580
Views
75
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Inflammatory Subtypes in Asthma are Related to Airway Hyperresponsiveness to Mannitol and Exhaled NO

, MD, PhD, , MD, , MD & , MD, DMSc
Pages 606-612 | Published online: 09 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Jie Gao, Feng Wu, Sifang Wu & Xing Yang. (2020) Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma. Journal of Inflammation Research 13, pages 1167-1173.
Read now
Zarqa Ali, Lisbeth Nilas & Charlotte Suppli Ulrik. (2017) Postpartum airway responsiveness and exacerbation of asthma during pregnancy – a pilot study. Journal of Asthma and Allergy 10, pages 261-267.
Read now
Young A. Park, Hyun Bin Park, Yoon Hee Kim, In Sook Sul, Seo Hee Yoon, Hye Ran Kim, Kyung Won Kim, Kyu-Earn Kim & Myung Hyun Sohn. (2017) Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide in children with asthma. Journal of Asthma 54:6, pages 644-651.
Read now
Pernille Bækgaard Udesen, Christian Grabow Westergaard, Celeste Porsbjerg & Vibeke Backer. (2017) Stability of FeNO and airway hyperresponsiveness to mannitol in untreated asthmatics. Journal of Asthma 54:5, pages 530-536.
Read now
Sandra D. Anderson. (2016) ‘Indirect’ challenges from science to clinical practice. European Clinical Respiratory Journal 3:1.
Read now
Christian G Westergaard, Celeste Porsbjerg & Vibeke Backer. (2015) Emerging corticosteroid agonists for the treatment of asthma. Expert Opinion on Emerging Drugs 20:4, pages 653-662.
Read now
Hannah H Walford & Taylor A Doherty. (2014) Diagnosis and management of eosinophilic asthma: a US perspective. Journal of Asthma and Allergy 7, pages 53-65.
Read now
Vibeke Backer, Asger Sverrild & Celeste Porsbjerg. (2014) FENO and AHR mannitol in patients referred to an out-of-hospital asthma clinic: a real-life study. Journal of Asthma 51:4, pages 411-416.
Read now
Ewa M. Świebocka, Grzegorz Siergiejko & Zenon Siergiejko. (2012) Mannitol Challenge Does Not Confirm Bronchial Hyperreactivity in Some Histamine-Responsive Asthmatic Children. Journal of Asthma 49:8, pages 817-821.
Read now
Asger Sverrild, Celeste Porsbjerg & Vibeke Backer. (2012) The use of inhaled mannitol in the diagnosis and management of asthma. Expert Opinion on Pharmacotherapy 13:1, pages 115-123.
Read now
Nesreen M. Hassan, Frederick E. Hargreave & Parameswaran Nair. (2010) Airway Responsiveness to Indirect Challenges in COPD. COPD: Journal of Chronic Obstructive Pulmonary Disease 7:2, pages 133-140.
Read now

Articles from other publishers (64)

Christiane Hammershaimb Mosbech, Nina Skavlan Godtfredsen, Charlotte Suppli Ulrik & Christian Grabow Westergaard. (2023) Biomarker-guided withdrawal of inhaled corticosteroids in asthma patients with a non-T2 inflammatory phenotype – a randomized controlled trial study protocol. BMC Pulmonary Medicine 23:1.
Crossref
Yinhe Feng, Xiaoyin LiuYubin Wang, Rao Du & Hui Mao. (2023) Delineating asthma according to inflammation phenotypes with a focus on paucigranulocytic asthma. Chinese Medical Journal 136:13, pages 1513-1522.
Crossref
Morten Hvidtfeldt, Asger Sverrild, Alexis Pulga, Laurits Frøssing, Alexander Silberbrandt, Morten Hostrup, Martin Thomassen, Caroline Sanden, Carl Magnus Clausson, Premkumar Siddhuraj, Daisy Bornesund, Juan Jose Nieto-Fontarigo, Lena Uller, Jonas Erjefält & Celeste Porsbjerg. (2023) Airway hyperresponsiveness reflects corticosteroid-sensitive mast cell involvement across asthma phenotypes. Journal of Allergy and Clinical Immunology 152:1, pages 107-116.e4.
Crossref
Takahiro Matsuyama, Kentaro Machida, Keiko Mizuno, Hiromi Matsuyama, Yoichi Dotake, Masahiro Shinmura, Koichi Takagi & Hiromasa Inoue. (2023) The Functional Role of Group 2 Innate Lymphoid Cells in Asthma. Biomolecules 13:6, pages 893.
Crossref
Efthymia Theofani, Aikaterini Tsitsopoulou, Ioannis Morianos & Maria Semitekolou. (2023) Severe Asthmatic Responses: The Impact of TSLP. International Journal of Molecular Sciences 24:8, pages 7581.
Crossref
Søren Malte Rasmussen, Erik Sören Halvard Hansen & Vibeke Backer. (2022) Asthma in elite athletes – do they have Type 2 or non-Type 2 disease? A new insight on the endotypes among elite athletes. Frontiers in Allergy 3.
Crossref
Philip W. Rouadi, Samar A. Idriss, Jean Bousquet, Tanya M. Laidlaw, Cecilio R. Azar, Mona S. Al-Ahmad, Anahi Yañez, Maryam Ali Y. Al-Nesf, Talal M. Nsouli, Sami L. Bahna, Eliane Abou-Jaoude, Fares H. Zaitoun, Usamah M. Hadi, Peter W. Hellings, Glenis K. Scadding, Peter K. Smith, Mario Morais-Almeida, René Maximiliano Gómez, Sandra N. Gonzalez Diaz, Ludger Klimek, Georges S. Juvelekian, Moussa A. Riachy, Giorgio Walter Canonica, David Peden, Gary W.K. Wong, James Sublett, Jonathan A. Bernstein, Lianglu Wang, Luciana K. Tanno, Manana Chikhladze, Michael Levin, Yoon-Seok Chang, Bryan L. Martin, Luis Caraballo, Adnan Custovic, Jose Antonio Ortego-Martell, Olivia J.Ly Lesslar, Erika Jensen-Jarolim, Motohiro Ebisawa, Alessandro Fiocchi & Ignacio J. Ansotegui. (2022) WAO-ARIA consensus on chronic cough – Part III: Management strategies in primary and cough-specialty care. Updates in COVID-19. World Allergy Organization Journal 15:5, pages 100649.
Crossref
Ivo Iavicoli, Luca Fontana, Veruscka Leso, Maria Carmela Macrini & Daniela Pelclova. (2020) Fractional Exhaled Nitric Oxide and Nanomaterial Exposure in Workplaces. Current Medicinal Chemistry 27:42, pages 7200-7212.
Crossref
Christianne M. Blais, Beth E. Davis & Donald W. Cockcroft. (2019) The effect of deep inhalation on mannitol responsiveness. Clinical & Experimental Allergy 50:3, pages 308-314.
Crossref
Efthymia Theofani, Maria Semitekolou, Ioannis Morianos, Konstantinos Samitas & Georgina Xanthou. (2019) Targeting NLRP3 Inflammasome Activation in Severe Asthma. Journal of Clinical Medicine 8:10, pages 1615.
Crossref
Omar Tliba & Reynold A. PanettieriJr.Jr.. (2019) Paucigranulocytic asthma: Uncoupling of airway obstruction from inflammation. Journal of Allergy and Clinical Immunology 143:4, pages 1287-1294.
Crossref
Janusz Ciółkowski, Andrzej Emeryk, Paweł Hydzik, Justyna Emeryk-Maksymiuk, Elwira Kosmala & Barbara Stasiowska. (2019) Eosinophilic airway inflammation is a main feature of unstable asthma in adolescents. Respiratory Medicine 147, pages 7-12.
Crossref
Pasquale Comberiati, Rohit K. Katial & Ronina A. Covar. (2018) Bronchoprovocation Testing in Asthma. Immunology and Allergy Clinics of North America 38:4, pages 545-571.
Crossref
R. S. Fassakhov. (2018) Severe eosinophilic asthma: therapeutic potential of Reslizumab. Medical Council:15, pages 70-75.
Crossref
Katrine Feldballe Bernholm, Anne-Sophie Homøe, Howraman Meteran, Camilla Bjørn Jensen, Celeste Porsbjerg & Vibeke Backer. (2018) F eNO -based asthma management results in faster improvement of airway hyperresponsiveness . ERJ Open Research 4:4, pages 00147-2017.
Crossref
Raja Veerapandian, John D. Snyder & Amali E. Samarasinghe. (2018) Influenza in Asthmatics: For Better or for Worse?. Frontiers in Immunology 9.
Crossref
Sandra D. Anderson, Evangelia Daviskas, John D. Brannan & Hak Kim Chan. (2018) Repurposing excipients as active inhalation agents: The mannitol story. Advanced Drug Delivery Reviews 133, pages 45-56.
Crossref
J. A. Revez, K. J. Killian, P. M. O'Byrne, L.-P. Boulet, J. W. Upham, G. M. Gauvreau & M. A. R. Ferreira. (2018) Sputum cytology during late-phase responses to inhalation challenge with different allergens. Allergy 73:7, pages 1470-1478.
Crossref
Ling Qian, Shiying Pan, Jingdong Shi, Yong Du, Qihui Huang & Zhijun Jie. (2018) Association between fractional exhaled nitric oxide (FeNO) cutoff values (25 ppb) and risk factors of cough. The Clinical Respiratory Journal 12:1, pages 193-199.
Crossref
Patricia C. Fulkerson & Marc E. Rothenberg. 2018. 1 34 .
Antonius Schneider, Klaus Linde, Johannes B. Reitsma, Susanne Steinhauser & Gerta Rücker. (2017) A novel statistical model for analyzing data of a systematic review generates optimal cutoff values for fractional exhaled nitric oxide for asthma diagnosis. Journal of Clinical Epidemiology 92, pages 69-78.
Crossref
Iulia Ioan, Aurélie Tatopoulos, Stéphanie Metche, Laurianne Coutier, Emmanuelle Houriez, Sébastien Kiefer, Aurore Blondé, Claude Bonabel, François Marchal, Jocelyne Derelle, Cyril E. Schweitzer & Silvia Demoulin-Alexikova. (2017) More Relaxation by Deep Breath on Methacholine- Than on Exercise-Induced bronchoconstriction during the Routine Testing of Asthmatic Children. Frontiers in Physiology 8.
Crossref
S. Jabbal, A. Manoharan & B. J. Lipworth. (2017) Bronchoprotective tolerance with indacaterol is not modified by concomitant tiotropium in persistent asthma. Clinical & Experimental Allergy 47:10, pages 1239-1245.
Crossref
Cyprianna E. Swiderski, Courtney L. Hunter, Jacquelyn E. Bowser, Lais R. Costa, A. James Cooley, Andrew Claude, Alison L. Eddy & Lauren A. Bright. (2017) Deciphering the Role of Bronchial Hyper-Responsiveness in Equine Pasture Asthma. Journal of Equine Veterinary Science 52, pages 29-35.
Crossref
Stefan Karrasch, Klaus Linde, Gerta Rücker, Harriet Sommer, Marlies Karsch-Völk, Jos Kleijnen, Rudolf A Jörres & Antonius Schneider. (2017) Accuracy of FE NO for diagnosing asthma: a systematic review . Thorax 72:2, pages 109-116.
Crossref
Jaisy Arikkatt, Md Ashik Ullah, Kirsty Renfree Short, Vivan Zhang, Wan Jun Gan, Zhixuan Loh, Rhiannon B Werder, Jennifer Simpson, Peter D Sly, Stuart B Mazzone, Kirsten M Spann, Manuel AR Ferreira, John W Upham, Maria B Sukkar & Simon Phipps. (2017) RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma. eLife 6.
Crossref
Sophie Demarche, Florence Schleich, Monique Henket, Virginie Paulus, Thierry Van Hees & Renaud Louis. (2016) Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory?. BMC Pulmonary Medicine 16:1.
Crossref
Geun-Mi Park, Hye Won Han, Jae Youn Kim, Eun Lee, Hyun-Ju Cho, Jisun Yoon, Soo-Jong Hong, Song-I Yang, Hyeon-Jong Yang & Jinho Yu. (2016) Association of symptom control with changes in lung function, bronchial hyperresponsiveness, and exhaled nitric oxide after inhaled corticosteroid treatment in children with asthma. Allergology International 65:4, pages 439-443.
Crossref
M. Thimmesch & E. Bodart. (2016) Peut-on prédire la positivité des tests cutanés allergiques en cas d’augmentation de la fraction exhalée du monoxyde d’azote chez l’enfant suspect d’asthme ?. Revue Française d'Allergologie 56:4, pages 349-356.
Crossref
Prescott G. Woodruff, Nirav R. Bhakta & John V. Fahy. 2016. Murray and Nadel's Textbook of Respiratory Medicine. Murray and Nadel's Textbook of Respiratory Medicine 713 730.e7 .
Antonius Schneider, Gudrun Wagenpfeil, Rudolf A Jörres & Stefan Wagenpfeil. (2015) Influence of the practice setting on diagnostic prediction rules using FENO measurement in combination with clinical signs and symptoms of asthma. BMJ Open 5:11, pages e009676.
Crossref
Celeste Porsbjerg, Asger Sverrild & Vibeke Backer. (2015) Combining the Mannitol Test and FeNO in the Assessment of Poorly Controlled Asthma. The Journal of Allergy and Clinical Immunology: In Practice 3:4, pages 553-559.
Crossref
Beth E. Davis, Sarah L. Stewart, Alexandra L. Martin & Donald W. Cockcroft. (2014) Low levels of fractional exhaled nitric oxide and deep inhalation bronchoprotection are associated with mannitol non-responsiveness in asthma. Respiratory Medicine 108:6, pages 859-864.
Crossref
Carl J. Ade, S. K. Rosenkranz & C. A. Harms. (2013) The effects of short-term fish oil supplementation on pulmonary function and airway inflammation following a high-fat meal. European Journal of Applied Physiology 114:4, pages 675-682.
Crossref
K. M. Oreo, P. G. Gibson, J. L. Simpson, L. G. Wood, V. M. McDonald & K. J. Baines. (2014) Sputum ADAM8 expression is increased in severe asthma and COPD. Clinical & Experimental Allergy 44:3, pages 342-352.
Crossref
Antonius Schneider, Bernhard Faderl, Johannes Schwarzbach, Lutz Welker, Marlies Karsch-Völk & Rudolf A. Jörres. (2014) Prognostic value of bronchial provocation and FENO measurement for asthma diagnosis – Results of a delayed type of diagnostic study. Respiratory Medicine 108:1, pages 34-40.
Crossref
Rakesh K. Kumar & Peter K. Jeffery. 2014. Middleton's Allergy. Middleton's Allergy 986 999 .
Jeroen Douwes & Neil Pearce. 2014. Handbook of Epidemiology. Handbook of Epidemiology 2263 2319 .
A. Żebrowska, B. Głuchowska, D. Jastrzębski, A. Kochańska-Dziurowicz, A. Stanjek-Cichoracka & I. Pokora. 2015. Body Metabolism and Exercise. Body Metabolism and Exercise 29 34 .
O M Kurbacheva & K S Pavlova. (2013) PHENOTYPES AND ENDOTYPES OF BRONCHIAL ASTHMA: FROM PATHOGENESIS AND CLINICAL FEATURES TO THERAPY. Russian Journal of Allergy 10:1, pages 15-24.
Crossref
Prescott G. Woodruff. (2013) Subtypes of Asthma Defined by Epithelial Cell Expression of Messenger RNA and MicroRNA. Annals of the American Thoracic Society 10:Supplement, pages S186-S189.
Crossref
Sandra D. Anderson & Pascale Kippelen. (2013) Assessment of EIB. Immunology and Allergy Clinics of North America 33:3, pages 363-380.
Crossref
Isabelle Hamon, Silvia Varechova, Rachel Vieux, Iulia Ioan, Claude Bonabel, Cyril Schweitzer, Jean Michel Hascoet & François Marchal. (2012) Exercise-induced bronchoconstriction in school-age children born extremely preterm. Pediatric Research 73:1-4, pages 464-468.
Crossref
Antonius Schneider, Johannes Schwarzbach, Bernhard Faderl, Lutz Welker, Marlies Karsch-Völk & Rudolf A. Jörres. (2013) FENO measurement and sputum analysis for diagnosing asthma in clinical practice. Respiratory Medicine 107:2, pages 209-216.
Crossref
William J. Anderson, Philip M. Short, Peter A. Williamson & Brian J. Lipworth. (2012) Inhaled Corticosteroid Dose Response Using Domiciliary Exhaled Nitric Oxide in Persistent Asthma. Chest 142:6, pages 1553-1561.
Crossref
Kristina Irander, Jörgen P Palm, Magnus P Borres & Bijar Ghafouri. (2012) Clara cell protein in nasal lavage fluid and nasal nitric oxide - biomarkers with anti-inflammatory properties in allergic rhinitis. Clinical and Molecular Allergy 10:1.
Crossref
Dora Ludviksdottir, Zuzana Diamant, Kjell Alving, Leif Bjermer & Andrei Malinovschi. (2012) Clinical aspects of using exhaled NO in asthma diagnosis and management . The Clinical Respiratory Journal 6:4, pages 193-207.
Crossref
Jennifer L. Ingram & Monica Kraft. (2012) IL-13 in asthma and allergic disease: Asthma phenotypes and targeted therapies. Journal of Allergy and Clinical Immunology 130:4, pages 829-842.
Crossref
I. Agache, C. Akdis, M. Jutel & J. C. Virchow. (2012) Untangling asthma phenotypes and endotypes. Allergy 67:7, pages 835-846.
Crossref
Christopher Randolph. (2011) Diagnostic Exercise Challenge Testing. Current Allergy and Asthma Reports 11:6, pages 482-490.
Crossref
F. Decimo, C. Capristo, R. Amelio, N. Maiello, A.F. Capristo & M. Miraglia Del Giudice. (2011) Evaluation of Bronchial Hyperreactivity with Mannitol Dry Powder Challenge Test in a Paediatric Population with Intermittent Allergic Asthma or Allergic Rhinitis. International Journal of Immunopathology and Pharmacology 24:4, pages 1069-1074.
Crossref
Raed A. Dweik, Peter B. Boggs, Serpil C. Erzurum, Charles G. Irvin, Margaret W. Leigh, Jon O. Lundberg, Anna-Carin Olin, Alan L. Plummer & D. Robin Taylor. (2011) An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (F e NO ) for Clinical Applications . American Journal of Respiratory and Critical Care Medicine 184:5, pages 602-615.
Crossref
Xiao Yan He, Jodie L. Simpson & Fang Wang. (2011) Inflammatory Phenotypes in Stable and Acute Childhood Asthma. Paediatric Respiratory Reviews 12:3, pages 165-169.
Crossref
Nirav R. Bhakta & Prescott G. Woodruff. (2011) Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunological Reviews 242:1, pages 220-232.
Crossref
S. J. H. Vijverberg, L. Koenderman, E. S. Koster, C. K. van der Ent, J. A. M. Raaijmakers & A.-H. Maitland-van der Zee. (2011) Biomarkers of therapy responsiveness in asthma: pitfalls and promises. Clinical & Experimental Allergy 41:5, pages 615-629.
Crossref
Sara K. Rosenkranz, Katherine E. Swain, Richard R. Rosenkranz, Bethany Beckman & Craig A. Harms. (2010) Modifiable lifestyle factors impact airway health in non‐asthmatic prepubescent boys but not girls. Pediatric Pulmonology 46:5, pages 464-472.
Crossref
Melissa A. McClean, Christopher Htun, Gregory G. King, Norbert Berend & Cheryl M. Salome. (2011) Cut-points for response to mannitol challenges using the forced oscillation technique. Respiratory Medicine 105:4, pages 533-540.
Crossref
Sandra D Anderson & John D Brannan. (2011) Bronchial provocation testing: the future. Current Opinion in Allergy & Clinical Immunology 11:1, pages 46-52.
Crossref
Asger Sverrild, Celeste Porsbjerg, Simon Francis Thomsen & Vibeke Backer. (2010) Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: A random-sample population study. Journal of Allergy and Clinical Immunology 126:5, pages 952-958.
Crossref
John D. Brannan. (2010) Bronchial Hyperresponsiveness in the Assessment of Asthma Control. Chest 138:2, pages 11S-17S.
Crossref
Sandra D. Anderson. (2010) Indirect Challenge Tests. Chest 138:2, pages 25S-30S.
Crossref
Sara K. Rosenkranz, Dana K. Townsend, Suzanne E. Steffens & Craig A. Harms. (2010) Effects of a high-fat meal on pulmonary function in healthy subjects. European Journal of Applied Physiology 109:3, pages 499-506.
Crossref
K. L. Clearie, P. A. Williamson, S. Vaidyanathan, P. Short, A. Goudie, P. Burns, P. Hopkinson, K. Meldrum, L. Howaniec & B. J. Lipworth. (2010) Disconnect between standardized field-based testing and mannitol challenge in Scottish elite swimmers. Clinical & Experimental Allergy.
Crossref
S. D. Anderson & J. D. Brannan. (2010) Bronchial provocation testing and collection of sputum with inhaled mannitol. Clinical & Experimental Allergy 40:2, pages 193-196.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.