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Original

The heat-induced γ-H2AX response does not play a role in hyperthermic cell killing

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Pages 199-209 | Received 17 Jun 2008, Accepted 17 Nov 2008, Published online: 09 Jul 2009

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Silvina B. Nadin, F. Darío Cuello-Carrión, Mayra L. Sottile, Daniel R. Ciocca & Laura M. Vargas-Roig. (2012) Effects of hyperthermia on Hsp27 (HSPB1), Hsp72 (HSPA1A) and DNA repair proteins hMLH1 and hMSH2 in human colorectal cancer hMLH1-deficient and hMLH1-proficient cell lines. International Journal of Hyperthermia 28:3, pages 191-201.
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Maria V. Abramova, Svetlana B. Svetlikova, Alexander N. Kukushkin, Nikolai D. Aksenov, Tatiana V. Pospelova & Valery A. Pospelov. (2011) HDAC inhibitor sodium butyrate sensitizes E1A+Ras-transformed cells to DNA damaging agents by facilitating formation and persistence of γH2AX foci. Cancer Biology & Therapy 12:12, pages 1069-1077.
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Noritomo Okamoto, Akihisa Takahashi, Ichiro Ota, Ken Ohnishi, Eiichiro Mori, Natsuko Kondo, Taichi Noda, Yosuke Nakagawa, Hirokazu Uemura, Katunari Yane, Hiroshi Hosoi & Takeo Ohnishi. (2011) siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells. International Journal of Hyperthermia 27:3, pages 297-304.
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Joseph L. Roti Roti, Raj K. Pandita, Jason D. Mueller, Peter Novak, Eduardo G. Moros & Andrei Laszlo. (2010) Severe, short-duration (0–3 min) heat shocks (50–52°C) inhibit the repair of DNA damage. International Journal of Hyperthermia 26:1, pages 67-78.
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Peymaneh Habibi, Seyed Naser Ostad, Ahad Heydari, Shima Aliebrahimi, Vahideh Montazeri, Abbas Rahimi Foroushani, Mohammad Reza Monazzam, Mahmoud Ghazi-Khansari & Farideh Golbabaei. (2022) Effect of heat stress on DNA damage: a systematic literature review. International Journal of Biometeorology 66:11, pages 2147-2158.
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Veronika A. Revkova, Inna V. Ilina, Svetlana A. Gurova, Rimma O. Shatalova, Mikhail A. Konoplyannikov, Vladimir A. Kalsin, Vladimir P. Baklaushev & Dmitry S. Sitnikov. (2022) Effects of high intensity non-ionizing pulses of terahertz radiation on human skin fibroblasts. Effects of high intensity non-ionizing pulses of terahertz radiation on human skin fibroblasts.
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Gary Hannon, Felista L. Tansi, Ingrid Hilger & Adriele Prina‐Mello. (2021) The Effects of Localized Heat on the Hallmarks of Cancer. Advanced Therapeutics 4:7, pages 2000267.
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Lucián Zastko, Petra Petrovičová, Anna Račková, Lukáš Jakl, Viera Jakušová, Eva Marková & Igor Belyaev. (2021) DNA damage response and apoptosis induced by hyperthermia in human umbilical cord blood lymphocytes. Toxicology in Vitro 73, pages 105127.
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Dmitry Sitnikov, Inna Ilina, Oleg Chefonov, Andrey Ovchinnikov, Veronika Revkova, Mikhail Konoplyannikov, Vladimir Kalsin & Vladimir Balkaushev. (2020) Double-stand DNA foci formation in human skin fibroblasts after high-power THz pulses exposure. Double-stand DNA foci formation in human skin fibroblasts after high-power THz pulses exposure.
D. S. Sitnikov, I. V. Ilina, S. A. Gurova, R. O. Shatalova & V. A. Revkova. (2020) Studying the Induction of Double-Strand Breaks in Human Fibroblasts by High-Intensity Terahertz Radiation. Bulletin of the Russian Academy of Sciences: Physics 84:11, pages 1370-1374.
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YUKARI YOSHIDA, SHINTARO TOMINAGA, LIQIU MA & AKIHISA TAKAHASHI. (2018) Heat Induces Histone γH2AX Formation under Hypoxia温熱は低酸素下でもヒストンγH2AX生成を誘導する. Thermal Medicine 34:3, pages 45-51.
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Michal W. Luczak & Anatoly Zhitkovich. (2018) Monoubiquitinated γ-H2AX: Abundant product and specific biomarker for non-apoptotic DNA double-strand breaks. Toxicology and Applied Pharmacology 355, pages 238-246.
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Nidhi Khurana, Shyamasree Laskar, Mrinal K. Bhattacharyya & Sunanda Bhattacharyya. (2016) Hsp90 induces increased genomic instability toward DNA-damaging agents by tuning down RAD53 transcription . Molecular Biology of the Cell 27:15, pages 2463-2478.
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Sachiko Yamashita, Masakazu Tanaka, Teruaki Sato, Chieri Ida, Narumi Ohta, Takashi Hamada, Taichi Uetsuki, Yoshisuke Nishi, Joel Moss & Masanao Miwa. (2016) Effect of mild temperature shift on poly(ADP-ribose) and γH2AX levels in cultured cells. Biochemical and Biophysical Research Communications 476:4, pages 594-599.
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Theodora Mantso, George Goussetis, Rodrigo Franco, Sotiris Botaitis, Aglaia Pappa & Mihalis Panayiotidis. (2016) Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies. Seminars in Cancer Biology 37-38, pages 96-105.
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Akihisa Takahashi. 2016. Hyperthermic Oncology from Bench to Bedside. Hyperthermic Oncology from Bench to Bedside 91 108 .
Akihisa Takahashi. 2016. Hyperthermic Oncology from Bench to Bedside. Hyperthermic Oncology from Bench to Bedside 19 32 .
Arlene L. Oei, Lianne E. M. Vriend, Johannes Crezee, Nicolaas A. P. Franken & Przemek M. Krawczyk. (2015) Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all. Radiation Oncology 10:1.
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Kirsten Lauber, Nikko Brix, Anne Ernst, Roman Hennel, Julia Krombach, Heike Anders & Claus Belka. (2015) Targeting the heat shock response in combination with radiotherapy: Sensitizing cancer cells to irradiation-induced cell death and heating up their immunogenicity. Cancer Letters 368:2, pages 209-229.
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María Sánchez-Flores, Eduardo Pásaro, Stefano Bonassi, Blanca Laffon & Vanessa Valdiglesias. (2015) γH2AX Assay as DNA Damage Biomarker for Human Population Studies: Defining Experimental Conditions. Toxicological Sciences 144:2, pages 406-413.
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Thomas Turner & Thomas Caspari. (2014) When heat casts a spell on the DNA damage checkpoints. Open Biology 4:3, pages 140008.
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Artem K. Velichko, Elena N. Markova, Nadezhda V. Petrova, Sergey V. Razin & Omar L. Kantidze. (2013) Mechanisms of heat shock response in mammals. Cellular and Molecular Life Sciences 70:22, pages 4229-4241.
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Andre Ivanov, Jeff Pawlikowski, Indrani Manoharan, John van Tuyn, David M. Nelson, Taranjit Singh Rai, Parisha P. Shah, Graeme Hewitt, Viktor I. Korolchuk, Joao F. Passos, Hong Wu, Shelley L. Berger & Peter D. Adams. (2013) Lysosome-mediated processing of chromatin in senescence. Journal of Cell Biology 202:1, pages 129-143.
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Vanessa Valdiglesias, Simona Giunta, Michael Fenech, Monica Neri & Stefano Bonassi. (2013) γH2AX as a marker of DNA double strand breaks and genomic instability in human population studies. Mutation Research/Reviews in Mutation Research 753:1, pages 24-40.
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Artem K. Velichko, Nadezhda V. Petrova, Omar L. Kantidze & Sergey V. Razin. (2012) Dual effect of heat shock on DNA replication and genome integrity. Molecular Biology of the Cell 23:17, pages 3450-3460.
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Yukihiro Furusawa, Takashi Iizumi, Yoshisada Fujiwara, Qing-Li Zhao, Yoshiaki Tabuchi, Takaharu Nomura & Takashi Kondo. (2011) Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress. Apoptosis 17:1, pages 102-112.
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Joseph L. Roti Roti, Robert P. VanderWaal & Andrei Laszlo. 2011. Molecular Determinants of Radiation Response. Molecular Determinants of Radiation Response 227 249 .
Akihisa TAKAHASHI, Eiichiro MORI, Xiaoming SU, Yosuke NAKAGAWA, Noritomo OKAMOTO, Hirokazu UEMURA, Natsuko KONDO, Taichi NODA, Atsushi TOKI, Yosuke EJIMA, David J. CHEN, Ken OHNISHI & Takeo OHNISHI. (2010) ATM is the Predominant Kinase Involved in the Phosphorylation of Histone H2AX after Heating. Journal of Radiation Research 51:4, pages 417-422.
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