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ORIGINAL ARTICLE

Dose‐dependent lowering of blood pressure by dairy peptides in mildly hypertensive subjects

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Pages 44-50 | Received 16 Oct 2008, Published online: 08 Jul 2009

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Muhammad Zohaib Aslam, Shumaila Firdos, Li Zhousi, Xiang Wang, Yangtai Liu, Xiaojie Qin, Shuo Yang, Yue Ma, Bolin Zhang & Qingli Dong. (2022) Managing hypertension by exploiting microelements and fermented dairy products. CyTA - Journal of Food 20:1, pages 327-342.
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Brij Pal Singh, Rotimi E. Aluko, Subrota Hati & Divyang Solanki. (2022) Bioactive peptides in the management of lifestyle-related diseases: Current trends and future perspectives. Critical Reviews in Food Science and Nutrition 62:17, pages 4593-4606.
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Zuhaib Fayaz Bhat, Sunil Kumar & Hina Fayaz Bhat. (2017) Antihypertensive peptides of animal origin: A review. Critical Reviews in Food Science and Nutrition 57:3, pages 566-578.
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Anu M. Turpeinen, Salme Järvenpää, Hannu Kautiainen, Riitta Korpela & Heikki Vapaatalo. (2013) Antihypertensive effects of bioactive tripeptides—a random effects meta-analysis. Annals of Medicine 45:1, pages 51-56.
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Articles from other publishers (38)

Rami M. Althnaibat, Heather L. Bruce, Jianping Wu & Michael G. Gänzle. (2023) Bioactive peptides in hydrolysates of bovine and camel milk proteins: A review of studies on peptides that reduce blood pressure, improve glucose homeostasis, and inhibit pathogen adhesion. Food Research International, pages 113748.
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Vera D’Amico, Michael Gänzle, Lisa Call, Benjamin Zwirzitz, Heinrich Grausgruber, Stefano D’Amico & Fred Brouns. (2023) Does sourdough bread provide clinically relevant health benefits?. Frontiers in Nutrition 10.
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Pauline Duffuler, Khushwant S. Bhullar, Stepheny C. de Campos Zani & Jianping Wu. (2022) Bioactive Peptides: From Basic Research to Clinical Trials and Commercialization. Journal of Agricultural and Food Chemistry 70:12, pages 3585-3595.
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Arby'in Pratiwi, Thoyib R. HakimMohammad Z. Abidin, Nanung A. Fitriyanto, Jamhari JamhariRusman RusmanYuny Erwanto. (2021) Angiotensin-converting enzyme inhibitor activity of peptides derived from Kacang goat skin collagen through thermolysin hydrolysis. Veterinary World 14:1, pages 161-167.
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Dino Demirovic Holmquist. 2021. Nutrition, Food and Diet in Ageing and Longevity. Nutrition, Food and Diet in Ageing and Longevity 193 198 .
Min Shi, Michael L. Mathai, Guoqin Xu, Andrew J. McAinch & Xiao Q. Su. (2019) The effects of supplementation with blueberry, cyanidin-3-O-β-glucoside, yoghurt and its peptides on obesity and related comorbidities in a diet-induced obese mouse model. Journal of Functional Foods 56, pages 92-101.
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Alberto Lana, Jose R. Banegas, Pilar Guallar-Castillón, Fernando Rodríguez-Artalejo & Esther Lopez-Garcia. (2018) Association of Dairy Consumption and 24-Hour Blood Pressure in Older Adults with Hypertension. The American Journal of Medicine 131:10, pages 1238-1249.
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John P. Gleeson, Jesús M. Frías, Sinéad M. Ryan & David J. Brayden. (2018) Sodium caprate enables the blood pressure-lowering effect of Ile-Pro-Pro and Leu-Lys-Pro in spontaneously hypertensive rats by indirectly overcoming PepT1 inhibition. European Journal of Pharmaceutics and Biopharmaceutics 128, pages 179-187.
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Li Chen, Qiuhong Zhang, Zhe Ji, Guowei Shu & He Chen. (2018) Production and fermentation characteristics of angiotensin-I-converting enzyme inhibitory peptides of goat milk fermented by a novel wild Lactobacillus plantarum 69. LWT 91, pages 532-540.
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B. Miralles, B. Hernández-Ledesma, S. Fernández-Tomé, L. Amigo & I. Recio. 2018. Proteins in Food Processing. Proteins in Food Processing 523 568 .
Alice B. Nongonierma & Richard J. FitzGerald. (2017) Strategies for the discovery and identification of food protein-derived biologically active peptides. Trends in Food Science & Technology 69, pages 289-305.
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Steffi Rudolph, Diana Lunow, Susanne Kaiser & Thomas Henle. (2017) Identification and quantification of ACE-inhibiting peptides in enzymatic hydrolysates of plant proteins. Food Chemistry 224, pages 19-25.
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Marette André, Picard-Deland Éliane & Fernandez Melissa Anne. 2017. Yogurt: Roles in Nutrition and Impacts on Health. Yogurt: Roles in Nutrition and Impacts on Health 81 88 .
Billie K. Alba, Anna E. Stanhewicz, W. Larry Kenney & Lacy M. Alexander. (2016) Acute dairy milk ingestion does not improve nitric oxide-dependent vasodilation in the cutaneous microcirculation. British Journal of Nutrition 116:2, pages 204-210.
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Gabriella A. M. Ten Have, Pieter C. van der Pijl, Arie K. Kies & Nicolaas E. P. Deutz. (2015) Enhanced Lacto-Tri-Peptide Bio-Availability by Co-Ingestion of Macronutrients. PLOS ONE 10:6, pages e0130638.
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Ágnes Fekete, D. Givens & Julie Lovegrove. (2015) Casein-Derived Lactotripeptides Reduce Systolic and Diastolic Blood Pressure in a Meta-Analysis of Randomised Clinical Trials. Nutrients 7:1, pages 659-681.
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A. Pihlanto & H. Korhonen. 2015. Advances in Fermented Foods and Beverages. Advances in Fermented Foods and Beverages 39 74 .
Yongfu Chen, Wenjun Liu, Jiangang Xue, Jie Yang, Xia Chen, Yuyu Shao, Lai-yu Kwok, Menghe Bilige, Lai Mang & Heping Zhang. (2014) Angiotensin-converting enzyme inhibitory activity of Lactobacillus helveticus strains from traditional fermented dairy foods and antihypertensive effect of fermented milk of strain H9. Journal of Dairy Science 97:11, pages 6680-6692.
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Hannu J. Korhonen & Pertti Marnila. 2013. Milk and Dairy Products in Human Nutrition. Milk and Dairy Products in Human Nutrition 148 171 .
A. F. G. Cicero, F. Aubin, V. Azais-Braesco & C. Borghi. (2013) Do the Lactotripeptides Isoleucine-Proline-Proline and Valine-Proline-Proline Reduce Systolic Blood Pressure in European Subjects? A Meta-Analysis of Randomized Controlled Trials. American Journal of Hypertension 26:3, pages 442-449.
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William J. Elliott. 2013. Hypertension: A Companion to Braunwald’s Heart Disease. Hypertension: A Companion to Braunwald’s Heart Disease 226 229 .
Glen S. Patten, Mahinda Y. Abeywardena, Richard J. Head & Louise E. Bennett. (2012) Processed dietary plants demonstrate broad capacity for angiotensin converting enzyme and angiotensin II receptor binding inhibition in vitro. Journal of Functional Foods 4:4, pages 851-863.
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. (2012) Scientific Opinion on the substantiation of health claims related to isoleucine‐proline‐proline (IPP) and valine‐proline‐proline (VPP) and maintenance of normal blood pressure (ID 661, 1831, 1832, 2891, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 10:6.
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Lotte Usinger, Christina Reimer & Hans Ibsen. (2012) Fermented milk for hypertension. Cochrane Database of Systematic Reviews.
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Ignacio Ricci-Cabello, Manuel Olalla Herrera & Reyes Artacho. (2012) Possible role of milk-derived bioactive peptides in the treatment and prevention of metabolic syndrome. Nutrition Reviews 70:4, pages 241-255.
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. (2011) Scientific Opinion on the substantiation of a health claim related to isoleucyl‐prolyl‐proline (IPP) and valyl‐prolyl‐proline (VPP) and maintenance of normal blood pressure pursuant to Article 13(5) of Regulation (EC) No 1924/2006. EFSA Journal 9:9.
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C. Muro UristaR. Álvarez Fernández, F. Riera Rodriguez, A. Arana Cuenca & A. Téllez Jurado. (2011) Review: Production and functionality of active peptides from milk. Food Science and Technology International 17:4, pages 293-317.
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Mary M. McGrane, Eve Essery, Julie Obbagy, Joan Lyon, Patricia MacNeil, Joanne Spahn & Linda Van Horn. (2011) Dairy Consumption, Blood Pressure, and Risk of Hypertension: An Evidence-Based Review of Recent Literature. Current Cardiovascular Risk Reports 5:4, pages 287-298.
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A F G Cicero, B Gerocarni, L Laghi & C Borghi. (2010) Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials. Journal of Human Hypertension 25:7, pages 425-436.
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H.J. Korhonen. 2011. Functional Foods. Functional Foods 471 511 .
Martha Phelan & David Kerins. (2011) The potential role of milk-derived peptides in cardiovascular disease. Food & Function 2:3-4, pages 153.
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Ravinder Nagpal, Pradip Behare, Rajiv Rana, Ashwani Kumar, Manoj Kumar, Sanu Arora, Fransesco Morotta, Shalini Jain & Hariom Yadav. (2011) Bioactive peptides derived from milk proteins and their health beneficial potentials: an update. Food Funct. 2:1, pages 18-27.
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Esther Boelsma & Joris Kloek. (2010) IPP-rich milk protein hydrolysate lowers blood pressure in subjects with stage 1 hypertension, a randomized controlled trial. Nutrition Journal 9:1.
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María del Mar Contreras, Beatriz Gómez-Sala, Pedro Jesús Martín-Álvarez, Lourdes Amigo, Mercedes Ramos & Isidra Recio. (2010) Monitoring the large-scale production of the antihypertensive peptides RYLGY and AYFYPEL by HPLC-MS. Analytical and Bioanalytical Chemistry 397:7, pages 2825-2832.
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Johanna M Geleijnse & Marielle F Engberink. (2010) Lactopeptides and human blood pressure. Current Opinion in Lipidology 21:1, pages 58-63.
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Pauliina Jäkälä & Heikki Vapaatalo. (2010) Antihypertensive Peptides from Milk Proteins. Pharmaceuticals 3:1, pages 251-272.
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. (2009) Scientific Opinion on the substantiation of health claims related to isoleucine-proline-proline (IPP) and valine-proline-proline (VPP) and maintenance of normal blood pressure (ID 615, 661, 1831, 1832, 2891), and maintenance of the elastic properties of t. EFSA Journal 7:10, pages 1259.
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Pauliina Jäkälä, Anne Hakala, Anu M. Turpeinen, Riitta Korpela & Heikki Vapaatalo. (2009) Casein-derived bioactive tripeptides Ile-Pro-Pro and Val-Pro-Pro attenuate the development of hypertension and improve endothelial function in salt-loaded Goto–Kakizaki rats. Journal of Functional Foods 1:4, pages 366-374.
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