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Invited Review

Nucleolar Adaptation in Human Cancer

, Ph.D. & , Ph.D.
Pages 599-608 | Published online: 11 Jun 2009

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Yinfeng Xu, Yaosen Wu, Lei Wang, Chuying Qian, Qian Wang & Wei Wan. (2020) Identification of curcumin as a novel natural inhibitor of rDNA transcription. Cell Cycle 19:23, pages 3362-3374.
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Yandong Zhang, Anthony J. Saporita & Jason D. Weber. (2013) p19ARF and RasV12 Offer Opposing Regulation of DHX33 Translation To Dictate Tumor Cell Fate. Molecular and Cellular Biology 33:8, pages 1594-1607.
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Amy E. Siebert, Amelita L. Sanchez, Sumi Dinda & Virinder K. Moudgil. (2011) Effects of Estrogen Metabolite 2-Methoxyestradiol on Tumor Suppressor Protein p53 and Proliferation of Breast Cancer Cells. Systems Biology in Reproductive Medicine 57:6, pages 279-287.
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Yandong Zhang, Jason T. Forys, Alexander P. Miceli, Abigail S. Gwinn & Jason D. Weber. (2011) Identification of DHX33 as a Mediator of rRNA Synthesis and Cell Growth. Molecular and Cellular Biology 31:23, pages 4676-4691.
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Leonard B. Maggi$suffix/text()$suffix/text(), Michael Kuchenruether, David Y. A. Dadey, Rachel M. Schwope, Silvia Grisendi, R. Reid Townsend, Pier Paolo Pandolfi & Jason D. Weber. (2008) Nucleophosmin Serves as a Rate-Limiting Nuclear Export Chaperone for the Mammalian Ribosome. Molecular and Cellular Biology 28:23, pages 7050-7065.
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Anthony J. Apicelli, Leonard B. Maggi$suffix/text()$suffix/text(), Angela C. Hirbe, Alexander P. Miceli, Mary E. Olanich, Crystal L. Schulte-Winkeler, Anthony J. Saporita, Michael Kuchenreuther, José Sanchez, Katherine Weilbaecher & Jason D. Weber. (2008) A Non-Tumor Suppressor Role for Basal p19ARF in Maintaining Nucleolar Structure and Function. Molecular and Cellular Biology 28:3, pages 1068-1080.
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Yue Yu, Leonard B. Maggi$suffix/text()$suffix/text(), Suzanne N. Brady, Anthony J. Apicelli, Mu-Shui Dai, Hua Lu & Jason D. Weber. (2006) Nucleophosmin Is Essential for Ribosomal Protein L5 Nuclear Export. Molecular and Cellular Biology 26:10, pages 3798-3809.
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F Scala, E Brighenti, M Govoni, E Imbrogno, F Fornari, D Treré, L Montanaro & M Derenzini. (2015) Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate. Oncogene 35:8, pages 977-989.
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Le Xuan Truong Nguyen, Aparna Raval, Jacqueline S. Garcia & Beverly S. Mitchell. (2015) Regulation of Ribosomal Gene Expression in Cancer. Journal of Cellular Physiology 230:6, pages 1181-1188.
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Corey L. Smith, Timothy D. Matheson, Daniel J. Trombly, Xiaoming Sun, Eric Campeau, Xuemei Han, John R. YatesIIIIII & Paul D. Kaufman. (2014) A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli. Molecular Biology of the Cell 25:18, pages 2866-2881.
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Denis Drygin, Sean E. O’Brien, Ross D. Hannan, Grant A. McArthur & Daniel D. Von Hoff. (2014) Targeting the nucleolus for cancer-specific activation of p53. Drug Discovery Today 19:3, pages 259-265.
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Mathieu D. Jacob, Timothy E. Audas, James Uniacke, Laura Trinkle-Mulcahy & Stephen Lee. (2013) Environmental cues induce a long noncoding RNA–dependent remodeling of the nucleolus. Molecular Biology of the Cell 24:18, pages 2943-2953.
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Mohamed Kodiha & Ursula Stochaj. 2013. Proteins of the Nucleolus. Proteins of the Nucleolus 149 172 .
Stefan Hübner & Athina Efthymiadis. (2012) Recent progress in histochemistry and cell biology. Histochemistry and Cell Biology 137:4, pages 403-457.
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Lorenzo Montanaro, Davide Treré & Massimo Derenzini. (2012) Changes in ribosome biogenesis may induce cancer by down-regulating the cell tumor suppressor potential. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1825:1, pages 101-110.
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Mohamed Kodiha, Piotr Bański & Ursula Stochaj. (2011) Computer-based fluorescence quantification: a novel approach to study nucleolar biology. BMC Cell Biology 12:1.
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Dale Corkery, Kendra L. Cann & Graham Dellaire. 2011. Cellular Domains. Cellular Domains 393 413 .
H D Kim, T-S Kim & J Kim. (2011) Aberrant ribosome biogenesis activates c-Myc and ASK1 pathways resulting in p53-dependent G1 arrest. Oncogene 30:30, pages 3317-3327.
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Kendra L. Cann, Sui Huang & Graham Dellaire. 2011. Advances in Nuclear Architecture. Advances in Nuclear Architecture 1 58 .
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Ramzey Abujarour, Jem Efe & Sheng Ding. (2010) Genome-wide gain-of-function screen identifies novel regulators of pluripotency. Stem Cells 28:9, pages 1487-1497.
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Stefano Rossetti, André T. Hoogeveen, Joseph Esposito & Nicoletta Sacchi. (2010) Loss of MTG16a (CBFA2T3), a novel rDNA repressor, leads to increased ribogenesis and disruption of breast acinar morphogenesis. Journal of Cellular and Molecular Medicine 14:6a, pages 1358-1370.
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Eva BártováAndrea Harničarová HorákováRadka UhlířováIvan RaškaGabriela GaliováDarya OrlovaStanislav Kozubek. (2009) Structure and Epigenetics of Nucleoli in Comparison With Non-nucleolar Compartments. Journal of Histochemistry & Cytochemistry 58:5, pages 391-403.
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Denis DryginWilliam G. RiceIngrid Grummt. (2010) The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer. Annual Review of Pharmacology and Toxicology 50:1, pages 131-156.
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Jason C. Paik, Bing Wang, Kang Liu, Jerry K. Lue & Weei-Chin Lin. (2010) Regulation of E2F1-induced Apoptosis by the Nucleolar Protein RRP1B. Journal of Biological Chemistry 285:9, pages 6348-6363.
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Emily F. Freed, Franziska Bleichert, Laura M. Dutca & Susan J. Baserga. (2010) When ribosomes go bad: diseases of ribosome biogenesis. Molecular BioSystems 6:3, pages 481.
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Denis Drygin, Adam Siddiqui-Jain, Sean O'Brien, Michael Schwaebe, Amy Lin, Josh Bliesath, Caroline B. Ho, Chris Proffitt, Katy Trent, Jeffrey P. Whitten, John K. C. Lim, Daniel Von Hoff, Kenna Anderes & William G. Rice. (2009) Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis. Cancer Research 69:19, pages 7653-7661.
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D. Moretti, B. Del Bello, E. Cosci, M. Biagioli, C. Miracco & E. Maellaro. (2009) Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions. Carcinogenesis 30:6, pages 960-967.
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Qi Shen, Xingzheng Zheng, Michael A. McNutt, Lizhao Guang, Ying Sun, Jiaochen Wang, Yilei Gong, Lin Hou & Bo Zhang. (2009) NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules. Experimental Cell Research 315:10, pages 1653-1667.
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Hui Li, Beibei Wang, Acong Yang, Rui Lu, Weicheng Wang, Yang Zhou, Guilai Shi, Sung Won Kwon, Yingming Zhao & Ying Jin. (2009) Ly-1 Antibody Reactive Clone Is an Important Nucleolar Protein for Control of Self-Renewal and Differentiation in Embryonic Stem Cells. Stem Cells 27:6, pages 1244-1254.
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Ilaria Russo, Anna Oksman & Daniel E. Goldberg. (2009) Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus. Molecular Microbiology 72:1, pages 229-245.
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Sébastien Storck, Marc Thiry & Philippe Bouvet. (2009) Conditional knockout of nucleolin in DT40 cells reveals the functional redundancy of its RNA-binding domains. Biology of the Cell 101:3, pages 153-171.
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Peter C. McKeown & Peter J. Shaw. (2008) Chromatin: linking structure and function in the nucleolus. Chromosoma 118:1, pages 11-23.
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Leticia Fröhlich Archangelo, Philipp A. Greif, Michael Hölzel, Thomas Harasim, Elisabeth Kremmer, Gerhard K.H. Przemeck, Dirk Eick, Aniruddha Jayant Deshpande, Christian Buske, Martin Hrabé de Angelis, Sara Teresinha Olalla Saad & Stefan K. Bohlander. (2008) The CALM and CALM/AF10 interactor CATS is a marker for proliferation. Molecular Oncology 2:4, pages 356-367.
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Mohammed Abdullahel Amin, Sachihiro Matsunaga, Susumu Uchiyama & Kiichi Fukui. (2008) Nucleophosmin is required for chromosome congression, proper mitotic spindle formation, and kinetochore-microtubule attachment in HeLa cells. FEBS Letters 582:27, pages 3839-3844.
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Lorenzo Montanaro, Davide Treré & Massimo Derenzini. (2008) Nucleolus, Ribosomes, and Cancer. The American Journal of Pathology 173:2, pages 301-310.
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Masaya Miyoshi, Tetsuya Okajima, Tsukasa Matsuda, Michiko N. FukudaDaita Nadano. (2007) Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. Biochemical Journal 404:3, pages 373-381.
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Maho Ishikawa, Fumiharu Yagasaki, Daisuke Okamura, Tomoya Maeda, Yuichi Sugahara, Itsuro Jinnai & Masami Bessho. (2007) A novel gene, ANKRD28 on 3p25, is fused with NUP98 on 11p15 in a cryptic 3-way translocation of t(3;5;11)(p25;q35;p15) in an adult patient with myelodysplastic syndrome/acute myelogenous leukemia. International Journal of Hematology 86:3, pages 238-245.
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Corey L. Pelletier, Leonard B. MaggiJr.Jr., Suzanne N. Brady, Danielle K. Scheidenhelm, David H. Gutmann & Jason D. Weber. (2007) TSC1 Sets the Rate of Ribosome Export and Protein Synthesis through Nucleophosmin Translation. Cancer Research 67:4, pages 1609-1617.
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