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PEDIATRIC ONCOLOGY

Metronomic Dosing of Chemotherapy: Applications in Pediatric Oncology

, Ph.D., , N.D. & , M.D.
Pages 432-443 | Published online: 11 Jun 2009

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Melissa Taylor, Jochen Rössler, Birgit Geoerger, Gilles Vassal & Françoise Farace. (2010) New anti-angiogenic strategies in pediatric solid malignancies: agents and biomarkers of a near future. Expert Opinion on Investigational Drugs 19:7, pages 859-874.
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David P Samuel, Patrick Y Wen & Mark W Kieran. (2009) Antiangiogenic (metronomic) chemotherapy for brain tumors: current and future perspectives. Expert Opinion on Investigational Drugs 18:7, pages 973-983.
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Per Albertsson, Bo Lennernäs & Klas Norrby. (2008) Dose effects of continuous vinblastine chemotherapy on mammalian angiogenesis mediated by VEGF-A. Acta Oncologica 47:2, pages 293-300.
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Articles from other publishers (21)

Raja Pramanik & Sameer Bakhshi. (2019) Metronomic therapy in pediatric oncology: A snapshot. Pediatric Blood & Cancer 66:9.
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William H. Isacoff, Howard A. Reber, Rudolph Bedford, William Hoos, Lola Rahib, Alexander Upfill-Brown, Timothy Donahue & O. Joe Hines. (2018) Low-Dose Continuous 5-Fluorouracil Combined with Leucovorin, nab-Paclitaxel, Oxaliplatin, and Bevacizumab for Patients with Advanced Pancreatic Cancer: A Retrospective Analysis. Targeted Oncology 13:4, pages 461-468.
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Andreza A. Senerchia, Carla Renata Macedo, Sima Ferman, Marcelo Scopinaro, Walter Cacciavillano, Erica Boldrini, Vera Lúcia Lins de Moraes, Guadalupe Rey, Claudia T. de Oliveira, Luis Castillo, Maria Tereza Almeida, Maria Luisa Borsato, Eduardo Lima, Daniel Lustosa, José Henrique Barreto, Tatiana El‐Jaick, Simone Aguiar, Algemir Brunetto, Lauro Greggiani, Hugo Cogo‐Moreira, Alvaro Atallah & Antonio Sergio Petrilli. (2016) Results of a randomized, prospective clinical trial evaluating metronomic chemotherapy in nonmetastatic patients with high‐grade, operable osteosarcomas of the extremities: A report from the Latin A merican Group of Osteosarcoma Treatment . Cancer 123:6, pages 1003-1010.
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El Bairi Khalid, EL-Meghawry EL-Kenawy Ayman, Heshu Rahman, Guaadaoui Abdelkarim & Agnieszka Najda. (2016) Natural products against cancer angiogenesis. Tumor Biology 37:11, pages 14513-14536.
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Giacomo Gotti, Veronica Biassoni, Elisabetta Schiavello, Filippo Spreafico, Manila Antonelli, Giuseppina Calareso, Emilia Pecori, Lorenza Gandola & Maura Massimino. (2015) A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib. Child's Nervous System 31:9, pages 1621-1623.
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Narges Baluch, Sushil Kumar, Reza Mokhtari & Sylvain Baruchel. 2014. Metronomic Chemotherapy. Metronomic Chemotherapy 157 172 .
Sushil Kumar, Reza Bayat Mokhtari, Indhira Dias Oliveira, Syed Islam, Silvia Regina Caminada Toledo, Herman Yeger & Sylvain Baruchel. (2013) Tumor Dynamics in Response to Antiangiogenic Therapy with Oral Metronomic Topotecan and Pazopanib in Neuroblastoma Xenografts. Translational Oncology 6:4, pages 493-503.
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T. N. Leach, M. O. Childress, S. N. Greene, A. S. Mohamed, G. E. Moore, D. R. Schrempp, S. R. Lahrman & D. W. Knapp. (2011) Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer. Veterinary and Comparative Oncology 10:2, pages 102-112.
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Chau-Ting Yeh, Hui-Chin Chen, Chang-Mu Sung, Cheng-Lung Hsu, Chen-Chun Lin, Kuang-Tse Pan, Jeng-Hwei Tseng & Chien-Fu Hung. (2011) Retrospective comparison between a regular and a split-dose protocol of 5-fluorouracil, cisplatin, and mitoxantrone for the treatment of far advanced hepatocellular carcinoma. BMC Cancer 11:1.
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Sushil Kumar, Reza Bayat Mokhtari, Reihaneh Sheikh, Bing Wu, Libo Zhang, Ping Xu, Shan Man, Indhira Dias Oliveira, Herman Yeger, Robert S. Kerbel & Sylvain Baruchel. (2011) Metronomic Oral Topotecan with Pazopanib Is an Active Antiangiogenic Regimen in Mouse Models of Aggressive Pediatric Solid Tumor. Clinical Cancer Research 17:17, pages 5656-5667.
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ÅSA JELLVERT, INGELA FRANCK LISSBRANT, MALIHA EDGREN, ELISABETH ÖVFERHOLM, KARIN BRAIDE, ANN-MARIE EKELUND OLVENMARK, JON KINDBLOM, PER ALBERTSSON & BO LENNERNÄS. (2011) Effective oral combination metronomic chemotherapy with low toxicity for the management of castration-resistant prostate cancer. Experimental and Therapeutic Medicine 2:4, pages 579-584.
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Jeong Won JangSeong Tae ParkJung Hyun KwonChan Ran YouJong Young ChoiChan-Kwon JungSi Hyun BaeSeung Kew Yoon. (2011) Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma. Experimental and Molecular Medicine 43:5, pages 305.
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Petr Chlapek, Martina Redova, Karel Zitterbart, Marketa Hermanova, Jaroslav Sterba & Renata Veselska. (2010) Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: an expression profiling study. Journal of Experimental & Clinical Cancer Research 29:1.
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Benjamin D. Zeitlin, Aaron C. Spalding, Marcia S. Campos, Naoki Ashimori, Zhihong Dong, Shaomeng Wang, Theodore S. Lawrence & Jacques E. N?r. (2010) Metronomic Small Molecule Inhibitor of Bcl-2 (TW-37) Is Antiangiogenic and Potentiates the Antitumor Effect of Ionizing Radiation. International Journal of Radiation Oncology*Biology*Physics 78:3, pages 879-887.
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Seong Tae Park, Jeong Won Jang, Gi Dae Kim, Joung Ah Park, Wonhee Hur, Hyun Young Woo, Jin Dong Kim, Jeong Hyun Kwon, Chan Ran Yoo, Si Hyun Bae, Jong Young Choi & Seung Kew Yoon. (2009) Beneficial effect of metronomic chemotherapy on tumor suppression and survival in a rat model of hepatocellular carcinoma with liver cirrhosis. Cancer Chemotherapy and Pharmacology 65:6, pages 1029-1037.
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Christine Chordas & Kristen Graham. 2010. Pediatric Oncology Nursing. Pediatric Oncology Nursing 203 232 .
Ajit S. Narang & Divyakant S. Desai. 2009. Pharmaceutical Perspectives of Cancer Therapeutics. Pharmaceutical Perspectives of Cancer Therapeutics 49 92 .
Nicholas J. Bacon, Nicole P. Ehrhart, William S. Dernell, Mary Lafferty & Stephen J. Withrow. (2008) Use of alternating administration of carboplatin and doxorubicin in dogs with microscopic metastases after amputation for appendicular osteosarcoma: 50 cases (1999–2006). Journal of the American Veterinary Medical Association 232:10, pages 1504-1510.
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Faruk Tas, Derya Duranyildiz, Hilal O. Soydinc, Irfan Cicin, Meltem Selam, Kazim Uygun, Rian Disci, Vildan Yasasever & Erkan Topuz. (2007) Effect of maximum-tolerated doses and low-dose metronomic chemotherapy on serum vascular endothelial growth factor and thrombospondin-1 levels in patients with advanced nonsmall cell lung cancer. Cancer Chemotherapy and Pharmacology 61:5, pages 721-725.
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Soledad Gallego Melcón. (2008) Incorporating new therapies in the treatment of paediatric solid tumours. Clinical and Translational Oncology 10:1, pages 1-2.
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Diana Stempak, Janet Gammon, Jacqueline Halton, Albert Moghrabi, Gideon Koren & Sylvain Baruchel. (2006) A Pilot Pharmacokinetic and Antiangiogenic Biomarker Study of Celecoxib and Low-dose Metronomic Vinblastine or Cyclophosphamide in Pediatric Recurrent Solid Tumors. Journal of Pediatric Hematology/Oncology 28:11, pages 720-728.
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