729
Views
55
CrossRef citations to date
0
Altmetric
Research Article

PLGA Nanoparticles for the Oral Delivery of 5-Fluorouracil Using High Pressure Homogenization-Emulsification as the Preparation Method and In Vitro/In Vivo Studies

, , , &
Pages 107-115 | Published online: 25 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Rudra Pangeni, Sang Won Choi, Ok-Cheol Jeon, Youngro Byun & Jin Woo Park. (2016) Multiple nanoemulsion system for an oral combinational delivery of oxaliplatin and 5-fluorouracil: preparation and in vivo evaluation. International Journal of Nanomedicine 11, pages 6379-6399.
Read now
Yu Huang, Yumeng Wei, Hongru Yang, Chao Pi, Hao Liu, Yun Ye & Ling Zhao. (2016) A 5-fluorouracil-loaded floating gastroretentive hollow microsphere: development, pharmacokinetic in rabbits, and biodistribution in tumor-bearing mice. Drug Design, Development and Therapy 10, pages 997-1008.
Read now
Junjie Bian, Zhixiang Yuan, Xiaoliang Chen, Yuan Gao, Chaoqun Xu & Jianyou Shi. (2016) Preparation of surface multiple-coated polylactide acid drug-loaded nanoparticles for intranasal delivery and evaluation on its brain-targeting efficiency. Drug Delivery 23:1, pages 269-276.
Read now
Sheikh Tasnim Jahan & Azita Haddadi. (2015) Investigation and optimization of formulation parameters on preparation of targeted anti-CD205 tailored PLGA nanoparticles. International Journal of Nanomedicine 10, pages 7371-7384.
Read now
Ran Liu, Yonglu Wang, Xueming Li, Wen Bao, Guohua Xia, Wei Chen, Jian Cheng, Yuanlong Xu, Liting Guo & Baoan Chen. (2015) Synthesis and characterization of tumor-targeted copolymer nanocarrier modified by transferrin. Drug Design, Development and Therapy 9, pages 2705-2719.
Read now
Seyed Hossein Mostafavi, Mahdi Aghajani, Amir Amani, Behrad Darvishi, Mona Noori Koopaei, Ali Mahmoud Pashazadeh, Mohamad Shahab Maghazei, Farhad Alvandifar, Iraj Nabipour, Fahimeh Karami, Majid Assadi & Rassoul Dinarvand. (2015) Optimization of paclitaxel-loaded poly (d,l-lactide-co-glycolide-N-p-maleimido benzoic hydrazide) nanoparticles size using artificial neural networks. Pharmaceutical Development and Technology 20:7, pages 845-853.
Read now
Doaa H. Mobarak, Salwa Salah & Seham A. Elkheshen. (2014) Formulation of ciprofloxacin hydrochloride loaded biodegradable nanoparticles: optimization of technique and process variables. Pharmaceutical Development and Technology 19:7, pages 891-900.
Read now
Shishu, Kamalpreet & Manjul Maheshwari. (2012) Development and evaluation of novel microemulsion based oral formulations of 5-fluorouracil using non-everted rat intestine sac model. Drug Development and Industrial Pharmacy 38:3, pages 294-300.
Read now

Articles from other publishers (46)

Gamaleldin I. Harisa, Saleh A. Alanazi, Mohamed M. Badran, Abdelrahman Y. Sherif, Saeed A. AlQahtani & Fars K. Alanazi. (2023) Tyloxapol and nanoliposomes induce selective delivery of 5‐fluorouracil into hepatic tissues via VLDL/LDL‐mediated pathway. European Journal of Lipid Science and Technology.
Crossref
Arvind Hariharan & Simon D. Tran. (2023) Localized Drug Delivery Systems: An Update on Treatment Options for Head and Neck Squamous Cell Carcinomas. Pharmaceutics 15:7, pages 1844.
Crossref
Rinki Verma, Varsha Rani & Manoj Kumar. (2023) In-vivo anticancer efficacy of self-targeted methotrexate-loaded polymeric nanoparticles in solid tumor-bearing rat. International Immunopharmacology 119, pages 110147.
Crossref
Moshera Samy, Heba M. Abdallah, Hanem M. Awad & Magdy M. H. Ayoub. (2022) Preparation, Characterization and In vitro Biological activity of 5-Fluorouracil Loaded onto poly (D, L-lactic-co-glycolic acid) Nanoparticles. Polymer Bulletin 80:6, pages 6197-6219.
Crossref
Ahsan Ali, Asadullah Madni, Hassan Shah, Talha Jamshaid, Nasrullah Jan, Safiullah Khan, Muhammad Muzamil Khan & Muhammad Ahmad Mahmood. (2023) Solid lipid-based nanoparticulate system for sustained release and enhanced in-vitro cytotoxic effect of 5-fluorouracil on skin Melanoma and squamous cell carcinoma. PLOS ONE 18:2, pages e0281004.
Crossref
Mengjie Li, Quanyou Guo, Yichen Lin, Hairong Bao & Song Miao. (2023) Recent Progress in Microencapsulation of Active Peptides—Wall Material, Preparation, and Application: A Review. Foods 12:4, pages 896.
Crossref
Leander Corrie, Monica Gulati, Bhupinder Kapoor, Jon Adams, Kamal Dua, Sachin Kumar Singh & Harish Dureja. 2023. Handbook of Oncobiology: From Basic to Clinical Sciences. Handbook of Oncobiology: From Basic to Clinical Sciences 1 26 .
Hend Mohamed Anter, Reham Mokhtar Aman, Ahmed Abdelaziz Shaaban, Irhan Ibrahim Abu Hashim & Mahasen Mohamed Meshali. (2022) Propitious maneuvering for delivery of the phytopharmaceutical “apocynin” to induced fulminant hepatitis in BALB/c mice: In vitro and in vivo assessments. International Journal of Pharmaceutics 626, pages 122165.
Crossref
Hui Ao, Likang Lu, Manzhen Li, Meihua Han, Yifei Guo & Xiangtao Wang. (2022) Enhanced Solubility and Antitumor Activity of Annona Squamosa Seed Oil via Nanoparticles Stabilized with TPGS: Preparation and In Vitro and In Vivo Evaluation. Pharmaceutics 14:6, pages 1232.
Crossref
Aditya N. Pandey, Kuldeep Rajpoot & Sunil K. Jain. (2021) 5-Fluorouracil Loaded Orally Administered WGA-decorated Poly(lacticco- glycolic Acid) Nanoparticles for Treatment of Colorectal Cancer: In Vivo Evaluation. Current Nanomedicine 11:1, pages 51-60.
Crossref
Preksha Vinchhi, Jayvadan K. Patel & Mayur M. Patel. 2021. Emerging Technologies for Nanoparticle Manufacturing. Emerging Technologies for Nanoparticle Manufacturing 263 285 .
Xia-Lin Dai, Chao Wu, Jin-Hui Li, Lian-Chao Liu, Xin He, Tong-Bu Lu & Jia-Mei Chen. (2020) Modulating the solubility and pharmacokinetic properties of 5-fluorouracil via cocrystallization . CrystEngComm 22:21, pages 3670-3682.
Crossref
Ting Li, Da Teng, Ruoyu Mao, Ya Hao, Xiumin Wang & Jianhua Wang. (2019) Recent progress in preparation and agricultural application of microcapsules. Journal of Biomedical Materials Research Part A 107:10, pages 2371-2385.
Crossref
Ketabat, Pundir, Mohabatpour, Lobanova, Koutsopoulos, Hadjiiski, Chen, Papagerakis & Papagerakis. (2019) Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives. Pharmaceutics 11:7, pages 302.
Crossref
Nazimuddin Chishti, Satveer Jagwani, Dinesh Dhamecha, Sunil Jalalpure & Mohamed Hassan Dehghan. (2019) Preparation, Optimization, and In Vivo Evaluation of Nanoparticle-Based Formulation for Pulmonary Delivery of Anticancer Drug. Medicina 55:6, pages 294.
Crossref
Manoj Kumar Gautam, Mousumi Besan, Divya Pandit, Sanjay Mandal & Renu Chadha. (2019) Cocrystal of 5-Fluorouracil: Characterization and Evaluation of Biopharmaceutical Parameters. AAPS PharmSciTech 20:4.
Crossref
Deepak Kumar & Samanwita Pal. (2019) Solution dynamics of 5-fluorouracil entrapped in poly lactic-co-glycolic acid (PLGA) microsphere-A study with 1D selective NMR methods. Magnetic Resonance in Chemistry 57:2-3, pages 118-128.
Crossref
Guanyu Chen, Darren Svirskis, Weiyue Lu, Man Ying, Yuan Huang & Jingyuan Wen. (2018) N -trimethyl chitosan nanoparticles and CSKSSDYQC peptide: N -trimethyl chitosan conjugates enhance the oral bioavailability of gemcitabine to treat breast cancer. Journal of Controlled Release 277, pages 142-153.
Crossref
Nattawut Leelakanok, Sean Geary & Aliasger Salem. (2018) Fabrication and Use of Poly(d,l-lactide-co-glycolide)-Based Formulations Designed for Modified Release of 5-Fluorouracil. Journal of Pharmaceutical Sciences 107:2, pages 513-528.
Crossref
Rajan Jog & Diane J. Burgess. 2018. Fundamentals of Nanoparticles. Fundamentals of Nanoparticles 279 342 .
Xiangyu Ma & Robert O. WilliamsIIIIII. (2017) Polymeric nanomedicines for poorly soluble drugs in oral delivery systems: an update. Journal of Pharmaceutical Investigation 48:1, pages 61-75.
Crossref
Aurelio Salerno, Concepción Domingo & Javier Saurina. (2017) PCL foamed scaffolds loaded with 5-fluorouracil anti-cancer drug prepared by an eco-friendly route. Materials Science and Engineering: C 75, pages 1191-1197.
Crossref
Essam Tawfik, Maqusood Ahamed, Abdulaziz Almalik, Mohammad Alfaqeeh & Aws Alshamsan. (2017) Prolonged exposure of colon cancer cells to 5-fluorouracil nanoparticles improves its anticancer activity. Saudi Pharmaceutical Journal 25:2, pages 206-213.
Crossref
Brahmeshwar Mishra & Sundeep Chaurasia. (2017) Design of novel chemotherapeutic delivery systems for colon cancer therapy based on oral polymeric nanoparticles. Therapeutic Delivery 8:1, pages 29-47.
Crossref
Ceyda T. Sengel-Turk, Mehmet Gumustas, Bengi Uslu & Sibel A. Ozkan. 2017. Nano- and Microscale Drug Delivery Systems. Nano- and Microscale Drug Delivery Systems 165 195 .
Yusuf Haggag, Yasser Abdel-Wahab, Opeolu Ojo, Mohamed Osman, Sanaa El-Gizawy, Mohamed El-Tanani, Ahmed Faheem & Paul McCarron. (2016) Preparation and in vivo evaluation of insulin-loaded biodegradable nanoparticles prepared from diblock copolymers of PLGA and PEG. International Journal of Pharmaceutics 499:1-2, pages 236-246.
Crossref
Faiyaz Shakeel, Fars K. Alanazi, Mohammad Raish, Nazrul Haq, Awwad A. Radwan & Ibrahim A. Alsarra. (2015) Pharmacokinetic and in vitro cytotoxic evaluation of cholesterol-rich nanoemulsion of cholesteryl-succinyl-5-fluorouracil. Journal of Molecular Liquids 211, pages 164-168.
Crossref
S.A. Gârea, A.I. Mihai, A. Ghebaur, C. Nistor & A. Sârbu. (2015) Porous clay heterostructures: A new inorganic host for 5-fluorouracil encapsulation. International Journal of Pharmaceutics 491:1-2, pages 299-309.
Crossref
Mohammad Tariq, Md. Aftab Alam, Anu T. Singh, Zeenat Iqbal, Amulya K. Panda & Sushama Talegaonkar. (2015) Biodegradable polymeric nanoparticles for oral delivery of epirubicin: In vitro, ex vivo, and in vivo investigations. Colloids and Surfaces B: Biointerfaces 128, pages 448-456.
Crossref
Kamla Pathak & Smita Raghuvanshi. (2015) Oral Bioavailability: Issues and Solutions via Nanoformulations. Clinical Pharmacokinetics 54:4, pages 325-357.
Crossref
Van-Minh Le, Jing-Jing Wang, Ming Yuan, The-Long Nguyen, Gui-Fang Yin, Yuan-Hong Zheng, Wei-Bin Shi, Mei-Dong Lang, Lei-Ming Xu & Jian-Wen Liu. (2015) An investigation of antitumor efficiency of novel sustained and targeted 5-fluorouracil nanoparticles. European Journal of Medicinal Chemistry 92, pages 882-889.
Crossref
M. Subudhi, Ankit Jain, Ashish Jain, Pooja Hurkat, Satish Shilpi, Arvind Gulbake & Sanjay Jain. (2015) Eudragit S100 Coated Citrus Pectin Nanoparticles for Colon Targeting of 5-Fluorouracil. Materials 8:3, pages 832-849.
Crossref
Sneha S Dhapare & Alekha K Dash. (2015) Effect of differential drying techniques on PLGA nanoparticles containing hydrophobic and hydrophilic anticancer agents. Therapeutic Delivery 6:1, pages 27-39.
Crossref
Qinqin Cheng, Hongdong Shi, Hai Huang, Zhiting Cao, Jun Wang & Yangzhong Liu. (2015) Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles. Chemical Communications 51:99, pages 17536-17539.
Crossref
Meghavi N. Patel, Sushant Lakkadwala, Mohamed S. Majrad, Elisha R. Injeti, Steven M. Gollmer, Zahoor A. Shah, Sai Hanuman Sagar Boddu & Jerry Nesamony. (2014) Characterization and Evaluation of 5-Fluorouracil-Loaded Solid Lipid Nanoparticles Prepared via a Temperature-Modulated Solidification Technique. AAPS PharmSciTech 15:6, pages 1498-1508.
Crossref
Garima Joshi, Abhinesh Kumar & Krutika Sawant. (2014) Enhanced bioavailability and intestinal uptake of Gemcitabine HCl loaded PLGA nanoparticles after oral delivery. European Journal of Pharmaceutical Sciences 60, pages 80-89.
Crossref
Milind Alai & Wen Jen Lin. (2014) Novel Lansoprazole-Loaded Nanoparticles for the Treatment of Gastric Acid Secretion-Related Ulcers: In Vitro and In Vivo Pharmacokinetic Pharmacodynamic Evaluation. The AAPS Journal 16:3, pages 361-372.
Crossref
F.K. Alanazi, N. Haq, A.A. Radwan, I.A. Alsarra & F. Shakeel. (2014) Potential of lipid nanoemulsion for drug delivery of cholesteryl-hexahydrophthaloyl-5-fluorouracil. Journal of Drug Delivery Science and Technology 24:5, pages 459-463.
Crossref
S.A. Abdel Halim & S. Salah. (2014) Development of nanoparticulate formulations for ocular delivery of prednisolone acetate: preparation and characterization. Journal of Drug Delivery Science and Technology 24:2, pages 159-165.
Crossref
Kaushik Thanki, Rahul P. Gangwal, Abhay T. Sangamwar & Sanyog Jain. (2013) Oral delivery of anticancer drugs: Challenges and opportunities. Journal of Controlled Release 170:1, pages 15-40.
Crossref
Yichao Wang, Puwang Li, Zheng Peng, Feng Hua She & Ling Xue Kong. (2013) Microencapsulation of nanoparticles with enhanced drug loading for pH-sensitive oral drug delivery for the treatment of colon cancer. Journal of Applied Polymer Science 129:2, pages 714-720.
Crossref
Zhun Zhou & Dennis Bong. (2012) Small-Molecule/Polymer Recognition Triggers Aqueous-Phase Assembly and Encapsulation. Langmuir 29:1, pages 144-150.
Crossref
RANJITH K AVERINENI, GOPAL V SHAVI, ARAVIND K GURRAM, PRAFUL B DESHPANDE, KARTHIK ARUMUGAM, NASEER MALIYAKKAL, SREENIVASA R MEKA & UDUPA NAYANABHIRAMA. (2012) PLGA 50:50 nanoparticles of paclitaxel: Development, in vitro anti-tumor activity in BT-549 cells and in vivo evaluation. Bulletin of Materials Science 35:3, pages 319-326.
Crossref
Michael C. FlickingerI.A. Rasiah, N. Parlane, K. Grage, R. Palanisamy, A.C. Jahns, J.A. Atwood & B. H.A. Rehm. 2009. Encyclopedia of Industrial Biotechnology. Encyclopedia of Industrial Biotechnology 1 96 .
C. Santos, M.A. Martins, R.-P. Franke, M.M. Almeida & M.E.V. Costa. (2009) Calcium phosphate granules for use as a 5-Fluorouracil delivery system. Ceramics International 35:4, pages 1587-1594.
Crossref
José Arias. (2008) Novel Strategies to Improve the Anticancer Action of 5-Fluorouracil by Using Drug Delivery Systems. Molecules 13:10, pages 2340-2369.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.