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Research Article

Mucoadhesive Dosage form of Lidocaine Hydrochloride: I. Mucoadhesive and Physicochemical Characterization

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Pages 855-864 | Published online: 26 Sep 2008

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Aseel Abu-Rumman, Rana Abu-Huwaij & Rania Hamed. (2022) Development and in vitro appraisal of Soluplus® and/or Carbopol® 971 buccoadhesive patches releasing atorvastatin. The Journal of Adhesion 98:7, pages 915-933.
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Sana Hanif, Rai Muhammad Sarfraz, Muhammad Ali Syed, Asif Mahmood, Muhammad Usman Minhas & Muhammad Irfan. (2021) Development and optimization of tibezonium iodide and lignocaine hydrochloride containing novel mucoadhesive buccal tablets: a pharmacokinetic investigation among healthy humans. Drug Development and Industrial Pharmacy 47:8, pages 1209-1222.
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Daniele Ribeiro de Araújo, Lígia Nunes de Morais Ribeiro & Eneida de Paula. (2019) Lipid-based carriers for the delivery of local anesthetics. Expert Opinion on Drug Delivery 16:7, pages 701-714.
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Therese Klemetsrud, Anna-Lena Kjøniksen, Marianne Hiorth, Jette Jacobsen & Gro Smistad. (2018) Polymer coated liposomes for use in the oral cavity – a study of the in vitro toxicity, effect on cell permeability and interaction with mucin. Journal of Liposome Research 28:1, pages 62-73.
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Michelle Franz-Montan, Lígia Nunes de Morais Ribeiro, Maria Cristina Volpato, Cintia Maria Saia Cereda, Francisco Carlos Groppo, Giovana Randomille Tofoli, Daniele Ribeiro de Araújo, Patrizia Santi, Cristina Padula & Eneida de Paula. (2017) Recent advances and perspectives in topical oral anesthesia. Expert Opinion on Drug Delivery 14:5, pages 673-684.
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Rachna Kumria, Anroop B. Nair & Bandar E. Al-Dhubiab. (2014) Loratidine buccal films for allergic rhinitis: development and evaluation. Drug Development and Industrial Pharmacy 40:5, pages 625-631.
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Yasser El-Malah & Sami Nazzal. (2013) “Real-time” disintegration analysis and D-optimal experimental design for the optimization of diclofenac sodium fast-dissolving films. Pharmaceutical Development and Technology 18:6, pages 1355-1360.
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Martina Jakovljević Kovač, Maja Molnar, Tomislav Jednačak, Tomislav Balić & Jurica Novak. (2023) Design, preparation and characterization of 7-hydroxy-4-methylcoumarin-based deep eutectic solvents. New Journal of Chemistry 47:35, pages 16484-16493.
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Dorota Wójcik-Pastuszka, Karolina Stawicka, Andrzej Dryś & Witold Musiał. (2023) Influence of HA on Release Process of Anionic and Cationic API Incorporated into Hydrophilic Gel. International Journal of Molecular Sciences 24:6, pages 5606.
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Sana Hanif, Rai Muhammad Sarfraz, Muhammad Ali Syed, Asif Mahmood & Zahid Hussain. (2022) Smart mucoadhesive buccal chitosan/ HPMC scaffold for sore throat: In vitro, ex vivo and pharmacokinetic profiling in humans. Journal of Drug Delivery Science and Technology 71, pages 103271.
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Tingting Zhu, Xixi Yu, Xin Yi, Xiaoli Guo, Longhao Li, Yuanping Hao & Wanchun Wang. (2022) Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia. Pharmaceutics 14:4, pages 686.
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Batool Mahdi, Rana Abu‐Huwaij & Iqbal Al‐khateeb. (2021) Development of topical patches releasing allicin using garlic extract. Journal of Cosmetic Dermatology 21:1, pages 396-402.
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Rania Hamed, Ahmad Farhan, Rana Abu-Huwaij, Nouf N. Mahmoud & Areej Kamal. (2019) Lidocaine Microemulsion-Laden Organogels as Lipid-Based Systems for Topical Delivery. Journal of Pharmaceutical Innovation 15:4, pages 521-534.
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May Thu Soe, Thaned Pongjanyakul, Ekapol Limpongsa & Napaphak Jaipakdee. (2020) Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug. Carbohydrate Polymers 245, pages 116556.
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Soma Sengupta, Shounak Sarkhel & Biswajit Mukherjee. (2020) Development and Characterization of Triple Action-Dental Mold. Current Dentistry 2:1, pages 60-69.
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Jingjunjiao Long, Alaitz Etxabide Etxeberria, Ashveen V. Nand, Craig R. Bunt, Sudip Ray & Ali Seyfoddin. (2019) A 3D printed chitosan-pectin hydrogel wound dressing for lidocaine hydrochloride delivery. Materials Science and Engineering: C 104, pages 109873.
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Suchipha Wannaphatchaiyong, Jirapornchai Suksaeree, Rungtiwa Waiprib, Apassorn Kaewpuang, Wiriya Saelee & Wiwat Pichayakorn. (2019) Gelatin/Gelatinized Sago Starch Biomembranes as a Drug Delivery System Using Rubber Latex as Plasticizer. Journal of Polymers and the Environment 27:11, pages 2380-2394.
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Deepak Sharma, Amit Sharma & Rajeev Garg. (2019) Preparation, Physicochemical Evaluation and Characterization of Mucoadhesive Buccal Gels Impregnated with Benzydamine Hydrochloride for the Effective Treatment of Aphthous Stomatitis: Effect of Different Grades of HPMC Polymer on In vitro and Ex vivo Performance. Drug Delivery Letters 9:4, pages 341-357.
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Shereen M. Assaf, Al Sayyed Alarabi Sallam & Aya M. Ghanem. (2019) Design and evaluation of transdermal delivery system containing tamsulosin hydrochloride. Journal of Drug Delivery Science and Technology 51, pages 524-534.
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Xu Liu, Xiangyu Ma, Eucharist Kun, Xiaodi Guo, Zhongxue Yu & Feng Zhang. (2018) Influence of lidocaine forms (salt vs. freebase) on properties of drug–eudragit® L100-55 extrudates prepared by reactive melt extrusion. International Journal of Pharmaceutics 547:1-2, pages 291-302.
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Renê Oliveira do Couto, Camila Cubayachi, Paulo Linares Calefi, Renata Fonseca Vianna Lopez, Vinícius Pedrazzi, Cristiane Masetto De Gaitani & Osvaldo de Freitas. (2017) Combining amino amide salts in mucoadhesive films enhances needle-free buccal anesthesia in adults. Journal of Controlled Release 266, pages 205-215.
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You Jin Jang, Jin Ho Lee, Tae Beom Seo & Se Heang Oh. (2017) Lidocaine/multivalent ion complex as a potential strategy for prolonged local anesthesia. European Journal of Pharmaceutics and Biopharmaceutics 115, pages 113-121.
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Maren Preis, Christina Woertz, Katharina Schneider, Jennifer Kukawka, Jens Broscheit, Norbert Roewer & Jörg Breitkreutz. (2014) Design and evaluation of bilayered buccal film preparations for local administration of lidocaine hydrochloride. European Journal of Pharmaceutics and Biopharmaceutics 86:3, pages 552-561.
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Rewathi R. Shiledar, Amol A. Tagalpallewar & Chandrakant R. Kokare. (2014) Formulation and in vitro evaluation of xanthan gum-based bilayered mucoadhesive buccal patches of zolmitriptan. Carbohydrate Polymers 101, pages 1234-1242.
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Christina Woertz, Maren Preis, Jörg Breitkreutz & Peter Kleinebudde. (2013) Assessment of test methods evaluating mucoadhesive polymers and dosage forms: An overview. European Journal of Pharmaceutics and Biopharmaceutics 85:3, pages 843-853.
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Jaya Gopal Meher, Magdaline Tarai, Narayan P. Yadav, Ansuman Patnaik, Paresh Mishra & Kuldeep Singh Yadav. (2013) Development and characterization of cellulose–polymethacrylate mucoadhesive film for buccal delivery of carvedilol. Carbohydrate Polymers 96:1, pages 172-180.
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Cristina Cavallari, Adamo Fini & Francesca Ospitali. (2013) Mucoadhesive multiparticulate patch for the intrabuccal controlled delivery of lidocaine. European Journal of Pharmaceutics and Biopharmaceutics 83:3, pages 405-414.
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Edward A. Shipton. (2012) New Formulations of Local Anaesthetics—Part I. Anesthesiology Research and Practice 2012, pages 1-11.
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Bhavesh D. Kevadiya, Ghanshyam V. Joshi, Haresh M. Mody & Hari C. Bajaj. (2011) Biopolymer–clay hydrogel composites as drug carrier: Host–guest intercalation and in vitro release study of lidocaine hydrochloride. Applied Clay Science 52:4, pages 364-367.
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Rana Abu-Huwaij, Rana M. Obaidat, Kamal Sweidan & Yusuf Al-Hiari. (2010) Formulation and In Vitro Evaluation of Xanthan Gum or Carbopol 934-Based Mucoadhesive Patches, Loaded with Nicotine. AAPS PharmSciTech 12:1, pages 21-27.
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Javier O. Morales & Jason T. McConville. (2011) Manufacture and characterization of mucoadhesive buccal films. European Journal of Pharmaceutics and Biopharmaceutics 77:2, pages 187-199.
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João F. Pinto. (2010) Site-specific drug delivery systems within the gastro-intestinal tract: From the mouth to the colon. International Journal of Pharmaceutics 395:1-2, pages 44-52.
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Soma Ghosh, Gopa Roy & Biswajit Mukherjee. (2009) Dental Mold: A Novel Formulation to Treat Common Dental Disorders. AAPS PharmSciTech 10:2, pages 692-702.
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