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Articles

Combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis

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Pages 11-14 | Accepted 22 Jul 2008, Published online: 12 Jul 2009

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Tomonori Kobayakawa, Toshihisa Kojima, Nobunori Takahashi, Masatoshi Hayashi, Yuichiro Yabe, Atsushi Kaneko, Tomone Shioura, Kiwamu Saito, Yuji Hirano, Yasuhide Kanayama, Hiroyuki Miyake, Nobuyuki Asai, Koji Funahashi, Shinya Hirabara, Masahiro Hanabayashi, Shuji Asai & Naoki Ishiguro. (2015) Drug retention rates of second biologic agents after switching from tumor necrosis factor inhibitors for rheumatoid arthritis in Japanese patients on low-dose methotrexate or without methotrexate. Modern Rheumatology 25:2, pages 251-256.
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Peter BB Jones & Douglas HN White. (2010) Reappraisal of the clinical use of leflunomide in rheumatoid arthritis and psoriatic arthritis. Open Access Rheumatology: Research and Reviews 2, pages 53-71.
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YH Lee, J-H Woo, SJ Choi, JD Ji, S-C Bae & GG Song. (2010) Tacrolimus for the treatment of active rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trials. Scandinavian Journal of Rheumatology 39:4, pages 271-278.
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Articles from other publishers (17)

Anastasia M. Kutskaya, Semyon A. Serkov, Vladimir V. Voronin, Maria S. Ledovskaya & Mikhail V. Polynski. (2022) Negligible Substituent Effect as Key to Synthetic Versatility: a Computational‐Experimental Study of Vinyl Ethers Addition to Nitrile Oxides. ChemistrySelect 7:10.
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Syed Wajih Ul Hassan. (2021) Pancytopenia Resulting From Low-Dose Methotrexate Use: A Diagnostic Challenge. Cureus.
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Veerle Stouten, Stijn Michiels, René Westhovens, Diederik De Cock, Amy Belba, Sofia Pazmino, Kristien Van der Elst, Johan Joly & Patrick Verschueren. (2020) Effectiveness of maintenance therapy with methotrexate compared with leflunomide for patients with RA having achieved disease control with both these drugs: results of a predefined sub-analysis of CareRA, a pragmatic RCT. Clinical Rheumatology 39:9, pages 2593-2601.
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Run-yue Huang, Hu-dan Pan, Jia-qi Wu, Hua Zhou, Zhan-guo Li, Ping Qiu, Ying-yan Zhou, Xiu-min Chen, Zhi-xin Xie, Yao Xiao, Qing-chun Huang & Liang Liu. (2019) Comparison of combination therapy with methotrexate and sinomenine or leflunomide for active rheumatoid arthritis: A randomized controlled clinical trial. Phytomedicine 57, pages 403-410.
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Eric Yarnell. (2017) Herbs for Rheumatoid Arthritis. Alternative and Complementary Therapies 23:4, pages 149-156.
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Wei Zhong, Ling Zhao, Tao Liu & Zhenyu Jiang. (2017) IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide. Scientific Reports 7:1.
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Wang Yali, Liu Jian, Wang Yuan & Sun Yue. (2015) Effect of Xinfeng capsule in the treatment of active rheumatoid arthritis: a randomized controlled trial. Journal of Traditional Chinese Medicine 35:6, pages 626-631.
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Mihaela Manole, Codruta Badescu, Manuela Ciocoiu, Magda Badescu & Mihaiela Chicu. (2014) Arava Treatment, between Beneficial Action on Joint Inflammation and Side Effects on Liver, Myocardium and Kidney in Experimental Murine Arthritis. Journal of Biomedical Science and Engineering 07:09, pages 712-720.
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PAUL BIRD, HEDLEY GRIFFITHS, KATHLEEN TYMMS, DAVE NICHOLLS, LYNDEN ROBERTS, MARK ARNOLD, SIMON BURNET, JULIEN de JAGER, JAMES SCOTT, JANE ZOCHLING & GEOFF LITTLEJOHN. (2013) The SMILE Study — Safety of Methotrexate in Combination with Leflunomide in Rheumatoid Arthritis. The Journal of Rheumatology 40:3, pages 228-235.
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Zhu Chen, Xiang-Pei Li, Zhi-Jun Li, Liang Xu & Xiao-Mei Li. (2013) Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis. International Immunopharmacology 15:3, pages 474-477.
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Kowoon JooWon ParkSeong-Ryul KwonMie-Jin Lim. (2013) Safety and Efficacy Evaluation for the Addition of Either Etanercept or Leflunomide in Korean Rheumatoid Arthritis Patients Inadequately Responding to Methotrexate. Journal of Rheumatic Diseases 20:3, pages 166.
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Rui LIU & Xiangyuan LIU. (2011) Leflunomide and rheumatoid interstitial lung disease. Chinese Journal of Multiple Organ Diseases in the Elderly 10:4, pages 374-376.
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Frank Behrens, Michaela Koehm & Harald Burkhardt. (2011) Update 2011: leflunomide in rheumatoid arthritis – strengths and weaknesses. Current Opinion in Rheumatology 23:3, pages 282-287.
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Norman T. Ilowite & Ronald M. Laxer. 2011. Textbook of Pediatric Rheumatology. Textbook of Pediatric Rheumatology 71 126 .
Sara A. Colopy, Theresa A. Baker & Peter Muir. (2010) Efficacy of leflunomide for treatment of immune-mediated polyarthritis in dogs: 14 cases (2006–2008). Journal of the American Veterinary Medical Association 236:3, pages 312-318.
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Jung-Yoon Choe. (2009) The Efficacy and Safety of Leflunomide in the Treatment of Rheumatoid Arthritis. The Journal of the Korean Rheumatism Association 16:2, pages 71.
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