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Acta Oncologica Volume 57, 2018 - Issue 6
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Original Articles: Upper GI Cancer

Neoadjuvant therapy offers longer survival than upfront surgery for poorly differentiated and higher stage pancreatic cancer

Anna NurmiDepartment of Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; ORCID Iconhttp://orcid.org/0000-0003-2235-1752View further author information
ORCID Icon,
Harri MustonenDepartment of Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; ORCID Iconhttp://orcid.org/0000-0001-5632-6796View further author information
ORCID Icon,
Helka ParviainenHUS Medical Imaging Centre, Radiology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; View further author information
,
Katriina PeltolaComprehensive Cancer Centre, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; View further author information
,
Caj HaglundDepartment of Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; ;Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, FinlandORCID Iconhttp://orcid.org/0000-0003-0456-4965View further author information
ORCID Icon &
Hanna SeppänenDepartment of Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; Correspondence[email protected]
View further author information
Pages 799-806 | Received 07 Jun 2017, Accepted 03 Dec 2017, Published online: 15 Dec 2017

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Roland Andersson & Bobby Tingstedt. (2023) Neoadjuvant chemo(radio)therapy in upfront resectable pancreatic cancer – can we stratify patients better in the future?. Scandinavian Journal of Gastroenterology 58:1, pages 1-2.
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Roland Andersson, Caj Haglund, Hanna Seppänen & Daniel Ansari. (2022) Pancreatic cancer – the past, the present, and the future. Scandinavian Journal of Gastroenterology 57:10, pages 1169-1177.
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Wenli Qiu, Na Duan, Xiao Chen, Shuai Ren, Yifen Zhang, Zhongqiu Wang & Rong Chen. (2019) Pancreatic Ductal Adenocarcinoma: Machine Learning–Based Quantitative Computed Tomography Texture Analysis For Prediction Of Histopathological Grade. Cancer Management and Research 11, pages 9253-9264.
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Articles from other publishers (25)

Krishan R. Jethwa, Ed Kim, Jordan Berlin, Christopher J. Anker, Leila Tchelebi, Gerard Abood, Christopher L. Hallemeier, Salma Jabbour, Timothy Kennedy, Rachit Kumar, Percy Lee, Navesh Sharma, William Small, Vonetta Williams & Suzanne Russo. (2024) Executive Summary of the American Radium Society Appropriate Use Criteria for Neoadjuvant Therapy for Nonmetastatic Pancreatic Adenocarcinoma. American Journal of Clinical Oncology 47:4, pages 185-199.
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Wei Liu, Tiansong Xie, Lei Chen, Wei Tang, Zehua Zhang, Yu Wang, Weiwei Deng, Xuebin Xie & Zhengrong Zhou. (2024) Dual-layer spectral detector CT: A noninvasive preoperative tool for predicting histopathological differentiation in pancreatic ductal adenocarcinoma. European Journal of Radiology 173, pages 111327.
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Youjia Wen, Zuhua Song, Qian Li, Dan Zhang, Xiaojiao Li, Jiayi Yu, Zongwen Li, Xiaofang Ren, Jiayan Zhang, Qian Liu, Jie Huang, Dan Zeng & Zhuoyue Tang. (2024) Development and validation of a model for predicting the expression of Ki-67 in pancreatic ductal adenocarcinoma with radiological features and dual-energy computed tomography quantitative parameters. Insights into Imaging 15:1.
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Si-qi Yang, Rui-qi Zou, Yu-shi Dai, Fu-yu Li & Hai-jie Hu. (2023) Comparison of the upfront surgery and neoadjuvant therapy in resectable and borderline resectable pancreatic cancer: an updated systematic review and meta-analysis. Updates in Surgery 76:1, pages 1-15.
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Tianxing Zhou, Jingrui Yan, Jihui Hao & Jun Yu. (2023) Pancreatic adenocarcinoma and aging: understanding the menace for better management. Journal of Pancreatology 6:4, pages 158-168.
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Yoshihiro Shirai, Shinji Onda, Yoshiaki Tanji, Ryoga Hamura, Michinori Matsumoto, Mitsuru Yanagaki, Masashi Tsunematsu, Tomohiko Taniai, Kochiro Haruki, Kenei Furukawa, Kyohei Abe, Taro Sakamoto, Takeshi Gocho, Tadashi Uwagawa & Toru Ikegami. (2023) Superior mesenteric vein/portal vein contact in preoperative imaging indicates biological malignancy in anatomically resectable pancreatic cancer. Surgical Oncology 51, pages 101998.
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Chun-Ye Zhang, Shuai Liu & Ming Yang. (2022) Clinical diagnosis and management of pancreatic cancer: Markers, molecular mechanisms, and treatment options. World Journal of Gastroenterology 28:48, pages 6827-6845.
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Michael Janisch, Gabriel Adelsmayr, Heimo Müller, Andreas Holzinger, Elmar Janek, Emina Talakic, Michael Fuchsjäger & Helmut Schöllnast. (2022) Non-contrast-enhanced CT texture analysis of primary and metastatic pancreatic ductal adenocarcinomas: value in assessment of histopathological grade and differences between primary and metastatic lesions. Abdominal Radiology 47:12, pages 4151-4159.
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Valeriya S. Tikhonova, Grigory G. Karmazanovsky, Evvgeny V. Kondratyev, Ivan S. Gruzdev, Kseniya A. Mikhaylyuk, Mikhail Y. Sinelnikov & Amiran Sh. Revishvili. (2022) Radiomics model–based algorithm for preoperative prediction of pancreatic ductal adenocarcinoma grade. European Radiology 33:2, pages 1152-1161.
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Aiste Gulla, Daisuke Hashimoto, Doris Wagner, Ryte Damaseviciute, Kestutis Strupas & Sohei Satoi. (2022) Interdisciplinary Approach of Establishing PDAC Resectability: Biochemical, Radiological and NAT Regimen Prognostic Factors—Literature Review. Medicina 58:6, pages 756.
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Anna Maria Nurmi, Jaana Hagström, Harri Mustonen, Hanna Seppänen & Caj Haglund. (2022) The expression and prognostic value of toll-like receptors (TLRs) in pancreatic cancer patients treated with neoadjuvant therapy. PLOS ONE 17:5, pages e0267792.
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Panu Aaltonen, Olli Carpén, Harri Mustonen, Pauli Puolakkainen, Caj Haglund, Katriina Peltola & Hanna Seppänen. (2022) Long-term nationwide trends in the treatment of and outcomes among pancreatic cancer patients. European Journal of Surgical Oncology 48:5, pages 1087-1092.
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. (2021) Korean clinical practice guideline for pancreatic cancer 2021: A summary of evidence-based, multi-disciplinary diagnostic and therapeutic approaches. Pancreatology 21:7, pages 1326-1341.
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Akhil Chawla & Andrew J. Aguirre. 2021. Clinical Pancreatology for Practising Gastroenterologists and Surgeons. Clinical Pancreatology for Practising Gastroenterologists and Surgeons 433 442 .
Annika Eurola, Ari Ristimäki, Harri Mustonen, Anna-Maria Nurmi, Jaana Hagström, Caj Haglund & Hanna Seppänen. (2021) Impact of histological response after neoadjuvant therapy on podocalyxin as a prognostic marker in pancreatic cancer. Scientific Reports 11:1.
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David Badovinac, Katja Goričar, Hana Zavrtanik, Miha Petrič, Teja Lavrin, Nina Mavec, Vita Dolžan, Aleš Tomažič & Metka Lenassi. (2021) Plasma Extracellular Vesicle Characteristics Correlate with Tumor Differentiation and Predict Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Surgery with Curative Intent. Journal of Personalized Medicine 11:2, pages 77.
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Anna M. Nurmi, Harri K. Mustonen, Ulf-Håkan Stenman, Hanna E. Seppänen & Caj H. Haglund. (2021) Combining CRP and CA19-9 in a novel prognostic score in pancreatic ductal adenocarcinoma. Scientific Reports 11:1.
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Bathiya Ratnayake, Alina Y. Savastyuk, Manu Nayar, Colin H. Wilson, John A. Windsor, Keith Roberts, Jeremy J. French & Sanjay Pandanaboyana. (2020) Recurrence Patterns for Pancreatic Ductal Adenocarcinoma after Upfront Resection Versus Resection Following Neoadjuvant Therapy: A Comprehensive Meta-Analysis. Journal of Clinical Medicine 9:7, pages 2132.
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Masashi Kudo, Tatsushi Kobayashi, Naoto Gotohda, Masaru Konishi, Shinichiro Takahashi, Shin Kobayashi, Motokazu Sugimoto, Satoshi Okubo, John MartinHoracio CabralGenichiro Ishii & Motohiro Kojima. (2020) Clinical Utility of Histological and Radiological Evaluations of Tumor Necrosis for Predicting Prognosis in Pancreatic Cancer. Pancreas 49:5, pages 634-641.
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Akhil Chawla, George Molina, Linda M. Pak, Michael Rosenthal, Joseph D. Mancias, Thomas E. Clancy, Brian M. Wolpin & Jiping Wang. (2019) Neoadjuvant Therapy is Associated with Improved Survival in Borderline-Resectable Pancreatic Cancer. Annals of Surgical Oncology 27:4, pages 1191-1200.
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Ashish Saharia, Lucy M. Potter, Flavio Baio, Ahmed Elaileh, Constance Mobley, Rafik M. Ghobrial, Maen Abdelrahim & Kirk Heyne. (2020) Is Surgery-first Still a Reasonable Option in the Era of Neoadjuvant Chemotherapy for Resectable Pancreatic Cancer?. American Journal of Clinical Oncology 43:4, pages 298-304.
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Vincent P. Groot, Alex B. Blair, Georgios Gemenetzis, Ding Ding, Richard A. Burkhart, Jun Yu, Inne H.M. Borel Rinkes, I. Quintus Molenaar, John L. Cameron, Matthew J. Weiss, Christopher L. Wolfgang & Jin He. (2019) Recurrence after neoadjuvant therapy and resection of borderline resectable and locally advanced pancreatic cancer. European Journal of Surgical Oncology 45:9, pages 1674-1683.
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Benjamin P.T. Loveday, Nathan Zilbert, Pablo E. Serrano, Koji Tomiyama, Amélie Tremblay, Adrian M. Fox, Maja Segedi, Martin O'Malley, Ayelet Borgida, Teresa Bianco, Sean Creighton, Anna Dodd, Adriana Fraser, Malcolm Moore, John Kim, Sean Cleary, Carol-anne Moulton, Paul Greig, Alice C. Wei, Steven Gallinger, Neesha Dhani & Ian D. McGilvray. (2019) Neoadjuvant therapy and major arterial resection for potentially reconstructable arterial involvement by stage 3 adenocarcinoma of the pancreas. HPB 21:6, pages 643-652.
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Margaret A. TemperoMokenge P. MalafaE. Gabriela ChioreanBrian CzitoCourtney ScaifeAmol K. NarangChristos FountzilasBrian M. WolpinMahmoud Al-HawaryHoracio AsbunStephen W. BehrmanAl B. BensonEllen BinderDana B. CardinCharles ChaVincent ChungMary DillhoffEfrat DotanCristina R. FerroneGeorge FisherJeffrey HardacreWilliam G. HawkinsAndrew H. KoNoelle LoConteAndrew M. LowyCassadie MoravekEric K. NakakuraEileen M. O’ReillyJorge ObandoSushanth ReddySarah ThayerRobert A. Wolff, Jennifer L. BurnsGriselda Zuccarino-Catania. (2019) Guidelines Insights: Pancreatic Adenocarcinoma, Version 1.2019. Journal of the National Comprehensive Cancer Network 17:3, pages 202-210.
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Alison Bradley & Robert Van Der Meer. (2019) Neoadjuvant therapy versus upfront surgery for potentially resectable pancreatic cancer: A Markov decision analysis. PLOS ONE 14:2, pages e0212805.
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