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Research Article

Morphological changes in degrading PLGA and P(DL)LA microspheres: implications for the design of controlled release systems

Pages 783-800 | Published online: 29 Sep 2008

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Hesham M. Tawfeek, Sayed H. Khidr, Eman M. Samy, Sayed M. Ahmed, Elsie E. Gaskell & Gillian A. Hutcheon. (2014) Evaluation of biodegradable polyester-co-lactone microparticles for protein delivery. Drug Development and Industrial Pharmacy 40:9, pages 1213-1222.
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Susanne Fredenberg, Mats Reslow & Anders Axelsson. (2007) Effect of Divalent Cations on Pore Formation and Degradation of Poly(D,L-lactide-co-glycolide). Pharmaceutical Development and Technology 12:6, pages 563-572.
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Romi Barat, A. Srinatha, J. K. Pandit, D. Ridhurkar, J. Balasubramaniam, Neelam Mittal & Deena Nath Mishra. (2006) Niridazole Biodegradable Inserts for Local Long-Term Treatment of Periodontitis: Possible New Life for an Orphan Drug. Drug Delivery 13:5, pages 365-373.
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Ge Fiona Gao, Mukul Ashtikar, Ryo Kojima, Takatsune Yoshida, Masanori Kaihara, Tomokazu Tajiri, Saeed Shanehsazzadeh, Harshvardhan Modh & Matthias G. Wacker. (2021) Predicting drug release and degradation kinetics of long-acting microsphere formulations of tacrolimus for subcutaneous injection. Journal of Controlled Release 329, pages 372-384.
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Xiaotian Xie, Haijun Wang, Gareth R. Williams, Yanbo Yang, Yongli Zheng, Junzi Wu & Li-Min Zhu. (2019) Erythrocyte Membrane Cloaked Curcumin-Loaded Nanoparticles for Enhanced Chemotherapy. Pharmaceutics 11:9, pages 429.
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Elias Baghdan, Michael Raschpichler, Walaa Lutfi, Shashank Reddy Pinnapireddy, Marcel Pourasghar, Jens Schäfer, Marc Schneider & Udo Bakowsky. (2019) Nano spray dried antibacterial coatings for dental implants. European Journal of Pharmaceutics and Biopharmaceutics 139, pages 59-67.
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Nahae Kim & Juyoung Kim. (2016) Preparation of Valuable Compounds Encapsulated Polymer Nanoparticles with High Payload Using Core-crosslinked Amphiphilic Polymer Nanoparticles. Applied Chemistry for Engineering 27:1, pages 26-34.
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Yujie Xia & Daniel W. Pack. (2015) Uniform biodegradable microparticle systems for controlled release. Chemical Engineering Science 125, pages 129-143.
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Bahareh Azimi, Parviz Nourpanah, Mohammad Rabiee & Shahram Arbab. (2014) Poly (lactide -co- glycolide) Fiber: An Overview. Journal of Engineered Fibers and Fabrics 9:1, pages 155892501400900.
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Huijun Zhu, Hongbo Chen, Xiaowei Zeng, Zhongyuan Wang, Xudong Zhang, Yanping Wu, Yongfeng Gao, Jinxie Zhang, Kewei Liu, Ranyi Liu, Lintao Cai, Lin Mei & Si-Shen Feng. (2014) Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance. Biomaterials 35:7, pages 2391-2400.
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Jian Li, Michael A. Washington, Kerri L. Bell, Ryan M. Weiss, Sam N. Rothstein, Steven R. Little, Harry M. Edenborn & Tara Y. Meyer. 2014. Sequence-Controlled Polymers: Synthesis, Self-Assembly, and Properties. Sequence-Controlled Polymers: Synthesis, Self-Assembly, and Properties 271 286 .
J.M. Mazzara, M.A. Balagna, M.D. Thouless & S.P. Schwendeman. (2013) Healing kinetics of microneedle-formed pores in PLGA films. Journal of Controlled Release 171:2, pages 172-177.
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Jennifer R. Weiser, Alice Yueh & David Putnam. (2013) Protein release from dihydroxyacetone-based poly(carbonate ester) matrices. Acta Biomaterialia 9:9, pages 8245-8253.
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Jian Li, Sam N. Rothstein, Steven R. Little, Harry M. Edenborn & Tara Y. Meyer. (2012) The Effect of Monomer Order on the Hydrolysis of Biodegradable Poly(lactic- co -glycolic acid) Repeating Sequence Copolymers . Journal of the American Chemical Society 134:39, pages 16352-16359.
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Susanne Fredenberg, Marie Wahlgren, Mats Reslow & Anders Axelsson. (2011) The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems—A review. International Journal of Pharmaceutics 415:1-2, pages 34-52.
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Marilyn N. Martinez, Michael J. Rathbone, Diane Burgess & Mai Huynh. (2010) Breakout session summary from AAPS/CRS joint workshop on critical variables in the in vitro and in vivo performance of parenteral sustained release products. Journal of Controlled Release 142:1, pages 2-7.
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M. L. Houchin & E. M. Topp. (2009) Physical properties of PLGA films during polymer degradation. Journal of Applied Polymer Science 114:5, pages 2848-2854.
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James P. Bertram, Steven M. Jay, Sara R. Hynes, Rebecca Robinson, Jason M. Criscione & Erin B. Lavik. (2009) Functionalized poly(lactic-co-glycolic acid) enhances drug delivery and provides chemical moieties for surface engineering while preserving biocompatibility. Acta Biomaterialia 5:8, pages 2860-2871.
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Parth N. Shah, Anthony A. Puntel, Stephanie T. Lopina & Yang H. Yun. (2009) Development and in vitro cytotoxicity of microparticle drug delivery system for proteins using l-tyrosine polyphosphate. Colloid and Polymer Science 287:10, pages 1195-1205.
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Marilyn Martinez, Michael Rathbone, Diane Burgess & Mai Huynh. (2008) In vitro and in vivo considerations associated with parenteral sustained release products: A review based upon information presented and points expressed at the 2007 Controlled Release Society Annual Meeting. Journal of Controlled Release 129:2, pages 79-87.
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Cory Berkland, Emily Pollauf, Chandrashekar Raman, Roshelle Silverman, Kyekyoon (Kevin) Kim & Daniel W. Pack. (2007) Macromolecule Release from Monodisperse PLG Microspheres: Control of Release Rates and Investigation of Release Mechanism. Journal of Pharmaceutical Sciences 96:5, pages 1176-1191.
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Muriel Stefani, Jean Coudane & Michel Vert. (2006) In vitro ageing and degradation of PEG–PLA diblock copolymer-based nanoparticles. Polymer Degradation and Stability 91:11, pages 2554-2559.
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Helen E. Williams, Jodanna Huxley, Mike Claybourn, Jonathan Booth, Matthew Hobbs, Elizabeth Meehan & Brian Clark. (2006) The effect of γ-irradiation and polymer composition on the stability of PLG polymer and microspheres. Polymer Degradation and Stability 91:9, pages 2171-2181.
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Weiwei Zhu, Takahisa Masaki, You Han Bae, Ramesh Rathi, Alfred K. Cheung & Steven E. Kern. (2006) Development of a sustained-release system for perivascular delivery of dipyridamole. Journal of Biomedical Materials Research Part B: Applied Biomaterials 77B:1, pages 135-143.
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Miechel L.T. Zweers, Gerard H.M. Engbers, Dirk W. Grijpma & Jan Feijen. (2004) In vitro degradation of nanoparticles prepared from polymers based on dl-lactide, glycolide and poly(ethylene oxide). Journal of Controlled Release 100:3, pages 347-356.
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Amy C. Richards Grayson, Michael J. Cima & Robert Langer. (2004) Molecular release from a polymeric microreservoir device: Influence of chemistry, polymer swelling, and loading on device performance. Journal of Biomedical Materials Research 69A:3, pages 502-512.
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P Turner, A.G.A Coombes & M Al-Rubeai. (2004) Measuring the heterogeneity of protein loading in PLG microspheres using flow cytometry. Journal of Controlled Release 96:1, pages 193-205.
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Guobao Wei, Glenda J. Pettway, Laurie K. McCauley & Peter X. Ma. (2004) The release profiles and bioactivity of parathyroid hormone from poly(lactic-co-glycolic acid) microspheres. Biomaterials 25:2, pages 345-352.
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Jayanth Panyam, Manisha M. Dali, Sanjeeb K. Sahoo, Wenxue Ma, Sudhir S. Chakravarthi, Gordon L. Amidon, Robert J. Levy & Vinod Labhasetwar. (2003) Polymer degradation and in vitro release of a model protein from poly(d,l-lactide-co-glycolide) nano- and microparticles. Journal of Controlled Release 92:1-2, pages 173-187.
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Yadong Wang, Yu Mi Kim & Robert Langer. (2003) In vivo degradation characteristics of poly(glycerol sebacate). Journal of Biomedical Materials Research 66A:1, pages 192-197.
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