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Research Article

Oxidative Stress as a Mechanism of Valproic Acid-Associated Hepatotoxicity

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Pages 627-639 | Published online: 09 Oct 2008

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Ertan Celik, Sevim Tunali, Selda Gezginci-Oktayoglu, Sehnaz Bolkent, Ayse Can & Refiye Yanardag. (2021) Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis. Toxicology Mechanisms and Methods 31:8, pages 600-608.
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Olaniyi Solomon Ola & Kayode Ezekiel Adewole. (2021) Anticlastogenic and hepatoprotective effects of Kolaviron on sodium valproate-induced oxidative toxicity in Wistar rats. Egyptian Journal of Basic and Applied Sciences 8:1, pages 167-179.
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Vijay Gayam, Amrendra Kumar Mandal, Mazin Khalid, Binav Shrestha, Pavani Garlapati & Mowyad Khalid. (2018) Valproic acid induced acute liver injury resulting in hepatic encephalopathy- a case report and literature review. Journal of Community Hospital Internal Medicine Perspectives 8:5, pages 311-314.
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Iman Jafarian, Mohammad Reza Eskandari, Vida Mashayekhi, Morteza Ahadpour & Mir-Jamal Hosseini. (2013) Toxicity of valproic acid in isolated rat liver mitochondria. Toxicology Mechanisms and Methods 23:8, pages 617-623.
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David E Amacher. (2012) The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 8:3, pages 335-347.
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Hartmut Jaeschke, Mitchell R. McGill & Anup Ramachandran. (2012) Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity. Drug Metabolism Reviews 44:1, pages 88-106.
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Claudia V Pereira, Sashi Nadanaciva, Paulo J Oliveira & Yvonne Will. (2012) The contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo . Expert Opinion on Drug Metabolism & Toxicology 8:2, pages 219-237.
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