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International Reviews of Immunology Volume 28, 2009 - Issue 5
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HIV-1 Tat-Based Vaccines: An Overview and Perspectives in the Field of HIV/AIDS Vaccine Development

Antonella Caputo Department of Histology, Microbiology and Medical Biotechnology, University of Padova, Padova, Italy
,
Riccardo Gavioli Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
,
Stefania Bellino National AIDS Center, Istituto Superiore di Sanità, Roma, Italy
,
Olimpia Longo National AIDS Center, Istituto Superiore di Sanità, Roma, Italy
,
Antonella Tripiciano San Gallicano Hospital, Istituti Fisioterapici Ospitalieri, Rome, Italy
,
Vittorio Francavilla San Gallicano Hospital, Istituti Fisioterapici Ospitalieri, Rome, Italy
,
Cecilia Sgadari National AIDS Center, Istituto Superiore di Sanità, Roma, Italy
,
Giovanni Paniccia San Gallicano Hospital, Istituti Fisioterapici Ospitalieri, Rome, Italy
,
Fausto Titti National AIDS Center, Istituto Superiore di Sanità, Roma, Italy
,
Aurelio Cafaro National AIDS Center, Istituto Superiore di Sanità, Roma, Italy
,
Flavia Ferrantelli National AIDS Center, Istituto Superiore di Sanità, Roma, Italy
,
Paolo Monini National AIDS Center, Istituto Superiore di Sanità, Roma, Italy
,
Fabrizio Ensoli San Gallicano Hospital, Istituti Fisioterapici Ospitalieri, Rome, Italy
&
Barbara Ensoli National AIDS Center, Istituto Superiore di Sanità, Roma, Italy
 show all
Pages 285-334 | Published online: 09 Sep 2009

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Valentina Finessi, Francesco Nicoli, Eleonora Gallerani, Fabio Sforza, Mariaconcetta Sicurella, Aurelio Cafaro, Antonella Caputo, Barbara Ensoli & Riccardo Gavioli. (2015) Effects of different routes of administration on the immunogenicity of the Tat protein and a Tat-derived peptide. Human Vaccines & Immunotherapeutics 11:6, pages 1489-1493.
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Anna Maria Luzi, Pietro Gallo, Anna Colucci, Simone Marcotullio, Stefania Bellino, Olimpia Longo & Barbara Ensoli. (2011) Communication, recruitment and enrolment in the preventative and therapeutic phase I clinical trial against HIV/AIDS based on the recombinant HIV-1 Tat protein. AIDS Care 23:8, pages 939-946.
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Articles from other publishers (28)

Barton F. Haynes, Kevin Wiehe, Priyamvada Acharya & Kevin O. Saunders. 2023. Plotkin's Vaccines. Plotkin's Vaccines 458 483.e15 .
Mehrdad Alemi, Fatemeh Kamali, Rouhollah Vahabpour Roudsari, Zahra Hajimahdi & Afshin Zarghi. (2022) Synthesis, Biological Evaluation, and Molecular Modeling Studies of New 8-methyl-4-oxo-1,4-dihydroquinoline-3-carbohydrazides as Potential Anti-HIV Agents. Iranian Journal of Pharmaceutical Research 21:1.
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Francesco Nicoli, Eleonora Gallerani, Mariaconcetta Sicurella, Salvatore Pacifico, Aurelio Cafaro, Barbara Ensoli, Peggy Marconi, Antonella Caputo & Riccardo Gavioli. (2020) The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation. Vaccines 8:2, pages 274.
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Samira Alipour & Atiyeh Mahdavi. (2020) Boosting Tat DNA vaccine with Tat protein stimulates strong cellular and humoral immune responses in mice. Biotechnology Letters.
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Marc H V Van RegenmortelMarc H V Van Regenmortel. 2019. HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design. HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design 163 188 .
Zeinab Panahi, Asghar Abdoli, Ghasem Mosayebi, Mehdi Mahdavi & Fariborz Bahrami. (2018) Subcutaneous administration CpG-ODNs acts as a potent adjuvant for an HIV-1-tat-based vaccine candidate to elicit cellular immunity in BALB/c mice. Biotechnology Letters 40:3, pages 527-533.
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Marc P. Girard & Wayne C. Koff. 2018. Plotkin's Vaccines. Plotkin's Vaccines 400 429.e25 .
Evan Clark, Brenda Nava & Massimo Caputi. (2017) Tat is a multifunctional viral protein that modulates cellular gene expression and functions. Oncotarget 8:16, pages 27569-27581.
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Samira Alipour, Atiyeh Mahdavi & Asghar Abdoli. (2017) The effects of CpG-ODNs and Chitosan adjuvants on the elicitation of immune responses induced by the HIV-1-Tat-based candidate vaccines in mice. Pathogens and Disease 75:2.
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Aizhang Xu, Jie Wu, Yufeng Xie, Rajni Chibbar, Andrew Fleywald & Jim Xiang. (2017) The Tat Protein Enhances CTL Responses and Therapeutic Immunity of Gag-Specific Exosome-Targeted T Cell-Based Gag/Tat-Texo Vaccine in Transgenic HLA-A2 Mice. World Journal of Vaccines 07:02, pages 11-25.
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Francesco Nicoli, Mkunde Chachage, Petra Clowes, Asli Bauer, Dickens Kowour, Barbara Ensoli, Aurelio Cafaro, Leonard Maboko, Michael Hoelscher, Riccardo Gavioli, Elmar Saathoff & Christof Geldmacher. (2016) Association between different anti-Tat antibody isotypes and HIV disease progression: data from an African cohort. BMC Infectious Diseases 16:1.
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Guannan Geng, Bingfeng Liu, Cancan Chen, Kang Wu, Jun Liu, Yijun Zhang, Ting Pan, Jun Li, Yue Yin, Junsong Zhang, Feng Huang, Fei Yu, Jingliang Chen, Xiancai Ma, Jie Zhou, Ersheng Kuang, Chao Liu, Weiping Cai & Hui Zhang. (2016) Development of an Attenuated Tat Protein as a Highly-effective Agent to Specifically Activate HIV-1 Latency. Molecular Therapy 24:9, pages 1528-1537.
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Khamis Tomusange, Danushka Wijesundara, Jason Gummow, Tamsin Garrod, Yanrui Li, Lachlan Gray, Melissa Churchill, Branka Grubor-Bauk & Eric J. Gowans. (2016) A HIV-Tat/C4-binding protein chimera encoded by a DNA vaccine is highly immunogenic and contains acute EcoHIV infection in mice. Scientific Reports 6:1.
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Sonia Mediouni, Maria Cecilia Garibaldi Marcondes, Courtney Miller, Jay P. McLaughlin & Susana T. Valente. (2015) The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders. Frontiers in Microbiology 6.
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Timothy R. FoutsKenneth BagleyIlia J. PradoKathryn L. BobbJennifer A. SchwartzRong XuRobert J. ZagurskyMichael A. EganJohn H. EldridgeCelia C. LaBrancheDavid C. MontefioriHélène Le BuanecDaniel ZaguryRanajit PalGeorge N. PavlakisBarbara K. FelberGenoveffa Franchini, Shari Gordon, Monica Vaccari, George K. Lewis, Anthony L. DeVico & Robert C. Gallo. (2015) Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection. Proceedings of the National Academy of Sciences 112:9.
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Mariaconcetta Sicurella, Francesco Nicoli, Eleonora Gallerani, Ilaria Volpi, Elena Berto, Valentina Finessi, Federica Destro, Roberto Manservigi, Aurelio Cafaro, Barbara Ensoli, Antonella Caputo, Riccardo Gavioli & Peggy C. Marconi. (2014) An Attenuated Herpes Simplex Virus Type 1 (HSV1) Encoding the HIV-1 Tat Protein Protects Mice from a Deadly Mucosal HSV1 Challenge. PLoS ONE 9:7, pages e100844.
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Francesco Nicoli, Valentina Finessi, Mariaconcetta Sicurella, Lara Rizzotto, Eleonora Gallerani, Federica Destro, Aurelio Cafaro, Peggy Marconi, Antonella Caputo, Barbara Ensoli & Riccardo Gavioli. (2013) The HIV-1 Tat Protein Induces the Activation of CD8+ T Cells and Affects In Vivo the Magnitude and Kinetics of Antiviral Responses. PLoS ONE 8:11, pages e77746.
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José Esparza. (2013) A brief history of the global effort to develop a preventive HIV vaccine. Vaccine 31:35, pages 3502-3518.
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Thorsten Demberg, Egidio Brocca-Cofano, Seraphin Kuate, Stanley Aladi, Diego A. Vargas-Inchaustegui, David Venzon, Irene Kalisz, V.S. Kalyanaraman, Eun Mi Lee, Ranajit Pal, Janet DiPasquale, Ruth M. Ruprecht, David C. Montefiori, Indresh Srivastava, Susan W. Barnett & Marjorie Robert-Guroff. (2013) Impact of antibody quality and anamnestic response on viremia control post-challenge in a combined Tat/Env vaccine regimen in rhesus macaques. Virology 440:2, pages 210-221.
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Barbara C. Bachler, Michael Humbert, Brisa Palikuqi, Nagadenahalli B. Siddappa, Samir K. Lakhashe, Robert A. Rasmussen & Ruth M. Ruprecht. (2013) Novel Biopanning Strategy To Identify Epitopes Associated with Vaccine Protection. Journal of Virology 87:8, pages 4403-4416.
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Marc P. Girard & Wayne C. Koff. 2013. Vaccines. Vaccines 1097 1121 .
Phyllis J. Kanki. 2013. Infectious Diseases. Infectious Diseases 27 62 .
Marc H. V. Van Regenmortel. (2011) Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine. Archives of Virology 157:1, pages 1-20.
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Phyllis J. Kanki. 2012. Encyclopedia of Sustainability Science and Technology. Encyclopedia of Sustainability Science and Technology 4996 5020 .
Alessandra Fraternale, Maria Filomena Paoletti, Sabrina Dominici, Costantina Buondelmonte, Antonella Caputo, Arianna Castaldello, Antonella Tripiciano, Aurelio Cafaro, Anna Teresa Palamara, Rossella Sgarbanti, Enrico Garaci, Barbara Ensoli & Mauro Magnani. (2011) Modulation of Th1/Th2 immune responses to HIV-1 Tat by new pro-GSH molecules. Vaccine 29:40, pages 6823-6829.
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Marc P. Girard, Saladin Osmanov, Olga M. Assossou & Marie-Paule Kieny. (2011) Human immunodeficiency virus (HIV) immunopathogenesis and vaccine development: A review. Vaccine 29:37, pages 6191-6218.
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Jennifer Serrière, Jean-Marc Dugua, Marc Bossus, Bernard Verrier, Richard Haser, Patrice Gouet & Christophe Guillon. (2011) Fab′-Induced Folding of Antigenic N-Terminal Peptides from Intrinsically Disordered HIV-1 Tat Revealed by X-ray Crystallography. Journal of Molecular Biology 405:1, pages 33-42.
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Alessandra Fraternale, Maria Filomena Paoletti, Sabrina Dominici, Antonella Caputo, Arianna Castaldello, Enrico Millo, Egidio Brocca-Cofano, Michaël Smietana, Pascal Clayette, Joël Oiry, Umberto Benatti & Mauro Magnani. (2010) The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice. Vaccine 28:48, pages 7676-7682.
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