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Original Articles

Formulating Drug Delivery Systems by Spray Drying

Pages 433-446 | Published online: 06 Feb 2007

Keep up to date with the latest research on this topic with citation updates for this article.

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I. B. Gumus, E. Kahraman, N. Erdol-Aydin & G. Nasun-Saygili. (2023) Drug loading of tannic acid crosslinked hydroxyapatite/gelatin composites via spray dryer and kinetic studies. Drying Technology 0:0, pages 1-15.
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Rajasekar Krishnamoorthy & Raja Balakrishnan. (2023) Experimental investigation on volumetric heat transfer coefficient during intermittent spray drying of mannitol solution. Drying Technology 41:12, pages 2012-2026.
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Sumit Kumar Saha, Amita Joshi, Romi Singh & Kiran Dubey. (2023) Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations. Pharmaceutical Development and Technology 28:7, pages 678-696.
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Bhaskar N. Thorat, Ayantika Sett & A. S. Mujumdar. (2022) Drying of Vaccines and Biomolecules. Drying Technology 40:3, pages 461-483.
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Sagar Pardeshi, Mahesh More, Pritam Patil, Chandrakantsing Pardeshi, Prashant Deshmukh, Arun Mujumdar & Jitendra Naik. (2021) A meticulous overview on drying-based (spray-, freeze-, and spray-freeze) particle engineering approaches for pharmaceutical technologies. Drying Technology 39:11, pages 1447-1491.
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Yue Su, Bolun Zhang, Ruowei Sun, Wenfang Liu, Qubo Zhu, Xun Zhang, Rongrong Wang & Chuanpin Chen. (2021) PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application. Drug Delivery 28:1, pages 1397-1418.
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Amir Rezvankhah, Zahra Emam-Djomeh & Gholamreza Askari. (2020) Encapsulation and delivery of bioactive compounds using spray and freeze-drying techniques: A review. Drying Technology 38:1-2, pages 235-258.
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Bisera Jurišić Dukovski, Lea Mrak, Katarzyna Winnicka, Marta Szekalska, Marina Juretić, Jelena Filipović-Grčić, Ivan Pepić, Jasmina Lovrić & Anita Hafner. (2019) Spray-dried nanoparticle-loaded pectin microspheres for dexamethasone nasal delivery. Drying Technology 37:15, pages 1915-1925.
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Anastasiya V. Murueva, Anna M. Shershneva, Kseniya V. Abanina, Svetlana V. Prudnikova & Ekaterina I. Shishatskaya. (2019) Development and characterization of ceftriaxone-loaded P3HB-based microparticles for drug delivery. Drying Technology 37:9, pages 1131-1142.
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Anna Shershneva, Anastasiya Murueva, Elena Nikolaeva, Ekaterina Shishatskaya & Tatiana Volova. (2018) Novel spray-dried PHA microparticles for antitumor drug release. Drying Technology 36:11, pages 1387-1398.
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Majid Hamzehloo, Jahangir Karimi, Narges Eghbali, Mohsen Mirzakhani, Kioumars Aghapoor & Hossein Reza Darabi. (2017) A new blend of polymeric encapsulation of azithromycin by spray-drying with a pH responsive in drug release. Drying Technology 35:14, pages 1688-1695.
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Jayshri Kailas Madagul, Durgesh Rameshlal Parakh, Rachana S. Kumar & Rakesh Ramesh Abhang. (2017) Formulation and evaluation of solid self-microemulsifying drug delivery system of chlorthalidone by spray drying technology. Drying Technology 35:12, pages 1433-1449.
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Moritz Beck-Broichsitter, Adam Bohr, Leticia Aragão-Santiago, Andreas Klingl & Thomas Kissel. (2017) Formulation and process considerations for the design of sildenafil-loaded polymeric microparticles by vibrational spray-drying. Pharmaceutical Development and Technology 22:6, pages 691-698.
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Marco Antonio Salazar-Miranda, Francisco Cruz-Sosa, María Eva Rodríguez-Huezo, Ruben Jiménez-Alvarado & César Pérez-Alonso. (2016) Microencapsulation of chlorthalidone by spray-drying of double emulsion and melt granulation coating. Drying Technology 34:9, pages 1118-1128.
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Durgesh Rameshlal Parakh, Moreshwar Pandharinath Patil, Neelam Laxman Dashputre & Sanjay Jayprakash Kshirsagar. (2016) Development of self-microemulsifying drug delivery system of mebendazole by spray drying technology: Characterization, in vitro and in vivo evaluation. Drying Technology 34:9, pages 1023-1042.
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Snehlata Dasharath Dharankar, Durgesh Rameshlal Parakh, Moreshwar Pandharinath Patil & Sanjay Jayprakash Kshirsagar. (2015) Spray-Dried Solid Self-Emulsifying Delivery System of Ketoprofen: Development and Its Characterization. Drying Technology 33:15-16, pages 2002-2011.
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Sabah Mounir, Tamara Allaf, Ismail Sulaiman & Karim Allaf. (2015) Instant Controlled Pressure Drop (DIC) Texturing of Heat-Sensitive Spray-Dried Powders: Phenomenological Modeling and Optimization. Drying Technology 33:13, pages 1524-1533.
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T. L. Durli, F. A. Dimer, M. C. Fontana, A. R. Pohlmann, R. C. R. Beck & S. S. Guterres. (2014) Innovative approach to produce submicron drug particles by vibrational atomization spray drying: influence of the type of solvent and surfactant. Drug Development and Industrial Pharmacy 40:8, pages 1011-1020.
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DiegoF. Cortés-Rojas & WanderleyP. Oliveira. (2012) Physicochemical Properties of Phytopharmaceutical Preparations as Affected by Drying Methods and Carriers. Drying Technology 30:9, pages 921-934.
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Arshad Khan, D. Sen, P. Kothalkar, B.K. Sapra, S. Mazumder & Y.S. Mayya. (2012) Design and Performance of a Laboratory Spray Dryer to Realize Evaporation-Induced Self-Assembly of Nanoparticles. Drying Technology 30:6, pages 679-686.
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V.M. Silva, L.E. Kurozawa, K.J. Park & M.D. Hubinger. (2012) Influence of Carrier Agents on the Physicochemical Properties of Mussel Protein Hydrolysate Powder. Drying Technology 30:6, pages 653-663.
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CláudiaR. F. Souza & WanderleyP. Oliveira. (2012) Microencapsulation of Ketoprofen in Blends of Acrylic Resins by Spray Drying. Drying Technology 30:3, pages 263-275.
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Ana Catarina Lima, Praveen Sher & João F Mano. (2012) Production methodologies of polymeric and hydrogel particles for drug delivery applications. Expert Opinion on Drug Delivery 9:2, pages 231-248.
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Marjana Dürrigl, Maja Lusina Kregar, Anita Hafner, Maja Šegvić Klarić & Jelena Filipović-Grčić. (2011) Mupirocin calcium microencapsulation via spray drying: feed solvent influence on microparticle properties, stability and antimicrobial activity. Drug Development and Industrial Pharmacy 37:12, pages 1402-1414.
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Ramesh Murugesan & Valérie Orsat. (2011) Spray Drying of Elderberry (Sambucus nigra L.) Juice to Maintain Its Phenolic Content. Drying Technology 29:14, pages 1729-1740.
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Agnieszka Pilarska, Ewa Markiewicz, Filip Ciesielczyk & Teofil Jesionowski. (2011) The Influence of Spray Drying on the Dispersive and Physicochemical Properties of Magnesium Oxide. Drying Technology 29:10, pages 1210-1218.
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Wei-Qiang Tang, Di-Cai Li, Yang-Xiao Lv & Jian-Guo Jiang. (2011) Concentration and Drying of Tea Polyphenols Extracted from Green Tea Using Molecular Distillation and Spray Drying. Drying Technology 29:5, pages 584-590.
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Xinsheng Fang, Jianhua Wang, Hongying Zhou, Xingkai Jiang, Guohui Zhang & Da Zhang. (2011) Multiple Response Optimization of Spray-Drying Process for the Preparation of Salvianolic Acids Microparticles and Evaluation for Potential Application in Dry Powder Inhalation. Drying Technology 29:5, pages 573-583.
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Banu Koc, Melike Sakin Yilmazer, Pınar Balkır & Figen Kaymak Ertekin. (2010) Spray Drying of Yogurt: Optimization of Process Conditions for Improving Viability and Other Quality Attributes. Drying Technology 28:4, pages 495-507.
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R. R. Araújo, C. C. C. Teixeira & L. A. P. Freitas. (2010) The Preparation of Ternary Solid Dispersions of an Herbal Drug via Spray Drying of Liquid Feed. Drying Technology 28:3, pages 412-421.
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Ching-Piao Liu & Shan-Da Liu. (2009) Low-Temperature Spray Drying for the Microencapsulation of the Fungus Beauveria bassiana . Drying Technology 27:6, pages 747-753.
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B. Riveros, J. Ferrer & R. Bórquez. (2009) Spray Drying of a Vaginal Probiotic Strain of Lactobacillus acidophilus . Drying Technology 27:1, pages 123-132.
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LucianaP. Fernandes, IzabelC. C. Turatti, NorbertoP. Lopes, JoseaneC. Ferreira, ReginaC. Candido & WanderleyP. Oliveira. (2008) Volatile Retention and Antifungal Properties of Spray-Dried Microparticles of Lippia sidoides Essential Oil. Drying Technology 26:12, pages 1534-1542.
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Bao-Guo Li, Yan Zhang, Wu-Jie Zhang & Ze-zhao Hua. (2008) Supercritical CO2 Spray Drying of Ethyl Cellulose (EC) for Preparing Microparticles. Drying Technology 26:4, pages 464-469.
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Sang-Hyun Pyo, Jin-Suk Cho, Ho-Joon Choi & Byung-Hee Han. (2007) Preparation and Dissolution Profiles of the Amorphous, Dihydrated Crystalline, and Anhydrous Crystalline Forms of Paclitaxel. Drying Technology 25:10, pages 1759-1767.
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K.S. Raghuram Gannena, D. Chaitanya Kumar Rao, Durbar Roy, Aloke Kumar & Saptarshi Basu. (2022) Bubble dynamics and atomization in evaporating polymeric droplets. Journal of Fluid Mechanics 951.
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Marina Paiva Abuçafy, Regina Celia Galvao Frem, Giulia Polinario, Fernando Rogerio Pavan, Heng Zhao, Angelika Mielcarek, Cedric Boissiere, Christian Serre & Leila Aparecida Chiavacci. (2022) MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System. International Journal of Molecular Sciences 23:14, pages 7670.
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Tyson Chasse, Stephen L. Conway, Gerald D. Danzer, Lili Feng, Anthony M. Leone, Michael McNevin, John Smoliga, Paul A. Stroud & Holger van Lishaut. (2022) Industry White Paper: Contemporary Opportunities and Challenges in Characterizing Crystallinity in Amorphous Solid Dispersions. Journal of Pharmaceutical Sciences 111:6, pages 1543-1555.
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Victoria Nahum & Abraham J. Domb. (2022) Solid lipid microspheres decorated nanoparticles as drug carriers. International Journal of Pharmaceutics 621, pages 121797.
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Jin Seok Park, Jinseong Yun, Byoungjin Chun & Hyun Wook Jung. (2022) Mild stratification in drying films of colloidal mixtures. Soft Matter 18:18, pages 3487-3497.
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Mina Heidari, Jacob Golenser & Andreas Greiner. (2022) Meeting the Needs of a Potent Carrier for Malaria Treatment: Encapsulation of Artemisone in Poly(lactide‐ co ‐glycolide) Micro‐ and Nanoparticles . Particle & Particle Systems Characterization 39:5.
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Avani Khristi, Lalit L. Jha & Abhay Dharamsi. (2021) SCREENING OF BIODEGRADABLE POLYMER AND MOST EFFECTIVE VARIABLES IN PREPARATION OF ESSENTIAL OIL LOADED NANO PARTICLES FOR PULMONARY DELIVERY USING TAGUCHI DESIGN. INDIAN DRUGS 58:02, pages 68-75.
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Tânia Marante, Cláudia Viegas, Inês Duarte, Ana S. Macedo & Pedro Fonte. (2020) An Overview on Spray-Drying of Protein-Loaded Polymeric Nanoparticles for Dry Powder Inhalation. Pharmaceutics 12:11, pages 1032.
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Jiayue Guo, Peilong Li, Lingyan Kong & Baojun Xu. (2020) Microencapsulation of curcumin by spray drying and freeze drying. LWT 132, pages 109892.
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S.E. Lapuk, T.A. Mukhametzyanov, C. Schick & A.V. Gerasimov. (2020) Kinetic stability of amorphous dipyridamole: A fast scanning calorimetry investigation. International Journal of Pharmaceutics 574, pages 118890.
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Ticiano G. do Nascimento, Gerson D. P. Redondo, Carla T. de Araújo Abreu, Valdemir C. Silva, Giselda M. Lira, Luciano A. Meireles Grillo, Marta Maria da Conceição, Johnnatan D. Freitas, Jonas S. Souza, João X. Araújo Júnior & Irinaldo D. Basílio-Júnior. (2019) Modified release microcapsules loaded with red propolis extract obtained by spray-dryer technique. Journal of Thermal Analysis and Calorimetry 138:5, pages 3559-3569.
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Carlos-A. Bernal Rodriguez, Valquiria Linck Bassani, Leonardo Castellanos, Freddy A. Ramos Rodríguez & Yolima Baena. (2019) Development of an oral control release system from Physalis peruviana L. fruits extract based on the co-spray-drying method. Powder Technology 354, pages 676-688.
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Burak Akdeniz & Emre Bukusoglu. (2019) Liquid Crystal Templates Combined with Photolithography Enable Synthesis of Chiral Twisted Polymeric Microparticles. Macromolecular Rapid Communications, pages 1900160.
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Xiaoyan Zhao, Hongkai Liu, Xiaowei Zhang, Guixiang Zhang & Haitao Zhu. (2018) Astaxanthin from Haematococcus pluvialis Microencapsulated by Spray Drying: Characterization and Antioxidant Activity . Journal of the American Oil Chemists' Society 96:1, pages 93-102.
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Amna Javed, Muhammad Imran, Nazir Ahmad & Abdullah Ijaz Hussain. (2018) Fatty acids characterization and oxidative stability of spray dried designer egg powder. Lipids in Health and Disease 17:1.
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Sunil Kumar Boda, Xiaoran Li & Jingwei Xie. (2018) Electrospraying an enabling technology for pharmaceutical and biomedical applications: A review. Journal of Aerosol Science 125, pages 164-181.
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David Walsh, Dolores R. Serrano, Zelalem Ayenew Worku, Atif M. Madi, Peter O'Connell, Brendan Twamley & Anne Marie Healy. (2018) Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion. International Journal of Pharmaceutics 551:1-2, pages 241-256.
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Zhen Chen, Kuan Yang, Chengbin Huang, Alan Zhu, Lian Yu & Feng Qian. (2018) Surface Enrichment and Depletion of the Active Ingredient in Spray Dried Amorphous Solid Dispersions. Pharmaceutical Research 35:2.
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Noriko Ogawa, Tomoki Hiramatsu, Ryohei Suzuki, Ryohei Okamoto, Kohei Shibagaki, Kosuke Fujita, Chisato Takahashi, Yoshiaki Kawashima & Hiromitsu Yamamoto. (2018) Improvement in the water solubility of drugs with a solid dispersion system by spray drying and hot-melt extrusion with using the amphiphilic polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer and d-mannitol. European Journal of Pharmaceutical Sciences 111, pages 205-214.
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L. Medina-Torres, F. Calderas, D. M. Nuñez Ramírez, E. E. Herrera-Valencia, M. J. Bernad Bernad & O. Manero. (2017) Spray drying egg using either maltodextrin or nopal mucilage as stabilizer agents. Journal of Food Science and Technology 54:13, pages 4427-4435.
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Sarah Brousseau, Zimeng Wang, Sweta K. Gupta & Samantha A. Meenach. (2017) Development of Aerosol Phospholipid Microparticles for the Treatment of Pulmonary Hypertension. AAPS PharmSciTech 18:8, pages 3247-3257.
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Aziz Maleki, Helene Kettiger, Aurélie Schoubben, Jessica M. Rosenholm, Valeria Ambrogi & Mehrdad Hamidi. (2017) Mesoporous silica materials: From physico-chemical properties to enhanced dissolution of poorly water-soluble drugs. Journal of Controlled Release 262, pages 329-347.
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Maximilian L. Eggersdorfer, Vitaly Koren, Elad Stolovicki, Esther Amstad & David A. Weitz. (2017) Rapid Production of Submicron Drug Substance Particles by Supersonic Spray Drying. Crystal Growth & Design 17:4, pages 2046-2053.
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Jingyuan Wen, Craig Bunt & Xudong Yao. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 715 731 .
Stephan Drusch, Yvonne Serfert, Frederic Tamm, Hanna Kastner & Karin Schwarz. 2016. Process-Spray. Process-Spray 53 87 .
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D.M. Cano-Higuita, C.R. Malacrida & V.R.N. Telis. (2015) Stability of Curcumin Microencapsulated by Spray and Freeze Drying in Binary and Ternary Matrices of Maltodextrin, Gum Arabic and Modified Starch. Journal of Food Processing and Preservation 39:6, pages 2049-2060.
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Moritz Beck-Broichsitter, Boris Strehlow & Thomas Kissel. (2015) Direct fractionation of spray-dried polymeric microparticles by inertial impaction. Powder Technology 286, pages 311-317.
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Angela Abruzzo, Teresa Cerchiara, Federica Bigucci, Maria Caterina Gallucci & Barbara Luppi. (2015) Mucoadhesive Buccal Tablets Based on Chitosan/Gelatin Microparticles for Delivery of Propranolol Hydrochloride. Journal of Pharmaceutical Sciences 104:12, pages 4365-4372.
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Diana Maria Cano-Higuita, Harvey Alexander Villa Vélez & Vania Regina Nicoletti Telis. (2015) MICROENCAPSULATION OF TURMERIC OLEORESIN IN BINARY AND TERNARY BLENDS OF GUM ARABIC, MALTODEXTRIN AND MODIFIED STARCH. Ciência e Agrotecnologia 39:2, pages 173-182.
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Adam Bohr, Feng Wan, Jakob Kristensen, Mark Dyas, Eleanor Stride, Stefania Baldursdottír, Mohan Edirisinghe & Mingshi Yang. (2015) Pharmaceutical microparticle engineering with electrospraying: the role of mixed solvent systems in particle formation and characteristics. Journal of Materials Science: Materials in Medicine 26:2.
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Diego Francisco Cortés-Rojas, Cláudia Regina Fernandes Souza & Wanderley Pereira Oliveira. (2015) Optimization of spray drying conditions for production of Bidens pilosa L. dried extract. Chemical Engineering Research and Design 93, pages 366-376.
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Katia P. Seremeta, María I. Reyes Tur, Sandra Martínez Pérez, Christian Höcht, Carlos Taira, Orestes D. López Hernández & Alejandro Sosnik. (2014) Spray-dried didanosine-loaded polymeric particles for enhanced oral bioavailability. Colloids and Surfaces B: Biointerfaces 123, pages 515-523.
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Carlos Filipe C. JoãoJoana Marta VasconcelosJorge Carvalho SilvaJoão Paulo Borges. (2014) An Overview of Inverted Colloidal Crystal Systems for Tissue Engineering. Tissue Engineering Part B: Reviews 20:5, pages 437-454.
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Rajesh Parikh & Sonali Dalwadi. (2014) Preparation and characterization of controlled release poly-ɛ-caprolactone microparticles of isoniazid for drug delivery through pulmonary route. Powder Technology 264, pages 158-165.
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Jeong Hoon Byeon, Aditya Kulkarni, Hee-Kwon Kim, David H. Thompson & Jeffrey T. Roberts. (2014) Photoassisted One-Step Aerosol Fabrication of Zwitterionic Chitosan Nanoparticles. Biomacromolecules 15:6, pages 2320-2325.
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Rajesh Parikh, Sonali Dalwadi, Pooja Aboti & Leena Patel. (2014) Inhaled microparticles of antitubercular antibiotic for in vitro and in vivo alveolar macrophage targeting and activation of phagocytosis. The Journal of Antibiotics 67:5, pages 387-394.
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Jeong Hoon Byeon, Hee-Kwon Kim, David H. Thompson & Jeffrey T. Roberts. (2014) Aerosol-Based Fabrication of Modified Chitosans and Their Application for Gene Transfection. ACS Applied Materials & Interfaces 6:7, pages 4597-4602.
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Peter Walzel & Takeshi Furuta. 2014. Modern Drying Technology. Modern Drying Technology 231 294 .
M. Faustini, C. Boissière, L. Nicole & D. Grosso. (2013) From Chemical Solutions to Inorganic Nanostructured Materials: A Journey into Evaporation-Driven Processes. Chemistry of Materials 26:1, pages 709-723.
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Ligeng Yin & Marc A. Hillmyer. (2013) Preparation and Performance of Hydroxypropyl Methylcellulose Esters of Substituted Succinates for in Vitro Supersaturation of a Crystalline Hydrophobic Drug . Molecular Pharmaceutics 11:1, pages 175-185.
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Valéry Tchanque Kemtchou, Maria Schäfer & Urs Alexander Peuker. 2014. Upscaling of Bio-Nano-Processes. Upscaling of Bio-Nano-Processes 97 116 .
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