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Research Article

On the Mechanism of Hepatocarcinogenesis of Benzodiazepines: Evidence that Diazepam and Oxazepam are CYP2B Inducers in Rats, and both CYP2B and CYP4A Inducers in Mice

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Pages 235-259 | Published online: 09 Oct 2008

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Katalin Mangó, Ádám Ferenc Kiss, Ferenc Fekete, Réka Erdős & Katalin Monostory. (2022) CYP2B6 allelic variants and non-genetic factors influence CYP2B6 enzyme function. Scientific Reports 12:1.
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Josef Skoda, Jan Dusek, Martin Drastik, Alzbeta Stefela, Klara Dohnalova, Karel Chalupsky, Tomas Smutny, Stanislav Micuda, Sabine Gerbal-Chaloin & Petr Pavek. (2020) Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain. Cells 9:12, pages 2532.
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Gentao Li, Hui Xiong, Khawar Saeed, Ruicong Ma, Yufeng Xing, Yajuan Bi, Caiyu Li, Jianhui Huang & Youcai Zhang. (2020) Comparative toxicity analysis of corannulene and benzo[a]pyrene in mice. Toxicology Letters 331, pages 130-142.
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Richard C. Peffer, Matthew J. LeBaron, Michael Battalora, Werner H. Bomann, Christoph Werner, Manoj Aggarwal, Rocky R. Rowe & Helen Tinwell. (2018) Minimum datasets to establish a CAR-mediated mode of action for rodent liver tumors. Regulatory Toxicology and Pharmacology 96, pages 106-120.
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Valerie Soldatow, Richard C. Peffer, O. Joseph Trask, David E. Cowie, Melvin E. Andersen, Edward LeCluyse & Chad Deisenroth. (2016) Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation. Toxicology in Vitro 36, pages 224-237.
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Ying Guo, Chad Pope, Xingguo Cheng, Honghao Zhou & Curtis D. Klaassen. (2011) Dose–response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice. Journal of Ethnopharmacology 138:1, pages 111-118.
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S. A. Lahousse, M. Hoenerhoff, J. Collins, T-V. T. Ton, T. Masinde, D. Olson, Y. Rebolloso, T. Koujitani, K. B. Tomer, H-H. L. Hong, J. Bucher & R. C. Sills. (2010) Gene Expression and Mutation Assessment Provide Clues of Genetic and Epigenetic Mechanisms in Liver Tumors of Oxazepam-Exposed Mice. Veterinary Pathology 48:4, pages 875-884.
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Haishan Li, Tao Chen, John Cottrell & Hongbing Wang. (2009) Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary Hepatocytes. Drug Metabolism and Disposition 37:5, pages 1098-1106.
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