2,506
Views
66
CrossRef citations to date
0
Altmetric
LETTERS TO THE EDITOR

Electrochemotherapy and calcium electroporation inducing a systemic immune response with local and distant remission of tumors in a patient with malignant melanoma – a case report

, , , , & ORCID Icon
Pages 1126-1131 | Received 23 Nov 2016, Accepted 30 Jan 2017, Published online: 22 Feb 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Mille Vissing, Lars Munch Larsen, Anne Juel Christensen, Louise Öwall, Sandra Sinius Pouplier, Anne-Vibeke Lænkholm & Julie Gehl. (2023) Calcium electroporation as an adjunct therapy for pembrolizumab-resistant bladder cancer: a case report. Acta Oncologica 62:6, pages 614-620.
Read now
Fredrik J Landström, Frida E Jakobsson & Stefan J Kristiansson. (2022) Successful Electrochemotherapy Treatment of a Large Bleeding Lymph Node Melanoma Metastasis. Melanoma Management 9:2.
Read now
Fausto Petrelli, Antonio Ghidini, Andrea Simioni & Luca Giovanni Campana. (2022) Impact of electrochemotherapy in metastatic cutaneous melanoma: a contemporary systematic review and meta-analysis. Acta Oncologica 61:5, pages 533-544.
Read now
Julie Gehl, Gregor Sersa, Louise Wichmann Matthiessen, Tobian Muir, Declan Soden, Antonio Occhini, Pietro Quaglino, Pietro Curatolo, Luca G. Campana, Christian Kunte, A. James P. Clover, Giulia Bertino, Victor Farricha, Joy Odili, Karin Dahlstrom, Marco Benazzo & Lluis M. Mir. (2018) Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases. Acta Oncologica 57:7, pages 874-882.
Read now
Joanna Vitfell-Rasmussen, Rikke Mulvad Sandvik, Karin Dahlstrøm, Gina Al-Farra, Anders Krarup-Hansen & Julie Gehl. (2018) Tumor reduction and symptom relief after electrochemotherapy in a patient with aggressive fibromatosis – a case report. Acta Oncologica 57:3, pages 431-434.
Read now
Hanne Falk, Patrick F. Forde, Marie Lund Bay, Uma Maheswari Mangalanathan, Pernille Hojman, Declan M. Soden & Julie Gehl. (2017) Calcium electroporation induces tumor eradication, long-lasting immunity and cytokine responses in the CT26 colon cancer mouse model. OncoImmunology 6:5.
Read now

Articles from other publishers (59)

Martynas Maciulevičius, Rūta Palepšienė, Salvijus Vykertas, Renaldas Raišutis, Aras Rafanavičius, Tomas Krilavičius & Saulius Šatkauskas. (2024) The comparison of the dynamics of Ca2+ and bleomycin intracellular delivery after cell sonoporation and electroporation in vitro. Bioelectrochemistry 158, pages 108708.
Crossref
Jianping Li, Cancan Wei, Youjia Chen, Zhigang Jin, Nen Wan, Jianming Wen, Jijie Ma & Yili Hu. (2024) Quantitative evaluation method of triboelectric nano-electroporation based on electrical impedance spectroscopy. Nano Energy 124, pages 109514.
Crossref
M. Broholm, R. Vogelsang, M. Bulut, M. Gögenur, T. Stigaard, A. Orhan, X. Schefte, A. M. K. Fiehn, J. Gehl & I. Gögenur. (2023) Neoadjuvant calcium electroporation for potentially curable colorectal cancer. Surgical Endoscopy 38:2, pages 697-705.
Crossref
Benjamin Hadzialjevic, Masa Omerzel, Blaz Trotovsek, Maja Cemazar, Tanja Jesenko, Gregor Sersa & Mihajlo Djokic. (2024) Electrochemotherapy combined with immunotherapy – a promising potential in the treatment of cancer. Frontiers in Immunology 14.
Crossref
Nina Rembiałkowska, Vitalij Novickij, Eivina Radzevičiūtė-Valčiukė, Eglė Mickevičiūtė, Agnieszka Gajewska-Naryniecka & Julita Kulbacka. (2023) Susceptibility of various human cancer cell lines to nanosecond and microsecond range electrochemotherapy: Feasibility of multi-drug cocktails. International Journal of Pharmaceutics 646, pages 123485.
Crossref
Charlotte Egeland, Lukas Balsevicius, Ismail Gögenur, Julie Gehl, Lene Baeksgaard, Rajendra Singh Garbyal & Michael Patrick Achiam. (2023) Calcium electroporation of esophageal cancer induces gene expression changes: a sub-study of a phase I clinical trial. Journal of Cancer Research and Clinical Oncology 149:17, pages 16031-16042.
Crossref
Mille Vissing, Mascha Pervan, John Pløen, Mazen Schnefeldt, Søren Rafael Rafaelsen, Lars Henrik Jensen, Achim Rody & Julie Gehl. (2023) Calcium electroporation in cutaneous metastases – A non-randomised phase II multicentre clinical trial. European Journal of Surgical Oncology 49:9, pages 106925.
Crossref
Eivina Radzevičiūtė-Valčiukė, Augustinas Želvys, Eglė Mickevičiūtė, Jovita Gečaitė, Auksė Zinkevičienė, Veronika Malyško-Ptašinskė, Vytautas Kašėta, Jurij Novickij, Tatjana Ivaškienė & Vitalij Novickij. (2023) Calcium Electrochemotherapy for Tumor Eradication and the Potential of High-Frequency Nanosecond Protocols. Pharmaceuticals 16:8, pages 1083.
Crossref
Luca G. Campana, Adil Daud, Francesco Lancellotti, Julio P. Arroyo, Rafael V. Davalos, Claudia Di Prata & Julie Gehl. (2023) Pulsed Electric Fields in Oncology: A Snapshot of Current Clinical Practices and Research Directions from the 4th World Congress of Electroporation. Cancers 15:13, pages 3340.
Crossref
Claudia Di Prata, Matteo Mascherini, Alastair MacKenzie Ross, Barbara Silvestri, Erika Kis, Joy Odili, Tommaso Fabrizio, Rowan Pritchard Jones, Christian Kunte, Antonio Orlando, James Clover, Siva Kumar, Francesco Russano, Paolo Matteucci, Tobian Muir, Francesca de Terlizzi, Julie Gehl & Eva-Maria Grischke. (2023) Efficacy of Electrochemotherapy in Breast Cancer Patients of Different Receptor Status: The INSPECT Experience. Cancers 15:12, pages 3116.
Crossref
Katarzyna Bieżuńska-Kusiak, Julita Kulbacka, Anna Choromańska, Nina Rembiałkowska, Olga Michel & Jolanta Saczko. (2023) Evaluation of the Anticancer Activity of Calcium Ions Introduced into Human Breast Adenocarcinoma Cells MCF-7/WT and MCF-7/DOX by Electroporation. Pharmaceuticals 16:6, pages 809.
Crossref
Barbara Lisec, Bostjan Markelc, Katja Ursic Valentinuzzi, Gregor Sersa & Maja Cemazar. (2023) The effectiveness of calcium electroporation combined with gene electrotransfer of a plasmid encoding IL-12 is tumor type-dependent. Frontiers in Immunology 14.
Crossref
Malene Broholm, Rasmus Vogelsang, Mustafa Bulut, Trine Stigaard, Hanne Falk, Stine Frandsen, Dorte Levin Pedersen, Trine Perner, Anne-Marie Kanstrup Fiehn, Ida Mølholm, Michael Bzorek, Andreas Weinberger Rosen, Christina Søs Auður Andersen, Niels Pallisgaard, Ismail Gögenur & Julie Gehl. (2023) Endoscopic calcium electroporation for colorectal cancer: a phase I study. Endoscopy International Open 11:05, pages E451-E459.
Crossref
Julita Kulbacka, Anna Choromańska, Anna Szewczyk, Olga Michel, Dagmara Baczyńska, Andrzej Sikora, Joanna Rossowska, Marek Kulbacki & Nina Rembiałkowska. (2023) Nanoelectropulse delivery for cell membrane perturbation and oxidation in human colon adenocarcinoma cells with drug resistance. Bioelectrochemistry 150, pages 108356.
Crossref
Aleksander Kiełbik, Pamela W. Sowa, Andrei G. Pakhomov, Emily Gudvangen, Uma Mangalanathan, Julita Kulbacka & Olga N. Pakhomova. (2023) Urine protects urothelial cells against killing with nanosecond pulsed electric fields. Bioelectrochemistry 149, pages 108289.
Crossref
Maura B. Bendix, Aileen Houston, Patrick F. Forde & Elizabeth Brint. (2022) Defining optimal parameters to maximize the effect of electrochemotherapy on lung cancer cells whilst preserving the integrity of immune cells. Bioelectrochemistry 148, pages 108257.
Crossref
Vitalij Novickij, Nina Rembiałkowska, Paulina Kasperkiewicz-Wasilewska, Dagmara Baczyńska, Adam Rzechonek, Piotr Błasiak & Julita Kulbacka. (2022) Pulsed electric fields with calcium ions stimulate oxidative alternations and lipid peroxidation in human non-small cell lung cancer. Biochimica et Biophysica Acta (BBA) - Biomembranes 1864:12, pages 184055.
Crossref
Xuan Gong, Zhou Chen, Jason J. Hu & Chao Liu. (2022) Advances of Electroporation-Related Therapies and the Synergy with Immunotherapy in Cancer Treatment. Vaccines 10:11, pages 1942.
Crossref
Charlotte Egeland, Lene Baeksgaard, Julie Gehl, Ismail Gögenur & Michael Patrick Achiam. (2022) Palliative Treatment of Esophageal Cancer Using Calcium Electroporation. Cancers 14:21, pages 5283.
Crossref
Maura B. Bendix, Aileen Houston, Patrick F. Forde & Elizabeth Brint. (2022) Electrochemotherapy and immune interactions; A boost to the system?. European Journal of Surgical Oncology 48:9, pages 1895-1900.
Crossref
Ahmet Savcı, Kenan Buldurun, Mehmet Eşref Alkış, Yusuf Alan & Nevin Turan. (2022) Synthesis, characterization, antioxidant and anticancer activities of a new Schiff base and its M(II) complexes derived from 5-fluorouracil. Medical Oncology 39:11.
Crossref
Katja Balantič, Victor U. Weiss, Günter Allmaier & Peter Kramar. (2022) Calcium ion effect on phospholipid bilayers as cell membrane analogues. Bioelectrochemistry 143, pages 107988.
Crossref
Diana Navickaitė, Paulius Ruzgys, Martynas Maciulevičius, Gerwin Dijk, Rodney P. O'Connor & Saulius Šatkauskas. (2021) Ca2+ roles in electroporation-induced changes of cancer cell physiology: From membrane repair to cell death. Bioelectrochemistry 142, pages 107927.
Crossref
Nastaran Alinezhadbalalami, Philip M. Graybill, Khan Mohammad Imran, Scott S. Verbridge, Irving C. Allen & Rafael V. Davalos. (2021) Generation of Tumor-activated T cells Using Electroporation. Bioelectrochemistry 142, pages 107886.
Crossref
Sanjeev Kumar Sagwal & Sander Bekeschus. (2021) ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities. Oxidative Medicine and Cellular Longevity 2021, pages 1-21.
Crossref
Paolo Marracino, Laura Caramazza, Maria Montagna, Ramin Ghahri, Marco D'Abramo, Micaela Liberti & Francesca Apollonio. (2021) Electric-driven membrane poration: A rationale for water role in the kinetics of pore formation. Bioelectrochemistry, pages 107987.
Crossref
Tina Batista Napotnik, Tamara Polajžer & Damijan Miklavčič. (2021) Cell death due to electroporation – A review. Bioelectrochemistry 141, pages 107871.
Crossref
Julia Rudno-Rudzińska, Wojciech Kielan, Maciej Guziński, Maciej Płochocki, Agnieszka Antończyk & Julita Kulbacka. (2021) New therapeutic strategy: Personalization of pancreatic cancer treatment-irreversible electroporation (IRE), electrochemotherapy (ECT) and calcium electroporation (CaEP) – A pilot preclinical study. Surgical Oncology 38, pages 101634.
Crossref
Gregor Sersa, Katja Ursic, Maja Cemazar, Richard Heller, Masa Bosnjak & Luca G. Campana. (2021) Biological factors of the tumour response to electrochemotherapy: Review of the evidence and a research roadmap. European Journal of Surgical Oncology 47:8, pages 1836-1846.
Crossref
Mille Vissing, John Ploen, Mascha Pervan, Kitt Vestergaard, Mazen Schnefeldt, Stine Krog Frandsen, Søren Rafael Rafaelsen, Christina Louise Lindhardt, Lars Henrik Jensen, Achim Rody & Julie Gehl. (2021) Study protocol designed to investigate tumour response to calcium electroporation in cancers affecting the skin: a non-randomised phase II clinical trial. BMJ Open 11:6, pages e046779.
Crossref
Anna Myriam Perrone, Gloria Ravegnini, Stefano Miglietta, Lisa Argnani, Martina Ferioli, Eugenia De Crescenzo, Marco Tesei, Marco Di Stanislao, Giulia Girolimetti, Giuseppe Gasparre, Anna Maria Porcelli, Francesca De Terlizzi, Claudio Zamagni, Alessio Giuseppe Morganti & Pierandrea De Iaco. (2021) Electrochemotherapy in Vulvar Cancer and Cisplatin Combined with Electroporation. Systematic Review and In Vitro Studies. Cancers 13:9, pages 1993.
Crossref
Hanne Falk, Mille Vissing, Gitte Wooler & Julie Gehl. (2021) Calcium Electroporation for Keloids: A First-in-Man Phase I Study. Dermatology 237:6, pages 961-969.
Crossref
Stine K. Frandsen, Martin S. Thoefner & Julie Gehl. 2021. Electroporation in Veterinary Oncology Practice. Electroporation in Veterinary Oncology Practice 145 164 .
Barbara Starešinič & Maja Čemažar. 2021. 8th European Medical and Biological Engineering Conference. 8th European Medical and Biological Engineering Conference 95 101 .
Zofia Łapińska, Michał Dębiński, Anna Szewczyk, Anna Choromańska, Julita Kulbacka & Jolanta Saczko. (2020) Electrochemotherapy with Calcium Chloride and 17β-Estradiol Modulated Viability and Apoptosis Pathway in Human Ovarian Cancer. Pharmaceutics 13:1, pages 19.
Crossref
Liam Friel Tremble, Cynthia C. B. B. Heffron & Patrick F. Forde. (2020) The effect of calcium electroporation on viability, phenotype and function of melanoma conditioned macrophages. Scientific Reports 10:1.
Crossref
Aleksander Kiełbik, Wojciech Szlasa, Olga Michel, Anna Szewczyk, Mounir Tarek, Jolanta Saczko & Julita Kulbacka. (2020) In Vitro Study of Calcium Microsecond Electroporation of Prostate Adenocarcinoma Cells. Molecules 25:22, pages 5406.
Crossref
Julia Rudno-Rudzińska, Wojciech Kielan, Maciej Guziński, Maciej Płochocki & Julita Kulbacka. (2020) The First Study of Irreversible Electroporation with Calcium Ions and Chemotherapy in Patients with Locally Advanced Pancreatic Adenocarcinoma. Applied Sciences 10:15, pages 5163.
Crossref
Stine K. Frandsen, Julie Gehl, Trine Tramm & Martin S. Thoefner. (2020) Calcium Electroporation of Equine Sarcoids. Animals 10:3, pages 517.
Crossref
Shirley Sharabi, David Guez, Dianne Daniels, Itzik Cooper, Dana Atrakchi, Sigal Liraz-Zaltsman, David Last & Yael Mardor. (2020) The application of point source electroporation and chemotherapy for the treatment of glioma: a randomized controlled rat study. Scientific Reports 10:1.
Crossref
Stine K. Frandsen, Mille Vissing & Julie Gehl. (2020) A Comprehensive Review of Calcium Electroporation—A Novel Cancer Treatment Modality. Cancers 12:2, pages 290.
Crossref
Dóra Ágoston, Eszter Baltás, Henriette Ócsai, Sándor Rátkai, Péter Gy Lázár, Irma Korom, Erika Varga, István Balázs Németh, Éva Dósa-Rácz Viharosné, Julie Gehl, Judit Oláh, Lajos Kemény & Erika Gabriella Kis. (2020) Evaluation of Calcium Electroporation for the Treatment of Cutaneous Metastases: A Double Blinded Randomised Controlled Phase II Trial. Cancers 12:1, pages 179.
Crossref
N. Beitel-White, R. C. G. Martin, Y. Li, R. M. Brock, I. C. Allen & R. V. Davalos. (2019) Real-time prediction of patient immune cell modulation during irreversible electroporation therapy. Scientific Reports 9:1.
Crossref
Vitalij Novickij, Robertas Čėsna, Emilija Perminaitė, Auksė Zinkevičienė, Dainius Characiejus, Jurij Novickij, Saulius Šatkauskas, Paulius Ruzgys & Irutė Girkontaitė. (2019) Antitumor Response and Immunomodulatory Effects of Sub-Microsecond Irreversible Electroporation and Its Combination with Calcium Electroporation. Cancers 11:11, pages 1763.
Crossref
Laurine Galant, Maxence Delverdier, Marie-Noëlle Lucas, Isabelle Raymond-Letron, Justin Teissie & Youssef Tamzali. (2019) Calcium electroporation: The bioelectrochemical treatment of spontaneous equine skin tumors results in a local necrosis. Bioelectrochemistry 129, pages 251-258.
Crossref
Stefania Romeo, Stine Krog Frandsen, Julie Gehl & Olga Zeni. (2019) Calcium Electroporation: An Overview of an Innovative Cancer Treatment Approach. Calcium Electroporation: An Overview of an Innovative Cancer Treatment Approach.
Luca G. Campana, Damijan Miklavčič, Giulia Bertino, Roberto Marconato, Sara Valpione, Ilaria Imarisio, Maria Vittoria Dieci, Elisa Granziera, Maja Cemazar, Mauro Alaibac & Gregor Sersa. (2019) Electrochemotherapy of superficial tumors – Current status:. Seminars in Oncology 46:2, pages 173-191.
Crossref
K. L. Hoejholt, T. Mužić, S. D. Jensen, L. T. Dalgaard, M. Bilgin, J. Nylandsted, T. Heimburg, S. K. Frandsen & J. Gehl. (2019) Calcium electroporation and electrochemotherapy for cancer treatment: Importance of cell membrane composition investigated by lipidomics, calorimetry and in vitro efficacy. Scientific Reports 9:1.
Crossref
Luca G. Campana, Ibrahim Edhemovic, Declan Soden, Anna M. Perrone, Marco Scarpa, Laura Campanacci, Maja Cemazar, Sara Valpione, Damijan Miklavčič, Simone Mocellin, Elisabetta Sieni & Gregor Sersa. (2019) Electrochemotherapy – Emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration. European Journal of Surgical Oncology 45:2, pages 92-102.
Crossref
Liam Friel Tremble, Morgan A. O'Brien, Declan M. Soden & Patrick F. Forde. (2019) Electrochemotherapy with cisplatin increases survival and induces immunogenic responses in murine models of lung cancer and colorectal cancer. Cancer Letters 442, pages 475-482.
Crossref
Christina Caroline Plaschke, Julie Gehl, Helle Hjorth Johannesen, Barbara Malene Fischer, Andreas Kjaer, Anne Fog Lomholt & Irene Wessel. (2019) Calcium electroporation for recurrent head and neck cancer: A clinical phase I study. Laryngoscope Investigative Otolaryngology 4:1, pages 49-56.
Crossref
Christina Caroline Plaschke, Helle Hjorth Johannesen, Rasmus Hvass Hansen, Helle Westergren Hendel, Katalin Kiss, Julie Gehl & Irene Wessel. (2018) The DAHANCA 32 study: Electrochemotherapy for recurrent mucosal head and neck cancer. Head & Neck 41:2, pages 329-339.
Crossref
Esin B. Sözer, C. Florencia Pocetti & P. Thomas Vernier. (2018) Transport of charged small molecules after electropermeabilization — drift and diffusion. BMC Biophysics 11:1.
Crossref
Barbara Staresinic, Tanja Jesenko, Urska Kamensek, Stine Krog Frandsen, Gregor Sersa, Julie Gehl & Maja Cemazar. (2018) Effect of calcium electroporation on tumour vasculature. Scientific Reports 8:1.
Crossref
Liam F. Tremble, Morgan A. O'Brien, Patrick F. Forde & Declan M. Soden. (2018) ICOS activation in combination with electrochemotherapy generates effective anti-cancer immunological responses in murine models of primary, secondary and metastatic disease. Cancer Letters 420, pages 109-115.
Crossref
Brittany Lassiter, Siqi Guo & Stephen Beebe. (2018) Nano-Pulse Stimulation Ablates Orthotopic Rat Hepatocellular Carcinoma and Induces Innate and Adaptive Memory Immune Mechanisms that Prevent Recurrence. Cancers 10:3, pages 69.
Crossref
Burçak Karaca, Gökçe Yayla, Mehmet Erdem & Tahir Gürler. (2018) Electrochemotherapy with anti-PD-1 treatment induced durable complete response in heavily pretreated metastatic melanoma patient. Anti-Cancer Drugs 29:2, pages 190-196.
Crossref
Stefania Romeo, Anna Sannino, Maria Rosaria Scarfì, P. Thomas Vernier, Ruggero Cadossi, Julie Gehl & Olga Zeni. (2018) ESOPE-Equivalent Pulsing Protocols for Calcium Electroporation: An In Vitro Optimization Study on 2 Cancer Cell Models . Technology in Cancer Research & Treatment 17, pages 153303381878807.
Crossref
Christina Caroline Plaschke, Giulia Bertino, James A. McCaul, Juan J. Grau, Remco de Bree, Gregor Sersa, Antonio Occhini, Ales Groselj, Cristobal Langdon, Derrek A. Heuveling, Maja Cemazar, Primoz Strojan, C. Rene Leemans, Marco Benazzo, Francesca De Terlizzi, Irene Wessel & Julie Gehl. (2017) European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results from the treatment of mucosal cancers. European Journal of Cancer 87, pages 172-181.
Crossref