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Articles

Combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis

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Pages 11-14 | Accepted 22 Jul 2008, Published online: 12 Jul 2009

References

  • Wolfe F., Sharp J. T. Radiographic outcome of recent‐onset rheumatoid arthritis: a 19‐year study of radiographic progression. Arthritis Rheum 1998; 41: 1571–82
  • Bukhari M. A., Wiles N. J., Lunt M., Harrison B. J., Scott D. G., Symmons D. P., et al. Influence of disease‐modifying therapy on radiographic outcome in inflammatory polyarthritis at five years: results from a large observational inception study. Arthritis Rheum 2003; 48: 46–53
  • Egsmose C., Lund B., Borg G., Pettersson H., Berg E., Brodin U., et al. Patients with rheumatoid arthritis benefit from early 2nd line therapy: 5‐year follow‐up of a prospective double blind placebo controlled study. J Rheumatol 1995; 22: 2208–13
  • Choy E. H., Smith C., Dore C. J., Scott D. L. A meta‐analysis of the efficacy and toxicity of combining disease‐modifying anti‐rheumatic drugs in rheumatoid arthritis based on patient withdrawal. Rheumatology (Oxford) 2005; 44: 1414–21
  • Weinblatt M. E., Kremer J. M., Coblyn J. S., Maier A. L., Helfgott S. M., Morrell M., et al. Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis. Arthritis Rheum 1999; 42: 1322–8
  • Kremer J. M., Genovese M. C., Cannon G. W., Caldwell J. R., Cush J. J., Furst D. E., et al. Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double‐blind, placebo‐controlled trial. Ann Intern Med 2002; 137: 726–33
  • Cohen S. Leflunomide (LEF) as initial therapy with methotrexate (MTX) added for rheumatoid arthritis patients with active disease. Arthritis Rheum 2002; 46: S538–9
  • Arnett F. C., Edworthy S. M., Bloch D. A., McShane D. J., Fries J. F., Cooper N. S., et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315–24
  • Kremer J., Genovese M., Cannon G. W., Caldwell J., Cush J., Furst D. E., et al. Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: open‐label extension of a randomized, double‐blind, placebo controlled trial. J Rheumatol 2004; 31: 1521–31
  • Li E. K., Tam L. S., Tomlinson B. Leflunomide in the treatment of rheumatoid arthritis. Clin Ther 2004; 26: 447–59

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