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Drying Technology
An International Journal
Volume 39, 2021 - Issue 11: Critical reviews of topics in drying science and technology
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Research Article

Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes

Joana T. Pintoa Research Center Pharmaceutical Engineering GmbH, Graz, AustriaView further author information
,
Eva Faulhammera Research Center Pharmaceutical Engineering GmbH, Graz, AustriaView further author information
,
Johanna Dieplingera Research Center Pharmaceutical Engineering GmbH, Graz, Austria;b Institute of Process and Particle Engineering, Graz University of Technology, Graz, AustriaView further author information
,
Michael Deknerc Baxter AG (part of Takeda), Vienna, AustriaView further author information
,
Christian Makertd Maag Germany GmbH, Grossostheim, GermanyView further author information
,
Marco Niederd Maag Germany GmbH, Grossostheim, GermanyView further author information
&
Amrit Paudela Research Center Pharmaceutical Engineering GmbH, Graz, Austria;b Institute of Process and Particle Engineering, Graz University of Technology, Graz, AustriaCorrespondence[email protected]
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Pages 1415-1446 | Received 01 Mar 2021, Accepted 03 Mar 2021, Published online: 15 Apr 2021

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Read on this site (3)

Rajasekar Krishnamoorthy & Raja Balakrishnan. (2023) Experimental investigation on volumetric heat transfer coefficient during intermittent spray drying of mannitol solution. Drying Technology 41:12, pages 2012-2026.
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R. Ohori, T. Akita & C. Yamashita. (2023) Scale-up/tech transfer issues of the lyophilization cycle for biopharmaceuticals and recently emerging technologies and approaches. Drying Technology 41:2, pages 233-250.
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Andrea Gonella, Sylvestre Grizot, Fang Liu, Adolfo López Noriega & Joël Richard. (2022) Long-acting injectable formulation technologies: challenges and opportunities for the delivery of fragile molecules. Expert Opinion on Drug Delivery 19:8, pages 927-944.
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Articles from other publishers (23)

Susana Farinha, João V. Sá, Paulo Roque Lino, Marco Galésio, João Pires, Miguel Ângelo Rodrigues & João Henriques. (2022) Spray Freeze Drying of Biologics: A Review and Applications for Inhalation Delivery. Pharmaceutical Research 40:5, pages 1115-1140.
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Yuncheng Wang, Dipesh Khanal, Adit B. Alreja, Hang Yang, Rachel YK Chang, Waiting Tai, Mengyu Li, Daniel C. Nelson, Warwick J Britton & Hak-Kim Chan. (2023) Bacteriophage endolysin powders for inhaled delivery against pulmonary infections. International Journal of Pharmaceutics 635, pages 122679.
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Tom Bellmann, Jana Thamm, Uwe Beekmann, Dana Kralisch & Dagmar Fischer. (2023) In situ Formation of Polymer Microparticles in Bacterial Nanocellulose Using Alternative and Sustainable Solvents to Incorporate Lipophilic Drugs. Pharmaceutics 15:2, pages 559.
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Mani Ordoubadi, Hui Wang & Reinhard Vehring. (2023) Mechanistic Formulation Design of Spray-Dried Powders. KONA Powder and Particle Journal 40:0, pages 149-171.
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Mahdieh Dagina Pedersen, Andrew Megarry, Kaisa Naelapää, Thomas Rades & Jenni Pessi. (2023) Enhancing tabletability of high-dose tablets by tailoring properties of spray-dried insulin particles. International Journal of Pharmaceutics 631, pages 122526.
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Fakhrossadat Emami, Mahsa Keihan Shokooh & Seyed Jamaleddin Mostafavi Yazdi. (2022) Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals. Journal of Pharmaceutical Investigation 53:1, pages 35-57.
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Cordin ArpagausCordin Arpagaus. 2023. Spray Drying of Vaccines. Spray Drying of Vaccines 531 589 .
Cordin ArpagausCordin Arpagaus. 2023. Spray Drying of Vaccines. Spray Drying of Vaccines 325 530 .
Denise Steiner, Leonie V. Schumann & Heike Bunjes. (2022) Processing of Lipid Nanodispersions into Solid Powders by Spray Drying. Pharmaceutics 14:11, pages 2464.
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Amerh Alahmadi & Anil Dmello. (2022) Detrimental Effects of Elevated Temperatures on the Structure and Activity of Phenylalanine Ammonia Lyase-Bovine Serum Albumin Mixtures and the Stabilizing Potential of Surfactant and Sugars. AAPS PharmSciTech 23:8.
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Harry W. Pan, Han Cong Seow, Jason C. K. Lo, Jinlin Guo, Lingqiao Zhu, Susan W. S. Leung, Chenghai Zhang & Jenny K. W. Lam. (2022) Spray-Dried and Spray-Freeze-Dried Powder Formulations of an Anti-Interleukin-4Rα Antibody for Pulmonary Delivery. Pharmaceutical Research 39:9, pages 2291-2304.
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Aaron O’Sullivan, Kevin M. Ryan & Luis Padrela. (2022) Production of biopharmaceutical dried-powders using supercritical CO2 technology. The Journal of Supercritical Fluids 187, pages 105645.
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Tuyen Thi Linh Nguyen, Thong Le Minh, Duong Quang Do & Ngoc-Van Thi Nguyen. (2022) Optimization of alcohol extraction and spray-drying conditions for efficient processing and quality evaluation of instant tea powder from lotus and green tea leaves. Pharmacia 69:3, pages 621-630.
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Daniela Fiedler, Carolina Alva, Joana T. Pinto, Martin Spoerk, Ramona Jeitler & Eva Roblegg. (2022) In-vial printing and drying of biologics as a personalizable approach. International Journal of Pharmaceutics 623, pages 121909.
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Carsten Grumbach & Peter Czermak. (2022) Process Analytical Technology for the Production of Parenteral Lipid Emulsions According to Good Manufacturing Practices. Processes 10:6, pages 1174.
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Nina Warner, Ilja Gasan Osojnik Črnivec, Vijay Kumar Rana, Menandro Cruz & Oren A. Scherman. (2022) A Platform Approach to Protein Encapsulates with Controllable Surface Chemistry. Molecules 27:7, pages 2197.
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Diana A. Fernandes, Eunice Costa, Paula Leandro & M. Luísa Corvo. (2022) Formulation of spray dried enzymes for dry powder inhalers: An integrated methodology. International Journal of Pharmaceutics 615, pages 121492.
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Andrea Milanesi, Francesco Rizzuto, Maurizio Rinaldi, Andrea Foglio Bonda, Lorena Segale & Lorella Giovannelli. (2022) Thermodynamic Balance vs. Computational Fluid Dynamics Approach for the Outlet Temperature Estimation of a Benchtop Spray Dryer. Pharmaceutics 14:2, pages 296.
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P. Martin-Salvador, T. De Beer & A. Kumar. 2022. 32nd European Symposium on Computer Aided Process Engineering. 32nd European Symposium on Computer Aided Process Engineering 259 264 .
Dave A. Miller, Daniel Ellenberger, Tiago Porfirio & Marco Gil. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 377 452 .
Clarinda Costa, Teresa Casimiro, Maria Luísa Corvo & Ana Aguiar-Ricardo. (2021) Solid Dosage Forms of Biopharmaceuticals in Drug Delivery Systems Using Sustainable Strategies. Molecules 26:24, pages 7653.
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Anca Filimon & Mihaela-Dorina Onofrei. (2021) New Insights on Solvent Implications in the Design of Materials Based on Cellulose Derivatives Using Experimental and Theoretical Approaches. Materials 14:21, pages 6627.
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Kimberly B. Shepard, David T. Vodak, Philip J. Kuehl, David Revelli, Yue Zhou, Amanda M. Pluntze, Molly S. Adam, Julia C. Oddo, Lauren Switala, Jonathan L. Cape, John M. Baumann & Michael Banks. (2021) Local Treatment of Non-small Cell Lung Cancer with a Spray-Dried Bevacizumab Formulation. AAPS PharmSciTech 22:7.
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