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REVIEW ARTICLE

Findings and implications of the Study on COgnition and Prognosis in the Elderly (SCOPE) – A review

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Pages 71-79 | Published online: 08 Jul 2009

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Maria G. Pavlatou, George Mastorakos, Ioannis Lekakis, Stavros Liatis, Georgia Vamvakou, Emmanuel Zoumakis, Ioannis Papassotiriou, Andreas D. Rabavilas, Nikolaos Katsilambros & George P. Chrousos. (2008) Chronic administration of an angiotensin II receptor antagonist resets the hypothalamic–pituitary–adrenal (HPA) axis and improves the affect of patients with diabetes mellitus type 2: Preliminary results. Stress 11:1, pages 62-72.
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F. Bompaire, C. Birzu, K. Bihan, V. Desestret, G. Fargeot, A. Farina, B. Joubert, D. Leclercq, L. Nichelli, A. Picca, C. Tafani, N. Weiss, D. Psimaras & D. Ricard. (2023) Advances in treatments of patients with classical and emergent neurological toxicities of anticancer agents. Revue Neurologique 179:5, pages 405-416.
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Marco Antônio Peliky Fontes, Lucas M. Kangussu & Ana Cristina Simões-e-Silva. 2023. Angiotensin. Angiotensin 623 640 .
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Michelle Canavan & Martin J. O'Donnell. (2022) Hypertension and Cognitive Impairment: A Review of Mechanisms and Key Concepts. Frontiers in Neurology 13.
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Juan M. Saavedra. (2021) Angiotensin Receptor Blockers Are Not Just for Hypertension Anymore. Physiology 36:3, pages 160-173.
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Ehab Farag, Chen Liang, Edward J. Mascha, Maged Y. Argalious, Jacob Ezell, Kamal Maheshwari, Wael Ali Sakr Esa, Christopher A. Troianos & Daniel I. Sessler. (2020) Association between Use of Angiotensin-converting Enzyme Inhibitors or Angiotensin Receptor Blockers and Postoperative Delirium. Anesthesiology 133:1, pages 119-132.
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Abdel G. Elkahloun & Juan M. Saavedra. (2019) Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis. Molecular Neurobiology 57:3, pages 1656-1673.
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Keren Asraf, Nofar Torika, Ron N. Apte & Sigal Fleisher-Berkovich. (2018) Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies. Frontiers in Cellular Neuroscience 12.
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Urmila Aswar, Shilpa Chepurwar, Sumit Shintre & Manoj Aswar. (2017) Telmisartan attenuates diabetes induced depression in rats. Pharmacological Reports 69:2, pages 358-364.
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I. Sebastião, E. Candeias, M. S. Santos, C. R. Oliveira, Paula I. Moreira & Ana I. Duarte. 2017. Neuroprotective Therapy for Stroke and Ischemic Disease. Neuroprotective Therapy for Stroke and Ischemic Disease 711 731 .
Juan M. Saavedra. (2016) Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer’s Disease. Cellular and Molecular Neurobiology 36:2, pages 259-279.
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Xiu-Li Yang, Chi Kyung Kim, Tae Jung Kim, Jing Sun, Doeun Rim, Young-Ju Kim, Sang-Bae Ko, Hyunduk Jang & Byung-Woo Yoon. (2015) Anti-inflammatory effects of fimasartan via Akt, ERK, and NFκB pathways on astrocytes stimulated by hemolysate. Inflammation Research 65:2, pages 115-123.
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Sonia Villapol, María G. Balarezo, Kwame Affram, Juan M. Saavedra & Aviva J. Symes. (2015) Neurorestoration after traumatic brain injury through angiotensin II receptor blockage. Brain 138:11, pages 3299-3315.
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Sonia Villapol & Juan M. Saavedra. (2015) Neuroprotective Effects of Angiotensin Receptor Blockers. American Journal of Hypertension 28:3, pages 289-299.
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John W. Wright, Leen H. Kawas & Joseph W. Harding. (2015) The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases. Progress in Neurobiology 125, pages 26-46.
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Astrid G. HornslienElse C. SandsetPhilip M. BathTorgeir B. WyllerEivind Berge. (2013) Effects of Candesartan in Acute Stroke on Cognitive Function and Quality of Life. Stroke 44:7, pages 2022-2024.
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Sonia Villapol, Alexandra K Yaszemski, Trevor T Logan, Enrique Sánchez-Lemus, Juan M Saavedra & Aviva J Symes. (2012) Candesartan, an Angiotensin II AT1-Receptor Blocker and PPAR-γ Agonist, Reduces Lesion Volume and Improves Motor and Memory Function After Traumatic Brain Injury in Mice. Neuropsychopharmacology 37:13, pages 2817-2829.
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Juan M. Saavedra. (2012) Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders. Clinical Science 123:10, pages 567-590.
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Juan M. Saavedra. (2011) Angiotensin II AT1 Receptor Blockers Ameliorate Inflammatory Stress: A Beneficial Effect for the Treatment of Brain Disorders. Cellular and Molecular Neurobiology 32:5, pages 667-681.
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Hanna Andersson & Mathias Hallberg. (2012) Discovery of Inhibitors of Insulin-Regulated Aminopeptidase as Cognitive Enhancers. International Journal of Hypertension 2012, pages 1-18.
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Juan M. Saavedra, Enrique Sánchez-Lemus & Julius Benicky. (2011) Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications. Psychoneuroendocrinology 36:1, pages 1-18.
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Dina Zekry & Gabriel Gold. (2010) Management of Mixed Dementia. Drugs & Aging 27:9, pages 715-728.
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Reinhard Ketelhut & Peter Bramlage. (2012) Candesartan Cilexetil/Hydrochlorothiazide Treatment in High-Risk Patients with Type 2 Diabetes Mellitus and Microalbuminuria. Clinical Drug Investigation 30:5, pages 301-311.
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Peter Bramlage, Eleonore Schönrock & Peter Odoj. (2008) Metabolic effects of an AT1-receptor blockade combined with HCTZ in cardiac risk patients: a non interventional study in primary care. BMC Cardiovascular Disorders 8:1.
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John W WrightJoseph W Harding. (2008) The angiotensin AT 4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer's disease . Journal of the Renin-Angiotensin-Aldosterone System 9:4, pages 226-237.
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Jan W. ErikssonPer-Anders JanssonBo CarlbergAnders HäggLisa KurlandMaria K. SvenssonHåkan AhlströmConny StrömLars LönnKristina ÖjbrandtLars JohanssonLars Lind. (2008) Hydrochlorothiazide, but not Candesartan, Aggravates Insulin Resistance and Causes Visceral and Hepatic Fat Accumulation. Hypertension 52:6, pages 1030-1037.
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E. Kim, M. H. Cho, K. R. Cha, J. S. Park, C-W. Ahn, B. H. Oh & C-H. Kim. (2008) Interactive effect of central obesity and hypertension on cognitive function in older out-patients with Type 2 diabetes. Diabetic Medicine 25:12, pages 1440-1446.
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Mehmet Ozaydin, Ozkan Dede, Ercan Varol, Sahin Kapan, Yasin Turker, Oktay Peker, Harun Duver & Erdogan Ibrisim. (2008) Effect of renin–angiotensin aldosteron system blockers on postoperative atrial fibrillation. International Journal of Cardiology 127:3, pages 362-367.
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K. Sakakura, S. Hoshide, J. Ishikawa, S.-i. Momomura, M. Kawakami, K. Shimada & K. Kario. (2008) Association of Body Mass Index With Cognitive Function in Elderly Hypertensive Japanese. American Journal of Hypertension 21:6, pages 627-632.
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V. H. Taylor & G. M. MacQueen. (2007) Cognitive dysfunction associated with metabolic syndrome. Obesity Reviews 8:5, pages 409-418.
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G.K. Aulakh, R.K. Sodhi & M. Singh. (2007) An update on non-peptide angiotensin receptor antagonists and related RAAS modulators. Life Sciences 81:8, pages 615-639.
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Patricio López-Jaramillo, Lina P Pradilla, Vicente Lahera, Federico A Silva Sieger, Christian F Rueda-Clausen & Gustavo A Márquez. (2006) A randomized, double blind, cross-over, placebo-controlled clinical trial to assess the effects of Candesartan on the insulin sensitivity on non diabetic, non hypertense subjects with dysglyce mia and abdominal obesity. "ARAMIA". Trials 7:1.
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Karen Ritchie & Florence Portet. (2006) ‘I think therefore I am’: improving cognition. Current Opinion in Psychiatry 19:6, pages 570-574.
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Greg L Plosker & Susan J Keam. (2006) Candesartan Cilexetil. PharmacoEconomics 24:12, pages 1249-1272.
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