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Journal of Biomolecular Structure and Dynamics Volume 37, 2019 - Issue 15
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Research Article

Double-sides sticking mechanism of vinblastine interacting with α,β-tubulin to get activity against cancer cells

Xiaowen ZhouCollege of Chemical Science and Technology and Pharmacy, Key Laboratory of Education Ministry for Medicinal Chemistry of Natural Resource, Yunnan University, Kunming, P. R. ChinaView further author information
,
Zeren XuCollege of Chemical Science and Technology and Pharmacy, Key Laboratory of Education Ministry for Medicinal Chemistry of Natural Resource, Yunnan University, Kunming, P. R. ChinaView further author information
,
Aijing LiCollege of Chemical Science and Technology and Pharmacy, Key Laboratory of Education Ministry for Medicinal Chemistry of Natural Resource, Yunnan University, Kunming, P. R. ChinaView further author information
,
Zhengqiong ZhangCollege of Chemical Science and Technology and Pharmacy, Key Laboratory of Education Ministry for Medicinal Chemistry of Natural Resource, Yunnan University, Kunming, P. R. ChinaView further author information
&
Sichuan XuCollege of Chemical Science and Technology and Pharmacy, Key Laboratory of Education Ministry for Medicinal Chemistry of Natural Resource, Yunnan University, Kunming, P. R. ChinaCorrespondence[email protected]
View further author information
Pages 4080-4091 | Received 08 Jul 2018, Accepted 17 Oct 2018, Published online: 18 Nov 2018

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Bajarang Vasant Kumbhar & Vishwambhar Vishnu Bhandare. (2021) Exploring the interaction of Peloruside-A with drug resistant αβII and αβIII tubulin isotypes in human ovarian carcinoma using a molecular modeling approach. Journal of Biomolecular Structure and Dynamics 39:6, pages 1990-2002.
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Bajarang Vasant Kumbhar, Vishwambhar Vishnu Bhandare, Dulal Panda & Ambarish Kunwar. (2020) Delineating the interaction of combretastatin A-4 with αβ tubulin isotypes present in drug resistant human lung carcinoma using a molecular modeling approach. Journal of Biomolecular Structure and Dynamics 38:2, pages 426-438.
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Articles from other publishers (13)

Aditya Banyal, Shubham Tiwari, Aparajita Sharma, Ishita Chanana, Sanjay Kumar Singh Patel, Saurabh Kulshrestha & Pradeep Kumar. (2023) Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges. 3 Biotech 13:6.
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Helena Pérez-Peña, Anne-Catherine Abel, Maxim Shevelev, Andrea E. Prota, Stefano Pieraccini & Dragos Horvath. (2023) Computational Approaches to the Rational Design of Tubulin-Targeting Agents. Biomolecules 13:2, pages 285.
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José M. Palma, Francisco J. Corpas & Luciano Freschi. (2022) Editorial: Fruit ripening: From present knowledge to future development, Volume II. Frontiers in Plant Science 13.
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Priyanka Gopi, Shweta Singh, Md Maidul Islam, Akankasha Yadav, Neelima Gupta & Prateek Pandya. (2022) Thermodynamic and structural profiles of multi‐target binding of vinblastine in solution . Journal of Molecular Recognition 35:12.
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Rui Qin, Feng-Ming You, Qian Zhao, Xin Xie, Cheng Peng, Gu Zhan & Bo Han. (2022) Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets. Journal of Hematology & Oncology 15:1.
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Karma Yeshi, Darren Crayn, Edita Ritmejerytė & Phurpa Wangchuk. (2022) Plant Secondary Metabolites Produced in Response to Abiotic Stresses Has Potential Application in Pharmaceutical Product Development. Molecules 27:1, pages 313.
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Alejandro Soto-Ospina, Pedronel Araque Marín, Gabriel de Jesús Bedoya & Andrés Villegas Lanau. (2021) Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer’s Disease Mutations. Biochemistry Research International 2021, pages 1-20.
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Andrey V. Lyubimov, Dmitriy V. Cherkashin, Semen V. Efimov, Andrey E. Alanichev, Valeriy S. Ivanov & Gennadiy G. Kutelev. (2021) Mechanisms and triggers of adaptation to hypoxia. Reviews on Clinical Pharmacology and Drug Therapy 19:3, pages 269-280.
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Mengnan Zeng, Yingjie Ren, Beibei Zhang, Shengchao Wang, Meng Liu, Jufang Jia, Pengli Guo, Qinqin Zhang, Xiaoke Zheng & Weisheng Feng. (2021) In vitro Non-Small Cell Lung Cancer Inhibitory Effect by New Diphenylethane Isolated From Stems and Leaves of Dioscorea oppositifolia L. via ERβ-STAT3 Pathway. Frontiers in Pharmacology 12.
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Fatemeh Khaki-Khatibi, Mahdi Zeinali, Bahman Ramezani, Mehdi Sabzichi, Jamal Mohammadian & Hamed Hamishehkar. (2020) Harnessing WYE-132 as an inhibitor of the mTOR signaling enriches the cytotoxicity effect of vinblastine in B16F10 melanoma cancer cells. Process Biochemistry 99, pages 123-130.
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Kamil Nosol, Ksenija Romane, Rossitza N. Irobalieva, Amer AlamJulia Kowal, Naoya Fujita & Kaspar P. Locher. (2020) Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1. Proceedings of the National Academy of Sciences 117:42, pages 26245-26253.
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Gökçe Şeker Karatoprak, Esra Küpeli Akkol, Yasin Genç, Hilal Bardakcı, Çiğdem Yücel & Eduardo Sobarzo-Sánchez. (2020) Combretastatins: An Overview of Structure, Probable Mechanisms of Action and Potential Applications. Molecules 25:11, pages 2560.
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Zhengqiong Zhang, Chengqi Lu, Pei Wang, Aijing Li, Hongbo Zhang & Sichuan Xu. (2019) Structural Basis and Mechanism for Vindoline Dimers Interacting with α,β-Tubulin. ACS Omega 4:7, pages 11938-11948.
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