. Pesticide, Veterinary and Other Residues in Food. Pesticide, Veterinary and Other Residues in Food 175 223 .
G. Re, P. Badino, I. De Angelis, R. Odore, C. Belloli, A. Stammati & F. Zucco. (2001) Identification and coupling to adenylate cyclase of three different [3H]CGP 12177 binding sites in Caco-2 cell membranes. Pharmacological Research 43:4, pages 393-398.
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