Formulating Drug Delivery Systems by Spray Drying

REFERENCES

• Masters , K. Spray Drying Handbook ; Halsted Press : New York , 1985 .
   Google Scholar
• Gibson , S.G. How to optimize your spray dryer's performance . Powder and Bulk Engineering 2001 , 4 , 31 – 53 .
   Google Scholar
• Maa , Y.F. ; Constantino , H.R. ; Nguten , P.A. ; Hsu , C.C. The effect of operating and formulation variables on the morphology of spray-dried protein particles . Pharmaceutical Development and Technology 1997 , 2 , 213 – 223 .
   PubMed Web of Science ®Google Scholar
• Broadhead , J. ; Rouan , S.K.E. ; Rhodes , C.T. The spray drying of pharmaceuticals . Drug Development and Industrial Pharmacy 1992 , 18 ( 11–12 ), 1169 – 1206 .
   Web of Science ®Google Scholar
• Ré , M.I. ; Messias , L.S. ; Schettini , H. The influence of the liquid properties and the atomizing conditions on the physical characteristics of the spray-dried ferrous sulfate microparticles . Paper presented at the annual International Drying Symposium , August 22–25 , 2004 , in Campinas , Brazil .
   Google Scholar
• Shahidi , F. ; Han , X.Q. Encapsulation of food ingredients . Critical Reviews in Food Science and Nutrition 1993 , 33 , 501 – 547 .
   PubMed Web of Science ®Google Scholar
• Gouin , S. Microencapsulation: industrial appraisal of existing technologies and trends . Trends in Food Science & Technology 2004 , 15 , 330 – 347 .
   Web of Science ®Google Scholar
• King , C.J. Spray drying food liquid and the retention of volatiles . Chemical Engineering Progress 1990 , 86 , 33 – 39 .
   Web of Science ®Google Scholar
• Ré , M.I. Microencapsulation by spray drying . Drying Technology 1998 , 16 , 1195 – 1236 .
   Web of Science ®Google Scholar
• Pérez-Alonso , C. ; Báez-González , J.G. ; Beristain , C.I. ; Vernon-Carter , E.J. ; Vizcarra-Mendoza , M.G. Estimation of the activation energy of carbohydrate polymers blends as selection criteria for their use as wall material for spray-dried microcapsules . Carbohydrate Polymers 2003 , 53 ( 2 ), 197 – 203 .
   Web of Science ®Google Scholar
• Pedroza-Islas , R. ; Vernon-Carter , E.J. ; Durán-Dominguez , C. ; Trejo-Martínez , S. Using biopolymer blends for shrimp feedstuff microencapsulation . I. Microcapsule particle size, morphology and microstructure. Food Research International 1999 , 32 ( 5 ), 367 – 374 .
   Google Scholar
• Rosenberg , M. ; Sheu , T.Y. Microencapsulation of volatiles by spray-drying in whey protein-based wall systems . International Dairy Journal 1996 , 6 , 273 – 284 .
   Web of Science ®Google Scholar
• Diosady , L.L. ; Alberti , J.O. ; Mannar , M.G.V. Microencapsulation for iodine stability in salt fortified with ferrous fumarate and potassium iodide . Food Research International 2002 , 35 ( 7 ), 635 – 642 .
   Web of Science ®Google Scholar
• Favaro-Trindade , C.S. ; Grosso , C.R.F. Microencapsulation of Lacidophilus (La-05) and B. lactis (Bb-12) and evaluation of their survival at the pH values of the stomach and in bile . Journal of Microencapsulation 2002 , 19 , 485 – 494 .
   PubMed Web of Science ®Google Scholar
• Di Martino , P. ; Scoppa , M. ; Joiris , E. ; Palmieri , G. F.; Andres, C.; Pourcelot, Y.; Martelli, S . The spray drying of acetalzolamide as method to modify crystal properties and to improve compression behaviour. International Journal of Pharmaceutics 2001 , 213 , 209 – 221 .
   Google Scholar
• Berggren , J. ; Frenning , G. ; Alderborn , G. Compression behaviour and tablet-forming ability of spray-dried amorphous composite particles . European Journal of Pharmaceutical Sciences 2004 , 22 , 191 – 200 .
   PubMed Web of Science ®Google Scholar
• Palmieri , G.F. ; Wehrlé , P. ; Stamm , A. Evaluation of spray drying as a method to prepare microparticles for controlled drug release. Drug Development and Industrial Pharmacy, 1994, 20 (18), 2859–2879.
   Web of Science ®Google Scholar
• Fernandes , C.M. ; Vieira , M.T. ; Veiga , F.J.B. Physicochemical characterization and in vitro dissolution behavior of nicardipine-cyclodextrins inclusion compounds . European Journal of Pharmaceutical Sciences 2002 , 15 , 79 – 88 .
   PubMed Web of Science ®Google Scholar
• Cerchiara , T. ; Luppi , B. ; Bigucci , F. ; Zecchi , V. Effect of chitosan on progesterone release from hydroxypropyl-β-cyclodextrin complexes . International Journal of Pharmaceutics 2003 , 258 , 209 – 215 .
   PubMed Web of Science ®Google Scholar
• Koester , L.S. ; Xavier , C.R. ; Mayorga , P. ; Bassani , V.L. Influence of β-cyclodextrin complexation on carbamazepine release from hydroxypropyl methylcellulose matrix tablets . European Journal of Pharmaceutics and Biopharmaceutics 2003 , 55 ( 1 ), 85 – 91 .
   PubMed Web of Science ®Google Scholar
• Koester , L.S. ; Bertuol , J.B. ; Groch , K.R. ; Xavier , C.R. ; Moellerke , R. ; Mayorga , P. ; Costa , T.D. ; Bassani , V.L. Bioavailability of carbamazepine: β-cyclodextrin complex in beagle dogs from hydroxypropylmethylcellulose matrix tablets . International Journal of Pharmaceutics 2004 , 22 ( 2–3 ), 201 – 207 .
   Google Scholar
• Takeuchi , H. ; Nagira , S. ; Yamamoto , H. ; Kawashima , Y. Solid dispersion particles of tolbutamide prepared with fine silica particles by the spray-drying method . Powder Technology 2004 , 141 , 187 – 195 .
   Web of Science ®Google Scholar
• Chen , R. ; Tagawa , M. ; Hoshi , N. ; Ogura , T. ; Okamoto , H. ; Danjo , K. Improved dissolution of an insoluble drug using a 4-fluid nozzle spray-drying technique . Chemical & Pharmaceutical Bulletin 2004 , 52 ( 9 ), 1066 – 1070 .
   PubMed Web of Science ®Google Scholar
• Takeuchi , H. ; Nagira , S. ; Yamamoto , H. ; Kawashima , Y. Solid dispersion particles of amorphous indomethacin with fine porous silica particles by using spray-drying method . International Journal of Pharmaceutics 2005 , 293 , 155 – 164 .
   PubMed Web of Science ®Google Scholar
• Di Martino , P. ; Scoppa , M. ; Joiris , E. ; Palmieri , G.F. ; Andres , C. ; Pourcelot , Y. ; Martelli , S. The spray drying of acetalzolamide as method to modify crystal properties and to improve compression behaviour . International Journal of Pharmaceutics 2001 , 213 , 209 – 221 .
   PubMed Web of Science ®Google Scholar
• Takeuchi , H. ; Sasaki , H. ; Niwa , T. ; Hino , T. ; Kawashima , Y. ; Uesugi , K. ; Kayano , M. ; Miyake , Y. Preparation of powdered redispersible vitamin E acetate emulsion by spray-drying technique . Chemical Pharmaceutical Bulletin 1991 , 39 , 1528 – 1531 .
   Web of Science ®Google Scholar
• Takeuchi , H. ; Sasaki , H. ; Niwa , T. ; Hino , T. ; Kawashima , Y. ; Uesugi , K. ; Kayano , M. ; Miyake , Y. Preparation of powdered redispersible vitamin E acetate emulsion by spray-drying technique . Chemical Pharmaceutical Bulletin 1991 , 39 , 1528 – 1531 .
   Web of Science ®Google Scholar
• Dollo , G. ; Corre , P.L. ; Guérin , A. ; Chevanne , F. ; Burgot , J.L. ; Leverge , R. Spray-dried redispersible oil-in-water emulsion to improve oral bioavailability of poorly soluble drugs . European Journal of Pharmaceutical Sciences 2003 , 19 ( 4 ), 273 – 280 .
   PubMed Web of Science ®Google Scholar
• Takeuchi , H. ; Sasaki , H. ; Niwa , T. ; Hino , T. ; Kawashima , Y. ; Uesugi , K. ; Ozawa , H. Design of redispersible dry emulsion as an advanced dosage form of oily drug (vitamin-E nicotinate) by spray-drying technique . Drug Development and Industrial Pharmacy 1992 , 18 , 919 – 937 .
   Web of Science ®Google Scholar
• Christensen , K.L. ; Pedersen , G.P. ; Kristensen , H.G. Preparation of redispersible dry emulsions by spray drying . International Journal of Pharmaceutics 2001 , 212 ( 2 ), 187 – 194 .
   PubMed Web of Science ®Google Scholar
• Hansen , T. ; Holm , P. ; Schultz , K. Process characteristics and compaction of spray-dried emulsions containing a drug dissolved in lipid . International Journal of Pharmaceutics 2004 , 287 ( 1–2 ), 55 – 66 .
   PubMed Web of Science ®Google Scholar
• Turchiuli , C. ; Fuchs , M. ; Bohin , M. ; Cuvelier , M.E. ; Ordonnaud , C. ; Peyrat-Maillard , M.N. ; Dumoulin , E. Oil encapsulation by spray drying and fluidised bed agglomeration . Innovative Food Science and Emerging Technologies 2005 , 6 , 29 – 35 .
   Web of Science ®Google Scholar
• Hansen , T. ; Holm , P. ; Rohde , M. ; Schultz , K. In vivo evaluation of tablets and capsules containing spray-dried o/w-emulsions for oral delivery of poorly soluble drugs . International Journal of Pharmaceutics 2005 , 293 ( 1–2 ), 203 – 211 .
   PubMed Web of Science ®Google Scholar
• Alves , G.P. ; Santana , M.H.A. Phospholipid dry powders produced by spray drying processing: Structural, thermodynamic and physical properties . Powder Technology 2004 , 145 ( 2 ), 139 – 148 .
   Web of Science ®Google Scholar
• Sham , J.O.H. ; Zhang , Y. ; Finlay , W.H. ; Roa , W.H. ; Löbenberg , R. Formulation and characterization of spray-dried powders containing nanoparticlas for aerosol delivery to the lung . International Journal of Pharmaceutics 2004 , 269 , 457 – 467 .
   PubMed Web of Science ®Google Scholar
• Cook , R.O. ; Pannu , R.K. ; Kellaway , I.W. Novel sustained release microspheres for pulmonary drug delivery . Journal of Controlled Release 2005 , 104 ( 1 ), 79 – 90 .
   PubMed Web of Science ®Google Scholar
• Pohlmann , A.R. ; Weiss , V. ; Mertins , O. ; da Silveira , N.P. ; Guterres , S.S. Spray-dried indomethacin-loaded polyester nanocapsules and nanospheres: Development, stability evaluation and nanostructure models . European Journal of Pharmaceutical Sciences 2002 , 16 ( 4–5 ), 305 – 312 .
   PubMed Web of Science ®Google Scholar
• Beck , R.C.R. ; Pohlmann , A.R. ; Guterres , S.S. Nanoparticle-coated microparticles: Preparation and characterization . Journal of Microencapsulation 2004 , 21 ( 5 ), 499 – 512 .
   PubMed Web of Science ®Google Scholar
• Mehnert , W. ; Mäder , K. Solid lipid nanoparticles: Production, characterization and applications . Advanced Drug Delivery Reviews 2001 , 47 , 165 – 196 .
   PubMed Web of Science ®Google Scholar
• Guterres , S.S. ; Pohlmann , A.R. ; Dalla Costa , T. ; Bassani , V. ; Muller , C.R. Processo de secagem de suspens[otilde]es coloidais de nanocápsulas e nanoesferas poliméricas por aspersão . Bazilian Patent Application INPI 9906081-7 , 1999 .
   Google Scholar
• Müller , C.R. ; Bassani , V.L. ; Pohlmann , A.R. ; Michalowski , C.B. ; Petrovick , P.R. ; Guterres , S.S. Preparation and characterization of spray-dried polymeric nanocapsules . Drug Development and Industrial Pharmacy 2000 , 26 ( 3 ), 343 – 347 .
   PubMed Web of Science ®Google Scholar
• Freitas , C. ; Müller , R.H. Spray-drying of solid lipid nanoparticles (SLN(TM)) . European Journal of Pharmaceutics and Biopharmaceutics 1998 , 46 ( 2 ), 145 – 151 .
   PubMed Web of Science ®Google Scholar
• Zigoulli , S. ; Grek , V. ; Barre , G. ; Goffinet , G. ; Thonart , P. ; Zinner , S. Microencapsulation of erythromycin and clarithromycin using a spray drying technique . Journal of Microencapsulation 1999 , 16 ( 5 ), 565 – 571 .
   PubMed Web of Science ®Google Scholar
• Wan , L.C.S. ; Heng , P.W.S. ; Chia , C.G.H. Spray drying as a process for microencapsulation and the effect of different coating polymers . Drug Development in Industrial Pharmacy 1992 , 18 , 997 – 1011 .
   Web of Science ®Google Scholar
• Wan , L.S.C. ; Heng , P.W.S. ; Chia , C.G.H. Sodium carboxymethylcellulose as a coating polymer by spray-dried products . STP Pharma Sciences 1993 , 3 ( 6 ), 448 – 452 .
   Google Scholar
• Billon , A. ; Petit , M. ; Doko , M.B. ; Bataille , B. ; Jacob , M. Effects of cellulose derivatives and additives in the spray-drying preparation of acetaminophen delivery systems . Drug Development and Industrial Pharmacy 1999 , 25 , 1149 – 1156 .
   PubMed Web of Science ®Google Scholar
• Oneda , F. ; Re , M.I. The effect of formulation variables on the dissolution and physical properties of spray-dried microspheres containing organic salts . Powder Technology 2003 , 130 ( 1–3 ), 377 – 384 .
   Web of Science ®Google Scholar
• Esposito , E. ; Cervellati , F. ; Menegatti , E. ; Nastruzzi , C. ; Cortesi , R. Spray dried Eudragit microparticles as encapsulation devices for vitamin C . International Journal of Pharmaceutics 2002 , 242 ( 1–2 ), 329 – 334 .
   PubMed Web of Science ®Google Scholar
• Asada , M. ; Takahashi , H. ; Okamoto , H. ; Tanino , H. ; Danjo , K. Theophylline particle design using chitosan by the spray drying . International Journal of Pharmaceutics 2004 , 270 ( 1–2 ), 167 – 174 .
   PubMed Web of Science ®Google Scholar
• Vidgren , P. ; Vidgren , M. ; Arppe , J. ; Hakuli , T. ; Laine , E.E. ; Paronen , P. In vitro evaluation of spray-dried mucoadhesive microspheres for nasal administration . Drug Development and Industrial Pharmacy 1992 , 18 ( 5 ), 581 – 597 .
   Web of Science ®Google Scholar
• He , P. ; Davis , S.S. ; Illum , L. Chitosan microspheres prepared by spray-drying . International Journal of Pharmaceutics 1999 , 187 ( 1 ), 53 – 65 .
   PubMed Web of Science ®Google Scholar
• Cilurzo , F. ; Selmin , F. ; Minghetti , P. ; Rimoldi , I. ; Demartin , F. ; Montanari , L. Fast-dissolving mucoadhesive microparticulate delivery system containing piroxicam. International Journal of Pharmaceutics 2005, 24, 355–361.
   Google Scholar
• Gavini , E. ; Rassu , G. ; Sanna , V. ; Cossu , M. ; Giunchedi , P. Mucoadhesive microspheres for nasal administration of an antiemetic drug, metoclopramide: In vitro/ex-vivo studies . Journal of Pharmacy and Pharmacology 2005 , 57 ( 3 ), 287 – 294 .
   PubMed Web of Science ®Google Scholar
• Oliveira , B.F. ; Santana , M.H.A. ; Ré , M.I. Spray-dried chitosan microspheres cross-linked with d,l-glyceraldehyde as a potential drug delivery system: Preparation and characterization . Brazilian Journal of Chemical Engineering 2005 , 22 ( 3 ), 353 – 360 .
   Web of Science ®Google Scholar
• Ermis , D. ; Yuksel , A. Preparation of spray-dried microspheres of indomethacin and examination of the effects of coating on dissolution rates . Journal of Microencapsulation 1999 , 16 ( 3 ), 315 – 324 .
   PubMed Web of Science ®Google Scholar
• Dodane , V. ; Vilivalam , V.D. Pharmaceutical applications of chitosan . Pharmaceutical Science & Technology Today 1998 , 1 ( 6 ), 246 – 253 .
   Google Scholar
• Agnihotri , S.A. ; Mallikarjuna , N.N. ; Aminabhavi , T.M. Recent advances on chitosan-based micro- and nanoparticles in drug delivery . Journal of Controlled Release 2004 , 100 ( 1 ), 5 – 28 .
   PubMed Web of Science ®Google Scholar
• Sinha , V.R. ; Singla , A.K. ; Wadhawan , S. ; Kaushik , R. ; Kumria , R. ; Bansal , K. ; Dhawan , S. Chitosan microspheres as a potential carrier for drugs . International Journal of Pharmaceutics 2004 , 274 ( 1–2 ), 1 – 33 .
   PubMed Web of Science ®Google Scholar
• Illum , L. ; Jabbal-Gill , I. ; Hinchcliffe , M. ; Fisher , A.N. ; Davis , S.S. Chitosan as a novel nasal delivery system for vaccines . Advanced Drug Delivery Reviews 2001 , 51 ( 1–3 ), 81 – 96 .
   PubMed Web of Science ®Google Scholar
• Hejazi , R. ; Amiji , M. Chitosan-based gastrointestinal delivery systems . Journal of Controlled Release 2003 , 89 ( 2 ), 151 – 165 .
   PubMed Web of Science ®Google Scholar
• Huang , Y.C. ; Chiang , C.H. ; Yeh , M.K. Optimizing formulation factors in preparing chitosan microparticles by spray-drying method . Journal of Microencapsulation 2003 , 20 ( 2 ), 247 – 260 .
   PubMed Web of Science ®Google Scholar
• Huang , Y.C. ; Yeh , M.K. ; Cheng , S.N. ; Chiang , C.H. The characteristics of betamethasone-loaded chitosan microparticles by spray-drying method . Journal of Microencapsulation 2003 , 20 ( 4 ), 459 – 472 .
   PubMed Web of Science ®Google Scholar
• Shi , X.Y. ; Tan , T.W. Preparation of chitosan/ethylcellulose complex microcapsule and its application in controlled release of vitamin D-2 . Biomaterials 2002 , 23 ( 23 ), 4469 – 4473 .
   PubMed Web of Science ®Google Scholar
• Takahashi , H. ; Chen , R. ; Okamoto , H. ; Danjo , K. Acetaminophen particle design using chitosan and a spray-drying technique . Chemical and Pharmaceutical Bulletin 2005 , 53 ( 1 ), 37 – 41 .
   PubMed Web of Science ®Google Scholar
• Alpar , H.O. ; Somavarapu , S. ; Atuah , K.N. ; Bramwell , V. Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery . Advanced Drug Delivery Reviews 2005 , 57 ( 3 ), 411 – 430 .
   PubMed Web of Science ®Google Scholar
• Kim , C.J. ; Lee , P.I. Synthesis and characterization of suspension-polymerized poly(vynil alcohol) beads with core-shell structure . Journal of Applied Polymer Science 1992 , 46 ( 12 ), 2147 – 2157 .
   Web of Science ®Google Scholar
• Ganza-Gonzalez , A. ; Anguiano-Igea , S. ; Otero-Espinar , F.J. ; Mendez , J.B. Chitosan and chondroitin microspheres for oral-administration controlled release of metoclopramide . European Journal of Pharmaceutics and Biopharmaceutics 1999 , 48 ( 2 ), 149 – 155 .
   PubMed Web of Science ®Google Scholar
• Vandelli , M.A. ; Pifferi , G. ; Seghizzi , R. ; Cameroni , R. Swelling behaviour of gelatin microspheres crosslinked with D,L-glyceraldehyde . The effect of the preparative factors. Pharmacy and Pharmacology Letters 1995 , 5 , 116 – 119 .
   Google Scholar
• Bittner , B. ; Kissel , T. Ultrasonic atomization for spray drying: A versatile technique for the preparation of protein loaded biodegradable microspheres . Journal of Microencapsulation 1999 , 16 , 325 – 341 .
   PubMed Web of Science ®Google Scholar
• Freitas , S. ; Merkle , H.P. ; Gander , B. Ultrasonic atomisation into reduced pressure atmosphere—envisaging aseptic spray-drying for microencapsulation . Journal of Controlled Release 2004 , 95 ( 2 ), 185 – 195 .
   PubMed Web of Science ®Google Scholar
• Amass , W. ; Amass , A. ; Tighe , B. A review of biodegradable polymers: Uses, current development in the synthesis and characterization of biodegradable polyesters, blends of polymers and recent advances in biodegradation studies . Polymer International 1998 , 47 , 89 – 144 .
   Web of Science ®Google Scholar
• Bodmeier , R. ; Chen , H.G. Preparation of biodegradable poly(+/−) lactide microparticles using a spray-drying technique . Journal of Pharmacy and Pharmacology 1988 , 40 ( 11 ), 754 – 757 .
   PubMed Web of Science ®Google Scholar
• Pavanetto , F. ; Genta , I. ; Giunchedi , P. ; Conti , B. Spray-drying as a method for biodegradable microspheres preparation . In Procceedings of 18th International Symposium on Controlled Release of Bioactive Materials , July 8–12 , 1991 , in Amsterdam , The Netherlands .
   Google Scholar
• Conte , U. ; Conti , B. ; Giunchedi , P. ; Maggi , L. Spray dried polylactide microsphere preparation: Influence of the technological parameters . Drug Development and Industrial Pharmacy 1994 , 20 , 235 – 258 .
   Web of Science ®Google Scholar
• Wagenaar , B.W. ; Müller , B.W. Piroxicam release from spray-dried biodegradable microspheres . Biomaterials 1994 , 15 ( 1 ), 49 – 54 .
   PubMed Web of Science ®Google Scholar
• Giunchedi , P. ; Alpar , H.O. ; Conte , U. PDLLA microspheres containing steroids: Spray-drying, o/w and w/o/w emulsifications as preparation methods . Journal of Microencapsulation 1998 , 15 ( 2 ), 185 – 195 .
   PubMed Web of Science ®Google Scholar
• Witschi , C. ; Doelker , E. Peptide degradation during preparation and in vitro release testing of poly(L-lactic acid) and poly(DL-lactic-co-glycolic acid) microparticles . International Journal of Pharmaceutics 1998 , 171 ( 1 ), 1 – 18 .
   Web of Science ®Google Scholar
• Bain , D.F. ; Munday , D.L. ; Smith , A. Solvent influence on spray dried biodegradable microspheres . Journal of Microencapsulation 1999 , 16 ( 4 ), 453 – 474 .
   PubMed Web of Science ®Google Scholar
• O'Hara , P. ; Hickley , A.J. Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: Manufacture and characterization . Pharmaceutical Research 2000 , 17 ( 8 ), 955 – 961 .
   PubMed Web of Science ®Google Scholar
• Baras , B. ; Benoit , M.A. ; Gillard , J. Parameters influencing the antigen release from spray-dried poly(DL-lactide) microparticles . International Journal of Pharmaceutics 2000 , 200 , 133 – 145 .
   PubMed Web of Science ®Google Scholar
• Johansen , P. ; Merkle , H.P. ; Gander , B. Technological considerations related to the up-scaling of protein microencapsulation by spray-drying . European Journal of Pharmaceutics and Biopharmaceutics 2000 , 50 , 413 – 417 .
   PubMed Web of Science ®Google Scholar
• Fu , Y.J. ; Mi , F.L. ; Wong , T.B. ; Shyu , S.S. Characteristic and controlled release of anticancer drug loaded poly (D,L-lactide) microparticles prepared by spray drying technique . Journal of Microencapsulation 2001 , 18 ( 6 ), 733 – 747 .
   PubMed Web of Science ®Google Scholar
• Blanco , M.D. ; Bernardo , M.V. ; Sastre , R.L. ; Olmo , R. ; Muñiz , E. ; Teijón , J.M. Preparation of bupivacaine-loaded poly(epsilon-caprolactone) microspheres by spray drying: Drug release studies and biocompatibility . European Journal of Pharmaceutics and Biopharmaceutics 2003 , 55 ( 2 ), 229 – 236 .
   PubMed Web of Science ®Google Scholar
• Blanco-Prieto , M.J. ; Campanero , M.A. ; Besseghir , K. ; Heimgatner , F. ; Gander , B. Importance of single or blended polymer types for controlled in vitro release and plasma levels of a somatostatin analogue entrapped in PLA/PLGA microspheres . Journal of Controlled Release 2004 , 96 ( 3 ), 437 – 448 .
   PubMed Web of Science ®Google Scholar
• Lin , R.Y. ; Ng , L.S. ; Wang , C.H. In vitro study of anticancer drug doxorubicin in PLGA-based microparticles . Biomaterials 2005 , 26 ( 21 ), 4476 – 4485 .
   PubMed Web of Science ®Google Scholar
• Naraharisetti , P.K. ; Lew , M.D.N. ; Fu , Y.C. ; Lee , D.J. ; Wang , C.H. Gentamicin-loaded discs and microspheres and their modifications: Characterization and in vitro release . Journal of Controlled Release 2005 , 102 ( 2 ), 345 – 359 .
   PubMed Web of Science ®Google Scholar
• Lacasse , F.X. ; Hildgen , P. ; McMullen , J.N. Surface and morphology of spray-dried pegylated PLA microspheres . International Journal of Pharmaceutics 1998 , 174 , 101 – 109 .
   Web of Science ®Google Scholar
• Billon , A. ; Bataille , B. ; Cassanas , G. ; Jacob , M. Development of spray-dried acetaminophen . Microparticles using experimental designs. International Journal of Pharmaceutics 2000 , 203 , 159 – 168 .
   PubMed Web of Science ®Google Scholar
• Prior , S. ; Gamazo , C. ; Irache , J.M. ; Merkle , H.P. ; Gander , B. Gentamicin encapsulation in PLA/PLGA microspheres in view of treating Brucella infections. International Journal of Pharmaceutics 2000, 196 (1), 115–125.
   PubMed Web of Science ®Google Scholar
• Rivera , P.A. ; Martinez-Oharriz , M.C. ; Rubio , M. ; Irache , J.M. ; Espuelas , S. Fluconazole encapsulation in PLGA microspheres by spray-drying . Journal of Microencapsulation 2004 , 21 ( 2 ), 203 – 211 .
   PubMed Web of Science ®Google Scholar
• Wang , F.J. ; Wang , C.H. Etanidazole-loaded microspheres fabricated by spray-drying different poly(lactide/glycolide) polymers: Effects on microsphere properties . Journal of Biomaterials Science-Polymer Edition 2003 , 14 , 157 – 183 .
   PubMed Web of Science ®Google Scholar
• Donbrow , M. Microcapsules and Nanoparticles in Medicine and Pharmacy ; CRC Press : Boca Raton , FL , 1992 .
   Google Scholar
• Baras , B. ; Benoit , M.A. ; Poulain-Godefroy , O. ; Schacht , A.M. ; Capron , A. ; Gillard , J. ; Riveau , G. Vaccine properties of antigens entrapped in microparticles produced by spray drying technique and using various polyester polymers . Vaccine 2000 , 18 , 1495 – 1505 .
   PubMed Web of Science ®Google Scholar
• Ohagan , D.T. ; Jeffery , H. ; Davis , S.S. The preparation and characterization of poly(lactide-co-glycolide) microparticles .3. Microparticle/polymer degradation rates and the in-vitro release of a model protein . International Journal of Pharmaceutics 1994 , 103 ( 1 ), 37 – 45 .
   Web of Science ®Google Scholar
• Sah , H.K. ; Toddywala , R. ; Chien , Y.W. The influence of biodegradable microcapsule formulations on the controlled release of a protein . Journal of Controlled Release 1994 , 30 ( 3 ), 201 – 211 .
   Web of Science ®Google Scholar
• Benoit , M.A. ; Baras , B. ; Gillard , J. Preparation and characterization of protein-loaded poly(epsilon-caprolactone) microparticles for oral vaccine delivery . International Journal of Pharmaceutics 1999 , 184 ( 1 ), 73 – 84 .
   PubMed Web of Science ®Google Scholar
• Giunchedi , P. ; Conti , B. ; Maggi , L. ; Conte , U. Cellulose-acetate butyrate and polycaprolactone for ketoprofen spray-dried microsphere preparation . Journal of Microencapsulation 1994 , 11 ( 4 ), 381 – 393 .
   PubMed Web of Science ®Google Scholar
• Sastre , R.L. ; Blanco , M.D. ; Teijón , C. ; Olmo , R. ; Teijón , J.M. Preparation and characterization of 5-fluorouracil-loaded poly(epsilon-caprolactone) microspheres for drug administration . Drug Development Research 2004 , 63 ( 2 ), 41 – 53 .
   Web of Science ®Google Scholar
• Buntner , B. ; Nowak , M. ; Casperczyk , J. ; Ryba , M. ; Grieb , P. ; Walski , M. ; Dobrzynski , P. ; Bero , M. The application of microspheres from the copolymers of lactide and epsilon-caprolactone to the controlled release of steroids . Journal of Controlled Release 1998 , 56 ( 1–3 ), 159 – 167 .
   PubMed Web of Science ®Google Scholar
• Anderson , A.J. ; Dawes , E.A. Occurence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates . Microbiological Reviews 1990 , 54 ( 4 ), 450 – 472 .
   PubMedGoogle Scholar
• Sendil , D. ; Gürsel , I. ; Wise , D.L. ; Hasirci , V. Antibiotic release from biodegradable PHBV microparticles . Journal of Controlled Release 1999 , 59 ( 2 ), 207 – 217 .
   PubMed Web of Science ®Google Scholar
• Baran , E.T. ; Özer , N. ; Hasirci , V. Poly(hydroxybutyrate-co-hydroxyvalerate) nanocapsules as enzyme carriers for cancer therapy: An in vitro study . Journal of Microencapsulation 2002 , 19 ( 3 ), 363 – 376 .
   PubMed Web of Science ®Google Scholar
• Maia , J.L. ; Santana , M.H.A. ; Ré , M.I. The effect of some processing conditions on the characteristics of biodegradable microspheres obtained by an emulsion solvent evaporation process . Brazilian Journal of Chemical Engineering 2004 , 21 ( 1 ), 1 – 12 .
   Web of Science ®Google Scholar
• Rodrigues , M.F.A. ; Gomez , J.G.C. ; Valentin , H.E. ; Steinbüchel , A. Biosynthesis of poly(3-hydroxybutyric acid-co-3-hydroxy-4-pentenoic acid) from unrelated substrates by Burkholderia sp . Applied Microbiology Biotechnology 1995 , 43 ( 5 ), 880 – 886 .
   Web of Science ®Google Scholar
• Ré , M.I. ; Zuccolo , M. ; Rodrigues , M.F.A. Processo de Produção e produto de Microparticulas Biodegradáveis a partir de Polimeros tais como mono ou Polihidroxialcanoatos em meio Aquoso . Brazilian Patent Application INPI 0203550-2 , 2002 .
   Google Scholar
• Pereira , F. ; Pradella , J.G. ; Ré , M.I. ; Zuccolo , M. ; Rodrigues , M.F.A. Production of the blend Poly-3-Hydroxybutyrate-Poly-3-Hydroxy-4-Pentenoate (P3HB/P3H4PE) by B.cepacia and its application to produce microcapsules for controlled drug release . Paper presented at the annual International Symposium on Biological Polyesters . Münster , Germany , 2002 .
   Google Scholar
• Ré , M.I. ; Ribeiro , A.M.M. ; Zuccolo , M. ; Carter , J.M. ; Netto , C.L.B. Séparation des biopolyméres par digestion enzymatique . Paper presented at the annual Congres Français de Génie de Procedes, in Lyon , France , 1995 .
   Google Scholar
• Ré , M.I. ; Rodrigues , M.F.A. ; Silva , E.S. ; Castro , I.M. ; Simioni , A.R. ; Pelisson , M.M.M. ; Júnior , M.B. ; Tedesco , A.C. New PHB/PHPE microspheres obtained from Burkholderia cepacia as biodegradable drug delivery systems for photodynamic therapy . Paper presented at the XIIth International Workshop on Bioencapsulation, September 24–26, 2004, in Vitoria-Gasteiz, Spain .
   Google Scholar
• Tedesco , A.C. ; Rotta , J.C.G. ; Lunardi , C.N. Synthesis, photophysical and photochemical aspects of phthalocyanines for photodynamic therapy . Current Organic Chemistry 2003 , 7 ( 2 ), 187 – 196 .
   Web of Science ®Google Scholar
• Pandey , R.K. Recent advances in photodynamic therapy . Journal of Porphyrins and Phthalocyanines 2000 , 4 ( 4 ), 368 – 373 .
   Web of Science ®Google Scholar
• Wheeler , B.L. ; Nagasubramanian , G. ; Bard , A.J. ; Schechtman , L.A. ; Dininny , D.R. ; Kenney , M.E. A silicon phthalocyanine and a silicon naphthalocyanine—synthesis, electrochemistry, and electrogenerated chemi-luminescence . Journal of the American Chemical Society 1984 , 106 ( 24 ), 7404 – 7410 .
   Web of Science ®Google Scholar
• Kortesuo , P. ; Ahola , M. ; Kangas , M. ; Jokinen , M. ; Leino , T. ; Vuorilehto , L. ; Laakso , S. ; Kiesvaara , J. ; Yli-Urpo , A. ; Maryola , M. Effect of synthesis parameters of the sol-gel processed spray-dried silica gel microparticles on the release rate of dexmedetomidine . Biomaterials 2002 , 23 ( 13 ), 2795 – 2801 .
   PubMed Web of Science ®Google Scholar
• Santos , E.M. ; Radin , D. ; Ducheyne , P. Sol-gel derived carrier for the controlled release of proteins . Biomaterials 1999 , 20 , 1695 – 1700 .
   PubMed Web of Science ®Google Scholar
• Ahola , M. ; Kortesuo , P. ; Kangasniemi , I. ; Kiesvaara , J. ; Yli-Urpo , A. Silica xerogel carrier material for controlled release of toremifene citrate . International Journal of Pharmaceutics 2000 , 195 ( 1–2 ), 219 – 227 .
   PubMed Web of Science ®Google Scholar
• Roveri , N. ; Morpurgo , M. ; Palazzo , B. ; Parma , B. ; Vivi , L. Silica xerogels as a delivery system for the controlled release of different molecular weight heparins . Analytical and Bioanalalytical Chemistry 2005 , 381 ( 3 ), 601 – 606 .
   PubMed Web of Science ®Google Scholar
• Kortesuo , P. ; Ahola , M. ; Karlsson , S. ; Kangasniemi , I. ; Yli-Urpo , A. ; Kiesvaara , J. Silica xerogel as an implantable carrier for controlled drug delivery—Evaluation of drug distribution and tissue effects after implantation . Biomaterials 2000 , 21 ( 2 ), 193 – 198 .
   PubMed Web of Science ®Google Scholar
• Moura , E.S. ; Vasconcelos , W.L. ; Ré , M.I. Sol-gel processed spray-dried silica microspheres as carrier for cyanocobalamin . Paper presented at the XIIIth International Workshop on Bioencapsulation, June 24–26, 2005, in Kingston , Canada .
   Google Scholar